期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 632, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.122571
关键词
Paediatric; Unpleasant drug; Taste masking; Multiparticulate system
Taste refers to the perception of sensations through taste buds, and the unpleasant taste of drugs can lead to refusal of medication in pediatric patients. The acceptability of pharmaceutical products is influenced by a variety of factors, including swallowability, palatability, appearance, ease of administration, and patient characteristics. Multiparticulate dosage forms provide a solution for pediatric patients who struggle with swallowing and the unpleasant taste of medications. This review provides insights into the considerations for preparing taste masked multiparticulate dosage forms for pediatric use.
Taste refers to those sensations perceived through taste buds on the tongue and oral cavity. The unpleasant taste of drugs leads to the refusal of taking the medicine in the paediatric population. It is widely known that a pharmaceutical product's general acceptability is the result of numerous contributing components such as swallowability, palatability (taste, flavour, texture, and mouthfeel), appearance, ease of administration, and patient characteristics. Multiparticulate as a dosage form is a platform technology for overcoming paediatrics' incapacity to swallow monolithic dosage forms, masking many medications' inherent nasty taste, and over-coming the obstacles of manufacturing a commercially taste masked dosage form. This review will discuss the considerations that must be taken into account to prepare taste masked multiparticulate dosage forms in the best way for paediatric use.
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