期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms232213929
关键词
siRNA; gene delivery; surface-functionalized nanoparticles; targeted drug delivery; lipid nanoparticle; polymer nanoparticle; antibody
资金
- DFG, German Research Foundation [316213987-SFB 1278]
- [SFB 1181]
The RNA interference mechanism may represent a breakthrough in the therapy of diseases caused by gene defects or requiring the inhibition of specific genes. The limitations of siRNA can be overcome by further developments in nanoparticulate drug delivery. Surface-modified siRNA nanoparticles hold promise for more efficient and safer targeting of specific tissues, but developing such delivery strategies remains a major challenge.
The mechanism of RNA interference (RNAi) could represent a breakthrough in the therapy of all diseases that arise from a gene defect or require the inhibition of a specific gene expression. In particular, small interfering RNA (siRNA) offers an attractive opportunity to achieve a new milestone in the therapy of human diseases. The limitations of siRNA, such as poor stability, inefficient cell uptake, and undesired immune activation, as well as the inability to specifically reach the target tissue in the body, can be overcome by further developments in the field of nanoparticulate drug delivery. Therefore, types of surface modified siRNA nanoparticles are presented and illustrate how a more efficient and safer distribution of siRNA at the target site is possible by modifying the surface properties of nanoparticles with antibodies. However, the development of such efficient and safe delivery strategies is currently still a major challenge. In consideration of that, this review article aims to demonstrate the function and targeted delivery of siRNA nanoparticles, focusing on the surface modification via antibodies, various lipid- and polymer-components, and the therapeutic effects of these delivery systems.
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