期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 630, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2022.122439
关键词
NIR-II; Immune response; Gold nanoclusters; Nitric oxide
This study developed hydrophobic photoluminescent polymeric nanoparticles and investigated their interaction with macrophages. The nanoparticles were efficiently engulfed by macrophages and showed anti-inflammatory properties when activated, making them potentially useful for treating inflammatory diseases.
Polymeric nanoparticles (NPs) are extremely promising for theranostic applications. However, their interest depends largely on their interactions with immune system, including the capacity to activate inflammation after their capture by macrophages. In the present study, we generated monodisperse poly(ethyl methacrylate) (PEMA) NPs loaded with hydrophobic photoluminescent gold nanoclusters (Au NCs) emitting in the NIR-II optical windows and studied their interaction in vitro with J774.1A macrophages. PEMA NPs showed an effi-cient time and dose dependent cellular uptake with up to 70 % of macrophages labelled in 24 h without detectable cell death. Interestingly, PEMA and Au-PEMA NPs induced an anti-inflammatory response and a strong down-regulation of nitric oxide level on lipopolysacharides (LPS) activated macrophages, but without influence on the levels of reactive oxygen species (ROS). These polymeric NPs may thus present a potential interest for the treatment of inflammatory diseases.
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