4.7 Article

RNA-Interference-Mediated miR-122-Based Gene Regulation in Colon Cancer, a Structural In Silico Analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

A plant immune protein enables broad antitumor response by rescuing microRNA deficiency

Ye Qi et al.

Summary: Aberrant accumulation of microRNA isoforms is found in many human primary tumors. By controlling the expression of RDR1 and repairing defective microRNA structures, cancer cell proliferation can be inhibited, showing broad antitumor effects.
Article Biochemistry & Molecular Biology

PANTHER version 16: a revised family classification, tree-based classification tool, enhancer regions and extensive API

Huaiyu Mi et al.

Summary: PANTHER is a resource for evolutionary and functional classification of protein-coding genes, with extensive improvements made in the past two years, including the refactoring of Protein Class ontology and addition of services for programmatic access. The resource provides comprehensive classification and annotation information for genes from different taxonomic groups and also allows users to add their own protein sequences for evolutionary context and fine-grained annotations.

NUCLEIC ACIDS RESEARCH (2021)

Article Oncology

DNA hypermethylation contributes to colorectal cancer metastasis by regulating the binding of CEBPB and TFCP2 to the CPEB1 promoter

Keke Shao et al.

Summary: Aberrant DNA methylation contributes to the pathogenesis of colorectal cancer (CRC) by silencing tumor suppressor genes. The candidate tumor suppressor gene CPEB1 was found to be hypermethylated and downregulated in CRC tissues, with its upregulation leading to decreased tumor growth, migration, invasion, and increased apoptosis. Transcription factors CEBPB and TFCP2 were identified as critical regulators of CPEB1 expression, with hypermethylation of the CPEB1 promoter affecting their binding and ultimately leading to decreased expression.

CLINICAL EPIGENETICS (2021)

Article Biology

In silico analysis and prediction of transcription factors of the proteins interacting with astrocyte elevated gene-1

Sushmitha Sriramulu et al.

Summary: This study analyzed the biological functions, pathways, and interactions of AEG-1 and its interacting proteins using bioinformatic tools, revealing the crosstalk and regulatory network between them.

COMPUTATIONAL BIOLOGY AND CHEMISTRY (2021)

Article Oncology

Analysis of MicroRNA Expression Changes During the Course of Therapy In Rectal Cancer Patients

Klara Cervena et al.

Summary: The study evaluated changes in miRNA expression levels in RC patients before and after therapy, identifying specific miRNA signatures reflecting disease progression and treatment response. MiR-122-5p and miR-142-5p were found to have significantly different expression levels between RC patients and controls, showing potential for RC screening, early detection, and assessing treatment outcomes. Patients responding to treatment showed modified miRNA expression profiles a year after diagnosis, while non-responding patients maintained low expression levels, indicating the effectiveness of miR-122-5p and miR-142-5p as biomarkers for assessing treatment response in RC.

FRONTIERS IN ONCOLOGY (2021)

Article Biotechnology & Applied Microbiology

Circular RNA circ_0007142 Facilitates Colorectal Cancer Progression by Modulating CDC25A Expression via miR-122-5p

Wenzhe Yin et al.

ONCOTARGETS AND THERAPY (2020)

Article Biochemistry & Molecular Biology

miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology

Le Chang et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Medicine, Research & Experimental

Identification of potential miRNA-mRNA regulatory network contributing to pathogenesis of HBV-related HCC

Weiyang Lou et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Article Biochemistry & Molecular Biology

Topological analysis of TMEM180, a newly identified membrane protein that is highly expressed in colorectal cancer cells

Takahiro Anzai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Cell Biology

Regulation of RhoA GTPase and various transcription factors in the RhoA pathway

Jae-Gyu Kim et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

MiR-122 exerts anti-proliferative and apoptotic effects on nasopharyngeal carcinoma cells via the PI3K/AKT signaling pathway

Chen Cheng et al.

CELLULAR AND MOLECULAR BIOLOGY (2018)

Article Oncology

Plasma miR-122 and miR-200 family are prognostic markers in colorectal cancer

Melanie Maierthaler et al.

INTERNATIONAL JOURNAL OF CANCER (2017)

Article Biochemistry & Molecular Biology

KEGG as a reference resource for gene and protein annotation

Minoru Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Gastroenterology & Hepatology

Role of Altered Expression of miR-146a, miR-155, and miR-122 in Pediatric Patients with Inflammatory Bowel Disease

Nora J. Beres et al.

INFLAMMATORY BOWEL DISEASES (2016)

Letter Biochemical Research Methods

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

Harsh Dweep et al.

NATURE METHODS (2015)

Article Biochemical Research Methods

Simultaneous generation of many RNA-seq libraries in a single reaction

Alexander A. Shishkin et al.

NATURE METHODS (2015)

Article Biochemical Research Methods

FunRich: An open access standalone functional enrichment and interaction network analysis tool

Mohashin Pathan et al.

PROTEOMICS (2015)

Article Mathematical & Computational Biology

cytoHubba: identifying hub objects and sub-networks from complex interactome

Chia-Hao Chin et al.

BMC SYSTEMS BIOLOGY (2014)

Article Multidisciplinary Sciences

miR-122 Targets Pyruvate Kinase M2 and Affects Metabolism of Hepatocellular Carcinoma

Angela M. Liu et al.

PLOS ONE (2014)

Article Biochemical Research Methods

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

Edward Y. Chen et al.

BMC BIOINFORMATICS (2013)

Review Oncology

The Role of MicroRNAs in Colorectal Cancer

Aaron J. Schetter et al.

CANCER JOURNAL (2012)

Article Gastroenterology & Hepatology

Molecular pathways in colorectal cancer

Sam Al-Sohaily et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2012)

Article Biochemical Research Methods

The Protein Interaction Network of Extracellular Vesicles Derived from Human Colorectal Cancer Cells

Dong-Sic Choi et al.

JOURNAL OF PROTEOME RESEARCH (2012)

Article Biochemical Research Methods

A travel guide to Cytoscape plugins

Rintaro Saito et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

clusterMaker: a multi-algorithm clustering plugin for Cytoscape

John H. Morris et al.

BMC BIOINFORMATICS (2011)

Article Biochemistry & Molecular Biology

MicroRNA: Biogenesis, Function and Role in Cancer

Leigh-Ann MacFarlane et al.

CURRENT GENOMICS (2010)

Article Gastroenterology & Hepatology

Role of TGF-β1, its receptor TGFβRII, and Smad proteins in the progression of colorectal cancer

Maya Gulubova et al.

INTERNATIONAL JOURNAL OF COLORECTAL DISEASE (2010)

Review Oncology

Non-coding RNAs: regulators of disease

Ryan J. Taft et al.

JOURNAL OF PATHOLOGY (2010)

Article Biochemical Research Methods

The HADDOCK web server for data-driven biomolecular docking

Sjoerd J. De Vries et al.

NATURE PROTOCOLS (2010)

Article Biochemistry & Molecular Biology

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

David Warde-Farley et al.

NUCLEIC ACIDS RESEARCH (2010)

Article Biochemical Research Methods

Differential protein expression on the cell surface of colorectal cancer cells associated to tumor metastasis

Jose Luis Luque-Garcia et al.

PROTEOMICS (2010)

Review Biotechnology & Applied Microbiology

The Argonaute protein family

Julia Hoeck et al.

GENOME BIOLOGY (2008)

Article Biochemistry & Molecular Biology

UniProt: the Universal Protein knowledgebase

R Apweiler et al.

NUCLEIC ACIDS RESEARCH (2004)

Article Biochemistry & Molecular Biology

Vienna RNA secondary structure server

IL Hofacker

NUCLEIC ACIDS RESEARCH (2003)

Article Biochemistry & Molecular Biology

Cytoscape: A software environment for integrated models of biomolecular interaction networks

P Shannon et al.

GENOME RESEARCH (2003)

Article Biochemistry & Molecular Biology

STRING: a database of predicted functional associations between proteins

C von Mering et al.

NUCLEIC ACIDS RESEARCH (2003)