☆ 4.7 Review

Role of Sex and Age in Fatal Outcomes of COVID-19: Women and Older Centenarians Are More Resilient

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Geriatrics & Gerontology

Centenarians born before 1919 are resistant to COVID-19

Calogero Caruso et al.

Summary: Although mortality from COVID-19 progressively increases with age, controversy remains regarding the probability of centenarians dying from COVID-19. This study found that oldest females are more resilient to COVID-19 than males, and centenarians born before 1919 show greater resilience than younger centenarians.

AGING CLINICAL AND EXPERIMENTAL RESEARCH (2023)

添加到收藏夹

Article Infectious Diseases

Sex differences in COVID-19 mortality in the Netherlands

Annabel Niessen et al.

Summary: This study provides a detailed description of sex differences in COVID-19 mortality in relation to age and comorbidities among cases, as well as in relation to age and sex-specific mortality in the general population of the Netherlands. The study confirms that male sex is a predisposing factor for severe outcomes of COVID-19, independent of age and comorbidities. COVID-19 specific mechanisms may contribute to this mortality discrepancy between males and females.

INFECTION (2022)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Centenarians From Long-Term Care Facilities and COVID-19-Relevant Hospital Admissions

Paul Gellert et al.

JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION (2022)

添加到收藏夹

Article Genetics & Heredity

Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease

Julie E. Horowitz et al.

Summary: A variant that downregulates ACE2 expression is found to reduce the risk of SARS-CoV-2 infection. Associations of previously reported risk variants are replicated, and certain variants are associated with worse outcomes in individuals infected with the virus. A genetic risk score improves the prediction of disease severity.

NATURE GENETICS (2022)

添加到收藏夹

Editorial Material Medicine, General & Internal

How Japan survived covid-19

Priyanka Borpujari

BMJ-BRITISH MEDICAL JOURNAL (2022)

添加到收藏夹

Review Immunology

Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change

Tamas Fulop et al.

Summary: Organismal ageing is associated with changes in the immune system, which can lead to age-related diseases and decreased vaccine responses. However, recent advances in vaccine technology and understanding of immune ageing have contributed to the development of vaccines that can protect the health of older adults as well as younger individuals.

VACCINES (2022)

添加到收藏夹

Article Endocrinology & Metabolism

Regulatory T Cell Proportion and Phenotype Are Altered in Women Using Oral Contraception

Lachlan M. Moldenhauer et al.

Summary: Research has shown that oral contraception use can impact the number and phenotype of Treg cells, leading to physiological changes and altered disease susceptibility.

ENDOCRINOLOGY (2022)

添加到收藏夹

Review Immunology

An immunologist's guide to immunosenescence and its treatment

Calogero Caruso et al.

Summary: Immunosenescence, which is influenced by individual immunological history, genetics, and environment, causes changes in the immune system with inter-individual variability. The clinical relevance of immunosenescence has been demonstrated by studies on SARS-CoV-2 and Yellow Fever vaccine, but longitudinal studies have shown that immunosenescence is highly context-dependent. Large projects have identified the drivers of immune system variance, including genetic and environmental factors. Personalized interventions are required for drug treatment of immunosenescence. Changes in lifestyle have shown potential as a therapeutic approach.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2022)

添加到收藏夹

Article Geriatrics & Gerontology

The oldest unvaccinated Covid-19 survivors in South America

Mateus de Castro et al.

Summary: Despite their advanced age, these supercentenarians exhibited strong humoral immune response against SARS-CoV-2 and enrichment of plasma proteins and metabolites related to innate immunity. They also did not carry rare gene variants related to immune disorders. This suggests a combination of genetic background and immune function contributed to their Covid-19 resilience.

IMMUNITY & AGEING (2022)

添加到收藏夹

Article Immunology

IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19

Ingrid Fricke-Galindo et al.

Summary: Interferon alpha and beta receptor subunit 2 (IFNAR2) gene variants are associated with COVID-19 mortality risk among patients with severe illness. However, the levels of soluble IFNAR2 (sIFNAR2) in plasma samples were not related to these genetic variants. Both IFNAR2 gene and soluble protein play a significant role in the clinical outcome of patients hospitalized with severe COVID-19.

FRONTIERS IN IMMUNOLOGY (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

How Can We Improve Vaccination Response in Old People? Part I: Targeting Immunosenescence of Innate Immunity Cells

Anna Aiello et al.

Summary: Vaccination is the most effective medical intervention, but immunosenescence reduces its efficacy in older people. In addition to T and B cells, innate immunity also experiences aging, potentially affecting vaccine response. This paper focuses on the immunosenescence of innate blood immune cells and discusses strategies, such as the use of new adjuvants like TLR agonists, to enhance vaccine efficiency in older individuals.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

添加到收藏夹

Review Microbiology

Characteristics of SARS-CoV-2 and COVID-19

Ben Hu et al.

Summary: This review summarizes the research progress on SARS-CoV-2 and COVID-19, including virology characteristics, pathogenesis, and recent advances in treatment methods. Furthermore, it discusses in detail the potential wildlife hosts and zoonotic origin of this emerging virus.

NATURE REVIEWS MICROBIOLOGY (2021)

添加到收藏夹

Article Cell Biology

Centenarians exposed to the Spanish flu in their early life better survived to COVID-19

Michel Poulain et al.

Aging-US (2021)

添加到收藏夹

Article Cell Biology

Centenarians in nursing homes during the COVID-19 pandemic

Anne-Laure Couderc et al.

Aging-US (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

The Role of Immunogenetics in COVID-19

Fanny Pojero et al.

Summary: COVID-19, induced by SARS-CoV-2, manifests a spectrum of clinical symptoms, with genetic variants in immunogenetics potentially playing a significant role in disease evolution and treatment. Researchers are investigating the impact of these variants on disease progression, aiming to improve patient outcomes through personalized therapeutic strategies and drug repurposing.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

添加到收藏夹

Letter Geriatrics & Gerontology

The COVID-19 pandemic appears to have increased longevity in Japanese centenarians

Yuji Aoki et al.

AGE AND AGEING (2021)

添加到收藏夹

Review Cell Biology

SARS CoV2 infection _The longevity study perspectives

Domenico Lio et al.

Summary: COVID-19 exhibits a wide range of clinical outcomes, with elderly males in Italy being the most susceptible group, although some individuals show surprising resistance.

AGEING RESEARCH REVIEWS (2021)

添加到收藏夹

Article Immunology

Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender

Mattia Emanuela Ligotti et al.

Summary: Ageing significantly impacts the number and function of both innate and adaptive arms of the immune system, particularly T cell subsets. Analysis of Sicilian subjects revealed that the changes in CD4(+) and CD8(+) T cell subgroups in older individuals are gender-dependent. The supercentenarian displayed an immunophenotypic profile resembling that of an octogenarian female, indicating a unique immune response compared to others in her age group.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2021)

添加到收藏夹

Article Demography

A world apart: Levels and determinants of excess mortality due to COVID-19 in care homes: The case of the Belgian region of Wallonia during the spring 2020 wave

Olivier J. Hardy et al.

Summary: The study found that the COVID-19 mortality rate inside care homes was 130 times higher than outside care homes, primarily due to the effects of differences in age and sex structure, health frailty, and infection risk. Male had higher COVID-19 mortality rate than female, and the mortality rates increased exponentially with age.

DEMOGRAPHIC RESEARCH (2021)

添加到收藏夹

Article Geriatrics & Gerontology

Hypothetical COVID-19 protection mechanism: hints from centenarians

Franca Rosa Guerini et al.

Summary: The COVID-19 pandemic poses a higher risk for older individuals, but some centenarians show remarkable recovery abilities; the human leukocyte antigen (HLA) may play a crucial role in influencing the severity of COVID-19 infection.

IMMUNITY & AGEING (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes

Mehdi Baratchian et al.

Summary: Sex discordance in COVID-19 outcomes may not be related to TMPRSS2 but may be associated with modest changes in ACE2.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Review Cell Biology

Immunopathology and Immunosenescence, the Immunological Key Words of Severe COVID-19. Is There a Role for Stem Cell Transplantation?

Mattia Emanuela Ligotti et al.

Summary: The severity of COVID-19 outcomes varies depending on individual factors like age, health status, and gender. Immunosenescence and inflammageing may play a key role in the progression of the disease, while stem cell-based therapies, especially multipotent mesenchymal stem cells, show promise in improving immune response and reducing inflammation.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Age- and Gender-Specific Prevalence of Frailty and Its Outcomes in the Longevous Population: The Chinese Longitudinal Healthy Longevity Study

Huai-yu Wang et al.

Summary: Frailty is prevalent among longevous population and associated with various adverse outcomes, such as limited physical performance, cognitive decline, and dependence. Frail males have a higher risk of mortality compared with frail females, and inactivity shows the strongest association with mortality risk in females.

FRONTIERS IN MEDICINE (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality

Tomoko Nakanishi et al.

Summary: The study identified an association between a common genetic risk factor for COVID-19 and increased risks of morbidity and mortality, especially among individuals aged 60 or younger. This risk factor was comparable or even more significant than established clinical risk factors, indicating potential implications for future clinical risk management.

JOURNAL OF CLINICAL INVESTIGATION (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Sex-differences in COVID-19 associated excess mortality is not exceptional for the COVID-19 pandemic

Jens Nielsen et al.

Summary: Europe experienced excess mortality from February through June, 2020 due to the COVID-19 pandemic, with more COVID-19-associated deaths in males compared to females. However, a difference in excess mortality among females compared to among males may be a more general phenomenon and should be investigated in none-COVID-19 situations as well.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Editorial Material Medicine, Research & Experimental

Why does Japan have so few cases of COVID-19?

Akiko Iwasaki et al.

EMBO MOLECULAR MEDICINE (2020)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

COVID-19 Spiraling of Frailty in Older Italian Patients

A. M. Abbatecola et al.

JOURNAL OF NUTRITION HEALTH & AGING (2020)

添加到收藏夹

Article Cell Biology

COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians

Gabriella Marcon et al.

Aging-US (2020)

添加到收藏夹

Review Medicine, General & Internal

COVID-19 Clinical Characteristics, and Sex-Specific Risk of Mortality: Systematic Review and Meta-Analysis

Mohammad Javad Nasiri et al.

FRONTIERS IN MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Lack of consensus on an aging biology paradigm? A global survey reveals an agreement to disagree, and the need for an interdisciplinary framework

Alan A. Cohen et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2020)

添加到收藏夹

Article Medicine, General & Internal

The influence of sex and gender domains on COVID-19 cases and mortality

Christina P. Tadiri et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2020)

添加到收藏夹

Editorial Material Medicine, General & Internal

Trained Innate Immunity, Epigenetics, and Covid-19

Alberto Mantovani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Geriatrics & Gerontology

A public health perspective of aging: do hyper-inflammatory syndromes such as COVID-19, SARS, ARDS, cytokine storm syndrome, and post-ICU syndrome accelerate short- and long-term inflammaging?

Arsun Bektas et al.

IMMUNITY & AGEING (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Sex differences in severity and mortality from COVID-19: are males more vulnerable?

Ajay Pradhan et al.

BIOLOGY OF SEX DIFFERENCES (2020)

添加到收藏夹

Article Immunology

Considering how biological sex impacts immune responses and COVID-19 outcomes

Eileen P. Scully et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Anna Aiello et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Genetics & Heredity

The X chromosome and sex-specific effects in infectious disease susceptibility

Haiko Schurz et al.

HUMAN GENOMICS (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Women live longer than men even during severe famines and epidemics

Virginia Zarulli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

添加到收藏夹

Article Economics

The long-run effects of pandemic influenza on the development of children from elite backgrounds: Evidence from industrializing Japan

Kota Ogasawara

ECONOMICS & HUMAN BIOLOGY (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Gut Microbiota and Extreme Longevity

Elena Biagi et al.

CURRENT BIOLOGY (2016)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Sex, gender and immunosenescence: a key to understand the different lifespan between men and women?

Calogero Caruso et al.

IMMUNITY & AGEING (2013)

添加到收藏夹

Review Immunology

The influence of sex and gender on the immune response

Sabine Oertelt-Prigione

AUTOIMMUNITY REVIEWS (2012)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Positive biology: the centenarian lesson

Calogero Caruso et al.

IMMUNITY & AGEING (2012)

添加到收藏夹

Article Geriatrics & Gerontology

Gender-Related Immune-Inflammatory Factors, Age-Related Diseases, and Longevity

Giuseppina Candore et al.

REJUVENATION RESEARCH (2010)

添加到收藏夹

Article Public, Environmental & Occupational Health

Lingering prenatal effects of the 1918 influenza pandemic on cardiovascular disease

B. Mazumder et al.

JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2010)

添加到收藏夹

Article Multidisciplinary Sciences

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Xiaocong Yu et al.

NATURE (2008)

添加到收藏夹

Article Immunology

TLR7 Ligands induce higher IFN-α production in females

Beate Berghofer et al.

JOURNAL OF IMMUNOLOGY (2006)

添加到收藏夹

Article Economics

Is the 1918 influenza pandemic over?: Long-term effects of in utero influenza exposure in the post-1940 US population

Douglas Almond

JOURNAL OF POLITICAL ECONOMY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Centenarians as a model for healthy aging

C Franceschi et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.