Use of low-field NMR and rheology to evaluate the microstructure and stability of a poly(D,L-lactide-co-glycolide)-based W/O emulsion to be processed by spray drying

Drug-loaded emulsions for spray drying should be optimised for their rheological behaviour and stability under operating conditions, as this is essential for achieving the desired physicochemical properties of the final dry product. Our aim was therefore to investigate the structure and stability of a water-in-oil (W/O) emulsion containing vancomycin hydrochloride as the active ingredient in the aqueous phase, poly(D,L-lactide-co-glyco-lide) as the structural polymer in the dichloromethane-based organic phase, and various stabilisers using low-field nuclear magnetic resonance (LF NMR) and rheological characterisation. Four emulsions were tested, namely-one without stabiliser, one with Poloxamer (R) 407, one with chitosan and SpanTM 80 and one with chi-tosan only. The theoretical interpretation of the rheological data allowed the determination of the velocity and the shear rate/stress profiles inside the feed path of the W/O emulsion, aspects that are critical for the industrial scale-up of the emulsion drying process. In addition, LF NMR demonstrated that shaking was sufficient to restore the original emulsion structure and that the droplet size of all emulsions was in the range of 1-10 mu m, although the emulsion with chitosan had the narrowest droplet size distribution and the higher zero shear viscosity, which accounts for the increased long-term stability due to impeded droplets movement.

Automated summary

Drug-loaded emulsions for spray drying need to be optimized for their rheological behavior and stability. The study investigated the structure and stability of a water-in-oil emulsion containing vancomycin hydrochloride as the active ingredient. The addition of chitosan improved the long-term stability of the emulsion, and rheological data provided information about the velocity and shear rate/stress profiles during the spray drying process.