☆ 4.7 Editorial Material

Molecular and Translational Research on Bone Tumors

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Biochemistry & Molecular Biology

Proteomic Assessment of Extracellular Vesicles from Canine Tissue Explants as a Pipeline to Identify Molecular Targets in Osteosarcoma: PSMD14/Rpn11 as a Proof of Principle

Anita K. Luu et al.

Summary: Osteosarcoma (OS) is a highly malignant bone tumor with limited improvements in treatment. Understanding the molecules contributing to OS biology can lead to the discovery of novel therapies. This study demonstrates the potential of extracellular vesicles (EVs) in revealing protein signatures related to OS and highlights a specific protein, PSMD14/Rpn11, as a potential prognostic marker and therapeutic target for OS.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Recent and Ongoing Research into Metastatic Osteosarcoma Treatments

Michael A. Harris et al.

Summary: The survival rate for metastatic osteosarcoma has remained stagnant for decades despite the introduction of chemotherapy as a treatment option. Efforts to identify potential therapies through animal studies and clinical trials have had limited success in improving survival outcomes for these patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

New Borane-Protected Derivatives of α-Aminophosphonous Acid as Anti-Osteosarcoma Agents: ADME Analysis and Molecular Modeling, In Vitro Studies on Anti-Cancer Activities, and NEP Inhibition as a Possible Mechanism of Anti-Proliferative Activity

Magdalena Mizerska-Kowalska et al.

Summary: This study evaluated the performance of new derivatives of phosphonous acid as potential drugs for osteosarcoma treatment and as inhibitors of NEP. Compound 4 showed promising results as an anti-osteosarcoma agent and a scaffold for the development of new NEP inhibitors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

CD44 Contributes to the Regulation of MDR1 Protein and Doxorubicin Chemoresistance in Osteosarcoma

Monserrat Gerardo-Ramirez et al.

Summary: Osteosarcoma is the most common type of pediatric bone tumor. Research shows that CD44 plays an important role in drug resistance of osteosarcoma cells, and abnormal expression of CD44 leads to molecular alterations.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Biochemistry & Molecular Biology

Analyzing BMP2, FGFR, and TGF Beta Expressions in High-Grade Osteosarcoma Untreated and Treated Autografts Using Proteomic Analysis

Rashmi Madda et al.

Summary: Biological reconstruction techniques have greatly improved the treatment of high-grade osteosarcoma patients by using liquid nitrogen and irradiation processes to remove tumors and reconstruct autografts. This proteomic study focuses on the expressions of growth factor family proteins in untreated and treated autografts, which play a crucial role in bone union, remodeling, and regeneration. The study found that these protein expressions were significantly higher in treated autografts, suggesting that the increased growth factor protein expression may contribute to bone regeneration healing and reduce the recurrence and spread of high-grade sarcoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Challenges of Systemic Therapy Investigations for Bone Sarcomas

Kenji Nakano

Summary: Bone sarcoma, a rare component of malignant solid tumors, presents various histological types and genomic mutations. Targeted drug investigations for bone sarcomas have not progressed like those for other solid tumors, with challenges in patient recruitment, especially among pediatric and young adult patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pathology

The 2020 WHO Classification of Tumors of Bone: An Updated Review

Joon Hyuk Choi et al.

Summary: Bone tumors are rare and heterogeneous neoplasms that require accurate histologic diagnosis for appropriate management. Significant advances have been made since 2013 in understanding bone tumor molecular biology, classification, and treatment. The 2020 WHO classification provides updated schemes and criteria for diagnosis.

ADVANCES IN ANATOMIC PATHOLOGY (2021)

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Article Biochemistry & Molecular Biology

15d-PGJ2 Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay

Mateja Mikulcic et al.

Summary: The study revealed that 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) exhibits significant anti-tumor effects on osteosarcoma cells by promoting apoptosis, increasing intracellular ROS levels, and activating the MAPK pathway, offering a promising natural compound to interfere with osteosarcoma tumor growth.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Suppression of Estrogen Receptor Alpha Inhibits Cell Proliferation, Differentiation and Enhances the Chemosensitivity of P53-Positive U2OS Osteosarcoma Cell

Jir-You Wang et al.

Summary: Osteosarcoma is a highly malignant musculoskeletal tumor commonly seen in various age groups, with a survival rate of 70-80%. ER alpha plays a significant role in osteosarcoma pathogenesis and chemosensitivity, with potential as a target for current treatments and a prognostic factor for chemotherapy response.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?

Viviana De Martino et al.

Summary: Osteosarcoma is a skeletal tumor that predominantly affects children and adolescents, often metastasizing to the lungs. Current treatment approaches involve surgery and chemotherapy, but drug resistance and side effects necessitate the search for new therapeutic strategies. Extracellular vesicles have sparked interest as potential diagnostic biomarkers and drug delivery vehicles for osteosarcoma, offering a promising avenue for treatment advancement.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article

Benign Bone-Forming Tumors

Fernanda Amary et al.

Surgical Pathology Clinics (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Revisiting the WHO classification system of bone tumours: emphasis on advanced magnetic resonance imaging sequences. Part 2

Shivani Ahlawat et al.

POLISH JOURNAL OF RADIOLOGY (2020)

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Review Oncology

The Emerging Roles of Extracellular Vesicles in Osteosarcoma

Francesca Perut et al.

FRONTIERS IN ONCOLOGY (2019)

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Article Oncology

Malignant bone tumors (other than Ewing's): clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS)

Andres Redondo et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2017)

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Article Medical Laboratory Technology

Primary malignant bone tumors-recent developments

Meera Hameed et al.

SEMINARS IN DIAGNOSTIC PATHOLOGY (2011)

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Review Genetics & Heredity

Osteosarcoma (Osteogenic sarcoma)

Piero Picci

ORPHANET JOURNAL OF RARE DISEASES (2007)

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