4.7 Article

Lophatherum gracile Bronghiart Suppresses Receptor Activator of Nuclear Factor Kappa-B Ligand-Stimulated Osteoclastogenesis and Prevents Ovariectomy-Induced Osteoporosis

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MDPI
DOI: 10.3390/ijms232213942

关键词

Lophatherum gracile Bronghiart; osteoporosis; bone loss; ovariectomy

资金

  1. Korea Institute of Oriental Medicine, Ministry of Science and ICT, Republic of Korea [KSN2021330]
  2. National Research Council of Science & Technology (NST), Republic of Korea [KSN2021330] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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The water extract of Lophatherum gracile leaves inhibits osteoclast differentiation and bone loss, making it a potential candidate for therapy and prevention of postmenopausal osteoporosis.
Lophatherum gracile Bronghiart, used in traditional herbal medicine, has many biological properties including antiviral, antipyretic, antitumor, vasorelaxation, and neutrophilic inflammatory effects. However, its modulatory effects on bone metabolism have not been investigated previously. In this study, we examined the effects of a water extract of the leaves of L. gracile (WELG) on osteoclast differentiation and bone loss, and explored its underlying mechanisms. We found that WELG inhibits osteoclastogenesis by suppressing both receptor activator of nuclear factor-kappa B ligand (RANKL)-induced early activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappa B)- and RANKL-induced modulation of the positive and negative regulators of osteoclastogenesis in osteoclast precursors. In vivo study demonstrated that WELG protects against bone loss, weight gain, and fat accumulation without affecting uterine atrophy in an ovariectomy-induced postmenopausal osteoporosis mice model. In addition, photochemical analysis of WELG identified active constituents known to have bone-protective effects. Overall, the results of this study suggest that WELG can be a potential candidate for therapy and prevention of postmenopausal osteoporosis.

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