4.7 Review

Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Medicine, Research & Experimental

Combined treatment with niclosamide ethanolamine and artemether combination improves type 1 diabetes via the targeting of liver mitochondria

Wenci Weng et al.

Summary: The combination therapy of niclosamide ethanolamine salt (NEN) and artemether (Art) improved glycometabolism and liver function in T1D mice, with potential involvement of liver mitochondrial regulation.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Article Cell Biology

Niclosamide Ethanolamine Salt Alleviates Idiopathic Pulmonary Fibrosis by Modulating the PI3K-mTORC1 Pathway

Xiaolin Pei et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is a serious disease that leads to respiratory failure and early mortality. This study found that Niclosamide ethanolamine salt (NEN) could significantly improve lung function and reduce fibrosis in an IPF animal model. The results also showed that NEN inhibits abnormal fibroblast proliferation and excessive extracellular matrix production through the regulation of the PI3K-mTORC1 and autophagy pathways. These findings provide strong evidence for the potential therapeutic role of NEN in IPF.
Review Pharmacology & Pharmacy

Niclosamide-A promising treatment for COVID-19

Shivani Singh et al.

Summary: This article reviews the pharmacology and scientific rationale for repurposing niclosamide, an anti-helminth drug, for the treatment of COVID-19. It highlights the drug's potent antiviral activity and its pleiotropic effects in preclinical and early clinical studies. The advantages and rationale for nebulized and intranasal formulations of niclosamide are also discussed, along with an overview of ongoing clinical trials.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Molecular interactions of niclosamide with hydroxyethyl cellulose in binary and ternary amorphous solid dispersions for synergistic enhancement of water solubility and oral pharmacokinetics in rats

Jigar S. Bhanushali et al.

Summary: This study reported the synergistic effect of hydroxyethyl cellulose on enhancing the solubility and dissolution of BCS class II anthelmintic drug niclosamide. The developed amorphous solid dispersions showed reproducible enhancement in solubility and dissolution, suggesting the need for validation in clinical settings.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

Article Microbiology

Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs

Shawn Herring et al.

Summary: Previous studies have shown that approved drugs developed for other clinical indications can inhibit EBOV and LASV, and combinations of these drugs may provide synergistic suppression of arenaviruses, indicating a potential proactive strategy for controlling arenavirus outbreaks.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2021)

Article Oncology

A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier

Georg Hilfenhaus et al.

Summary: High-content screen identified niclosamide as an effective drug that restricts tumor cell extravasation by enhancing endothelial barrier stability through modulation of molecular signaling, chemokines, and tumor-endothelial cell interactions.

CANCER RESEARCH (2021)

Article Pharmacology & Pharmacy

Combined chemotherapy for triple negative breast cancer treatment by paclitaxel and niclosamide nanocrystals loaded thermosensitive hydrogel

Deqian Zhao et al.

Summary: An injectable PTX and NLM nanocrystals co-loaded PLGA-PEG-PLGA thermosensitive hydrogel was designed for intratumoral treatment of TNBC. The formulation realized high drug loading and appropriate particle size, displaying sustained drug release and high tumor growth inhibition rate in vivo, with potential to prevent TNBC recurrence and metastasis.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Discovery of a Small Molecule Inhibitor of Human Adenovirus Capable of Preventing Escape from the Endosome

Jimin Xu et al.

Summary: Compound 16 (JMX0493) is reported as a potent inhibitor of HAdV infection, displaying submicromolar IC50 values, a higher selectivity index (SI > 100), and a 2.5-fold virus yield reduction compared to the hit compound niclosamide. Mechanistic studies suggest that compound 16 achieves its antiviral activity against HAdV through inhibition of viral particle escape from the endosome, blocking subsequent uncoating and presentation of lytic protein VI.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Multidisciplinary Sciences

Development and evaluation of inhalable composite niclosamide-lysozyme particles: A broad-spectrum, patient-adaptable treatment for coronavirus infections and sequalae

Ashlee D. Brunaugh et al.

Summary: The co-formulation of Niclosamide with human lysozyme enables the direct aerosol delivery of the drug to the respiratory tract, effectively treating COVID-19 by targeting the primary site of virus acquisition and spread. The novel formulation demonstrates potent activity against various coronavirus strains and may offer protection against secondary inflammatory lung damage, with low-cost development approach ensuring rapid clinical development and widespread utilization.

PLOS ONE (2021)

Review Oncology

Targeting Cancer Stem Cells with Repurposed Drugs to Improve Current Therapies

Dunne Fong et al.

Summary: Cancer is a complex multistep process involving genetic and environmental factors leading to genetic and epigenetic changes. Cancer stem cells play a crucial role in tumor progression and are a subpopulation of tumor cells with self-renewal and differentiation abilities. Repurposing FDA-approved drugs to target resistant cancer cells, such as CSCs, can improve cancer treatment efficacy.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

Phase Ib trial of reformulated niclosamide with abiraterone/prednisone in men with castration-resistant prostate cancer

Mamta Parikh et al.

Summary: The study aimed to evaluate the efficacy and tolerability of a novel reformulated orally-bioavailable niclosamide in combination with abiraterone and prednisone for castration-resistant prostate cancer. The results showed that this combination therapy demonstrated good tolerability and treatment response in patients, warranting further research.

SCIENTIFIC REPORTS (2021)

Article Biochemical Research Methods

Bioanalysis of niclosamide in plasma using liquid chromatography-tandem mass and application to pharmacokinetics in rats and dogs

Hae-In Choi et al.

Summary: A study developed a LC-MS/MS method for determining niclosamide concentration in animals, revealing its antiviral effects against the SARS-CoV-2 virus. Pharmacokinetic studies showed dose-independent pharmacokinetics of niclosamide in rats and dogs, with low drug exposure after oral administration.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2021)

Article Oncology

Anthelminthic niclosamide inhibits tumor growth and invasion in cisplatin-resistant human epidermal growth factor receptor 2-positive breast cancer

Junjun Liu et al.

Summary: Chemotherapy-resistant breast cancer, especially HER2-positive, shows aggressive behavior with epithelial-mesenchymal transition and stem cell characteristics. Niclosamide, a drug used for tapeworm disease, has shown potential in inhibiting proliferation and stem-like properties in breast cancer cells. Combined with cisplatin, niclosamide demonstrated inhibition of resistance, invasion, and epithelial-mesenchymal transition in HER2-positive breast cancer, suggesting a novel therapeutic approach.

ONCOLOGY LETTERS (2021)

Article Oncology

A Synergistic Combination of Niclosamide and Doxorubicin as an Efficacious Therapy for All Clinical Subtypes of Breast Cancer

Garima Lohiya et al.

Summary: Drug resistance is a major challenge in cancer chemotherapy, with aberrantly expressed Wnt/beta-catenin signaling playing a crucial role. Combining the FDA-approved antihelminthic drug niclosamide as a Wnt signaling inhibitor with the conventional anticancer agent doxorubicin shows promising synergistic effects in inducing apoptosis and cell death in breast cancer, regardless of the clinical subtype.

CANCERS (2021)

Article Oncology

Metformin and Niclosamide Synergistically Suppress Wnt and YAP in APC-Mutated Colorectal Cancer

Hee Eun Kang et al.

Summary: This study revealed that Axin2, a downstream target of canonical Wnt, activates Hippo pathway in APC-mutated CRC, limiting the therapeutic potential of niclosamide. By combining niclosamide with metformin, Hippo pathway can be activated synergistically with suppression of canonical Wnt in APC-mutated CRC. This combinatory approach offers a novel therapeutic strategy for FAP and CRC patients by targeting both Wnt and Hippo pathways.

CANCERS (2021)

Article Oncology

Niclosamide and Pyrvinium Are Both Potential Therapeutics for Osteosarcoma, Inhibiting Wnt-Axin2-Snail Cascade

Young Yi et al.

Summary: Epithelial-mesenchymal transition (EMT) is a key mechanism of cancer progression, activated by Wnt signaling which stabilizes Snail and beta-catenin. Study found that niclosamide and pyrvinium target Axin2, inhibiting Wnt/Snail axis and suppressing EMT in osteosarcoma cells. Axin2 and Snail are potential therapeutic targets in osteosarcoma, and anthelminthic agents niclosamide and pyrvinium may be effective in treating osteosarcoma.

CANCERS (2021)

Article Oncology

Repurposing Niclosamide for Targeting Pancreatic Cancer by Inhibiting Hh/Gli Non-Canonical Axis of Gsk3β

Jyoti B. Kaushal et al.

Summary: The study evaluated the therapeutic efficacy of Niclosamide on pancreatic cancer and found that it induced cell death through mitochondrial stress and mTORC1-dependent autophagy. Niclosamide inhibited the Hedgehog (Hh) signaling pathway and promoted cell death through regulation of p-Gsk3 beta.

CANCERS (2021)

Review Medicine, General & Internal

An update of anti-viral treatment of COVID-19

Serap Simsek Yavuz et al.

Summary: Monoclonal antibodies appear to be the most effective treatment for COVID-19 based on available evidence, while drugs like lopinavir/ritonavir, hydroxychloroquine, merimepodib, and umifenovir have been found to be ineffective. Further studies are needed to determine the efficacy of other potential treatments for COVID-19.

TURKISH JOURNAL OF MEDICAL SCIENCES (2021)

Article Engineering, Biomedical

Injectable pegylated niclosamide (polyethylene glycol-modified niclosamide) for cancer therapy

Rui Ma et al.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2020)

Review Chemistry, Medicinal

Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential

Jimin Xu et al.

ACS INFECTIOUS DISEASES (2020)

Article Biochemistry & Molecular Biology

Niclosamide and its derivative DK-520 inhibit RANKL-induced osteoclastogenesis

Yurui Jiao et al.

FEBS OPEN BIO (2020)

Review Medicine, General & Internal

Drug Resistance in Cancer Therapy and the Role of Epigenetics

Takeshi Asano

JOURNAL OF NIPPON MEDICAL SCHOOL (2020)

Review Chemistry, Medicinal

Mitochondria-centric bioenergetic characteristics in cancer stem-like cells

Min-Kyue Shin et al.

ARCHIVES OF PHARMACAL RESEARCH (2019)

Editorial Material Biochemistry & Molecular Biology

New insights into niclosamide action: autophagy activation in colorectal cancer

Phillip T. Newton

BIOCHEMICAL JOURNAL (2019)

Article Oncology

Nanoliposomal Encapsulation Enhances In Vivo Anti-Tumor Activity of Niclosamide against Melanoma

Mahdi Hatamipour et al.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2019)

Article Biochemistry & Molecular Biology

Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity

Jeong Su Park et al.

FREE RADICAL BIOLOGY AND MEDICINE (2019)

Article Biochemistry & Molecular Biology

Effective and new potent drug combination: Histone deacetylase and Wnt/β-catenin pathway inhibitors in lung carcinoma cells

Oguzhan Akgun et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2019)

Review Oncology

Targeting mTOR for cancer therapy

Hui Hua et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Review Pharmacology & Pharmacy

Niclosamide repositioning for treating cancer: Challenges and nano-based drug delivery opportunities

Eduardo Jose Barbosa et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Article Oncology

Cancer and the Immune System: The History and Background of Immunotherapy

Maura Abbott et al.

SEMINARS IN ONCOLOGY NURSING (2019)

Review Biochemistry & Molecular Biology

Mitochondrial dynamics and metastasis

Dario C. Altieri

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Article Rheumatology

The Anti-Rheumatoid Activity of Niclosamide in Collagen-induced Arthritis in Rats

Ali Al-Gareeb et al.

ARCHIVES OF RHEUMATOLOGY (2019)

Article Psychiatry

Niclosamide piperazine prevents high-fat diet-induced obesity and diabetic symptoms in mice

Jingjing Guo et al.

EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY (2019)

Article Medicine, Research & Experimental

Overexpression of ALK4 inhibits cell proliferation and migration through the inactivation of JAK/STAT3 signaling pathway in glioma

Chaojun Song et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Pharmacology & Pharmacy

Octenylsuccinate hydroxypropyl phytoglycogen enhances the solubility and in-vitro antitumor efficacy of niclosamide

Ying Xie et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2018)

Article Endocrinology & Metabolism

Niclosamide ethanolamine improves kidney injury in db/db mice

Pengxun Han et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2018)

Review Oncology

Revisiting the role of ABC transporters in multidrug-resistant cancer

Robert W. Robey et al.

NATURE REVIEWS CANCER (2018)

Article Materials Science, Biomaterials

Design, synthesis and characterization of poly (methacrylic acid-niclosamide) and its effect on arterial function

Rui Ma et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

Article Chemistry, Multidisciplinary

Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth

Jayanta Bhattacharyya et al.

NANOSCALE (2017)

Article Pharmacology & Pharmacy

Niclosamide ethanolamine inhibits artery constriction

Shan-Liang Li et al.

PHARMACOLOGICAL RESEARCH (2017)

Article Pharmacology & Pharmacy

Drug Repurposing of the Anthelmintic Niclosamide to Treat Multidrug-Resistant Leukemia

Sami Hamdoun et al.

FRONTIERS IN PHARMACOLOGY (2017)

Review Cell Biology

Niclosamide: Beyond an antihelminthic drug

Wei Chen et al.

CELLULAR SIGNALLING (2017)

Article Pharmacology & Pharmacy

Niclosamide inhibits lytic replication of Epstein-Barr virus by disrupting mTOR activation

Lu Huang et al.

ANTIVIRAL RESEARCH (2017)

Article Immunology

Niclosamide induces apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes

Mingcheng Huang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

Article Medicine, Research & Experimental

Niclosamide inhibits colon cancer progression through downregulation of the Notch pathway and upregulation of the tumor suppressor miR-200 family

Mohammed A. Suliman et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2016)

Article Dermatology

Improvement of Sclerodermatous Graft-Versus-Host Disease in Mice by Niclosamide

Florence Morin et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2016)

Article Chemistry, Medicinal

Design and evaluation of injectable niclosamide nanocrystals prepared by wet media milling technique

Yanghuan Ye et al.

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY (2015)

Article Multidisciplinary Sciences

Repurposing Salicylanilide Anthelmintic Drugs to Combat Drug Resistant Staphylococcus aureus

Rajmohan Rajamuthiah et al.

PLOS ONE (2015)

Review Oncology

Androgen receptor signaling in prostate cancer

Zoran Culig et al.

CANCER AND METASTASIS REVIEWS (2014)

Article Biochemistry & Molecular Biology

Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice

Hanlin Tao et al.

NATURE MEDICINE (2014)

Article Multidisciplinary Sciences

Drug Screening Identifies Niclosamide as an Inhibitor of Breast Cancer Stem-Like Cells

Yu-Chi Wang et al.

PLOS ONE (2013)

Article Chemistry, Medicinal

Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication

Andrew V. Stachulski et al.

JOURNAL OF MEDICINAL CHEMISTRY (2011)

Article Chemistry, Medicinal

Identification of Niclosamide as a New Small-Molecule Inhibitor of the STAT3 Signaling Pathway

Xiaomei Ren et al.

ACS MEDICINAL CHEMISTRY LETTERS (2010)

Article Biochemistry & Molecular Biology

The Anti-Helminthic Niclosamide Inhibits Wnt/Frizzled1 Signaling

Minyong Chen et al.

BIOCHEMISTRY (2009)

Article Biochemistry & Molecular Biology

Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death

Ping Jun Zhu et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2009)

Article Biochemistry & Molecular Biology

The Autonomous Notch Signal Pathway Is Activated by Baicalin and Baicalein But Is Suppressed by Niclosamide in K562 Cells

An-Ming Wang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2009)

Review Oncology

Signal integration by JNK and p38 MAPK pathways in cancer development

Erwin F. Wagner et al.

NATURE REVIEWS CANCER (2009)

Review Oncology

The MAPK signalling pathways and colorectal cancer

JY Fang et al.

LANCET ONCOLOGY (2005)

Article Microbiology

Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide

CJ Wu et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)