期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/ijms232415972
关键词
dimethyl itaconate; angiogenesis; endothelial cells
资金
- MICINN [PID2019-105010RB-I00]
- FEDER [PID2019-105010RB-I00, UMA18-FEDERJA-220, PY20_00257]
- Andalusian Government [UMA18-FEDERJA-220, PY20_00257, BIO 267]
The potential of dimethyl itaconate as an anti-angiogenic compound was evaluated in this study, and the results indicate that it interferes with multiple key steps of the angiogenic process.
The dimethyl derivative of the immunomodulator itaconate has been previously shown to have anti-inflammatory, anti-oxidative, and immunomodulatory effects. In the present work, we evaluate the potential of dimethyl itaconate as an anti-angiogenic compound by using cultured endothelial cells and several in vitro assays that simulate key steps of the angiogenic process, including endothelial cell proliferation, migration, invasion, and tube formation. Our results show that dimethyl itaconate interferes with all the previously mentioned steps of the angiogenic process, suggesting that dimethyl itaconate behaves as an anti-angiogenic compound.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据