期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/ijms24010887
关键词
oxidative stress; immune response; cancer; melanoma; ion channels; Ca2+ signaling
Oxidative stress and immune response are important factors in the development of cancers, including melanoma. Ion channels, which are aberrantly expressed in tumor cells, play a role in neoplastic transformation, malignant progression, and resistance to therapy. These ion channels, located in cellular membranes, are targets of oxidative stress, which is particularly elevated in melanoma. They also represent promising targets for therapeutic intervention in melanoma.
Oxidative stress and immune response play an important role in the development of several cancers, including melanoma. Ion channels are aberrantly expressed in tumour cells and regulate neoplastic transformation, malignant progression, and resistance to therapy. Ion channels are localized in the plasma membrane or other cellular membranes and are targets of oxidative stress, which is particularly elevated in melanoma. At the same time, ion channels are crucial for normal and cancer cell physiology and are subject to multiple layers of regulation, and therefore represent promising targets for therapeutic intervention. In this review, we analyzed the effects of oxidative stress on ion channels on a molecular and cellular level and in the context of melanoma progression and immune evasion. The possible role of ion channels as targets of alternative therapeutic strategies in melanoma was discussed.
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