4.7 Article

Comparison of the Chemical Components, Efficacy and Mechanisms of Action of Chrysanthemum morifolium Flower and Its Wild Relative Chrysanthemum indicum Flower against Liver-Fire Hyperactivity Syndrome of Hypertension via Integrative Analyses

期刊

出版社

MDPI
DOI: 10.3390/ijms232213767

关键词

Chrysanthemum morifolium flower; Chrysanthemum indicum flower; liver-fire hyperactivity syndrome of hypertension; network pharmacology; molecular pharmacology; metabolomics; traditional Chinese medicine

资金

  1. National Natural Science Foundations of China [81973464/H3203, 82104379/H3203, 82104126/H3410]
  2. China Postdoctoral Science Foundation [2020M680989]
  3. Liaoning Provincial Doctoral Research Start-up Fund Project [2020-BS-126]
  4. Liaoning Distinguished Professor Project
  5. Liaoning BaiQianWan Talents Program in 2019 [A-37]
  6. Shenyang Science and Technology Innovation Project for Young and Middle-aged Talents [RC190505]
  7. Basic Scientific Research project of Higher education Department of Liaoning Province [LJKQZ2021033]
  8. Basic Research Project of Colleges and Universities of Education Department of Liaoning Province [LJKZ0929]

向作者/读者索取更多资源

This study examines the differences in the clinical application scope of Chrysanthemum morifolium flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs with similar origin. The study employs a combination of network pharmacology, molecular pharmacology, and metabolomics to investigate the similarities and differences in chemical components, efficacy, and mechanisms of action of the two herbs. The results show that while CMF and CIF have similar effects in lowering blood pressure, resistance to tissue damage, and improving dyslipidemia, they exhibit distinct effects in regulating inflammatory response, signaling pathways, lipid anabolism, and metabolic abnormalities. The study suggests that the comparable efficacies of CMF and CIF, despite their distinct mechanisms of action, may be attributed to the integration and counteraction of their different regulating capabilities.
To clarify the differences in the clinical application scope of Chrysanthemum morifolium flower (CMF) and Chrysanthemum indicum flower (CIF), two herbs of similar origin, an integrated strategy of network pharmacology, molecular pharmacology, and metabolomics was employed, with a view to investigating the commonalities and dissimilarities in chemical components, efficacy and mechanisms of action. Initial HPLC-Q-TOF-MS analysis revealed that CMF and CIF had different flavonoid constituents. The biological processes underlying the therapeutic effects of CMF and CIF on liver-fire hyperactivity syndrome of hypertension (LFHSH) were predicted to be related to inflammatory response, fatty acid production, and other pathways based on network pharmacology analysis. ELISA, molecular docking, Western blot, and metabolomics techniques showed similar effects of CMF and CIF in lowering blood pressure, resistance to tissue, organ and functional damage, and dyslipidemia. However, distinct effects were found in the regulation of inflammatory response, PI3K-Akt and NF-kappa B signaling pathways, lipid anabolism, renin-angiotensin system, and metabolic abnormalities. The comparable efficacies of CMF and CIF, despite having distinct mechanisms of action, may be attributed to the integration and counteraction of their different regulating capabilities on the above anti-LFHSH mechanisms. This study offers a vital platform for assessment of differential and precise applications of herbs of close origin with similar but slightly different medicinal properties, and provides a research strategy for bridging Chinese medicine and modern precision medicine.

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