4.7 Article

Another Brick to Confirm the Efficacy of Rigosertib as Anticancer Agent

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Rigosertib and Cholangiocarcinoma: A Cell Cycle Affair

Alessio Malacrida et al.

Summary: This study investigated the mechanism of action of Rigosertib on cholangiocarcinoma cells EGI-1 using Western blotting technique. The results showed an increase in EMI1 and Cyclin B protein levels and a significant reduction in CDK1 phosphorylation after Rigosertib treatment. The expression of PLK1 increased after 24 hours of treatment and decreased after 48 hours. Additionally, p53 levels increased and its activity was found to be necessary for the effects of Rigosertib on cell viability in EGI-1 cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Biochemistry & Molecular Biology

Therapeutic targets and biomarkers of tumor immunotherapy: response versus non-response

Dong-Rui Wang et al.

Summary: Cancers are complex diseases characterized by malignant cell overgrowth and altered immune response. Immunotherapy, including immune checkpoint blockade and adoptive cell transfer, has shown success in inducing long-term regression of refractory tumors. Combination therapy and biomarker discovery are important for improving the overall clinical response rate of tumor immunotherapy.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

Article Cell Biology

Rigosertib elicits potent anti-tumor responses in colorectal cancer by inhibiting Ras signaling pathway

Farzad Rahmani et al.

Summary: The study found that Rigosertib inhibits cell proliferation and cell cycle progression in dedifferentiated colorectal cancer cells, regulates apoptosis and induces cell senescence, and inhibits angiogenesis and metastatic behavior. This suggests that Rigosertib may serve as a potential therapy for colorectal cancer patients.

CELLULAR SIGNALLING (2021)

Article Biochemistry & Molecular Biology

In Vitro Evaluation of Rigosertib Antitumoral and Radiosensitizing Effects against Human Cholangiocarcinoma Cells

Alessio Malacrida et al.

Summary: Cholangiocarcinoma is the most common cancer of the biliary tract, and surgical resection is currently the only potentially curative option with low survival rates. Research shows that Rigosertib may be a potential therapeutic option for nonresectable patients with cholangiocarcinoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Oncology

Anti-tumor effects of rigosertib in high-risk neuroblastoma

Katarzyna Radke et al.

Summary: Rigosertib shows promising therapeutic effects on MYCN-amplified neuroblastomas, inducing apoptosis and cell cycle arrest. Combination therapy with existing agents, such as vincristine, may further enhance its efficacy.

TRANSLATIONAL ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent

Marco Jost et al.

MOLECULAR CELL (2020)

Review Medicine, General & Internal

Current Diagnosis and Management of Small-Cell Lung Cancer

Shuhang Wang et al.

MAYO CLINIC PROCEEDINGS (2019)

Review Medicine, General & Internal

Lung cancer: current therapies and new targeted treatments

Fred R. Hirsch et al.

LANCET (2017)

Article Biochemistry & Molecular Biology

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

Sai Krishna Athuluri-Divakar et al.

Review Oncology

The safety and efficacy of rigosertib in the treatment of myelodysplastic syndromes

Shyamala C. Navada et al.

EXPERT REVIEW OF ANTICANCER THERAPY (2016)

Article Biochemistry & Molecular Biology

Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit

Daniel A. Ritt et al.

MOLECULAR CELL (2016)

Editorial Material Biochemistry & Molecular Biology

The RAS/MAPK Axis Gets Stressed Out

Scott A. Foster et al.

MOLECULAR CELL (2016)

Article Pharmacology & Pharmacy

Gefitinib

CR Culy et al.