Overview of the Role of Vanillin in Neurodegenerative Diseases and Neuropathophysiological Conditions

Nowadays, bioactive natural products play key roles in drug development due to their safety profile and strong antioxidant power. Vanillin is a natural phenolic compound found in several vanilla beans and widely used for food, cosmetic, and pharmaceutical products. Besides its industrial applications, vanillin possesses several beneficial effects for human health, such as antioxidant activity in addition to anti-inflammatory, anti-mutagenic, anti-metastatic, and anti-depressant properties. Moreover, vanillin exhibits neuroprotective effects on multiple neurological disorders and neuropathophysiological conditions. This study reviews the mechanisms of action by which vanillin prevents neuroinflammation and neurodegeneration in vitro and in vivo systems, in order to provide the latest views on the beneficial properties of this molecule in chronic neurodegenerative diseases and neuropathophysiological conditions.

Automated summary

Nowadays, bioactive natural products are vital for drug development due to their safety and strong antioxidant power. Vanillin, a natural phenolic compound found in vanilla beans, is widely used in various industries. In addition to its industrial applications, vanillin has numerous beneficial effects on human health, such as being an antioxidant and possessing anti-inflammatory, anti-mutagenic, anti-metastatic, and anti-depressant properties. Furthermore, vanillin exhibits neuroprotective effects on neurological disorders and neuropathophysiological conditions. This study reviews the mechanisms by which vanillin prevents neuroinflammation and neurodegeneration, providing the latest insights into its beneficial properties for chronic neurodegenerative diseases.