4.7 Article

Spatial Memory Training Counteracts Hippocampal GIRK Channel Decrease in the Transgenic APPSw,Ind J9 Alzheimer's Disease Mouse Model

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Spatial Training Attenuates Long-Term Alzheimer's Disease-Related Pathogenic Processes in APP/PS1 Mice

Yang Zhao et al.

Summary: The study demonstrated that one-month MWM training in APP/PS1 mice could attenuate Aβ deposition, decrease BACE1 and AβPP expression, and have long-term effects, while also increasing synapse-related protein expression in the hippocampus. MWM training also increased adult hippocampal neurogenesis in AD model mice, but did not alleviate cognitive deficits at an early stage.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Review Cell Biology

Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: a systematic review

Danko Jeremic et al.

Summary: Alzheimer's disease is the most common neurodegenerative disease in aging population with lack of effective treatments. Accumulation of Aβ peptides is considered one of the fundamental neuropathological pillars of the disease, thus many therapies target Aβ.

AGEING RESEARCH REVIEWS (2021)

Review Pharmacology & Pharmacy

Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system

Danko Jeremic et al.

Summary: GirK channels play a crucial role in the central nervous system by regulating membrane potential and neurotransmission, and are associated with a variety of diseases.

PHARMACOLOGY & THERAPEUTICS (2021)

Article Biochemistry & Molecular Biology

The Expression and Localisation of G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channels Is Differentially Altered in the Hippocampus of Two Mouse Models of Alzheimer's Disease

Rocio Alfaro-Ruiz et al.

Summary: This study investigated the expression and localization patterns of GIRK2 channels in two transgenic mouse models of Alzheimer's disease. The results showed significant reduction of GIRK2 expression in P301S mice, but no change in APP/PS1 mice. Ultrastructural approaches revealed decreased surface localization of GIRK2 in CA1 pyramidal cells in both transgenic mice models. These findings suggest a redistribution of GIRK channels and potential contribution to cognitive dysfunctions in Alzheimer's disease animal models.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Neurosciences

Hyperactivity Induced by Soluble Amyloid-β Oligomers in the Early Stages of Alzheimer's Disease

Audrey Hector et al.

Summary: Recent studies suggest that memory decline in early stages of Alzheimer's disease may be related to neuronal hyperactivity induced by soluble amyloid-beta oligomers, rather than hypoactivity as traditionally believed. Evidence shows that A beta o may induce neuronal hyperactivity in AD animal models, in vitro, and in humans. Cellular and molecular mechanisms are emerging to explain how A beta o induces neuronal hyperactivity, with implications for developing disease-modifying interventions at the onset of AD.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Cell Biology

Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

Fernando Maestu et al.

Summary: Our incomplete understanding of the link between Alzheimer's Disease pathology and symptomatology hinders therapeutic success. Disturbance of neuronal activity, particularly an imbalance in underlying excitation/inhibition (E/I), plays a central role in connecting structural brain pathology and cognitive dysfunction in AD. While there are emerging options to influence this imbalance, the complexity of human brain dynamics complicates identification of an optimal approach.

AGEING RESEARCH REVIEWS (2021)

Article Neurosciences

G-Protein-Gated Inwardly Rectifying Potassium (Kir3/GIRK) Channels Govern Synaptic Plasticity That Supports Hippocampal-Dependent Cognitive Functions in Male Mice

Souhail Djebari et al.

Summary: The G-protein-gated inwardly rectifying potassium (Kir3/GIRK) channel plays a crucial role in hippocampal-dependent cognitive functions. Pharmacological modulation of GIRK activity can affect neural excitability and synaptic plasticity in the hippocampus.

JOURNAL OF NEUROSCIENCE (2021)

Review Biochemistry & Molecular Biology

Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer's Disease

Sofia Toniolo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Role of GirK Channels in Long-Term Potentiation of Synaptic Inhibition in an In Vivo Mouse Model of Early Amyloid- Pathology

Irene Sanchez-Rodriguez et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Neurosciences

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

Benedikt Zott et al.

ANNUAL REVIEW OF NEUROSCIENCE, VOL 41 (2018)

Article Multidisciplinary Sciences

GIRK2 splice variants and neuronal G protein-gated K+ channels: implications for channel function and behavior

Ezequiel Marron Fernandez de Velasco et al.

SCIENTIFIC REPORTS (2017)

Article Behavioral Sciences

Assessing rodent hippocampal involvement in the novel object recognition task. A review

Sarah J. Cohen et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

Review Biochemistry & Molecular Biology

Neuronal hyperactivity - A key defect in Alzheimer's disease?

Marc Aurel Busche et al.

BIOESSAYS (2015)

Article Multidisciplinary Sciences

Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus

Jennifer Mayordomo-Cava et al.

PLOS ONE (2015)

Review Neurosciences

Gene expression parallels synaptic excitability and plasticity changes in Alzheimer's disease

Carlos A. Saura et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Neurosciences

Crtc1 Activates a Transcriptional Program Deregulated at Early Alzheimer's Disease-Related Stages

Arnaldo Parra-Damas et al.

JOURNAL OF NEUROSCIENCE (2014)

Review Neurosciences

New insights into the therapeutic potential of Girk channels

Rafael Lujan et al.

TRENDS IN NEUROSCIENCES (2014)

Article Multidisciplinary Sciences

Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice

Ayelet Cooper et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model

Pascal E. Sanchez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Medicine, Research & Experimental

Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction

Lennart Mucke et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Article Neurosciences

Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain

Laura Fernandez-Alacid et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2011)

Review Neurosciences

APP Transgenic Mice: Their Use and Limitations

Claudia Balducci et al.

NEUROMOLECULAR MEDICINE (2011)

Review Neurosciences

Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease

Christian Luescher et al.

NATURE REVIEWS NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Alzheimer's Disease Amyloid-β Links Lens and Brain Pathology in Down Syndrome

Juliet A. Moncaster et al.

PLOS ONE (2010)

Article Multidisciplinary Sciences

Plastic modifications induced by object recognition memory processing

Julia Rosauro Clarke et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Neurosciences

Amyloid β-Induced Neuronal Hyperexcitability Triggers Progressive Epilepsy

Rimante Minkeviciene et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Behavioral Sciences

Behavioral characterization of mice lacking GIRK/Kir3 channel subunits

M. Pravetoni et al.

GENES BRAIN AND BEHAVIOR (2008)

Article Geriatrics & Gerontology

Alzheimer disease and Down syndrome: factors in pathogenesis

IT Lott et al.

NEUROBIOLOGY OF AGING (2005)

Article Multidisciplinary Sciences

Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits

JJ Palop et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biology

Long-term potentiation and the ageing brain

CA Barnes

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2003)