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May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Article Oncology

EphrinA3 is a key regulator of malignant behaviors and a potential prognostic factor in lung adenocarcinoma

Ruzetuoheti Yiminniyaze et al.

Summary: In this study, the researchers found that EphrinA3 is highly expressed in lung adenocarcinoma and its expression level is associated with patient prognosis. EphrinA3 promotes proliferation, migration, and invasion of lung adenocarcinoma cells. Mechanistically, EphrinA3 activates multiple signaling pathways and upregulates the expression of specific proteins.

CANCER MEDICINE (2023)

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Review Biochemistry & Molecular Biology

A perspective to weaponize microRNAs against lung cancer

Dhanashree Murugan et al.

Summary: MicroRNAs have great potential in lung cancer therapy, but their clinical effectiveness is limited due to delivery strategy limitations. Advances in nanotechnology, biomaterial science, and disease molecular pathology offer opportunities to overcome these limitations.

NON-CODING RNA RESEARCH (2023)

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Article Oncology

TPD7 inhibits the non-small cell lung cancer HCC827 cell growth by regulating EGFR signalling pathway

Xiaoyan Zhang et al.

Summary: TPD7, a novel taspine derivative, exerts strong inhibitory effects on EGFR-dependent HCC827 cells by regulating cell cycle and inducing apoptosis, presenting a potential EGFR inhibitor in the treatment of NSCLC.

JOURNAL OF CHEMOTHERAPY (2022)

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Article Biochemistry & Molecular Biology

The EPH/Ephrin System in Gynecological Cancers: Focusing on the Roots of Carcinogenesis for Better Patient Management

Iason Psilopatis et al.

Summary: The dysregulation of the EPH/ephrin system plays an important role in the development and progression of gynecological cancers. EPHs and ephrins show abnormal expression in gynecological tumors and have effects on different stages and clinicopathological parameters.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

The EPH/Ephrin System in Bone and Soft Tissue Sarcomas' Pathogenesis and Therapy: New Advancements and a Literature Review

Argyris C. Hadjimichael et al.

Summary: Musculoskeletal sarcomas are rare heterogeneous malignancies of mesenchymal origin, with two distinct subtypes, bone and soft tissue sarcomas. The EPH/ephrin signaling pathway plays an important role in sarcoma progression, with significant interactions with various normal and abnormal cascades. EPHs and ephrins have potential as candidates for diagnosis, monitoring, and therapy against bone and soft tissue sarcomas.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Biochemistry & Molecular Biology

Utilizing Exosomal-EPHs/Ephrins as Biomarkers and as a Potential Platform for Targeted Delivery of Therapeutic Exosomes

Dimitrios Goutas et al.

Summary: Exosomes, cell-secreted nanoparticles, play a crucial role in intercellular communication. They have advantages over synthetic drugs in terms of biocompatibility, tissue infiltration ability, and stability. However, artificial exosomes have limited targeting ability and efficacy. Therefore, researchers have been engineering stem cell-derived exosomes to improve their selectiveness and effectiveness.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

A phase 1 safety and bioimaging trial of antibody DS-8895a against EphA2 in patients with advanced or metastatic EphA2 positive cancers

Hui K. Gan et al.

Summary: This study reports a phase I dose escalation and biodistribution study of DS-8895a, an anti-EphA2 antibody, in patients with advanced EphA2 positive cancers. The results show limited therapeutic efficacy of DS-8895a and highlight the importance of biodistribution studies in drug development.

INVESTIGATIONAL NEW DRUGS (2022)

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Review Pharmacology & Pharmacy

Emerging Albumin-Binding Anticancer Drugs for Tumor-Targeted Drug Delivery: Current Understandings and Clinical Translation

Hanhee Cho et al.

Summary: Albumin has the potential to improve the delivery of anticancer drugs by acting as a natural carrier. It can enhance the circulation time of the drugs and passively target tumors through enhanced permeability and retention. However, the delivery efficiency of exogenous albumin formulations is low, which increases the risk of systemic toxicity. Prodrugs that bind endogenous albumin have been investigated as a safer and more effective drug delivery option.

PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Lung Cancer Targeted Chemoradiotherapy via Dual-Stimuli Responsive Biodegradable Core-Shell Nanoparticles

Roshni Iyer et al.

Summary: Lung cancer is a major cause of cancer-related deaths worldwide. Conventional clinical therapies have limitations in treating lung cancer, but a new study has developed dual-stimuli nanoparticles that target cancer cells and release chemotherapy drugs and radiation sensitizer, potentially improving treatment efficacy and reducing side effects.

PHARMACEUTICS (2022)

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Article Immunology

EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma

Wenyue Zhao et al.

Summary: EphA10 is overexpressed in LUAD tissues, with higher expression in tissues at advanced tumor stages and positively correlated with EGFR. Knockdown of EphA10 suppresses proliferation, migration, invasion, and epithelial-mesenchymal transition of LUAD cells, reduces PD-L1 expression, and enhances NK cell-mediated anti-tumor effects.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Biochemistry & Molecular Biology

The EPH/Ephrin System in Colorectal Cancer

Stavros P. Papadakos et al.

Summary: The EPH/ephrin system is a bidirectional signaling pathway that plays an important role in carcinogenesis. Despite advancements in the diagnosis and treatment of CRC, it remains a leading cause of global death. Recent research has provided new insights into the role of EPH/ephrins in the pathogenesis and treatment of CRC.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Oncology

EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma

Mingming Deng et al.

Summary: In this study, we found that increased EFNA3 expression in LUAD patients predicted worse clinical prognosis, promoted LUAD cell proliferation and glycolysis ability, and was related to immunotherapy response. Mechanistically, EFNA3 may be involved in pathways related to nuclear division, synaptic function, and ion channel activity. Furthermore, EFNA3 was negatively correlated with immunity, stromal infiltration, and various tumor infiltrating immune cells (TIICs), but positively associated with multiple immunotherapy biomarkers.

CANCER CELL INTERNATIONAL (2021)

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Review Oncology

The Role of the Eph Receptor Family in Tumorigenesis

Meg Anderton et al.

Summary: The Eph receptor family plays a dual role in tumorigenesis, acting as both promoters and suppressors depending on the context. EphA2 is particularly associated with Kaposi's sarcoma (KS) development and plays a significant role in this cancer type. Further research is needed to establish the links between EphA2 signaling and KS oncogenesis.

CANCERS (2021)

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Article Oncology

EPHA2 Interacts with DNA-PKcs in Cell Nucleus and Controls Ionizing Radiation Responses in Non-Small Cell Lung Cancer Cells

Vitaliy O. Kaminskyy et al.

Summary: This study investigates the role of Ephrin type-A receptor 2 (EphA2) in DNA damage response signaling and cellular effects of ionizing radiation (IR) in NSCLC cells. Silencing EphA2 sensitizes cells to IR, leading to increased caspase-3 activation, PARP-1 cleavage, and reduced clonogenic survival. EphA2 interacts with DNA-PKcs in the cell nucleus, suggesting a novel mechanism involving EphA2 in DDR signaling and IR responsiveness.

CANCERS (2021)

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Article Medicine, General & Internal

Ephrin Receptors (Ephs) Expression in Thymic Epithelial Tumors: Prognostic Implications and Future Therapeutic Approaches

Christos Masaoutis et al.

Summary: The study found that Eph receptors are expressed differently in thymic epithelial tumors, with correlations to tumor subtypes and Masaoka stage.

DIAGNOSTICS (2021)

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Review Biochemistry & Molecular Biology

RNA-based therapies: A cog in the wheel of lung cancer defense

Parvez Khan et al.

Summary: Lung cancer, comprising mainly NSCLC and SCLC, remains a challenging disease with low survival rates, but RNA-mediated gene inhibition technologies hold promise for innovative therapeutic approaches.

MOLECULAR CANCER (2021)

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Review Pharmacology & Pharmacy

Insight Into the Prospects for RNAi Therapy of Cancer

Zhili Tian et al.

Summary: RNA interference (RNAi) shows great potential in treatment, but faces challenges such as delivery to target sites and toxic side effects. Research on RNAi therapy for COVID-19 is of significant importance.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

The Clinical Impact of the EPH/Ephrin System in Cancer: Unwinding the Thread

Alexandros Pergaris et al.

Summary: The EPH/ephrin system plays a crucial role in the pathogenesis of diseases, including cancer, and is associated with clinical characteristics of malignant tumors, potentially serving as novel therapeutic targets.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer

Ren Nanamiya et al.

Summary: Osimertinib exerts significant inhibitory effects on cell growth and progression independently of EGFR by promoting the phosphorylation of p53 and p21 and decreasing cyclin D1 expression. EphB4 is significantly suppressed by osimertinib and promotes cell growth and sensitivity to osimertinib. EphB4 is associated with the EGFR-independent suppressive effects of osimertinib on cell cycle and with a poor clinical outcome.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Critical Care Medicine

Targeted Therapy for Non-Small Cell Lung Cancer

Zorawar S. Noor et al.

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Cell Biology

Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

Caroline Volz et al.

CELL REPORTS (2020)

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Review Oncology

Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy

Charles Pottier et al.

CANCERS (2020)

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Article Multidisciplinary Sciences

Activation of EPHA2-ROBO1 Heterodimer by SLIT2 Attenuates Non-canonical Signaling and Proliferation in Squamous Cell Carcinomas

Saumya Srivastava et al.

ISCIENCE (2020)

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Article Oncology

EPHA mutation as a predictor of immunotherapeutic efficacy in lung adenocarcinoma

Hua Bai et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

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Article Oncology

Ligand-independent EphB1 signaling mediates TGF-beta-activated CDH2 and promotes lung cancer cell invasion and migration

Lujuan Wang et al.

JOURNAL OF CANCER (2020)

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Review Immunology

Monoclonal Antibodies in Cancer Therapy

David Zahavi et al.

ANTIBODIES (2020)

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Article Biochemistry & Molecular Biology

EphA2 inhibition suppresses proliferation of small-cell lung cancer cells through inducing cell cycle arrest

Hirotoshi Ishigaki et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

Formulation optimization of an ephrin A2 targeted immunoliposome encapsulating reversibly modified taxane prodrugs

Zhaohua Richard Huang et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Biochemistry & Molecular Biology

Heart failure with preserved ejection fraction: present status and future directions

Somy Yoon et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2019)

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Review Biotechnology & Applied Microbiology

Differential Expression Patterns of Eph Receptors and Ephrin Ligands in Human Cancers

Chung-Ting Jimmy Kou et al.

BIOMED RESEARCH INTERNATIONAL (2018)

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Article Nanoscience & Nanotechnology

Paclitaxel-Loaded Core-Shell Magnetic Nanoparticles and Cold Atmospheric Plasma Inhibit Non-Small Cell Lung Cancer Growth

Hongli Yu et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Oncology

Overexpression of junctional adhesion molecule-A and EphB2 predicts poor survival in lung adenocarcinoma patients

Chen Zhao et al.

TUMOR BIOLOGY (2017)

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Article Multidisciplinary Sciences

Dual-Drug Containing Core-Shell Nanoparticles for Lung Cancer Therapy

Jyothi U. Menon et al.

SCIENTIFIC REPORTS (2017)

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Review Oncology

A review on Eph/ephrin, angiogenesis and lymphangiogenesis in gastric, colorectal and pancreatic cancers

Julia Rudno-Rudzinska et al.

CHINESE JOURNAL OF CANCER RESEARCH (2017)

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Article Medicine, Research & Experimental

Taspine derivative 12k suppressed A549 cell migration through the Wnt/β-catenin and EphrinB2 signaling pathway

Bingling Dai et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

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Article Oncology

EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

Katherine R. Amato et al.

CANCER RESEARCH (2016)

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Article Oncology

Knockdown of ephrin receptor A7 suppresses the proliferation and metastasis of A549 human lung cancer cells

Ronghui Li et al.

MOLECULAR MEDICINE REPORTS (2016)

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Review Cell Biology

Mechanisms of ephrin-Eph signalling in development, physiology and disease

Artur Kania et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

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Article Oncology

A taspine derivative supresses Caco-2 cell growth by competitively targeting EphrinB2 and regulating its pathway

Bingling Dai et al.

ONCOLOGY REPORTS (2016)

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Article Oncology

EPHA3 regulates the multidrug resistance of small cell lung cancer via the PI3K/BMX/STAT3 signaling pathway

Juan Peng et al.

TUMOR BIOLOGY (2016)

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Article Oncology

Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer

Ghazal Efazat et al.

ONCOTARGET (2016)

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Article Biochemistry & Molecular Biology

Receptor Tyrosine Kinase EphA5 Is a Functional Molecular Target in Human Lung Cancer

Fernanda I. Staquicini et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Biochemical Research Methods

Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition

Heiner Koch et al.

JOURNAL OF PROTEOME RESEARCH (2015)

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Article Chemistry, Medicinal

Albumin-bound paclitaxel in solid tumors: clinical development and future directions

Madappa Kundranda et al.

Drug Design Development and Therapy (2015)

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Article Biochemical Research Methods

Structures of an Eph receptor tyrosine kinase and its potential activation mechanism

Qiang Wei et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2014)

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Article Medicine, General & Internal

Ephrin (Eph) receptor A1, A4, A5 and A7 expression in human non-small cell lung carcinoma: associations with clinicopathological parameters, tumor proliferative capacity and patients' survival

Constantinos Giaginis et al.

BMC CLINICAL PATHOLOGY (2014)

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Article Endocrinology & Metabolism

After repeated division, bone marrow stromal cells express inhibitory factors with osteogenic capabilities, and EphA5 is a primary candidate

Tsuyoshi Yamada et al.

BONE (2013)

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Article Multidisciplinary Sciences

The EphB4 Receptor Tyrosine Kinase Promotes Lung Cancer Growth: A Potential Novel Therapeutic Target

Benjamin D. Ferguson et al.

PLOS ONE (2013)

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Article Oncology

A Novel Taspine Derivative, HMQ1611, Inhibits Breast Cancer Cell Growth via Estrogen Receptor α and EGF Receptor Signaling Pathways

Yingzhuan Zhan et al.

CANCER PREVENTION RESEARCH (2012)

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Review Biochemistry & Molecular Biology

Immunoliposomes

E. Paszko et al.

CURRENT MEDICINAL CHEMISTRY (2012)

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Article Plant Sciences

Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines

Monica Montopoli et al.

JOURNAL OF ETHNOPHARMACOLOGY (2012)

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Article Oncology

Global Evaluation of Eph Receptors and Ephrins in Lung Adenocarcinomas Identifies EphA4 as an Inhibitor of Cell Migration and Invasion

Pierre Saintigny et al.

MOLECULAR CANCER THERAPEUTICS (2012)

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Article Oncology

Higher expression of EphA2 and ephrin-A1 is related to favorable clinicopathological features in pathological stage I non-small cell lung carcinoma

Masashi Ishikawa et al.

LUNG CANCER (2012)

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Article Multidisciplinary Sciences

Mutations of the EPHB6 Receptor Tyrosine Kinase Induce a Pro-Metastatic Phenotype in Non-Small Cell Lung Cancer

Etmar Bulk et al.

PLOS ONE (2012)

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Article Oncology

A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis

Wen Lu et al.

ONCOLOGY LETTERS (2012)

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Article Multidisciplinary Sciences

EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex

Guo Li et al.

NATURE COMMUNICATIONS (2012)

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Article Pharmacology & Pharmacy

Targeted lung cancer therapy using ephrinA1-loaded albumin microspheres

Hung-Yen Lee et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2011)

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Article Biochemical Research Methods

Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor

Sara Stahl et al.

JOURNAL OF PROTEOME RESEARCH (2011)

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Article Biochemistry & Molecular Biology

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

Jiannong Li et al.

NATURE CHEMICAL BIOLOGY (2010)

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Review Oncology

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

Elena B. Pasquale

NATURE REVIEWS CANCER (2010)

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Article Medicine, Research & Experimental

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

Martin L. Sos et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

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Small RNAs in development and disease

Bryan K. Sun et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2008)

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Transcriptional Profiling of Non-Small Cell Lung Cancer Cells with Activating EGFR Somatic Mutations

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