☆ 4.7 Article

The Predictive Role of Extracellular NAPRT for the Detection of Advanced Fibrosis in Biopsy-Proven Non-Alcoholic Fatty Liver Disease

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Gastroenterology & Hepatology

Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: an individual patient data meta-analysis

Ferenc Emil Mozes et al.

Summary: Liver biopsy is still necessary for fibrosis staging in patients with non-alcoholic fatty liver disease. This study evaluated the diagnostic performance of liver stiffness measurement, FIB-4 Index, and NAFLD Fibrosis Score, and showed that sequential combinations of markers can reduce the need for liver biopsies.

GUT (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4

Giorgia Colombo et al.

Summary: This article investigates the effects of eNAMPT on macrophage-driven inflammation. The study finds that eNAMPT triggers an M1-skewed transcriptional program and selectively boosts IFN gamma-driven transcriptional activation via STAT1/3 phosphorylation. Furthermore, the secretion of eNAMPT promotes the chemotactic recruitment of myeloid cells, creating a positive feedback loop for inflammation. The research also reveals the involvement of receptors other than the recognized TLR4 receptor.

ISCIENCE (2022)

添加到收藏夹

Article Chemistry, Medicinal

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery

Moustafa S. Ghanem et al.

Summary: Depriving cancer cells of sufficient NAD levels, mainly through interfering with their NAD-producing capacity, has been considered as a promising anti-cancer strategy. However, current inhibitors targeting NAD-producing enzyme NAMPT have limited efficacy in clinical trials, suggesting that alternative NAD-producing enzymes may be utilized by cancer cells. Recent studies have highlighted the relevance of NAPRT as a rate-limiting enzyme in the Preiss-Handler NAD-production pathway in human cancers. In this study, a NAPRT inhibitor, 2-hydroxynicotinic acid, was found to work cooperatively with the NAMPT inhibitor FK866 to kill NAPRT-proficient cancer cells. Furthermore, two additional chemical scaffolds with NAPRT inhibitory activity were identified through high-throughput virtual screening.

PHARMACEUTICALS (2022)

添加到收藏夹

Article Chemistry, Medicinal

Structure-Based Identification and Biological Characterization of New NAPRT Inhibitors

Jorge Franco et al.

Summary: In this study, a collection of diverse compounds that efficiently inhibit NAPRT were identified through in silico screening and cell-based assays. These compounds showed potential for anticancer activity through synergistic interaction with NAMPT inhibitors.

PHARMACEUTICALS (2022)

添加到收藏夹

Review Biochemistry & Molecular Biology

Insulin Resistance across the Spectrum of Nonalcoholic Fatty Liver Disease

Angelo Armandi et al.

Summary: Insulin resistance is defined as a lower-than-expected response to insulin action from target tissues, leading to the development of type 2 diabetes, and is also associated with nonalcoholic fatty liver disease and the progression of nonalcoholic steatohepatitis. Major contributors for the development and worsening of insulin resistance include the liver, adipose tissue, and skeletal muscle.

METABOLITES (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis-2021 update

Annalisa Berzigotti et al.

Summary: The article provides the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for assessing liver disease severity and prognosis, with a focus on topics with relevant evidence published in the last 5 years.

JOURNAL OF HEPATOLOGY (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Natural history of NASH

Angelo Armandi et al.

Summary: Non-alcoholic fatty liver disease (NAFLD) is the fastest growing cause of chronic liver disease globally with a substantial clinical burden, affecting approximately 25% of the world population. Besides liver-related mortality, cardiovascular diseases are the most common cause of death in NAFLD patients. There is significant variability in susceptibility to liver disease among individuals.

LIVER INTERNATIONAL (2021)

添加到收藏夹

Review Immunology

The Extracellular NADome Modulates Immune Responses

Valentina Audrito et al.

Summary: NADome refers to the complex network of enzymes that regulate the synthesis or degradation of NAD, both intracellularly and extracellularly, as well as the receptors involved. Recent studies have shown that NAD has biological activity outside of cells, potentially linked to immunomodulation and non-enzymatic activities. Extracellular NAD can trigger inflammatory responses, similar to ATP.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Medicine, General & Internal

Serum Visfatin Levels in Nonalcoholic Fatty Liver Disease and Liver Fibrosis: Systematic Review and Meta-Analysis

Abdulrahman Ismaiel et al.

Summary: After analyzing the role of visfatin in nonalcoholic fatty liver disease, it was found that visfatin levels are not associated with NAFLD, presence or severity of hepatic steatosis, liver fibrosis, lobar inflammation, NASH, and gender.

JOURNAL OF CLINICAL MEDICINE (2021)

添加到收藏夹

Article Gastroenterology & Hepatology

Metabolic Inflammation-A Role for Hepatic Inflammatory Pathways as Drivers of Comorbidities in Nonalcoholic Fatty Liver Disease?

Nadine Gehrke et al.

GASTROENTEROLOGY (2020)

添加到收藏夹

Review Oncology

NAMPT and NAPRT: Two Metabolic Enzymes With Key Roles in Inflammation

Valentina Audrito et al.

FRONTIERS IN ONCOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

Crosstalk between adipose tissue insulin resistance and liver macrophages in non-alcoholic fatty liver disease

Chiara Rosso et al.

JOURNAL OF HEPATOLOGY (2019)

添加到收藏夹

Article Oncology

NAMPT and NAPRT, Key Enzymes in NAD Salvage Synthesis Pathway, Are of Negative Prognostic Value in Colorectal Cancer

Xiao-qin Li et al.

FRONTIERS IN ONCOLOGY (2019)

添加到收藏夹

Article Chemistry, Medicinal

Identification of potent triazolylpyridine nicotinamide phosphoribosyltransferase (NAMPT) inhibitors bearing a 1,2,3-triazole tail group

Cristina Travelli et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

添加到收藏夹

Article Multidisciplinary Sciences

Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation

Antonella Manago et al.

NATURE COMMUNICATIONS (2019)

添加到收藏夹

Review Gastroenterology & Hepatology

Determinants of fibrosis progression and regression in NASH

Detlef Schuppan et al.

JOURNAL OF HEPATOLOGY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Liver fibrosis: Direct antifibrotic agents and targeted therapies

Detlef Schuppan et al.

MATRIX BIOLOGY (2018)

添加到收藏夹

Review Gastroenterology & Hepatology

Increased Risk of Mortality by Fibrosis Stage in Nonalcoholic Fatty Liver Disease: Systematic Review and Meta-Analysis

Parambir S. Dulai et al.

HEPATOLOGY (2017)

添加到收藏夹

Article Gastroenterology & Hepatology

Global Epidemiology of Nonalcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence, and Outcomes

Zobair M. Younossi et al.

HEPATOLOGY (2016)

添加到收藏夹

Review Endocrinology & Metabolism

Physiological and pathophysiological roles of NAMPT and NAD metabolism

Antje Garten et al.

NATURE REVIEWS ENDOCRINOLOGY (2015)

添加到收藏夹

Article Multidisciplinary Sciences

Unique Toll-Like Receptor 4 Activation by NAMPT/PBEF Induces NFκB Signaling and Inflammatory Lung Injury

Sara M. Camp et al.

SCIENTIFIC REPORTS (2015)

添加到收藏夹

Review Biochemistry & Molecular Biology

Pre-B cell colony enhancing factor (PBEF), a cytokine with multiple physiological functions

Zhongjie Sun et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Monocytes Contribute to Differential Immune Pressure on R5 versus X4 HIV through the Adipocytokine Visfatin/NAMPT

Rafael Van den Bergh et al.

PLOS ONE (2012)

添加到收藏夹

Article Gastroenterology & Hepatology

Influence of Visfatin on Histopathological Changes of Non-alcoholic Fatty Liver Disease

R. Aller et al.

DIGESTIVE DISEASES AND SCIENCES (2009)

添加到收藏夹

Article Gastroenterology & Hepatology

Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection

Richard K. Sterling et al.

HEPATOLOGY (2006)

添加到收藏夹

Article Gastroenterology & Hepatology

Design and validation of a histological scoring system for nonalcoholic fatty liver disease

DE Kleiner et al.

HEPATOLOGY (2005)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.