4.8 Article

Multitheragnostic Multi-GNRs Crystal-Seeded Magnetic Nanoseaurchin for Enhanced In Vivo Mesenchymal-Stem-Cell Homing, Multimodal Imaging, and Stroke Therapy

期刊

ADVANCED MATERIALS
卷 27, 期 41, 页码 6488-+

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201502784

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资金

  1. Chen-Han Foundation for Education
  2. Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence [MOHW104-TDU-B-212-113002]
  3. China Medical University Hospital, Academia Sinica Taiwan Biobank, Stroke Biosignature Project [BM104010092]
  4. NRPB Stroke Clinical Trial Consortium [MOST 104-2325-B-039-005]
  5. Tseng-Lien Lin Foundation, Taichung, Taiwan
  6. Taiwan Brain Disease Foundation, Taipei, Taiwan
  7. Katsuzo and Kiyo Aoshima Memorial Funds, Japan
  8. Topnotch Stroke Research Center (China Medical University) [CMU98-CT-24, CMU98-CT-32]
  9. National Chiao Tung University (NCTU)
  10. Ministry of Science and Technology of the Republic of China, Taiwan [NSC97-2314-B-039-036-MY3, NSC99-2632-B-039-001-MY3, NSC100-2314-B-039-002-MY3, NSC101-2321-B-039-004, NSC101-2321-B-039-006, NSC101-2321-B-039-008, NSC102-2325-B-039-006, NSC102-2325-B-039-001, NSC102-2221-E-007-012-MY3, MOST 102-2221-E-010-011-MY3, MOST 104-2632-B-039-002, MOST 102-2221-E-009- 023-MY3]
  11. Aim for the Top University program of the National Chiao Tung University
  12. Ministry of Education, Taiwan, Republic of China
  13. Ministry of Education [MOE2014-T2-2-145]

向作者/读者索取更多资源

A multifunctional nanoseaurchin probe in which mesoporous silica nanobeads with iron oxide nanoparticles embedded and multi-gold nanorods crystal-seeded are fabricated and labeled with umbilical cord mesenchymal stem cells through endocytosis. This nanoplatform enables efficient magnetic remote-controlled guiding for stem cell homing, and provides dual modalities of photoacoustic imaging and magnetic resonance imaging for in situ tracking and long-term monitoring to achieve therapeutic efficacy.

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