4.7 Article

3D printing: Innovative solutions for patients and pharmaceutical industry

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Pharmacology & Pharmacy

Binder jetting 3D printing of challenging medicines: From low dose tablets to hydrophobic molecules

Marta Kozakiewicz-Latala et al.

Summary: This paper introduces a strategy for formulating fast dissolving tablets using binder jetting technology, demonstrating its effects with model APIs. The proposed printing method can produce model tablets with uniform drug content, excellent mechanical properties, and a highly porous structure.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2022)

Article Pharmacology & Pharmacy

An audit of pharmaceutical continuous manufacturing regulatory submissions and outcomes in the US

Adam C. Fisher et al.

Summary: Continuous manufacturing (CM) eliminates hold times and reduces processing times, resulting in improved product quality, reduced waste, lower costs, and increased manufacturing flexibility and agility. Comparing CM applications to traditional batch applications, it was found that CM applicants had shorter times to approval and market, leading to significant early revenue benefits.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Engineering, Manufacturing

Volumetric 3D printing for rapid production of medicines

Lucia Rodriguez-Pombo et al.

Summary: 3D printing has potential in personalized medicine era, volumetric printing allows rapid drug printing with advantages in speed and overcoming limitations, drug release rates can be controlled by adjusting resin composition ratios.

ADDITIVE MANUFACTURING (2022)

Review Chemistry, Multidisciplinary

3D-printed microneedle arrays for drug delivery

Rong Li et al.

Summary: This review article provides an overview of the art, advantages, and considerations of 3D printing in the manufacturing of microneedle arrays.

JOURNAL OF CONTROLLED RELEASE (2022)

Review Chemistry, Multidisciplinary

3D printed oral solid dosage form: Modified release and improved solubility

Ning Wang et al.

Summary: This article reviews the formulation selection and structure design of 3D printed oral solid dosage form, providing more ideas for improving drug release and solubility through scientific and extensive formulation selection and sophisticated structural design.

JOURNAL OF CONTROLLED RELEASE (2022)

Article Chemistry, Multidisciplinary

Novel 3D Printed Modular Tablets Containing Multiple Anti-Viral Drugs: a Case of High Precision Drop-on-Demand Drug Deposition

Anqi Lu et al.

Summary: This study demonstrates the use of 3D printing technology for drug delivery systems, specifically using drop-on-demand droplet deposition to accurately dispense drug solutions on multi-compartment tablets. The study shows that printing parameters greatly affect the dispersal volume and uniformity of the drugs on the tablets. Solid-state characterization and surface analysis confirm the even distribution and release effects of the drugs in the 3D printed tablets. This research provides valuable insights for tailoring drug release rates and developing personalized drug delivery systems.

PHARMACEUTICAL RESEARCH (2022)

Article Pharmacology & Pharmacy

Haptic Evaluation of 3D-printed Braille-encoded Intraoral Films

Georgios K. Eleftheriadis et al.

Summary: The application of 3D printing technology in the pharmaceutical field not only enables personalized dosing and formulation designs, but also allows for the direct imprinting of haptic identifiers on drug surfaces, catering to specific populations such as visually impaired individuals. Research shows that using fused deposition modelling (FDM) technique to manufacture intraoral films with Braille characters can provide novel design concepts for drug delivery, demonstrating the potential of FDM technology in combining individualized therapies and customized services for specific populations.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Pharmacology & Pharmacy

Quality considerations on the pharmaceutical applications of fused deposition modeling 3D printing

Alice Melocchi et al.

Summary: 3D printing technology, particularly FDM, has rapidly become a hot topic in pharmaceutical research and media attention, with significant growth expected in 2020. Further development of FDM 2.0 process is needed to ensure the production of safe, high-quality personalized drug products.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Additive manufacturing in drug delivery: Innovative drug product design and opportunities for industrial application

Heloise Ragelle et al.

Summary: Additive manufacturing or 3D printing is revolutionizing product design, with significant impact and opportunities in drug delivery. AM offers unconventional release, customization, and miniaturization features for various applications in drug product fabrication.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Pharmaceutical applications of powder-based binder jet 3D printing process - A review

Koyel Sen et al.

Summary: Pharmaceutical applications of 3D printing have matured with FDA approval of Spritam, the first commercial 3D printed dosage form, but there is still a lack of understanding regarding the effect of raw materials on printed dosage forms and the feasibility of using this technology beyond conventional methods.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Computer Science, Interdisciplinary Applications

Artificial intelligence based design of 3D-printed tablets for personalise d me dicine

Zdenek Grof et al.

Summary: A computational method based on an Evolutionary Algorithm is introduced to find tablet internal structures that result in prescribed dissolution profiles of each API. The algorithm has been tested on known solutions and successfully applied to finding tablet structures that result in delayed release and step-wise release profiles. This approach, combined with patient-specific requirements, can be used for automated design of 3D-printed tablets in the framework of personalized medicine.

COMPUTERS & CHEMICAL ENGINEERING (2021)

Article Pharmacology & Pharmacy

3D screen printing - An innovative technology for large-scale manufacturing of pharmaceutical dosage forms

Daniel Moldenhauer et al.

Summary: This study utilized three-dimensional screen printing to fabricate oral dosage forms of different shapes and sizes, demonstrating high uniformity in size and mass of the tablets, as well as showing that drug release rate depends on the surface-area-to-volume ratio. The results indicate the potential of 3D screen printing for producing complex oral dosage forms with high reproducibility in mass production settings.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Pharmacology & Pharmacy

Smartphone-enabled 3D printing of medicines

Xiaoyan Xu et al.

Summary: 3D printing technology is being widely used in personalized pharmaceuticals, and portable, easy-to-operate printers are needed to realize the potential of point-of-care manufacturing of personalized medications.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Opportunities and challenges of three-dimensional printing technology in pharmaceutical formulation development

Mengsuo Cui et al.

Summary: Three-dimensional printing technology prints products layer by layer, offering competitive advantages in product design complexity, personalization, and on-demand manufacturing. This technology shows innovative potential in drug delivery systems, while also facing limitations and challenges in pharmaceutical formulation development.

ACTA PHARMACEUTICA SINICA B (2021)

Review Pharmacology & Pharmacy

Harnessing artificial intelligence for the next generation of 3D printed medicines

Moe Elbadawi et al.

Summary: Artificial intelligence is reshaping various sectors, but its potential in the pharmaceutical industry has yet to be fully tapped. The integration of AI and 3D printing technology offers opportunities for personalized medicine production and streamlined processes. Leveraging AI in pharmaceutical 3DP can enhance efficiency and drive the development of personalized medicine.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Pharmacology & Pharmacy

3D printing of four-in-one oral polypill with multiple release profiles for personalized delivery of caffeine and vitamin B analogues

Wei Jiang Goh et al.

Summary: The personalized supplementation market is rapidly growing, with the development of a 3D printing method for creating oral polypills with flexible release profiles, providing significant benefits for both the industry and consumers.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Advances in powder bed fusion 3D printing in drug delivery and healthcare

Atheer Awad et al.

Summary: Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source. PBF technologies offer benefits such as superior printing resolution and speed, as well as the ability to create complex products without the need for secondary supports, making them well suited for bespoke drug-laden formulations, devices, and implants.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

3D printing as a transformative tool for microneedle systems: Recent advances, manufacturing considerations and market potential

Sophia N. Economidou et al.

Summary: This review identified key progress points in using 3D printing to manufacture microneedles over the past 3 years, particularly focusing on advances in photopolymerization and extrusion-based 3D printing. The study highlighted that printing resolution and material properties are the two critical parameters that significantly influence the outcome of microneedle printing endeavors. Finally, the authors attempted to estimate the impact of 3D printing on the transdermal drug delivery market.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Translating 3D printed pharmaceuticals: From hype to real-world clinical applications

Iria Seoane-Viano et al.

Summary: 3D printing technology is revolutionizing the pharmaceutical industry by enabling the production of personalized drug products on demand. Despite its demonstrated benefits, the full clinical potential of the technology is yet to be realized.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Pharmacology & Pharmacy

Controlling drug release with additive manufacturing-based solutions

Shriya K. Patel et al.

Summary: 3D printing technology has the potential to revolutionize solid dosage form manufacturing, with advantages such as rapid prototyping and the ability to fabricate complex geometries. Different printing technologies and materials can be used to create matrices with varying drug release properties, while methods to manipulate release patterns are critically evaluated.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Article Pharmacology & Pharmacy

Melt extrusion deposition (MED™) 3D printing technology - A paradigm shift in design and development of modified release drug products

Yu Zheng et al.

Summary: A extrusion-based 3D printer using Melt Extrusion Deposition (MED) 3D printing technology was developed for pharmaceutical applications, allowing for precise and versatile drug release characteristics in fabricated tablets. This technology offers a novel approach for efficient pharmaceutical product development, potentially impacting drug delivery and pharmaceutical product development.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Machine learning predicts 3D printing performance of over 900 drug delivery systems

Brais Muniz Castro et al.

Summary: Three-dimensional printing (3DP) is a transformative technology in pharmaceutical research, producing personalized drug products. However, slow progress has been made due to the lengthy trial-and-error optimization process. Artificial intelligence (AI) has the potential to revolutionize pharmaceutical 3DP by analyzing large datasets.

JOURNAL OF CONTROLLED RELEASE (2021)

Review Pharmacology & Pharmacy

Disrupting 3D printing of medicines with machine learning

Moe Elbadawi et al.

Summary: 3D printing technology has the potential to revolutionize pharmaceutical development, but its integration into clinical settings can be accelerated by partnering with modern technologies like machine learning. This collaboration can expedite drug product development and inspire innovative dosage-form design, marking the next era of personalized medicine.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

Article Pharmacology & Pharmacy

The Chronotopic™ System for Pulsatile and Colonic Delivery of Active Molecules in the Era of Precision Medicine: Feasibility by 3D Printing via Fused Deposition Modeling (FDM)

Alice Melocchi et al.

Summary: The study focused on evaluating 3D printing for the Chronotopic(TM) system and testing various multiple-step manufacturing processes, aiming to explore the feasibility of the system's different parts.

PHARMACEUTICS (2021)

Review Pharmacology & Pharmacy

Additive Manufacturing Technologies for Drug Delivery Applications

Abdullah Mohammed et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Article Polymer Science

3D Printing of Tunable Zero-Order Release Printlets

Fabrizio Fina et al.

POLYMERS (2020)

Article Pharmacology & Pharmacy

I Spy with My Little Eye: A Paediatric Visual Preferences Survey of 3D Printed Tablets

Patricija Januskaite et al.

PHARMACEUTICS (2020)

Article Pharmacology & Pharmacy

M3DISEEN: A novel machine learning approach for predicting the 3D printability of medicines

Moe Elbadawi et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Pharmacology & Pharmacy

Shaping the future: recent advances of 3D printing in drug delivery and healthcare

Sarah J. Trenfield et al.

EXPERT OPINION ON DRUG DELIVERY (2019)

Article Pharmacology & Pharmacy

Perceptions, preferences and acceptability of patient designed 3D printed medicine by polypharmacy patients: a pilot study

Mark Moller Fasto et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACY (2019)

Article Pharmacology & Pharmacy

Multi-purposable filaments of HPMC for 3D printing of medications with tailored drug release and timed-absorption

Hossam Kadry et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Multidisciplinary Sciences

3D printing of a wearable personalized oral delivery device: A first-in-human study

Kun Liang et al.

SCIENCE ADVANCES (2018)

Article Pharmacology & Pharmacy

3D printed capsules for quantitative regional absorption studies in the GI tract

Derrick Smith et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Pharmacology & Pharmacy

Patient acceptability of 3D printed medicines

Alvaro Goyanes et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Article Pharmacology & Pharmacy

Stereolithographic (SLA) 3D printing of oral modified-release dosage forms

Jie Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Article Pharmacology & Pharmacy

Adaptation of pharmaceutical excipients to FDM 3D printing for the fabrication of patient-tailored immediate release tablets

Muzna Sadia et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2016)

Article Chemistry, Multidisciplinary

3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles

Shaban A. Khaled et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Review Biochemistry & Molecular Biology

The pharmacogenomics of Warfarin - Closing in on personalized medicine

Allan E. Rettie et al.

MOLECULAR INTERVENTIONS (2006)