4.7 Article

AKBA Promotes Axonal Regeneration via RhoA/Rictor to Repair Damaged Sciatic Nerve

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: molecular mechanism

Yao Wang et al.

Summary: This study reveals that AKBA can promote sciatic nerve injury repair by modulating phagosome pathway and neurotrophic factor signaling pathway. AKBA administration can inhibit myeloperoxidase expression and reduce inflammatory reactions, which leads to increased expression of neurotrophic factors, thus promoting myelin sheath and axon regeneration in the injured sciatic nerve.

NEURAL REGENERATION RESEARCH (2022)

Article Biochemistry & Molecular Biology

Transplanting neurofibromatosis-1 gene knockout neural stem cells improve functional recovery in rats with spinal cord injury by enhancing the mTORC2 pathway

Guoliang Chen et al.

Summary: The knockout of NF-1 improves the survival and efficiency of stem cell transplants for spinal cord injury. It enhances the neuronal differentiation and tissue repair, leading to functional recovery in rat models. This findings highlight the valuable role of NF-1 in neural stem cell biology and provide a promising strategy for spinal cord injury treatment.

EXPERIMENTAL AND MOLECULAR MEDICINE (2022)

Article Immunology

Fingolimod (FTY720) prevents chronic rejection of rodent cardiac allografts through inhibition of the RhoA pathway

Wei Chen et al.

Summary: FTY720, approved for MS treatment, prevents immune cell-dependent CNS injury by binding S1P receptors and down-regulating RhoA and mTORC2 pathways. It blocks chronic rejection of cardiac transplants by inhibiting macrophage infiltration, indicating its potential as an anti-chronic rejection drug in clinical transplantation.

TRANSPLANT IMMUNOLOGY (2021)

Article Environmental Sciences

H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway

Qianru Chi et al.

Summary: The study found that hydrogen sulfide (H2S) levels exceeded national standards in chicken houses in Harbin, posing a hazard to poultry health. By establishing H2S exposure and NaHS exposure models, the mechanisms of H2S toxicity on the immune system of chickens were revealed.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Cell Biology

Myosin II and Arp2/3 cross-talk governs intracellular hydraulic pressure and lamellipodia formation

Shivani Patel et al.

Summary: The study reveals that RhoA activity inhibits lamellipodia formation in high-pressure cells by increasing intracellular pressure and disrupting actomyosin contractility and water influx. Increasing osmotic pressure triggers a second RhoA pathway through nonmuscle myosin II to disrupt lamellipodia and elevate pressure.

MOLECULAR BIOLOGY OF THE CELL (2021)

Article Biochemistry & Molecular Biology

Nrf2/HO-1 Signaling Activator Acetyl-11-keto-beta Boswellic Acid (AKBA)-Mediated Neuroprotection in Methyl Mercury-Induced Experimental Model of ALS

Elizabeth Minj et al.

Summary: Methylmercury (MeHg) is a potent neurotoxin that causes neuronal cell death and demyelination, while AKBA, as a Nrf2/HO-1 activator, shows protective effects in an experimental ALS model.

NEUROCHEMICAL RESEARCH (2021)

Review Biochemistry & Molecular Biology

ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion

Almudena Garcia-Ortiz et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

RhoA Controls Axon Extension Independent of Specification in the Developing Brain

Sebastian Dupraz et al.

CURRENT BIOLOGY (2019)

Article Multidisciplinary Sciences

Myelin sheath structure and regeneration in peripheral nerve injury repair

Bin Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Neurosciences

RhoA regulates Schwann cell differentiation through JNK pathway

Jinkun Wen et al.

EXPERIMENTAL NEUROLOGY (2018)

Article Neurosciences

RhoA activation in axotomy-induced neuronal death

Guixin Zhang et al.

EXPERIMENTAL NEUROLOGY (2018)

Article Biochemistry & Molecular Biology

Mechanisms of RhoA inactivation and CDC42 and Rac1 activation during zebrafish optic nerve regeneration

Toru Matsukawa et al.

NEUROCHEMISTRY INTERNATIONAL (2018)

Article Multidisciplinary Sciences

Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

Carlos Pardo-Pastor et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Locally translated mTOR controls axonal local translation in nerve injury

Marco Terenzio et al.

SCIENCE (2018)

Article Neurosciences

Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization

Alexa Kiss et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Positional Stability and Membrane Occupancy Define Skin Fibroblast Homeostasis In Vivo

Edward Marsh et al.

Review Cell Biology

RhoA as a target to promote neuronal survival and axon regeneration

Jianli Hu et al.

NEURAL REGENERATION RESEARCH (2017)

Article Multidisciplinary Sciences

Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination

Mark D. Grier et al.

PLOS ONE (2017)

Article Neurosciences

Rho kinase inhibition enhances axonal regeneration in the injured CNS

AE Fournier et al.

JOURNAL OF NEUROSCIENCE (2003)