Formulation for the Targeted Delivery of a Vaccine Strain of Oncolytic Measles Virus (OMV) in Hyaluronic Acid Coated Thiolated Chitosan as a Green Nanoformulation for the Treatment of Prostate Cancer: A Viro-Immunotherapeutic Approach

Review Oncology

Review Article: Immune Landscape and Immunotherapy Options in Cervical Carcinoma

Kousain Kousar et al.

Summary: This article summarizes the immune players that are perturbed in cervical cancer and the immunotherapy options being exploited, providing important insights for the development of more targeted therapies with the fewest side effects.

CANCERS (2022)

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Article Oncology

Ursolic Acid and Its Nanoparticles Are Potentiators of Oncolytic Measles Virotherapy against Breast Cancer Cells

Ching-Hsuan Liu et al.

Summary: Ursolic acid (UA) and its nanoparticles enhance oncolytic measles virus (MV) activity against breast cancer cells, inducing apoptosis and showing potential synergistic anticancer effects.

CANCERS (2021)

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Review Oncology

Measles Virus as an Oncolytic Immunotherapy

Christine E. Engeland et al.

Summary: Measles virus is being investigated as an innovative cancer treatment that selectively replicates in and kills cancer cells. Genetic engineering can enhance tumor specificity and therapeutic efficacy, while also activating antitumor immune responses. Clinical trials have shown promising results, and future research will focus on virus engineering and combination immunotherapies to improve clinical outcomes.

CANCERS (2021)

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Review Pharmacology & Pharmacy

Advanced Therapeutic Options for Treatment of Metastatic Castration Resistant Prostatic Adenocarcinoma

Faiza Naseer et al.

Summary: This article discusses advanced therapeutic regimens for prostatic adenocarcinoma (PaC), including chemotherapy, hormonal therapy, immunotherapy, and gene therapy. These therapies target the androgen receptors and inhibit steroidogenic enzymes to reduce testosterone and dihydrotestosterone levels. Targeting DNA damage repair pathways is also a focus to overcome resistance mechanisms in the treatment of mCRPC.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Immunology

Chitosan-Based Nanoparticles Against Viral Infections

Homa Boroumand et al.

Summary: Viral infections can damage host cells and compromise the host immune system. Nanotechnology offers potential solutions for developing effective antiviral drugs with enhanced selectivity to protect healthy cells.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Review Pharmacology & Pharmacy

Thiolated-Polymer-Based Nanoparticles as an Avant-Garde Approach for Anticancer Therapies-Reviewing Thiomers from Chitosan and Hyaluronic Acid

Roberto Grosso et al.

Summary: Thiomers, or thiolated polymers, have emerged as avant-garde approaches in anticancer therapy due to their reactivity and properties closely related to their applications. Research has shown that thiol-rich nanoformulations can address major drawbacks in administering various active pharmaceutical ingredients, especially in cancer therapy. This review focuses on synthetic tools available for thiolating polymers, particularly chitosan and hyaluronic acid, and outlines NP formation procedures, highlighting their use in cancer therapy.

PHARMACEUTICS (2021)

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Article Virology