☆ 4.7 Review

Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2023)

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Summary: Metabolomics in preterm infants, particularly focusing on NEC and LOS, is a relatively new field with promising potential for identifying novel biomarkers and understanding disease processes. Studies have shown significant changes in metabolite profiles post-partum and throughout the first year of life, with associations between metabolites in serum, urine, and stool in health and disease. Further research is needed to identify specific metabolites associated with disease and the impact of microbially produced metabolites on immunoregulation in infants.

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Risk factors for mortality in preterm infants with necrotizing enterocolitis: a retrospective multicenter analysis

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FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Yun Chao Lin et al.

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Epidemiology of necrotizing enterocolitis in preterm infants in China: A multicenter cohort study from 2015 to 2018

Xincheng Cao et al.

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The predictors of necrotizing enterocolitis in newborns with low birth weight A retrospective analysis

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Summary: This retrospective cohort study investigates the influencing factors of necrotizing enterocolitis (NEC) in low birth weight (LBW) newborns. The study finds that congenital heart disease, sepsis, and blood transfusion are independent risk factors for NEC, while breastfeeding and probiotics feeding are protective factors. The study also suggests that infants who undergo surgery for NEC have better prognosis. Comprehensive interventions targeting the risk and protective factors are recommended to improve the prognosis of LBW infants with NEC.

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Longitudinal gut virome analysis identifies specific viral signatures that precede necrotizing enterocolitis onset in preterm infants

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Summary: This study found that changes in the viral and bacterial composition of the gut precede the onset of necrotizing enterocolitis (NEC) in preterm infants. The results suggest that the early life virome signatures in preterm infants may play a role in NEC.

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Gut microbiota and short-chain fatty acids may be new biomarkers for predicting neonatal necrotizing enterocolitis: A pilot study

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Association between gut microbiota and preeclampsia-eclampsia: a two-sample Mendelian randomization study

Pengsheng Li et al.

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Eric E. Irons et al.

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The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling

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Review Medicine, General & Internal

Review of claudin proteins as potential biomarkers for necrotizing enterocolitis

Victoria Griffiths et al.

Summary: Claudin proteins play a crucial role in the pathophysiology of NEC by regulating intestinal permeability, maturity, and inflammation. Urinary claudin measurements could serve as a potential new method for predicting the development of NEC. Further research is needed to fully understand the relevance and potential use of claudin proteins as a biomarker in NEC.

IRISH JOURNAL OF MEDICAL SCIENCE (2021)

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Evidence-Based Practices Reduce Necrotizing Enterocolitis and Improve Nutrition Outcomes in Very Low-Birth-Weight Infants

Suresh Chandran et al.

Summary: Implementing evidence-based best practices significantly reduced the incidence of necrotizing enterocolitis in very-low-birth-weight infants and improved their nutritional outcomes.

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Maternal H-antigen secretor status is an early biomarker for potential preterm delivery

Jennifer Caldwell et al.

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Summary: This study successfully differentiated between NEC and SIP using a machine learning model with high predictive accuracy and feasibility. After analyzing data from 40 patients, a 98% AUROC was achieved. The results of this study provide a new method for distinguishing these two diseases in preterm neonates.

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Colonization of fecal microbiota from patients with neonatal necrotizing enterocolitis exacerbates intestinal injury in germfree mice subjected to necrotizing enterocolitis-induction protocol via alterations in butyrate and regulatory T cells

Yu He et al.

Summary: The study found differences in the microbiota structure and butyrate levels between NEC patients and healthy controls. In mouse experiments, fecal transplantation from NEC patients resulted in more severe intestinal injuries, and alterations in microbiota and butyrate levels were maintained post-transplantation. The microbiota was implicated in NEC, with the microbial butyrate-T-reg axis identified as a potential mechanism for the observed effects.

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The decrease of fucosylation in intestinal epithelium is related to the development of necrotizing enterocolitis

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Prenatal Immunity and Influences on Necrotizing Enterocolitis and Associated Neonatal Disorders

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Necrotizing Enterocolitis and Intestinal Microbiota: The Timing of Disease and Combined Effects of Multiple Species

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FRONTIERS IN PEDIATRICS (2021)

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Intrauterine Hypoxia Changed the Colonization of the Gut Microbiota in Newborn Rats

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Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth

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Article Cell Biology

Preterm infant meconium microbiota transplant induces growth failure, inflammatory activation, and metabolic disturbances in germ-free mice

Henni Hiltunen et al.

Summary: The study found that very preterm birth is associated with a distinct meconium microbiota composition, and fecal microbiota transplant of very preterm infant meconium results in impaired growth, altered intestinal immune function, and metabolic parameters. Therefore, measures aiming to minimize the long-term adverse consequences of very preterm birth should be commenced during pregnancy or directly after birth.

CELL REPORTS MEDICINE (2021)

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Review Pediatrics

Breast milk: more than just nutrition!

Giulia Nuzzi et al.

Summary: Exclusive human milk feeding for the first 6 months of life, with continued breastfeeding for 1 to 2 years, is considered the gold standard nourishment for infants due to its species-specific composition and numerous bioactive molecules that offer protection against infection and inflammation, contribute to immune maturation, organ development, and healthy microbial colonization. Breastfeeding has been associated with decreased morbidity and mortality in infants, as well as lower incidences of various diseases.

MINERVA PEDIATRICS (2021)

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Review Physiology

Maternal microbiome in preeclampsia pathophysiology and implications on offspring health

Jeanne A. Ishimwe

Summary: Preeclampsia is a devastating hypertensive pregnancy disorder affecting 2%-8% of pregnancies globally, with maternal and fetal mortality and morbidity. Recent advances suggest aberrations in the microbiome may play a role in the pathogenesis of various diseases, including preeclampsia. Maternal and uteroplacental environments greatly influence long-term health outcomes in offspring.

PHYSIOLOGICAL REPORTS (2021)

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Article Food Science & Technology

Decrease in abundance of bacteria of the genus Bifidobacterium in gut microbiota may be related to pre-eclampsia progression in women from East China

Tingting Miao et al.

Summary: The study found that gut microbiota dysbiosis may occur in patients with pre-eclampsia, which could be associated with metabolic syndrome. Alterations in the abundance of certain bacterial genera (such as increased abundance of Blautia and Ruminococcus, decreased abundance of Bifidobacterium) may be linked to the development of pre-eclampsia.

FOOD & NUTRITION RESEARCH (2021)

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Review Gastroenterology & Hepatology

A systematic review of the factors influencing microbial colonization of the preterm infant gut

Miriam Aguilar-Lopez et al.

Summary: Factors such as postnatal age, mode of delivery, antibiotic use, and human milk consumption have been found to have an impact on the gut microbiota of preterm infants. Limited evidence exists for associations with race, sex, use of different fortifiers, macronutrients, and other medications. Further studies with rich metadata are needed to explore the impact of the preterm exposome on microbiota development in this high-risk population.

GUT MICROBES (2021)

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Article Food Science & Technology

Decrease in abundance of bacteria of the genus Bifidobacterium in gut microbiota may be related to pre-eclampsia progression in women from East China Bifidobacterium

Tingting Miao et al.

Summary: The gut microbiota dysbiosis in patients with pre-eclampsia (PE) may contribute to an increased risk of metabolic syndrome. Changes in the abundance of certain bacterial genera are associated with the development of PE, and the overnutrition in PE patients is related to alterations in the gut microbiota composition.

FOOD & NUTRITION RESEARCH (2021)

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Article Obstetrics & Gynecology

Preterm infant gut microbial patterns related to the development of necrotizing enterocolitis

Tristan P. Lindberg et al.

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE (2020)

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Article Pediatrics

Hypoxic-ischemic enterocolitis: a proposal of a new terminology for early NEC or NEC-like disease in preterm infants, a single-center prospective observational study

Ozge Onay et al.

EUROPEAN JOURNAL OF PEDIATRICS (2020)

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Review Medicine, Research & Experimental

Necrotizing enterocolitis: It's not all in the gut

Alissa L. Meister et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2020)

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Article Gastroenterology & Hepatology

Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation

Xia Chen et al.

GUT (2020)

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Review Pediatrics

An Overview of Systematic Reviews of Randomized-Controlled Trials for Preventing Necrotizing Enterocolitis in Preterm Infants

Tao Xiong et al.

NEONATOLOGY (2020)

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Review Nutrition & Dietetics

Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation

Mikiyasu Sakanaka et al.

NUTRIENTS (2020)

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Article Pediatrics

Dynamics of the bacterial gut microbiota in preterm and term infants after intravenous amoxicillin/ceftazidime treatment

Romy D. Zwittink et al.

BMC PEDIATRICS (2020)

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Article Medicine, General & Internal

Gut microbiota dysbiosis in preeclampsia patients in the second and third trimesters

Jing Wang et al.

CHINESE MEDICAL JOURNAL (2020)

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Meeting Abstract Biochemistry & Molecular Biology

Novel insights into the fucose metabolism challenging the old dogma

Paulina Sosicka et al.

FASEB JOURNAL (2020)

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Review Nutrition & Dietetics

The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being

Magdalena Orczyk-Pawilowicz et al.

NUTRIENTS (2020)

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Article Immunology

Autoinducer-2 May Be a New Biomarker for Monitoring Neonatal Necrotizing Enterocolitis

Chun-Yan Fu et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Review Pediatrics

Necrotizing Enterocolitis: The Future

Josef Neu

NEONATOLOGY (2020)

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Review Pharmacology & Pharmacy

Pre-Eclampsia: Microbiota possibly playing a role

Elham Ahmadian et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Pediatrics

Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis

Amer Alsaied et al.

BMC PEDIATRICS (2020)

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Article Cell Biology

SIRT1 relieves Necrotizing Enterocolitis through inactivation of Hypoxia-inducible factor (HIF)-1a

Ming Bai et al.

CELL CYCLE (2020)

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Article Immunology

Differences in Compositions of Gut Bacterial Populations and Bacteriophages in 5-11 Year-Olds Born Preterm Compared to Full Term

Thilini N. Jayasinghe et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Medicine, General & Internal

Evolution of Gut Microbiome and Metabolome in Suspected Necrotizing Enterocolitis: A Case-Control Study

Camille Brehin et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Review Gastroenterology & Hepatology

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

Matthew R. Kudelka et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

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Article Food Science & Technology

Human Milk Oligosaccharides Protect against Necrotizing Enterocolitis by Activating Intestinal Cell Differentiation

Bo Li et al.

MOLECULAR NUTRITION & FOOD RESEARCH (2020)

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Article Pediatrics

Grading the evidence to identify strategies to modify risk for necrotizing enterocolitis

Sheila M. Gephart et al.

PEDIATRIC RESEARCH (2020)

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Article Multidisciplinary Sciences

Remote ischemic conditioning counteracts the intestinal damage of necrotizing enterocolitis by improving intestinal microcirculation

Yuhki Koike et al.

NATURE COMMUNICATIONS (2020)

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Review Nutrition & Dietetics

The Role of Human Milk Oligosaccharides and Probiotics on the Neonatal Microbiome and Risk of Necrotizing Enterocolitis: A Narrative Review

Lila S. Nolan et al.

NUTRIENTS (2020)

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Article Biotechnology & Applied Microbiology

Systematic analysis of gut microbiota in pregnant women and its correlations with individual heterogeneity

Hongling Yang et al.

NPJ BIOFILMS AND MICROBIOMES (2020)

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Article Pediatrics

Hypoxic/ischemic hits predispose to necrotizing enterocolitis in (near) term infants with congenital heart disease: a case control study

Martin van der Heide et al.

BMC PEDIATRICS (2020)

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Article Immunology

Risk factors of necrotizing enterocolitis in neonates with sepsis: A retrospective case-control study

Zheng-Li Wang et al.

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY (2020)

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Article Gastroenterology & Hepatology

Prenatal inflammation impairs intestinal microvascular development through a TNF-dependent mechanism and predisposes newborn mice to necrotizing enterocolitis

Xiaocai Yan et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2019)

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Article Pediatrics

Are antibiotics a risk factor for the development of necrotizing enterocolitiscase-control retrospective study

Ali Ahmed Raba et al.

EUROPEAN JOURNAL OF PEDIATRICS (2019)

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Review Biology

Factors influencing the gut microbiome in children: from infancy to childhood

Shreyas V. Kumbhare et al.

JOURNAL OF BIOSCIENCES (2019)

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Article Pediatrics

Maternal and placental risk factors associated with the development of necrotizing enterocolitis (NEC) and its severity

Miriam Duci et al.

JOURNAL OF PEDIATRIC SURGERY (2019)

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Article Biochemical Research Methods

A pilot case-control study of urine metabolomics in preterm neonates with necrotizing enterocolitis

Agathi Thomaidou et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)

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Article Immunology

Early-Onset Preeclampsia Is Associated With Gut Microbial Alterations in Antepartum and Postpartum Women

Li-Juan Lv et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Review Oncology

The Diverse Contributions of Fucose Linkages in Cancer

Tyler S. Keeley et al.

CANCERS (2019)

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Article Cell Biology

Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis

Yong Chen et al.

DISEASE MODELS & MECHANISMS (2019)

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Review Nutrition & Dietetics

Preterm Birth: A Narrative Review of the Current Evidence on Nutritional and Bioactive Solutions for Risk Reduction

Tinu M. Samuel et al.

NUTRIENTS (2019)

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Article Gastroenterology & Hepatology

Association of Maternal Secretor Status and Human Milk Oligosaccharides With Milk Microbiota: An Observational Pilot Study

Raul Cabrera-Rubio et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2019)

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Article Multidisciplinary Sciences

Necrotizing enterocolitis is preceded by increased gut bacterial replication, Klebsiella, and fimbriae-encoding bacteria

Matthew R. Olm et al.

SCIENCE ADVANCES (2019)

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Article Immunology

Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia

Jing Wang et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

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Article Infectious Diseases

Molecular epidemiology of Clostridium neonatale and its relationship with the occurrence of necrotizing enterocolitis in preterm neonates

M. Hosny et al.

NEW MICROBES AND NEW INFECTIONS (2019)

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Article Biotechnology & Applied Microbiology

Human milk oligosaccharides and infant gut bifidobacteria: Molecular strategies for their utilization

Pamela Thomson et al.

FOOD MICROBIOLOGY (2018)

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Article Pediatrics

Intestinal tight junctions are severely altered in NEC preterm neonates

Amir Bein et al.

PEDIATRICS AND NEONATOLOGY (2018)

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Article Microbiology

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Pamela Ferretti et al.

CELL HOST & MICROBE (2018)

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Review Biochemistry & Molecular Biology

Oxidative Stress in Preeclampsia and Placental Diseases

Rajaa Aouache et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Review Pediatrics

Risk Factors for Necrotizing Enterocolitis: A Prospective Multicenter Case-Control Study

Daniel J. C. Berkhout et al.

NEONATOLOGY (2018)

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Article Pediatrics

Surgical necrotizing enterocolitis in extremely premature neonates is associated with genetic variations in an intergenic region of chromosome 8

Tamas Jilling et al.

PEDIATRIC RESEARCH (2018)

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Article Multidisciplinary Sciences

Maternal, fetal and perinatal factors associated with necrotizing enterocolitis in Sweden. A national case-control study

Margareta Ahle et al.

PLOS ONE (2018)

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Article Microbiology

The Microbiome and Metabolome of Preterm Infant Stool Are Personalized and Not Driven by Health Outcomes, Including Necrotizing Enterocolitis and Late-Onset Sepsis

Stephen Wandro et al.

MSPHERE (2018)

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Article Medicine, General & Internal

Maternal pregnancy-induced hypertension increases subsequent neonatal necrotizing enterocolitis risk A nationwide population-based retrospective cohort study in Taiwan

Chih-Chieh Yang et al.

MEDICINE (2018)

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Article Multidisciplinary Sciences

Distinct mucosal microbial communities in infants with surgical necrotizing enterocolitis correlate with age and antibiotic exposure

Joann Romano-Keeler et al.

PLOS ONE (2018)

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Article Pediatrics

A critical analysis of risk factors for necrotizing enterocolitis

Allison Thomas Rose et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2018)

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Article Pediatrics

Intestinal microcirculation and necrotizing enterocolitis: The vascular endothelial growth factor system

Rakhee M. Bowker et al.

SEMINARS IN FETAL & NEONATAL MEDICINE (2018)

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Article Microbiology

Dichotomous development of the gut microbiome in preterm infants

Thao T. B. Ho et al.

MICROBIOME (2018)

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Review Nutrition & Dietetics

Human Milk Oligosaccharides to Prevent Gut Dysfunction and Necrotizing Enterocolitis in Preterm Neonates

Stine Brandt Bering

NUTRIENTS (2018)

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Review Gastroenterology & Hepatology

Toll-Like Receptor-Mediated Intestinal Inflammatory Imbalance in the Pathogenesis of Necrotizing Enterocolitis

David J. Hackam et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

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Article Infectious Diseases

Remodeling of the gut microbiota and structural shifts in Preeclampsia patients in South China

J. Liu et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2017)

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Article Biochemistry & Molecular Biology

Core fucose is critical for CD14-dependent Toll-like receptor 4 signaling

Junko Iijima et al.

GLYCOBIOLOGY (2017)

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Article Gastroenterology & Hepatology

Influence of Gestational Age, Secretor, and Lewis Blood Group Status on the Oligosaccharide Content of Human Milk

Clemens Kunz et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2017)

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Article Biochemical Research Methods

Metaproteomics reveals functional differences in intestinal microbiota development of preterm infants

Romy D. Zwittink et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

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Article Multidisciplinary Sciences

Gut microbiome of mothers delivering prematurely shows reduced diversity and lower relative abundance of Bifidobacterium and Streptococcus

Cecilie Dahl et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Replication and refinement of a vaginal microbial signature of preterm birth in two racially distinct cohorts of US women

Benjamin J. Callahan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Review Obstetrics & Gynecology

Surgical necrotizing enterocolitis

Jamie R. Robinson et al.

SEMINARS IN PERINATOLOGY (2017)

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Review Obstetrics & Gynecology

Genetic alterations in necrotizing enterocolitis

Alain Cuna et al.

SEMINARS IN PERINATOLOGY (2017)

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Article Microbiology

Low Microbial Diversity and Abnormal Microbial Succession Is Associated with Necrotizing Enterocolitis in Preterm Infants

Priscila T. Dobbler et al.

FRONTIERS IN MICROBIOLOGY (2017)

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Review Microbiology

Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis

Mohan Pammi et al.

MICROBIOME (2017)

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Review Immunology

Regulation of immunity and inflammation by hypoxia in immunological niches

Cormac T. Taylor et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Article Nutrition & Dietetics

Nutritional strategies and gut microbiota composition as risk factors for necrotizing enterocolitis in very-preterm infants

Jean-Christophe Roze et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2017)

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Review Pediatrics

Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies

Noor Samuels et al.

BMC PEDIATRICS (2017)

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Article Gastroenterology & Hepatology

Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model

Yueyue Yu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

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Article Biochemistry & Molecular Biology

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites

Gerard E. Kaiko et al.

CELL (2016)

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Article Immunology

A Necrotizing Enterocolitis-Associated Gut Microbiota Is Present in the Meconium: Results of a Prospective Study

Fardou H. Heida et al.

CLINICAL INFECTIOUS DISEASES (2016)

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Review Pharmacology & Pharmacy

Prevention of Necrotizing Enterocolitis Through Manipulation of the Intestinal Microbiota of the Premature Infant

Kannikar Vongbhavit et al.

CLINICAL THERAPEUTICS (2016)

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Article Microbiology

Metabolic competition as a driver of bacterial population structure

Eleanor R. Watkins et al.

FUTURE MICROBIOLOGY (2016)

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Article Peripheral Vascular Disease

Increased Systolic and Diastolic Blood Pressure Is Associated With Altered Gut Microbiota Composition and Butyrate Production in Early Pregnancy

Luisa F. Gomez-Arango et al.

HYPERTENSION (2016)

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Article Medicine, General & Internal

Gut bacteria dysbiosis and necrotising enterocolitis in very low birthweight infants: a prospective case-control study

Barbara B. Warner et al.

LANCET (2016)

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Article Cell Biology

Metagenomic Sequencing with Strain-Level Resolution Implicates Uropathogenic E-coli in Necrotizing Enterocolitis and Mortality in Preterm Infants

Doyle V. Ward et al.

CELL REPORTS (2016)

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Article Microbiology

Temporal bacterial and metabolic development of the preterm gut reveals specific signatures in health and disease

Christopher J. Stewart et al.

MICROBIOME (2016)

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Article Microbiology

Dynamics and Stabilization of the Human Gut Microbiome during the First Year of Life

Fredrik Backhed et al.

CELL HOST & MICROBE (2015)

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Article Biochemistry & Molecular Biology

Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells

Ana I. Belo et al.

FEBS LETTERS (2015)

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Article Pediatrics

FUT 2 polymorphism and outcome in very-low-birth-weight infants

Martin Demmert et al.

PEDIATRIC RESEARCH (2015)

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Article Multidisciplinary Sciences

Temporal and spatial variation of the human microbiota during pregnancy

Daniel B. DiGiulio et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Microbiology

Maternal fucosyltransferase 2 status affects the gut bifidobacterial communities of breastfed infants

Zachery T. Lewis et al.

MICROBIOME (2015)

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Article Multidisciplinary Sciences

Longitudinal Analysis of the Premature Infant Intestinal Microbiome Prior to Necrotizing Enterocolitis: A Case-Control Study

Yanjiao Zhou et al.

PLOS ONE (2015)

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Article Multidisciplinary Sciences

Secretor Status Is Strongly Associated with Microbial Alterations Observed during Pregnancy

Himanshu Kumar et al.

PLOS ONE (2015)

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Article Pediatrics

Late onset of necrotizing enterocolitis in the full-term infant is associated with increased mortality: Results from a two-center analysis

Scott S. Short et al.

JOURNAL OF PEDIATRIC SURGERY (2014)

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Article Obstetrics & Gynecology

Discrimination of GutCheckNEC: a clinical risk index for necrotizing enterocolitis

S. M. Gephart et al.

JOURNAL OF PERINATOLOGY (2014)

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Article Pediatrics

Necrotizing Enterocolitis in Small-for-Gestational-Age Neonates: A Matched Case-Control Study

Isabelle M. C. Ree et al.

NEONATOLOGY (2014)

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Article Multidisciplinary Sciences

A Data-Driven Algorithm Integrating Clinical and Laboratory Features for the Diagnosis and Prognosis of Necrotizing Enterocolitis

Jun Ji et al.

PLOS ONE (2014)

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Article Multidisciplinary Sciences

Patterned progression of bacterial populations in the premature infant gut

Patricio S. La Rosa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Peripheral Vascular Disease

A novel role for inducible Fut2 in angiogenesis

Pei-Suen Tsou et al.

ANGIOGENESIS (2013)

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Review Biochemistry & Molecular Biology

Recent Advances in Studies on Milk Oligosaccharides of Cows and Other Domestic Farm Animals

Tadasu Urashima et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2013)

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Article Pediatrics

Genes regulating tight junctions and cell adhesion are altered in early experimental necrotizing enterocolitis

Niclas Hogberg et al.

JOURNAL OF PEDIATRIC SURGERY (2013)

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Article Multidisciplinary Sciences

Bacterial Diversity in Meconium of Preterm Neonates and Evolution of Their Fecal Microbiota during the First Month of Life

Laura Moles et al.

PLOS ONE (2013)

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Article Multidisciplinary Sciences

Transforming Growth Factor β Signaling Upregulates the Expression of Human GDP-Fucose Transporter by Activating Transcription Factor Sp1

Yu-Xin Xu et al.

PLOS ONE (2013)

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Article Microbiology

Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants

Ardythe L. Morrow et al.

MICROBIOME (2013)

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Article Biotechnology & Applied Microbiology

Lactobacillus casei Ferments the N-Acetylglucosamine Moiety of Fucosyl-α-1,3-N-Acetylglucosamine and Excretes L-Fucose

Jesus Rodriguez-Diaz et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2012)

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Article Biochemistry & Molecular Biology

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

Omry Koren et al.

CELL (2012)

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Article Gastroenterology & Hepatology

Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice

Chhinder P. Sodhi et al.

GASTROENTEROLOGY (2012)

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Article Biochemical Research Methods

Lacto-N-Tetraose, Fucosylation, and Secretor Status Are Highly Variable in Human Milk Oligosaccharides From Women Delivering Preterm

Maria Lorna A. De Leoz et al.

JOURNAL OF PROTEOME RESEARCH (2012)

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Article Pediatrics

Fucosyltransferase 2 Non-Secretor and Low Secretor Status Predicts Severe Outcomes in Premature Infants

Ardythe L. Morrow et al.

JOURNAL OF PEDIATRICS (2011)

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Review Biochemistry & Molecular Biology

Are pathogenic bacteria just looking for food? Metabolism and microbial pathogenesis

Laurence Rohmer et al.

TRENDS IN MICROBIOLOGY (2011)

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Article Biochemistry & Molecular Biology

Enzymatic activity of α-L-fucosidase and L-fucokinase across vertebrate animal species

Bradley J. Honas et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY (2009)

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Article Pediatrics

Prolonged Duration of Initial Empirical Antibiotic Treatment Is Associated With Increased Rates of Necrotizing Enterocolitis and Death for Extremely Low Birth Weight Infants

C. Michael Cotten et al.

PEDIATRICS (2009)

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Review Obstetrics & Gynecology

THE EFFECTS OF ABSENT OR REVERSED END-DIASTOLIC UMBILICAL ARTERY DOPPLER FLOW VELOCITY

Kuo-Gon Wang et al.

TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY (2009)

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Article Pediatrics

Antenatal umbilical Doppler abnormalities: an independent risk factor for early onset neonatal necrotizing enterocolitis in premature infants

V. M. Kamoji et al.

ACTA PAEDIATRICA (2008)

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Review Gastroenterology & Hepatology

Necrotizing enterocolitis: A multifactorial disease with no cure

Kareena L. Schnabl et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2008)

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Article Biochemistry & Molecular Biology

Characterization and role of fucose mutarotase in mammalian cells

Dongkyu Park et al.

GLYCOBIOLOGY (2007)

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Review Biochemistry & Molecular Biology

Fucose: biosynthesis and biological function in mammals

DJ Becker et al.

GLYCOBIOLOGY (2003)

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