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The Bright Side of Psychedelics: Latest Advances and Challenges in Neuropharmacology

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Neurosciences

Virtual screening and in vitro experiments highlight cannabidiol as a drug-like phosphodiesterase 9 inhibitor

Giovanni Ribaudo et al.

Summary: This study investigates the therapeutic potential of Cannabis sativa extracts in treating neurodegenerative diseases through computational analysis and experimental assays. The findings support cannabidiol (CBD) as a potential selective PDE9 ligand, indicating its potential as a therapeutic option for neurodegeneration.

EUROPEAN JOURNAL OF NEUROSCIENCE (2023)

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Article Geriatrics & Gerontology

The Safety and Efficacy of Psychedelic-Assisted Therapies for Older Adults: Knowns and Unknowns

C. Bree Johnston et al.

Summary: Psychedelics and related compounds are effective in treating various prevalent conditions in older adults, such as mood disorders, psychological distress, PTSD, and prolonged grief disorder. They also have potential therapeutic benefits for dementing disorders and personal growth in healthy older adults. This article focuses on psilocybin and MDMA, which act on the 5HT2A receptor. Administration of psychedelics to healthy adults can be safe, but caution is needed for older adults with cardiovascular disease. Limited inclusion of older adults in clinical trials raises concerns about generalizability. Research on psychedelics in older adults can provide insights into aging brain and future clinical applications.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2023)

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Article Pharmacology & Pharmacy

Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome

Antonio Inserra et al.

Summary: This study found that repeated administration of lysergic acid diethylamide (LSD) induces prosocial effects in mice and affects the composition of the hippocampal endocannabinoidome and gut microbiota.

BRITISH JOURNAL OF PHARMACOLOGY (2023)

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Article Neurosciences

Mescaline: The forgotten psychedelic*

Ioanna A. Vamvakopoulou et al.

Summary: The article reviews the pharmacology and behavioral effects of mescaline, a hallucinogenic substance with its main effects mediated via the 5HT2A receptor. Studies suggest that mescaline has anxiolytic-like effects in animals and can induce hallucinations and improve mental health in humans.

NEUROPHARMACOLOGY (2023)

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Article Biophysics

The substrate import mechanism of the human serotonin transporter

Matthew C. Chan et al.

Summary: This study investigated the structural dynamics of human SERT to various intermediate states and elucidated the complete substrate import pathway. The transition from the occluded to inward-facing state was found to be the rate-limiting step for substrate import, and the substrate decreased the free energy barriers for achieving the inward-facing state.

BIOPHYSICAL JOURNAL (2022)

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Article Mycology

Diversity, biology, and history of psilocybin-containing fungi: Suggestions for research and technological development

R. C. Van Court et al.

Summary: Therapeutic use of psilocybin has gained attention in recent international research, highlighting the importance of understanding psilocybin-producing fungi for consumer safety.

FUNGAL BIOLOGY (2022)

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Review Clinical Neurology

N,N-dimethyltryptamine and Amazonian ayahuasca plant medicine

Edward James et al.

Summary: This article explores the potential uses and mechanisms of action of ayahuasca and DMT in contemporary healthcare. Compounds in ayahuasca bind to various receptors and modulate brain neurosystem activities. Different biological processes and consciousness models have been proposed to explain the subjective effects, but more research is needed. Further studies are necessary to understand the mechanisms and develop accessible treatments for the public worldwide.

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL (2022)

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Article Clinical Neurology

Efficacy and safety of psilocybin-assisted treatment for major depressive disorder: Prospective 12-month follow-up

Natalie Gukasyan et al.

Summary: This study demonstrates that psilocybin-assisted therapy can have long-lasting antidepressant effects in patients with moderate to severe depression, as observed over a 12-month period.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

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Review Psychology, Clinical

Why was early therapeutic research on psychedelic drugs abandoned?

Wayne Hall

Summary: This paper briefly describes research in the 1950s and 1960s in North America on the therapeutic use of LSD, and discusses the reasons that led to its abandonment. The factors include tighter regulation of pharmaceutical research, discrepancies between clinical trial results and the claims made by psychedelic advocates, and lack of interest from the pharmaceutical industry in funding clinical trials.

PSYCHOLOGICAL MEDICINE (2022)

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Article Multidisciplinary Sciences

Structure-based discovery of nonhallucinogenic psychedelic analogs

Dongmei Cao et al.

Summary: This study provides structural insights into the binding of drugs to 5-HT2AR and offers a foundation for the design of safe and effective nonhallucinogenic psychedelic analogs for the treatment of neuropsychiatric diseases.

SCIENCE (2022)

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Review Pharmacology & Pharmacy

Evaluating the Potential Use of Serotonergic Psychedelics in Autism Spectrum Disorder

Athanasios Markopoulos et al.

Summary: Recent evidence suggests that psychedelic compounds, such as LSD and psilocybin, may have therapeutic potential for alleviating some of the behavioral abnormalities associated with autism spectrum disorder (ASD). However, further research is needed to assess the risks and benefits of using these compounds in treating ASD and to determine if targeting the 5-HT2A receptor could be an effective approach.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Pharmacology & Pharmacy

Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines

Karolina E. Kolaczynska et al.

Summary: The psychedelic alkaloids, scalines and 3C-scalines, were found to have similar effects to mescaline and could potentially be used as novel therapeutics for psychedelic-assisted therapy. These compounds interacted with various monoamine receptors, with higher affinity observed at 5-HT2A and 5-HT2C receptors.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Clinical Neurology

The epidemiology of mescaline use: Pattern of use, motivations for consumption, and perceived consequences, benefits, and acute and enduring subjective effects

Malin Vedoy Uthaug et al.

Summary: The study found that the majority of English-speaking adults use mescaline infrequently for spiritual exploration or to connect with nature, with low potential for abuse and positive effects on mental health. Most respondents reported improvements in their psychiatric conditions following their most memorable mescaline experience.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

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Article Anthropology

Communalistic use of psychoactive plants as a bridge between traditional healing practices and Western medicine: A new path for the Global Mental Health movement

Genis Ona et al.

Summary: The Global Mental Health (GMH) movement aims to provide treatment to those with mental illness, especially in low- and middle-income countries. There is much debate among GMH advocates regarding the best way to provide mental health services due to the complexity of dealing with people from different cultures. Traditional rituals involving the communal use of psychoactive plants should be respected, protected, and promoted as valuable tools for mental health care at the community level.

TRANSCULTURAL PSYCHIATRY (2022)

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Article Biochemistry & Molecular Biology

Genetic Survey of Psilocybe Natural Products

Sebastian Doerner et al.

Summary: Genomic analysis of Psilocybe magic mushrooms reveals a diverse and unexplored secondary metabolome, providing insights into the potential pharmacological and toxicological effects associated with consumption of these mushrooms.

CHEMBIOCHEM (2022)

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Article Plant Sciences

Teacher plants - Indigenous Peruvian-Amazonian dietary practices as a method for using psychoactives

Ilana Berlowitz et al.

Summary: The Peruvian-Amazonian dieta is a complex therapeutic intervention that uses psychoactive plants. It has multifaceted applications and effects in various domains and is portrayed as transformative. The dieta involves specific dietary conditions, the use of teacher plants, and the guidance of skilled healers. Risk assessment revealed safety measures and the importance of adequate training for healers. This traditional method should not be neglected in the current interest in psychedelic therapies.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

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Article Clinical Neurology

Safety, tolerability, pharmacokinetics, and subjective effects of 50, 75, and 100 μg LSD in healthy participants within a novel intervention paradigm: A proof-of-concept study

Neiloufar Family et al.

Summary: Classic psychedelics like LSD show promise as therapeutics with favorable safety profiles in healthy adults, inducing mystical-type subjective experiences. Further research is needed to evaluate their effects and cost-effectiveness in clinical populations.

JOURNAL OF PSYCHOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

Increased global integration in the brain after psilocybin therapy for depression

Richard E. Daws et al.

Summary: Psilocybin therapy has the potential to treat depression by increasing brain network integration, according to two clinical trials. The antidepressant response to psilocybin was rapid and sustained, while escitalopram had milder effects on brain network organization.

NATURE MEDICINE (2022)

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Article Neurosciences

Exploratory study of the dose-related safety, tolerability, and efficacy of dimethyltryptamine (DMT) in healthy volunteers and major depressive disorder

Deepak Cyril D'Souza et al.

Summary: This study explored the safety and efficacy of DMT as a treatment for depression. The results showed that DMT was tolerated by both healthy individuals and patients with treatment-resistant depression. Patients with depression experienced improved mood one day after receiving DMT. The adverse effects of DMT were mostly mild and short-lived. This study provides a foundation for further investigation into the antidepressant effects of DMT.

NEUROPSYCHOPHARMACOLOGY (2022)

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Article Neurosciences

Role of 5-HT2A receptors in the effects of ayahuasca on ethanol self-administration using a two-bottle choice paradigm in male mice

Yasmim A. Serra et al.

Summary: The study found that ayahuasca treatment can block the expression of alcohol self-administration in mice, and the activation of 5-HT2A receptors is critical for these effects. This suggests the potential of ayahuasca and other 5-HT2A receptor agonists as adjunctive pharmacotherapies for the treatment of AUD.

PSYCHOPHARMACOLOGY (2022)

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Article Neurosciences

Structure-Activity Relationships of Dopamine Transporter Pharmacological Chaperones

Charles Sutton et al.

Summary: Mutations in the dopamine transporter gene (SLC6A3) have been linked to Dopamine Transporter Deficiency Syndrome (DTDS), a disease characterized by minimal functional dopamine transporter protein and severe motor symptoms. Two pharmacological chaperones, bupropion and ibogaine, have shown efficacy in rescuing disease-causing variants. In this study, structure-activity relationships (SARs) were explored for these two compounds, identifying the important chemical features required for their chaperone activity. The findings contribute to the development of improved dopamine transporter pharmacological chaperones.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

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Article Biochemistry & Molecular Biology

Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior

Adam Wojtas et al.

Summary: Clinical studies suggest that ketamine and psilocybin may have potential as fast-acting antidepressants. This study used microdialysis to investigate the effect of these drugs on neurotransmitter levels in rat brain regions. The findings showed that both ketamine and psilocybin affected neurotransmitter levels, but did not significantly alter animal behavior.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Nutrition & Dietetics

Different Seasonal Collections of Ficus carica L. Leaves Diversely Modulate Lipid Metabolism and Adipogenesis in 3T3-L1 Adipocytes

Mariachiara Pucci et al.

Summary: This study evaluated the effects of Ficus carica leaf extracts collected in autumn and spring on lipid metabolism and adipogenesis in 3T3-L1 adipocytes. The results showed that autumn-collected extracts significantly decreased lipid content and downregulated the transcriptional pathway of adipogenesis and insulin sensitivity. These findings support further research on Ficus carica leaf extracts as a potential source of compounds for targeting obesity and diabetes.

NUTRIENTS (2022)

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Article Cell Biology

Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors

Ryan H. Gumpper et al.

Summary: RNA editing is a process that alters protein function by modifying mRNA nucleotides. The 5HT(2C) serotonin receptor, which undergoes multiple RNA-editing events, displays isoforms with different constitutive activity and agonist signaling. A study on three representative isoforms revealed a hydrogen-bonding network affected by RNA editing, leading to variations in GPCR activity.

CELL REPORTS (2022)

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Review Psychology, Multidisciplinary

Psychedelic-Assisted Psychotherapy-A Systematic Review of Associated Psychological Interventions

Mauro Cavarra et al.

Summary: Modern clinical research on psychedelics shows interesting outcomes in various clinical conditions when used in combination with psychotherapy. Individual and contextual factors seem to influence the psychedelic experience and clinical outcomes. These findings highlight the importance of investigating environmental and relational factors in therapeutic contexts.

FRONTIERS IN PSYCHOLOGY (2022)

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Article Chemistry, Medicinal

Structure-Activity Relationships for Psilocybin, Baeocystin, Aeruginascin, and Related Analogues to Produce Pharmacological Effects in Mice

Grant C. Glatfelter et al.

Summary: 4-Phosphoryloxy-N,N-dimethyltryptamine (psilocybin), a naturally occurring substance found in mushrooms, induces psychedelic effects through its activity at the 5-HT2A receptor. This study explored the structure-activity relationships of psilocybin and its analogues, revealing their affinity and efficacy at various 5-HT receptor subtypes. Psilocybin and its analogues were found to induce head twitch responses and decrease body temperature and locomotor activity. The phosphoryloxy analogues showed weaker pharmacological effects. Psilacetin, a prodrug for psilocin, displayed significant serotonin receptor activities of its own.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2022)

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Article Anthropology

Modalities of the psychedelic experience: Microclimates of set and setting in hallucinogen research and culture

Ido Hartogsohn

Summary: This article examines the diversity of interpretations on psychedelic effects in mid-20th-century America, and explores the concept of psychedelic modalities, discussing how distinct sociocultural microclimates contribute to different outcomes and experiences.

TRANSCULTURAL PSYCHIATRY (2022)

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Article Medicine, Research & Experimental

Serotonin 5-HT2A, 5-HT2c and 5-HT1A receptor involvement in the acute effects of psilocybin in mice. In vitro pharmacological profile and modulation of thermoregulation and head-twich response

I Erkizia-Santamaria et al.

Summary: The study found that psilocin showed similar affinities for 5HT2AR, 5HT2CR, and 5HT1AR in both human and mice brain. Psilocybin induced a dose-dependent head-twitch response (HTR) and affected body temperature, which were both mediated by 5HT2AR, 5HT2CR, and 5HT1AR. These findings provide key insights into the mechanism of action of psilocybin and its therapeutic effects.

BIOMEDICINE & PHARMACOTHERAPY (2022)

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Article Chemistry, Analytical

Development and validation of an LC-MS/MS method for the quantification of mescaline and major metabolites in human plasma

Jan Thomann et al.

Summary: In this study, a bioanalytical method was developed for the rapid quantification of mescaline and its metabolites in human plasma. The method showed reliability and ease of use, making it suitable for forensic applications as well as investigating the clinical pharmacokinetics of mescaline.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2022)

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Article Neurosciences

Signaling snapshots of a serotonin receptor activated by the prototypical psychedelic LSD

Can Cao et al.

Summary: This study determines the binding of LSD to HTR2B receptors in different states using cryo-EM structures, providing molecular insights into the mechanism of LSD's psychedelic effects and accelerating the discovery of novel psychedelic drugs.

NEURON (2022)

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Article Neurosciences

Psychedelic-assisted psychotherapy to treat psychiatric and existential distress in life-threatening medical illnesses and palliative care

S. Ross et al.

Summary: Psychiatric and existential distress are common in advanced cancer and other serious medical illnesses. Current treatments are limited in effectiveness, and psychedelic-assisted psychotherapy shows promise as a novel intervention. Further research is needed to evaluate its effectiveness and mechanisms of action.

NEUROPHARMACOLOGY (2022)

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Article Medicine, General & Internal

Single-Dose Psilocybin for a Treatment-Resistant Episode of Major Depression

Guy M. Goodwin et al.

Summary: Psilocybin may be effective in treating treatment-resistant depression, but dosage and adverse effects need further investigation.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Psychiatry

Knowing and being known: Psychedelic-assisted psychotherapy and the sense of authenticity

Lawrence G. G. Fischman

Summary: New beliefs emerging from MDMA and psychedelic-assisted psychotherapy bring a sense of authenticity, derived from a simultaneous feeling of knowing and being known, shared with therapists and others.

FRONTIERS IN PSYCHIATRY (2022)

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Review Biochemistry & Molecular Biology

Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant

Giordano Novak Rossi et al.

Summary: Ayahuasca is a psychoactive brew traditionally used in indigenous and religious rituals in South America. Recent research has shown its potential therapeutic and antidepressant effects, which may be attributed to its complex pharmacological profile and modulation of various neurological systems.

BIOMOLECULES (2022)

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Review Biology

Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy

Giulia Abate et al.

Summary: This paper summarizes the potential and limitations of cannabinoids as therapeutics for AD, focusing on recent pre-clinical and clinical evidence. AD is a detrimental brain disorder characterized by cognitive decline and neuronal deterioration, with current treatments effective only in the early stages. Emerging research shows promising effects of cannabinoids in reducing amyloid plaque deposition and stimulating hippocampal neurogenesis in AD rodent models.

BIOLOGY-BASEL (2021)

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Article Plant Sciences

Is distyly in subtropical Psychotria brachyceras (Rubiaceae) similar to the general trends observed for the genus?

Renata Trevizan et al.

Summary: Distyly is a floral polymorphism that promotes cross-pollination, and Psychotria brachyceras belongs to a population of Distylous Rubiaceae. The population exhibits typical Distyly characteristics, with high reciprocity, evenly distributed inaccuracy values between sexual organs, and a functional heteromorphic incompatibility system.

ACTA BOTANICA BRASILICA (2021)

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Meeting Abstract Clinical Neurology

Synergistic effects of lysergic acid diethylamide (LSD) and cannabidiol (CBD)

A. Inserra et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

A non-hallucinogenic psychedelic analogue with therapeutic potential

Lindsay P. Cameron et al.

Summary: The study identifies key structural elements of the potential therapeutic pharmacophore of ibogaine and designs tabernanthalog, a safer, non-hallucinogenic analogue of ibogaine. Tabernanthalog is found to promote neural plasticity, reduce addiction-related behavior, and produce antidepressant effects in rodents. Through careful chemical design, it is possible to modify psychedelic compounds to produce safer, non-hallucinogenic variants with therapeutic potential.

NATURE (2021)

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Article Multidisciplinary Sciences

Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

Danilo De Gregorio et al.

Summary: Clinical studies have shown that LSD can enhance empathy and social behavior in humans. This study in male mice found that LSD promotes social behavior by potentiating glutamatergic neurotransmission in the medial prefrontal cortex through the 5-HT2A/AMPA receptors and mTOR signaling. The results suggest that activating these pathways with psychedelic drugs could be explored for treating mental disorders characterized by social behavior impairments.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Health Care Sciences & Services

A Conformation Variant of p53 Combined with Machine Learning Identifies Alzheimer Disease in Preclinical and Prodromal Stages

Giulia Abate et al.

Summary: Early diagnosis of Alzheimer's disease is crucial in disease management. Blood-based biomarkers, such as U-p53(2D3A8+), show promise as additional candidate biomarkers for AD diagnosis. Machine learning algorithms combining U-p53(2D3A8+) plasma levels with other markers can accurately predict AD likelihood risk and classify patients with aMCI who will develop AD.

JOURNAL OF PERSONALIZED MEDICINE (2021)

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Article Behavioral Sciences

Investigating the role of 5-HT2A and 5-HT2C receptor activation in the effects of psilocybin, DOI, and citalopram on marble burying in mice

Anna U. Odland et al.

Summary: This study confirmed that psychedelics acting as 5-HT2AR agonists can reduce compulsive-like digging behavior in mice, while also suggesting that both 5-HT2A and 5-HT(2C)Rs may work in parallel on this behavior. Results with psilocybin indicate that a 5-HT2R-independent mechanism may also contribute to its effect on repetitive digging behavior.

BEHAVIOURAL BRAIN RESEARCH (2021)

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Article Biochemical Research Methods

Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin ' s main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma

Karolina E. Kolaczynska et al.

Summary: A rapid LC-MS/MS method was developed and validated for quantifying psilocin and its metabolite 4-HIAA in human plasma, showing good accuracy and precision over three validation runs. This method could assess the pharmacokinetics of psilocin and 4-HIAA and facilitate the clinical development of psilocybin.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)

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Article Clinical Neurology

Connected to the spirit of the frog: An Internet-based survey on Kambo, the secretion of the Amazonian Giant Maki Frog (Phyllomedusa bicolor): Motivations for use, settings and subjective experiences

Tomislav Majic et al.

Summary: The survey found that participants who use Kambo are mainly well-educated individuals with various motivations, including healing, detoxification, and spiritual growth. Acute effects of using Kambo include physical reactions and mild psychoactive effects, with some participants reporting feeling connected to the frog's spirit. The majority of users claimed beneficial effects from Kambo and considered it to have high personal and spiritual significance.

JOURNAL OF PSYCHOPHARMACOLOGY (2021)

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Article Psychiatry

Study Protocol for Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study

Meg J. Spriggs et al.

Summary: This study aims to assess the feasibility, brain mechanisms, and preliminary outcomes of treating anorexia nervosa with psilocybin-assisted therapy. Feedback obtained through Public Patient Involvement (PPI) and the protocol design will be crucial for shaping future Randomized Control Trials (RCTs).

FRONTIERS IN PSYCHIATRY (2021)

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Review Psychiatry

Registered clinical studies investigating psychedelic drugs for psychiatric disorders

Ashley N. Siegel et al.

Summary: This paper summarizes and analyzes 70 registered clinical studies on clinicaltrials.gov that evaluate the treatment of psychiatric disorders with psychedelics, with the majority focusing on investigating the therapeutic effects of MDMA and psilocybin, especially for PTSD and MDD. Ongoing studies on psychedelics highlight the importance of considering relevant research priorities for future proposed studies by researchers and stakeholders.

JOURNAL OF PSYCHIATRIC RESEARCH (2021)

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Review Chemistry, Medicinal

Rediscovering Psilocybin as an Antidepressive Treatment Strategy

Rene Zeiss et al.

Summary: Recent interest in the use of psilocybin in psychiatric treatment, particularly for major depressive disorder, has led to advanced studies on its mechanisms and potential benefits. While initial findings show promise, further research is needed to fully understand its effects and address safety concerns.

PHARMACEUTICALS (2021)

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Review Biochemistry & Molecular Biology

The Therapeutic Potential of Psilocybin

Henry Lowe et al.

Summary: The psychedelic effects of certain plants and fungi have been intentionally utilized by humans for religious and spiritual purposes for centuries, with mushrooms serving as a primary source of naturally occurring psychedelics. Amidst negative stigma associated with psychedelic use, the U.S. government classified psychedelics as Schedule 1 drugs in 1970, impeding scientific research progress. Recent studies on the therapeutic potential of psilocybin in treating neuropsychiatric conditions have reignited interest and efforts in psilocybin research, leading to significant advances in understanding its chemical properties and uses.

MOLECULES (2021)

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Review Biochemistry & Molecular Biology

Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans

Paul Cumming et al.

Summary: Hallucinogens are a group of compounds that can evoke intense visual and emotional experiences, leading to a renewed interest in research, particularly in their psychotherapeutic potential. Molecular imaging techniques can depict the uptake and binding distribution of these compounds in the brain, but there is still abundant room for basic imaging research in this area.

MOLECULES (2021)

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Article Medicine, General & Internal

Trial of Psilocybin versus Escitalopram for Depression

Robin Carhart-Harris et al.

Summary: The study compared the efficacy of psilocybin and escitalopram in treating patients with major depressive disorder. While there was no significant difference in antidepressant effects between the two drugs at week 6, secondary outcomes generally favored psilocybin over escitalopram, though these results were not adjusted for multiple comparisons. Larger and longer trials are needed to further compare psilocybin with established antidepressants.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Psychology, Multidisciplinary

An Encounter With the Other: A Thematic and Content Analysis of DMT Experiences From a Naturalistic Field Study

Pascal Michael et al.

Summary: This study provides a systematic and in-depth analysis of the nuanced content of the otherworldly encounter within the breakthrough DMT experience, as well as elaborating on the resonances both with previous DMT studies focusing on entity encounters and other types of extraordinary experiences entailing such encounters. It discusses the potential neural mechanisms of these features of the DMT experience and its promise as a psychotherapeutic agent.

FRONTIERS IN PSYCHOLOGY (2021)

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Review Biochemistry & Molecular Biology

Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives

Francesca Serena Abatematteo et al.

Summary: The sigma-1 receptor is a pluripotent chaperone protein that interacts with several client proteins at the mitochondria-endoplasmic reticulum membrane interfaces. Developing multifunctional ligands targeting sigma-1 receptors may be a successful strategy in overcoming pharmacokinetic issues associated with the administration of diverse drugs. The evidence of unintentional binding between some clinically used drugs and sigma-1 protein supports the potential of targeting sigma-1 receptors with MTDLs for the treatment of multifactorial pathologies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Neurosciences

N,N-Dimethyltryptamine attenuates spreading depolarization and restrains neurodegeneration by sigma-1 receptor activation in the ischemic rat brain

Irisz Szabo et al.

Summary: The study suggests that DMT may serve as an adjuvant pharmacological therapy in the management of acute cerebral ischemia, by mitigating spreading depolarizations (SDs) and promoting neuronal survival, reducing the number of apoptotic and ferroptotic cells.

NEUROPHARMACOLOGY (2021)

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Editorial Material Plant Sciences

(2816) Proposal to conserve the name Echinocactus williamsii Lem. ex Salm-Dyck (Lophophora williamsii) against E. williamsianus Lem. (Cactaceae)

Anton Hofer

TAXON (2021)

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Review Pharmacology & Pharmacy

Neuroplasticity as a convergent mechanism of ketamine and classical psychedelics

Lily R. Aleksandrova et al.

Summary: The emerging therapeutic efficacy of ketamine and classical psychedelics for depression has sparked considerable interest in the mechanisms underlying neuroplasticity. Preclinical and clinical evidence suggests that these drugs induce synaptic, structural, and functional changes, particularly in pyramidal neurons in the prefrontal cortex, resulting in adaptive rewiring of pathological neurocircuitry.

TRENDS IN PHARMACOLOGICAL SCIENCES (2021)

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Article Pharmacology & Pharmacy

Role of the 5-HT2A Receptor in Acute Effects of LSD on Empathy and Circulating Oxytocin

Friederike Holze et al.

Summary: The study found that LSD can enhance empathy with dose-dependent effects on emotional empathy and also increase plasma oxytocin levels, partially independent of the primary action on 5-HT2A receptors. These findings provide important implications for further research investigating the therapeutic effects of LSD in patients with empathy deficits and impairments in social functioning.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Ibogaine Blocks Cue- and Drug-Induced Reinstatement of Conditioned Place Preference to Ethanol in Male Mice

Gabrielle M. Henriques et al.

Summary: Ibogaine may have therapeutic properties for the treatment of alcohol use disorder without having rewarding effects per se. The study results show that ibogaine can block the reinstatement of ethanol-induced CPP, suggesting its potential as a treatment option for alcohol use disorder.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Psychiatry

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

Cato M. H. de Vos et al.

Summary: Clinical studies suggest that psychedelics induce rapid changes in neuroplasticity mechanisms, leading to alterations in gene and protein expression, increased neurotrophic factor levels, and enhanced dendritic complexity. Repeated administration of psychedelics can directly stimulate neurogenesis and elevate BDNF mRNA levels, indicating potential long-lasting effects on brain plasticity. Future research could focus on deciphering specific cellular mechanisms activated by different psychedelics to better understand their therapeutic potential.

FRONTIERS IN PSYCHIATRY (2021)

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Article Plant Sciences

Variation in Phytochemical, Antioxidant and Volatile Composition of Pomelo Fruit (Citrus grandis (L.) Osbeck) during Seasonal Growth and Development

Arun Kumar Gupta et al.

Summary: This study investigated the changes in phytochemical compounds in different parts of pomelo fruit during two consecutive growing seasons, revealing a systematic metabolism of these compounds during fruit development. The results have implications for the food processing industry in producing high-quality foods and introducing health-beneficial products into daily diets.

PLANTS-BASEL (2021)

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Article Chemistry, Medicinal

Investigation of the Structure-Activity Relationships of Psilocybin Analogues

Adam K. Klein et al.

Summary: This study investigated the pharmacological properties of tryptamine derivatives containing N,N-dialkyl substituents and a 4-hydroxy or 4-acetoxy group, revealing their similar potencies at 5-HT2A and 5-HT2B receptors. The compounds acted as full or partial agonists at 5-HT2 subtypes and induced LSD-like head twitches in mice. O-acetylation reduced the in vitro potency of the compounds but had little effect on their in vivo head twitch response potency, suggesting a prodrug mechanism.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

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Article Chemistry, Medicinal

Naturalistic Use of Mescaline Is Associated with Self-Reported Psychiatric Improvements and Enduring Positive Life Changes

Gabrielle Agin-Liebes et al.

Summary: Mescaline, a naturally occurring psychoactive alkaloid, has shown potential for mental health benefits with users reporting improvements in conditions like depression, anxiety, PTSD, AUD, and DUD. Those with acute psychological insights during mescaline experiences were more likely to report improvements in mental health conditions like depression, anxiety, AUD, and DUD. Further research is needed to confirm these findings and investigate mescaline's efficacy for psychiatric treatment in controlled clinical trials.

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE (2021)

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Article Archaeology

Potential identification of an entheogenic plant species on the Chi Silk Manuscript

Benjamin Pothier

Summary: The study suggests a possible connection between the plants depicted in the Chu Silk Manuscript and the hallucinogenic plant Caesalpinia decapetala, known for its shamanic properties. This potential link could help identify substances used in trance-facilitating drugs during shamanic rituals in the Chu state era and before.

TIME & MIND-THE JOURNAL OF ARCHAEOLOGY CONSCIOUSNESS AND CULTURE (2021)

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Meeting Abstract Psychiatry

Lysergic acid diethylamide (LSD) promotes social behaviour through 5-HT2A and ampa in the medial prefrontal cortex (MPFC)

A. Markopoulos et al.

EUROPEAN PSYCHIATRY (2021)

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Article Biochemistry & Molecular Biology

Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression

Meghan Hibicke et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Article Mycology

Diversity of Claviceps paspali reveals unknown lineages and unique alkaloid genotypes

H. Oberti et al.

MYCOLOGIA (2020)

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Article Neurosciences

Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers

Neiloufar Family et al.

PSYCHOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

A Single Administration of the Atypical Psychedelic Ibogaine or Its Metabolite Noribogaine Induces an Antidepressant-Like Effect in Rats

Paola Rodriguez et al.

ACS CHEMICAL NEUROSCIENCE (2020)

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Article Multidisciplinary Sciences

Effects of ayahuasca on mental health and quality of life in naive users: A longitudinal and cross-sectional study combination

Daniel F. Jimenez-Garrido et al.

SCIENTIFIC REPORTS (2020)

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Article Biochemical Research Methods

Pharmacokinetics and subjective effects of 1P-LSD in humans after oral and intravenous administration

Christina Grumann et al.

DRUG TESTING AND ANALYSIS (2020)

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Article Neurosciences

N,N-dimethyltryptamine reduces infarct size and improves functional recovery following transient focal brain ischemia in rats

Sandor Nardai et al.

EXPERIMENTAL NEUROLOGY (2020)

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Review Neurosciences

Rethinking Therapeutic Strategies for Anorexia Nervosa: Insights From Psychedelic Medicine and Animal Models

Claire J. Foldi et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Pharmacology & Pharmacy

Acute Effects of 2C-E in Humans: An Observational Study

Esther Papaseit et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Neurosciences

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

N. L. Mason et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Article Biology

Chemical and structural investigation of the paroxetine-human serotonin transporter complex

Jonathan A. Coleman et al.

ELIFE (2020)

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Article Plant Sciences

Neuroprotective potential of Ayahuasca and untargeted metabolomics analyses: applicability to Parkinson's disease

Albert Katchborian-Neto et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

Kuglae Kim et al.

CELL (2020)

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Article Multidisciplinary Sciences

Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

Yang Lee et al.

NATURE (2020)

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Review Plant Sciences

Plant behaviour: an evolutionary response to the environment?

A. Kumar et al.

PLANT BIOLOGY (2020)

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Article Clinical Neurology

Mood and cognition after administration of low LSD doses in healthy volunteers: A placebo controlled dose-effect finding study

Nadia R. P. W. Hutten et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2020)

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Article Agronomy

Taxonomic Study of the Genus Pholiota (Strophariaceae, Basidiomycota) in Korea

Jun Won Lee et al.

MYCOBIOLOGY (2020)

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Review Chemistry, Medicinal

Toxicokinetics and Toxicodynamics of Ayahuasca Alkaloids N,N-Dimethyltryptamine (DMT), Harmine, Harmaline and Tetrahydroharmine: Clinical and Forensic Impact

Andreia Machado Brito-da-Costa et al.

PHARMACEUTICALS (2020)

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Article Pharmacology & Pharmacy

Novel treatment of opioid use disorder using ibogaine and iboga in two adults

Claire Wilson et al.

JOURNAL OF PSYCHEDELIC STUDIES (2020)

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Review Neurosciences

Psychedelics as a Treatment for Alzheimer's Disease Dementia

Simon Andrew Vann Jones et al.

FRONTIERS IN SYNAPTIC NEUROSCIENCE (2020)

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Article Anthropology

The Ibogaine Experience: A Qualitative Study on the Acute Subjective Effects of Ibogaine

Maja Kohek et al.

ANTHROPOLOGY OF CONSCIOUSNESS (2020)

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Article Substance Abuse

Microdosing psychedelics: Motivations, subjective effects and harm reduction

Toby Lea et al.

INTERNATIONAL JOURNAL OF DRUG POLICY (2020)

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Article Psychology, Clinical

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Fernanda Palhano-Fontes et al.

PSYCHOLOGICAL MEDICINE (2019)

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Article Psychology, Clinical

Differentiating PTSD from anxiety and depression: Lessons from the ICD-11 PTSD diagnostic criteria

Anna C. Barbano et al.

DEPRESSION AND ANXIETY (2019)

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Article Clinical Neurology

Comparison of the behavioral effects of mescaline analogs using the head twitch response in mice

Adam L. Halberstadt et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2019)

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Review Plant Sciences

Cannabimimetic plants: are they new cannabinoidergic modulators?

Amit Kumar et al.

PLANTA (2019)

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Article Multidisciplinary Sciences

A systematic study of microdosing psychedelics

Vince Polito et al.

PLOS ONE (2019)

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Article Psychology, Clinical

5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety

Alan K. Davis et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2019)

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Article Pharmacology & Pharmacy

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

Soledad Marton et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Endocrinology & Metabolism

Updated View on the Relation of the Pineal Gland to Autism Spectrum Disorders

Tal Shomrat et al.

FRONTIERS IN ENDOCRINOLOGY (2019)

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Article Multidisciplinary Sciences

Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport

Jonathan A. Coleman et al.

NATURE (2019)

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Article Neurosciences

A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms

M. V. Uthaug et al.

PSYCHOPHARMACOLOGY (2019)

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Article Immunology

N,N-dimethyltryptamine Prevents Renal Ischemia-Reperfusion Injury in a Rat Model

Balazs Nemes et al.

TRANSPLANTATION PROCEEDINGS (2019)

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Article Multidisciplinary Sciences

Conformational dynamics of the human serotonin transporter during substrate and drug binding

Ingvar R. Moller et al.

NATURE COMMUNICATIONS (2019)

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Review Pharmacology & Pharmacy

Metabolism of lysergic acid diethylamide (LSD): an update

Rui Filipe Libanio Osorio Marta

DRUG METABOLISM REVIEWS (2019)

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Review Neurosciences

Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases

Daniel A. Ryskamp et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Review Clinical Neurology

Classical psychedelics for the treatment of depression and anxiety: A systematic review

Silvia Muttoni et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

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Article Cell Biology

Inappropriate Intrusion of an Axonal Mitochondrial Anchor into Dendrites Causes Neurodegeneration

Dinesh C. Joshi et al.

CELL REPORTS (2019)

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Review Biochemistry & Molecular Biology

Pharmacokinetic and Pharmacodynamic Aspects of Peyote and Mescaline: Clinical and Forensic Repercussions

Ricardo Jorge Dinis-Oliveira et al.

CURRENT MOLECULAR PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Chronic, Intermittent Microdoses of the Psychedelic N,N-Dimethyltryptamine (DMT) Produce Positive Effects on Mood and Anxiety in Rodents

Lindsay P. Cameron et al.

ACS CHEMICAL NEUROSCIENCE (2019)

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Article Chemistry, Multidisciplinary

Structural insight into the serotonin (5-HT) receptor family by molecular docking, molecular dynamics simulation and systems pharmacology analysis

Yuan-qiang Wang et al.

ACTA PHARMACOLOGICA SINICA (2019)

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Article Psychology, Multidisciplinary

Modulation of Serum Brain-Derived Neurotrophic Factor by a Single Dose of Ayahuasca: Observation From a Randomized Controlled Trial

Raissa Nobrega de Almeida et al.

FRONTIERS IN PSYCHOLOGY (2019)

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Article Neurosciences

LSD modulates effective connectivity and neural adaptation mechanisms in an auditory oddball paradigm

Christopher Timmermann et al.

NEUROPHARMACOLOGY (2018)

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Article Psychology, Clinical

Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study

Geoffrey E. Noller et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2018)

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Article Psychology, Clinical

Treatment of opioid use disorder with ibogaine: detoxification and drug use outcomes

Thomas Kingsley Brown et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2018)

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Review Biochemistry & Molecular Biology

Dark Classics in Chemical Neuroscience: Mescaline

Bruce K. Cassels et al.

ACS CHEMICAL NEUROSCIENCE (2018)

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Article Plant Sciences

Anatomically distinct representatives of Cactaceae Juss. family have different response to acute heat shock stress

Nataliia Nuzhyna et al.

FLORA (2018)

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Review Neurosciences

Psychedelics: Where we are now, why we got here, what we must do

Sean J. Belouin et al.

NEUROPHARMACOLOGY (2018)

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Article Cell Biology

Psychedelics Promote Structural and Functional Neural Plasticity

Calvin Ly et al.

CELL REPORTS (2018)

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Article Pharmacology & Pharmacy

Hypothesis: The Psychedelic Ayahuasca Heals Traumatic Memories via a Sigma 1 Receptor-Mediated Epigenetic-Mnemonic Process

Antonio Inserra

FRONTIERS IN PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

Deborah C. Mash et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Pharmacology & Pharmacy

The Psychedelic Debriefing in Alcohol Dependence Treatment: Illustrating Key Change Phenomena through Qualitative Content Analysis of Clinical Sessions

Elizabeth M. Nielson et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Cell Biology

Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist

Wanchao Yin et al.

CELL DISCOVERY (2018)

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Article Clinical Neurology

Serum and plasma brain-derived neurotrophic factor and response in a randomized controlled trial of riluzole for treatment resistant depression

Samuel T. Wilkinson et al.

JOURNAL OF AFFECTIVE DISORDERS (2018)

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Review Plant Sciences

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

Sara Anna Bonini et al.

JOURNAL OF ETHNOPHARMACOLOGY (2018)

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Meeting Abstract Biochemical Research Methods

Ergot alkaloid production in Claviceps purpurea is regulated by tryptophan related genes

M. Hradilov et al.

NEW BIOTECHNOLOGY (2018)

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Review Neurosciences

N, N-Dimethyltryptamine (DMT), an Endogenous Hallucinogen: Past, Present, and Future Research to Determine Its Role and Function

Steven A. Barker

FRONTIERS IN NEUROSCIENCE (2018)

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Article Psychology, Experimental

Synesthetic hallucinations induced by psychedelic drugs in a congenitally blind man

Sara Dell'Erba et al.

CONSCIOUSNESS AND COGNITION (2018)

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Article Psychology, Clinical

Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine

Benjamin J. Malcolm et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2018)

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Article Biochemistry & Molecular Biology

Protocols for Subtomogram Averaging of Membrane Proteins in the Dynamo Software Package

Paula P. Navarro et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2018)

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Review Developmental Biology

Dendrite and Spine Modifications in Autism and Related Neurodevelopmental Disorders in Patients and Animal Models

Veronica Martinez-Cerdeno

DEVELOPMENTAL NEUROBIOLOGY (2017)

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Review Clinical Neurology

Psilocybin for treating substance use disorders?

Bas T. H. de Veen et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

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Article Psychology, Clinical

Long-term follow-up of psilocybin-facilitated smoking cessation

Matthew W. Johnson et al.

AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE (2017)

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Review Clinical Neurology

Psilocybin for treating substance use disorders?

Bas T. H. de Veen et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2017)

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Article Medicine, Research & Experimental

Disrupted integration of sensory stimuli with information about the movement of the body as a mechanism explaining LSD-induced experience

Grzegorz R. Juszczak

MEDICAL HYPOTHESES (2017)

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Article Neurosciences

The Mechanisms of Psychedelic Visionary Experiences: Hypotheses from Evolutionary Psychology

Michael J. Winkelman

FRONTIERS IN NEUROSCIENCE (2017)

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Review Neurosciences

Disease modification and Neuroprotection in neurodegenerative disorders

Jeffrey Cummings

TRANSLATIONAL NEURODEGENERATION (2017)

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Review Medicine, Research & Experimental

Drug Abuse and Psychosis: New Insights into Drug- induced Psychosis

Suji Ham et al.

EXPERIMENTAL NEUROBIOLOGY (2017)

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Article Pharmacology & Pharmacy

Pharmacokinetics of Escalating Doses of Oral Psilocybin in Healthy Adults

Randall T. Brown et al.

CLINICAL PHARMACOKINETICS (2017)

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Article Psychology, Clinical

Examination of the Phenomenology of the Ibogaine Treatment Experience: Role of Altered States of Consciousness and Psychedelic Experiences

Annamarie Heink et al.

JOURNAL OF PSYCHOACTIVE DRUGS (2017)

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Article Multidisciplinary Sciences

Psychotria viridis: Chemical constituents from leaves and biological properties

Debora B. S. Soares et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2017)

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Article Biochemistry & Molecular Biology

Crystal Structure of an LSD-Bound Human Serotonin Receptor

Daniel Wacker et al.

CELL (2017)

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Review Neurosciences

The role of adult neurogenesis in psychiatric and cognitive disorders

Deana M. Apple et al.

BRAIN RESEARCH (2017)

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Review Neurosciences

Neuropharmacology of N,N-dimethyltryptamine

Theresa M. Carbonaro et al.

BRAIN RESEARCH BULLETIN (2016)

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Review Toxicology

How toxic is ibogaine?

Ruud P. W. Litjens et al.

CLINICAL TOXICOLOGY (2016)

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Article Pharmacology & Pharmacy

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression A SPECT Study

Rafael Faria Sanches et al.

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY (2016)

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Article Multidisciplinary Sciences

X-ray structures and mechanism of the human serotonin transporter

Jonathan A. Coleman et al.

NATURE (2016)

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Article Clinical Neurology

Classic hallucinogens in the treatment of addictions

Michael P. Bogenschutz et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

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Review Psychiatry

Ibogaine and addiction in the animal model, a systematic review and meta-analysis

M. Belgers et al.

TRANSLATIONAL PSYCHIATRY (2016)

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Article Neurosciences

The Endogenous Hallucinogen and Trace Amine N,N-Dimethyltryptamine (DMT) Displays Potent Protective Effects against Hypoxia via Sigma-1 Receptor Activation in Human Primary iPSC-Derived Cortical Neurons and Microglia-Like Immune Cells

Attila Szabo et al.

FRONTIERS IN NEUROSCIENCE (2016)

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Review Pharmacology & Pharmacy

Antidepressive, anxiolytic, and antiaddictive effects of ayahuasca, psilocybin and lysergic acid diethylamide (LSD): a systematic review of clinical trials published in the last 25 years

Rafael G. dos Santos et al.

THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY (2016)

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Article Psychology, Biological

Behavioural and neurotoxic effects of ayahuasca infusion (Banisteriopsis caapi and Psychotria viridis) in female Wistar rat

Aline Pic-Taylor et al.

BEHAVIOURAL PROCESSES (2015)

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Article Pharmacology & Pharmacy

Effect of Psilocin on Extracellular Dopamine and Serotonin Levels in the Mesoaccumbens and Mesocortical Pathway in Awake Rats

Yuichi Sakashita et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)

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Review Biochemistry & Molecular Biology

The Anti-Addiction Drug Ibogaine and the Heart: A Delicate Relation

Xaver Koenig et al.

MOLECULES (2015)

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Article Psychiatry

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Flavia de L. Osorio et al.

REVISTA BRASILEIRA DE PSIQUIATRIA (2015)

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Article Medical Laboratory Technology

Urine Mescaline Screening With a Biochip Array Immunoassay and Quantification by Gas Chromatography-Mass Spectrometry

Dilek Battal et al.

THERAPEUTIC DRUG MONITORING (2015)

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Article Food Science & Technology

Research on Acute Toxicity and the Behavioral Effects of Methanolic Extract from Psilocybin Mushrooms and Psilocin in Mice

Olga Zhuk et al.

TOXINS (2015)

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Article Pharmacology & Pharmacy

Ascending-Dose Study of Noribogaine in Healthy Volunteers: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability

Paul Glue et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2015)

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Article Clinical Neurology

LSD-assisted psychotherapy for anxiety associated with a life-threatening disease: A qualitative study of acute and sustained subjective effects

Peter Gasser et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2015)

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Article Neurosciences

The role of 5-HT2A, 5-HT2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice

Theresa M. Carbonaro et al.

PSYCHOPHARMACOLOGY (2015)

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Article Anthropology

Ayahuasca from Peru to Uruguay: Ritual Design and Redesign through a Distributed Cognition Approach

Ismael Apud

ANTHROPOLOGY OF CONSCIOUSNESS (2015)

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Article Clinical Neurology

Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases

Peter Gasser et al.

JOURNAL OF NERVOUS AND MENTAL DISEASE (2014)

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Article Clinical Neurology

Psychopharmacological Neuroprotection in Neurodegenerative Disease: Assessing the Preclinical Data

Edward C. Lauterbach et al.

JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES (2014)

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Article Clinical Neurology

Treating drug dependence with the aid of ibogaine: A retrospective study

Eduardo Ekman Schenberg et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2014)

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Article

The Consumption of Psychoactive Plants in Ancient Global and Anatolian Cultures During Religious Rituals: The Roots of the Eruption of Mythological Figures and Common Symbols in Religions and Myths

H. Umit Sayin

NeuroQuantology (2014)

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Article Chemistry, Medicinal

Novel pyrazole derivatives as neutral CB1 antagonists with significant activity towards food intake

Ilaria Manca et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

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Review Clinical Neurology

A possibly sigma-1 receptor mediated role of dimethyltryptamine in tissue protection, regeneration, and immunity

Ede Frecska et al.

JOURNAL OF NEURAL TRANSMISSION (2013)

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Article Neurosciences

Role of the 5-HT2A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice

Adam L. Halberstadt et al.

NEUROPHARMACOLOGY (2013)

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Article Multidisciplinary Sciences

Structural Basis for Molecular Recognition at Serotonin Receptors

Chong Wang et al.

SCIENCE (2013)

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Article Behavioral Sciences

NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile

Andrea Mastinu et al.

BEHAVIOURAL BRAIN RESEARCH (2012)

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Article Plant Sciences

Metabolic plasticity and the energy economizing effect of ibogaine, the principal alkaloid of Tabernanthe iboga

Roman Paskulin et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

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Article Clinical Neurology

Lysergic acid diethylamide (LSD) for alcoholism: meta-analysis of randomized controlled trials

Teri S. Krebs et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2012)

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Article Plant Sciences

A Prehistoric Mural in Spain Depicting Neurotropic Psilocybe Mushrooms?

Brian P. Akers et al.

ECONOMIC BOTANY (2011)

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Article Clinical Neurology

Acute, subacute and long-term subjective effects of psilocybin in healthy humans: a pooled analysis of experimental studies

Erich Studerus et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2011)

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Article Biochemistry & Molecular Biology

Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment

M. L. Molendijk et al.

MOLECULAR PSYCHIATRY (2011)

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Article Neurosciences

Partial Agonists of the α3β4*Neuronal Nicotinic Acetylcholine Receptor Reduce Ethanol Consumption and Seeking in Rats

Susmita Chatterjee et al.

NEUROPSYCHOPHARMACOLOGY (2011)

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Article Neurosciences

Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists

Jose L. Moreno et al.

NEUROSCIENCE LETTERS (2011)

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Review Biochemistry & Molecular Biology

Non-Competitive Inhibition by Active Site Binders

Yuval Blat

CHEMICAL BIOLOGY & DRUG DESIGN (2010)

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Article Philosophy

Sacred plants and visionary consciousness

Jose Luis Diaz

PHENOMENOLOGY AND THE COGNITIVE SCIENCES (2010)

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Article Clinical Neurology

Dimethyltryptamine and other hallucinogenic tryptamines exhibit substrate behavior at the serotonin uptake transporter and the vesicle monoamine transporter

Nicholas V. Cozzi et al.

JOURNAL OF NEURAL TRANSMISSION (2009)

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Article Multidisciplinary Sciences

The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator

Dominique Fontanilla et al.

SCIENCE (2009)

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Article Biochemistry & Molecular Biology

When the Endogenous Hallucinogenic Trace Amine N,N-Dimethyltryptamine Meets the Sigma-1 Receptor

Tsung-Ping Su et al.

SCIENCE SIGNALING (2009)

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Review Neurosciences

LSD-assisted psychotherapy in persons suffering from anxiety associated with advanced-stage life threatening diseases. A phase-II, double-blind, placebo-controlled dose-response pilot study

Torsten Passie et al.

CNS NEUROSCIENCE & THERAPEUTICS (2008)

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Article Plant Sciences

Hallucinogenic Mushrooms in Mexico: An Overview

Gaston Guzman

ECONOMIC BOTANY (2008)

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Article Biochemistry & Molecular Biology

Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter

Miriam T. Jacobs et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

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Article Neurosciences

Hallucinogens recruit specific cortical 5-HT2A receptor-mediated signaling pathways to affect behavior

Javier Gonzalez-Maeso et al.

NEURON (2007)

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Article Psychology, Clinical

The creativity of Crumb: Research on the effects of psychedelic drugs on the comic art of Robert Crumb

Matthew T. Jones

JOURNAL OF PSYCHOACTIVE DRUGS (2007)

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Article Chemistry, Medicinal

C-(4,5,6-trimethoxyindan-1-yl)methanamine:: A mescaline analogue designed using a homology model of the 5-HT2A receptor

Thomas H. McLean et al.

JOURNAL OF MEDICINAL CHEMISTRY (2006)

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Article Pharmacology & Pharmacy

Psychological effects of (S)-ketamine and N,N-dimethyltryptamine (DMT): A double-blind, cross-over study in healthy volunteers

E Gouzoulis-Mayfrank et al.

PHARMACOPSYCHIATRY (2005)

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Article Neurosciences

The 5-HT1A receptor and the stimulus effects of LSD in the rat

CJ Reissig et al.

PSYCHOPHARMACOLOGY (2005)

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Review Cell Biology

Nicotinic agonists, antagonists, and modulators from natural sources

JW Daly

CELLULAR AND MOLECULAR NEUROBIOLOGY (2005)

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Article Biotechnology & Applied Microbiology

Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors

L Lindemann et al.

GENOMICS (2005)

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Article Neurosciences

Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption

DY He et al.

JOURNAL OF NEUROSCIENCE (2005)

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Article Biochemistry & Molecular Biology

Characterization of an allosteric citalopram-binding site at the serotonin transporter

FH Chen et al.

JOURNAL OF NEUROCHEMISTRY (2005)

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Review Pharmacology & Pharmacy

Hallucinogens

DE Nichols

PHARMACOLOGY & THERAPEUTICS (2004)

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Article Pharmacology & Pharmacy

Novel iboga alkaloid congeners block nicotinic receptors and reduce drug self-administration

CJ Pace et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2004)

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Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

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Letter Biochemistry & Molecular Biology

Announcing the worldwide Protein Data Bank

H Berman et al.

NATURE STRUCTURAL BIOLOGY (2003)

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Review Clinical Neurology

Lbogaine attenuation of morphine withdrawal in mice:: role of glutamate N-methyl-D-aspartate receptors

MB Leal et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)

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Review Neurosciences

Plasma membrane monoamine transporters: Structure, regulation and function

GE Torres et al.

NATURE REVIEWS NEUROSCIENCE (2003)

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Review Biochemistry & Molecular Biology

One hundred and seventeen clades of euagarics

JM Moncalvo et al.

MOLECULAR PHYLOGENETICS AND EVOLUTION (2002)

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Article Pharmacology & Pharmacy

Antagonism of alpha 3 beta 4 nicotinic receptors as a strategy to reduce opioid and stimulant self-administration

SD Glick et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2002)

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Article Behavioral Sciences

Iboga compounds reverse the behavioural disinhibiting and corticosterone effects of acute methamphetamine:: Implications for their antiaddictive properties

KK Szumlinski et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2001)

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