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Article
Biochemistry & Molecular Biology
Lea Scherschinski et al.
Summary: The receptor tyrosine kinase AXL (RTK-AXL) plays a crucial role in therapy resistance in glioblastoma multiforme (GBM). The shedding product of RTK-AXL, CT-AXL, acts as a surrogate marker for radio-resistance. Overexpression of endogenous RTX-AXL leads to therapy resistance, but combination therapy of AXL TKI with standard treatments can increase therapeutic effects significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Maximilian Scheer et al.
Summary: NF1 gene mutations are found in various tumors, and loss of NF1 function plays a crucial role in inducing the aggressive MES subtype in glioblastoma. This process is mediated through the NF1-MAPK-FOSL1 axis and may offer novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fabiana Moresi et al.
Summary: This study applied a bioinformatic approach to investigate specific sub-proteomes in Cavitating Ultrasound Aspirator (CUSA) fluid pools of glioblastomas, aiming to understand the aggressive behavior of this brain cancer. The results showed the over-representation of certain pathways in different protein classifications and revealed variations in protein distribution between newly diagnosed and recurrent tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Yutao Li et al.
Summary: Glioblastoma multiforme (GBM) is a devastating disease with poor prognosis and challenging treatment. Conventional therapies have limited success, prompting the exploration of immunotherapeutic approaches such as adjuvant NKT immunotherapy. This article discusses the current strategies of NKT therapy for GBM and their potential for improving clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Carcelen et al.
Summary: The HIF2 alpha-mediated upregulation of ODZ1 enhances transcriptional control of this migration factor in glioblastoma stem cells under hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Antonio C. Fuentes-Fayos et al.
Summary: This study found that sst5TMD4 is overexpressed in human GBM and is associated with malignant features. The results suggest that sst5TMD4 may serve as a novel diagnostic/prognostic biomarker and potential therapeutic target in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Francesca Lombardi et al.
Summary: TMZ-resistance is a major limitation in the treatment of glioblastoma (GBM). COX-2/PGE2 system plays a role in GBM TMZ resistance, with a dose-dependent up-regulation of COX-2 expression observed in TMZ-treated cells. Combination of NS398 with TMZ can reduce cell proliferation, induce cell cycle arrest and apoptosis, and prevent the up-regulation of COX-2, beta-catenin, MGMT, and SOX-2 in GBM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Justin Choi et al.
Summary: This study examined the effect of a novel anti-cancer agent, GZ17-6.02, on two types of glioblastoma stem cells. The results showed that GZ17-6.02 inhibited cell growth and downregulated pathways related to steroid synthesis and cell cycle progression. Animal experiments also demonstrated that GZ17-6.02 inhibited glioblastoma growth. The study concludes that GZ17-6.02 is a promising drug for inhibiting the growth of a subset of glioblastomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lona Zeneyedpour et al.
Summary: We investigated the feasibility of detecting the presence of specific autoantibodies against potential tumor-associated peptide antigens by enriching these antibody-peptide complexes using Melon Gel resin and mass spectrometry. We successfully detected immunoreactivity against specific phospho-peptides in the plasma of high-grade glioma patients using this method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Philippe Aretz et al.
Summary: The study reveals the crucial role of beta-catenin in attracting monocytes towards GBM cells and suggests that the interaction between beta-catenin and CCL2 may contribute to the maintenance of GSCs by modulating immune cell interaction and promoting GBM growth and recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mariana P. Pinho et al.
Summary: This case study investigated the treatment of glioblastoma in a 25-year-old female patient with a dendritic-tumor cell fusion vaccine. The findings suggest that tumor-specific CD4+ T-cell numbers and phenotype could serve as biomarkers for treatment efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria Beatrice Morelli et al.
Summary: 《The Impact of TRPML2 on Temozolomide Resistance and Patient Survival in Glioblastoma Stem Cells》This study found that increased expression of TRPML2 mRNA is associated with increased resistance to temozolomide treatment in glioblastoma stem cells and worse survival outcomes in patients with glioblastoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Giorgio Santoni et al.
Summary: This study found that TRPML1 and TRPML2 channels are differently expressed in GBM patients and cell lines, and these channels partially colocalize in ER and lysosomal compartments. Silencing of TRPML1 or TRPML2 affects the expression of the other receptor at protein level, and double knockdown of TRPML1 and TRPML2 increases GBM cell survival, migration, and invasion ability. The expression levels of TRPML1 and TRPML2 are correlated with the overall survival of GBM patients, and loss of both channels is associated with the worst prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Nadia Senhaji et al.
Summary: Glioblastoma is an aggressive malignant tumor with a low survival rate. The difficulty in obtaining tumor material hinders real-time monitoring of tumor progression. Identifying specific biomarkers is crucial for accurate diagnosis and personalized treatment. Liquid biopsy holds promise as a minimally invasive approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Marianna A. Zolotovskaia et al.
Summary: Activation levels of algorithmically reconstructed gene-centric pathways are a potent class of new-generation diagnostic and prognostic biomarkers for gliomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alejandro Rodriguez-Camacho et al.
Summary: Glioblastoma is a lethal tumor with limited treatment options. Efforts are being made in various research areas to find new therapies that can improve patient survival and quality of life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ugur Sener et al.
Summary: Glioblastoma is the most common malignant brain tumor, and immunotherapy approaches for its treatment are still challenging, although multiple studies are underway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Angelica Pace et al.
Summary: Lectins, glycan-binding proteins, play important roles in immune cells, endothelial cells, and tumor cells, highlighting the correlation among immunity, tumor microenvironment, and vascularization. In glioblastoma, altered glycans and lectins contribute to tumor progression, immune evasion, and immunosuppression, making them potential therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Denise Drongitis et al.
Summary: This study highlights the role of chromatin remodeling gene KDM5C in Glioblastoma multiforme (GBM) and suggests HIF1A-KDM5C axis as a potential therapeutic target for the hypoxic microenvironment in GBM. The study provides extensive analysis of clinical, expression, and functional data, integrated with publicly available omic datasets, to show the contribution of KDM5C in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Angela Rocchi et al.
Summary: Protein quality control is crucial for maintaining proteostasis in eukaryotes under changing conditions. Bag3 plays a key role in this process and excessive activity of Bag3-HSP70 has been linked to sustained and propagated cancers. Targeting Bag3 is essential for the successful treatment of glioblastoma, a highly recurrent cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Louis Larrouquere et al.
Summary: The study investigated the effects of sodium selenite (SS) on glioblastoma (GBM) cells, finding that a certain dose of SS showed tumor growth inhibition in orthotopically implanted nude mice, increased brain selenium concentration, and outperformed TMZ (a conventional treatment drug) in terms of anti-tumor efficacy. New insights on the mechanisms of SS and its potential use in chemotherapy were provided.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Erik S. Pena et al.
Summary: Glioblastoma multiforme (GBM) is the most common form of primary brain cancer with poor prognosis, and interstitial therapy offers a promising approach for improving survival rates. By utilizing polymer implants to release drugs locally at the site of resection, interstitial therapy can bypass the blood-brain barrier, reduce systemic toxicity, and optimize combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Nomi Zalcman et al.
Summary: The study demonstrates the involvement of EGFR signaling in AR activation in glioblastoma, showing that inhibiting EGFR signaling can reduce AR nuclear translocation. Combination therapy of EGFR and AR antagonists has synergistic therapeutic efficacy in cells overexpressing EGFR and EGFRvIII.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Andrea Magali Gonzalez-Mora et al.
Summary: Hormonal factors, specifically estrogen receptors (ERs), may play a role in the development and treatment of glioblastoma. Understanding the function of ERs could lead to the development of more effective therapies for this aggressive brain tumor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Laurence Dery et al.
Summary: Chemoattraction is a critical process in glioblastoma tumorigenesis, and exploiting this behavior by using chemoattractants released by a biodegradable hydrogel has shown promising results in inducing migration of tumor cells. In vitro and in vivo experiments demonstrate the potential of specific chemoattractants to strongly attract neoplastic glioblastoma cells, suggesting a new therapeutic approach for primary brain tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Robert Cornelison et al.
Summary: Glioblastoma is the most common and deadliest adult neural malignancy, with limited therapeutic options and high recurrence rates. Novel targeted therapies have shown limited success in treating GBM, highlighting the need to explore new chemotherapeutic directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giacomo Casati et al.
Summary: Glioblastoma is a deadly tumor type with strong multidrug resistance and an immunosuppressive microenvironment. Understanding chemoresistance and immune response stimulation in GBM is crucial. The Hippo pathway plays a key role in these processes and is a promising target for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Carolin Seifert et al.
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Masashi Okada et al.
Summary: The study found that folate antagonists such as MTX and pemetrexed have selective cytotoxic effects on GSCs, suggesting that folate metabolism may be a promising target for anti-GSC therapy. Furthermore, the combination of cytotoxic and differentiation therapies may be a novel approach to effectively eliminate cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sara Manzano et al.
Summary: C3G, a guanine nucleotide exchange factor for GTPases from the Ras superfamily, has been found to be downregulated in GBM, promoting a mesenchymal phenotype and enhancing migration and invasion. It may serve as a potential biomarker for GBM diagnosis, prognosis, and personalized treatment, with the quantification of C3G levels in circulating tumor cells as a useful tool to improve patient outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
