4.7 Article

Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

The serotonin theory of depression: a systematic umbrella review of the evidence

Joanna Moncrieff et al.

Summary: The serotonin hypothesis of depression, which suggests that depression is caused by lowered serotonin activity or concentrations, lacks consistent evidence based on the synthesis and evaluation of research in this field. This umbrella review found no substantial association between serotonin and depression, while suggesting that long-term antidepressant use may reduce serotonin concentration.

MOLECULAR PSYCHIATRY (2023)

Review Neurosciences

Large-Scale Transcriptomics Studies Provide Insight Into Sex Differences in Depression

Marianne L. Seney et al.

Summary: The text discusses the impact of gender differences in major depressive disorder (MDD), including differences in incidence, symptoms, severity, and response to antidepressants, as well as the possible biological basis. It also focuses on the findings from human postmortem studies on molecular changes in the brains of depressed men and women, and suggests approaches to address research challenges and future directions.

BIOLOGICAL PSYCHIATRY (2022)

Article Neurosciences

Behavioral Engagement With Playable Objects Resolves Stress-Induced Adaptive Changes by Reshaping the Reward System

Jin-Young Park et al.

Summary: Continual engagement with playable objects in mice subjected to chronic stress can alleviate depressive-like behaviors, possibly by modifying the reward system.

BIOLOGICAL PSYCHIATRY (2022)

Review Clinical Neurology

Transcriptional biomarkers of response to pharmacological treatments in severe mental disorders: A systematic review

Claudia Pisanu et al.

Summary: The study focused on investigating the expression levels of genes involved in drug disposition and action in tissues of pharmacological importance in patients treated with psychotropic drugs. Promising findings include the role of genes in inflammation, neurotransmission, and mitochondrial function. However, studies on antipsychotics or mood stabilizers often had smaller sample sizes and lacked replication compared to studies on antidepressants.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2022)

Review Cell Biology

Mechanisms of lncRNA biogenesis as revealed by nascent transcriptomics

Takayuki Nojima et al.

Summary: Mammalian genomes express protein-coding and non-coding RNA genes. Recent studies have revealed differences in transcription initiation and termination between non-coding RNA genes and protein-coding genes, which are relevant to genomic stress and DNA damage.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2022)

Article Neurosciences

Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats

Anouschka S. Ramsteijn et al.

Summary: This study reveals the sex-specific effects of perinatal fluoxetine exposure on brain development in juvenile rats. Males show stronger behavioral outcomes and differential gene expression in the prefrontal cortex and basolateral amygdala. Epigenetic regulation may underlie these developmental changes.

NEUROPSYCHOPHARMACOLOGY (2022)

Article Multidisciplinary Sciences

Evaluation of animal model congruence to human depression based on large-scale gene expression patterns of the CNS

Stephen C. Gammie

Summary: This study evaluates the congruence of large-scale gene expression patterns between animal models and human depression. The findings suggest that some animal models exhibit similar gene expression patterns to humans with depression, providing new insights for understanding and treating depression.

SCIENTIFIC REPORTS (2022)

Article Neurosciences

Integrative Analysis of Long Non-coding RNAs, Messenger RNAs, and MicroRNAs Indicates the Neurodevelopmental Dysfunction in the Hippocampus of Gut Microbiota-Dysbiosis Mice

Lanxiang Liu et al.

Summary: This study investigates the role of the gut microbiota in major depressive disorder (MDD) and identifies dysregulated genes and pathways associated with MDD. The results show that dysbiosis of the gut microbiota leads to differential expression of mRNA, lncRNA, and miRNA in the hippocampus of mice. Functional analysis reveals that dysregulated inflammatory response and neurodevelopmental processes are key pathological changes in MDD. Moreover, a microbial-regulated lncRNA-miRNA-mRNA network is constructed, highlighting the potential genetic and epigenetic biomarkers for microbial-associated depression. This study sheds light on the pathogenesis of MDD and provides insights for the development of gut microbiota-based antidepressants.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Article Pharmacology & Pharmacy

Impact of Fluoxetine Treatment and Folic Acid Supplementation on the Mammary Gland Transcriptome During Peak Lactation

Celeste M. Sheftel et al.

Summary: Serotonin is a key regulator of mammary gland homeostasis during lactation, and this study found that selective serotonin reuptake inhibitors (SSRIs) alter gene expression in the mammary gland, affecting milk synthesis and mammary gland function. Folic acid supplementation also has an impact on the mammary gland transcriptome, but it does not reverse the effects caused by SSRI treatment.

FRONTIERS IN PHARMACOLOGY (2022)

Article Biochemistry & Molecular Biology

DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)

Brad T. Sherman et al.

Summary: DAVID, a popular bioinformatics resource system, has undergone updates in 2021, including the rebuilding of the DAVID Gene system, increasing the number of gene-term records for annotation types, adding new annotations, assigning specific subgroups, and adding a species parameter for improved user experience.

NUCLEIC ACIDS RESEARCH (2022)

Article Clinical Neurology

Emerging roles of long non-coding RNA in depression

Wen-Zhi Hao et al.

Summary: Depression is a common psychiatric disorder with unclear underlying mechanisms. Recent research suggests that long non-coding RNAs (lncRNA) play a regulatory role in depression, mediating its development through various pathways. Additionally, lncRNAs may serve as potential biomarkers for differential diagnosis of depression and other mental illnesses. Further exploration is needed to understand the therapeutic targets and diagnostic biomarkers of lncRNAs in depression.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2022)

Article Cell Biology

The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes

Laura Gerosa et al.

Summary: In this study, a synapse-to-nucleus signaling pathway mediated by PCDH19 was discovered, linking neuronal activity with gene expression. The proteolytic cleavage of PCDH19 generates a C-terminal fragment that enters the nucleus and associates with chromatin and LSD1, regulating the expression of IEGs. These findings provide insights into the role of PCDH19 in neuronal homeostasis and hyperexcitability.

CELL REPORTS (2022)

Article Neurosciences

Mineralocorticoid receptor and glucocorticoid receptor work alone and together in cell-type-specific manner: Implications for resilience prediction and targeted therapy

Nikolaos P. Daskalakis et al.

Summary: This article explores the role of glucocorticoid receptors in stress responses, emphasizing the importance of balancing mineralocorticoid receptors and glucocorticoid receptors for overall health. The limited understanding of sexual dimorphism in glucocorticoid actions is also highlighted. The article concludes with the prospects of genetically and epigenetically regulated receptor variants and selective receptor modulators for enhancing resilience.

NEUROBIOLOGY OF STRESS (2022)

Review Clinical Neurology

Peripheral oxytocin concentrations in psychiatric disorders - A systematic review and methanalysis: Further evidence

Adriana Colar Ferreira et al.

Summary: This study provides a systematic review and meta-analysis on the relationship between peripheral oxytocin levels and psychiatric disorders. The findings suggest that lower oxytocin concentrations are associated with certain disorders, while higher levels are found in bipolar disorder and obsessive disorder. However, caution is needed in interpreting the results due to the heterogeneity among studies. Further research is needed to understand the oxytocin levels in disorders such as body dysmorphic disorder, posttraumatic stress disorder, and trichotillomania.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2022)

Article Biochemistry & Molecular Biology

Integrative multi-omics landscape of fluoxetine action across 27 brain regions reveals global increase in energy metabolism and region-specific chromatin remodelling

Nirmala Arul Rayan et al.

Summary: This study comprehensively characterizes the molecular landscape of gene regulatory changes associated with fluoxetine, a widely-used SSRI. It reveals significant regional and cell type-specific heterogeneity in the response to fluoxetine, as well as shared mechanisms of action such as changes in energy metabolism and chromatin remodeling. The findings provide valuable insights into the mechanisms of antidepressant drugs and offer potential therapeutic targets for depression and anxiety.

MOLECULAR PSYCHIATRY (2022)

Article Psychiatry

Circulating microRNA associated with future relapse status in major depressive disorder

Qingqin S. S. Li et al.

Summary: This study investigated the relationship between circulating microRNAs (miRNAs) and relapsing major depressive disorder (MDD), and identified four miRNAs nominally associated with relapse status. Enrichment analysis revealed potential involvement of these miRNAs in multiple signaling pathways related to MDD. These findings hold potential for developing a miRNA signature to identify patients at risk of relapse and enable early intervention.

FRONTIERS IN PSYCHIATRY (2022)

Review Neurosciences

Neurobiology of resilience in depression: immune and vascular insights from human and animal studies

Katarzyna A. Dudek et al.

Summary: MDD is a common psychiatric disorder with significant impact on individuals and the economy. Chronic stress is a major environmental risk factor for depression, with women being more susceptible. Rodent models of depression focusing on susceptibility and resilience provide valuable insights into the mechanisms underlying the disease.

EUROPEAN JOURNAL OF NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Cell-type specific modulation of NMDA receptors triggers antidepressant actions

Santosh Pothula et al.

Summary: Both NMDA receptor positive allosteric modulators (PAM) and antagonists have rapid antidepressant effects through different mechanisms, affecting specific cell types and subunits. Electrophysiological and behavioral studies showed that NMDAR PAM directly enhances NMDAR activity in principal glutamatergic neurons, while ketamine blocks NMDAR in GABA interneurons causing glutamate release. These findings suggest unique cellular triggers and converging effects on specific cell signaling pathways that underline the antidepressant actions of NMDAR positive modulation versus NMDAR blockade.

MOLECULAR PSYCHIATRY (2021)

Review Psychiatry

A new molecular risk pathway for postpartum mood disorders: clues from steroid sulfatase-deficient individuals

Harish Thippeswamy et al.

Summary: Postpartum mood disorders are common in women shortly after childbirth, with a range of symptoms that can greatly impact the mother's health and family dynamics. Despite the unclear biological factors that contribute to these disorders, pharmacological treatments may be effective but come with risks. A better understanding of the biological factors involved could lead to improved clinical management and development of new therapeutic targets.

ARCHIVES OF WOMENS MENTAL HEALTH (2021)

Article Biochemistry & Molecular Biology

Brain-wide cellular mapping of acute stress-induced activation in male and female mice

Woonhee Kim et al.

Summary: Mood disorders are more prevalent and severe in women, but the underlying mechanisms of this sexual prevalence remain unclear. A study comparing brain activation in male and female mice after acute stress exposure found sexually dimorphic activation in certain brain areas, though core stress responding mechanisms were largely shared between sexes. Stress strengthened intra-circuitries in the hippocampus, amygdala, and prefrontal cortex in female mice, while longer-range connections were highlighted in stressed male mice. This study provides a valuable neuroanatomical framework for investigating the circuit mechanism underlying the higher vulnerability to depression in women.

FASEB JOURNAL (2021)

Review Biochemistry & Molecular Biology

The miRNome of Depression

Dariusz Zurawek et al.

Summary: Depression is a result of complex interactions between genetic, epigenetic, and environmental factors, with multiple molecular changes associated. RNA interference (RNAi) has the potential to fine-tune the overall balance of the brain, playing an important role in the development of depression.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Psychiatry

A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells

David P. Herzog et al.

Summary: The study revealed differentially expressed genes associated with paroxetine treatment and candidate mechanisms related to good treatment response, such as neuropeptide signaling and synaptic transmission. The results suggest that general paroxetine effects can be distinguished from treatment response-associated molecular signatures, offering potential new targets for future antidepressant treatments.

TRANSLATIONAL PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Plinio C. Casarotto et al.

Summary: The study reveals that antidepressant drugs bind directly to the TRKB receptor, facilitating its activation at the synapse and potentially explaining the mechanism behind antidepressant action.
Article Multidisciplinary Sciences

Creation of a gene expression portrait of depression and its application for identifying potential treatments

Stephen C. Gammie

Summary: This study analyzed large-scale neural gene expression datasets of depression patients to identify characteristics of depressed brain and create depression portraits for different genders. The study found decreased signaling for GABA and neuropeptides, enrichment of MAP kinase and BDNF pathways with overlapping genes. Using drug repurposing approach, exercise was identified as the top treatment for depression, with other non-traditional treatments like curcumin, creatine, and fluoxetine also showing promising results.

SCIENTIFIC REPORTS (2021)

Article Biochemistry & Molecular Biology

A shared transcriptional code orchestrates temporal patterning of the central nervous system

Andreas Sagner et al.

Summary: The study reveals a global temporal patterning program in the vertebrate nervous system, which stratifies neurons based on the developmental time they are generated, increasing neuronal diversity. This temporal program operates throughout the central nervous system in parallel to spatial patterning and is under the control of the TGF beta signaling pathway. Targeted perturbation of components of the temporal program demonstrates their functional requirement for the generation of specific neuronal subtypes.

PLOS BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Precision medicine for mood disorders: objective assessment, risk prediction, pharmacogenomics, and repurposed drugs

H. Le-Niculescu et al.

Summary: Mood disorders are common and disabling, often co-morbid with other psychiatric disorders. Lack of objective measures and personalized treatments could be addressed by blood gene expression biomarkers for tracking mood states. These biomarkers are transdiagnostic, involving circadian mechanisms and neurotrophic factors, with promising validation in multiple studies.

MOLECULAR PSYCHIATRY (2021)

Article Psychiatry

Ahi1 regulates the nuclear translocation of glucocorticoid receptor to modulate stress response

Bin Wang et al.

Summary: Research has shown that AHI1 is a crucial regulator of GR levels, and its deficiency can affect the efficacy of antidepressants and stress responses. Ahi1 interacts with GR to stabilize each other in the cytoplasm, facilitating the nuclear translocation of GR under stress conditions.

TRANSLATIONAL PSYCHIATRY (2021)

Article Pharmacology & Pharmacy

Expression Biomarkers of Pharmacological Treatment Outcomes in Women with Unipolar and Bipolar Depression

Monika Dmitrzak-Weglarz et al.

Summary: This study aimed to identify expression biomarkers of treatment response for unipolar (UD) and bipolar (BD) depression through gene expression profiling in a naturalistic hospital setting. The results showed differentially-expressed genes (DEGs) in UD and BD patients after pharmacological treatment, indicating potential biomarkers associated with treatment response. Additional research focused on outlined genes may provide predictive markers for treatment outcomes in UD and BD.

PHARMACOPSYCHIATRY (2021)

Review Psychiatry

Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify biomarkers

Nicole Mariani et al.

Summary: The development of major depressive disorder (MDD) is thought to be influenced by a combination of genetic, environmental, and psychological factors, as well as immune system, stress response, and neurotransmitter regulation, leading to a focus on the interplay between the periphery and the Central Nervous System (CNS). Studies have analyzed gene expression levels in postmortem brain tissue and blood samples of MDD patients, with a particular interest in mRNA levels as biomarkers for predicting therapy outcomes. Additionally, the choice of antidepressant medication for each individual still remains largely uncertain.

TRANSLATIONAL PSYCHIATRY (2021)

Article Zoology

Fluoxetine ameliorates depressive symptoms by regulating lncRNA expression in the mouse hippocampus

Chuan-Ling Zhang et al.

Summary: Research has shown that altered expressions of long non-coding RNAs (lncRNAs) in the brain can affect neurodevelopment and modulate functions during depression. Through differential expression analysis after RNA-sequencing, it was found that fluoxetine effectively ameliorated depressive symptoms in a chronic unpredictable mild stress (CUMS) mouse model by regulating lncRNAs in the hippocampus. Furthermore, the dysregulated lncRNAs identified may be involved in inflammatory response pathways according to Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.

ZOOLOGICAL RESEARCH (2021)

Article Biochemistry & Molecular Biology

Royal jelly reduces depression-like behavior through possible effects on adrenal steroidogenesis in a murine model of unpredictable chronic mild stress

Noriyuki Iegaki et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2020)

Article Neurosciences

Exploring lithium's transcriptional mechanisms of action in bipolar disorder: a multi-step study

Ibrahim A. Akkouh et al.

NEUROPSYCHOPHARMACOLOGY (2020)

Article Neurosciences

Shared Transcriptional Signatures in Major Depressive Disorder and Mouse Chronic Stress Models

Joseph R. Scarpa et al.

BIOLOGICAL PSYCHIATRY (2020)

Article Biochemistry & Molecular Biology

A psychiatric disease-related circular RNA controls synaptic gene expression and cognition

Amber J. Zimmerman et al.

MOLECULAR PSYCHIATRY (2020)

Review Medicine, Research & Experimental

Rodent models for psychiatric disorders: problems and promises

Matthew Baker et al.

LABORATORY ANIMAL RESEARCH (2020)

Review Neurosciences

Neurobiology of Resilience: Interface Between Mind and Body

Flurin Cathomas et al.

BIOLOGICAL PSYCHIATRY (2019)

Review Psychiatry

Prognosis and improved outcomes in major depression: a review

Christoph Kraus et al.

TRANSLATIONAL PSYCHIATRY (2019)

Article Multidisciplinary Sciences

Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant

Brendan D. Hare et al.

NATURE COMMUNICATIONS (2019)

Article Neurosciences

Opposite Molecular Signatures of Depression in Men and Women

Marianne L. Seney et al.

BIOLOGICAL PSYCHIATRY (2018)

Article Neurosciences

Distinct Proteomic, Transcriptomic, and Epigenetic Stress Responses in Dorsal and Ventral Hippocampus

Amalia Floriou-Servou et al.

BIOLOGICAL PSYCHIATRY (2018)

Article Biochemistry & Molecular Biology

Hippocampal MicroRNAs Respond to Administration of Antidepressant Fluoxetine in Adult Mice

Nan Miao et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Antidepressive effects of targeting ELK-1 signal transduction

Kallia Apazoglou et al.

NATURE MEDICINE (2018)

Article Psychiatry

Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression

Hiroaki Hori et al.

JOURNAL OF PSYCHIATRIC RESEARCH (2018)

Review Medicine, General & Internal

Depression

Gin S. Malhi et al.

LANCET (2018)

Article Clinical Neurology

A novel human pain insensitivity disorder caused by a point mutation in ZFHX2

Abdella M. Habib et al.

Article Genetics & Heredity

Highly Polygenic Architecture of Antidepressant Treatment Response: Comparative Analysis of SSRI and NRI Treatment in an Animal Model of Depression

Karim Malki et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2017)

Article Clinical Neurology

Chronic vortioxetine treatment in rodents modulates gene expression of neurodevelopmental and plasticity markers

Jessica A. Waller et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Precision medicine for suicidality: from universality to subtypes and personalization

A. B. Niculescu et al.

MOLECULAR PSYCHIATRY (2017)

Review Clinical Neurology

The recent progress in animal models of depression

Qingzhong Wang et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2017)

Article Multidisciplinary Sciences

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Juan Pablo Lopez et al.

NATURE COMMUNICATIONS (2017)

Article Neurosciences

Genetic Deletion of Akt3 Induces an Endophenotype Reminiscent of Psychiatric Manifestations in Mice

Yan Bergeron et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Article Neurosciences

Translational Identification of Transcriptional Signatures of Major Depression and Antidepressant Response

Mylene Herve et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)

Review Biochemistry & Molecular Biology

Striatal-enriched Tyrosine Protein Phosphatase (STEP) in the Mechanisms of Depressive Disorders

Elizabeth Kulikova et al.

CURRENT PROTEIN & PEPTIDE SCIENCE (2017)

Review Endocrinology & Metabolism

Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor

E. R. de Kloet et al.

JOURNAL OF NEUROENDOCRINOLOGY (2016)

Article Clinical Neurology

Genome-wide microarray analysis of gene expression profiling in major depression and antidepressant therapy

Eugene Lin et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2016)

Editorial Material Biotechnology & Applied Microbiology

The primary reasons behind data sharing, its wider benefits and how to cope with the realities of commercial data

Ross L. Tellam et al.

BMC GENOMICS (2015)

Article Immunology

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

Sean T. Anderson et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Article Biochemistry & Molecular Biology

Understanding and predicting suicidality using a combined genomic and clinical risk assessment approach

A. B. Niculescu et al.

MOLECULAR PSYCHIATRY (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Open TG-GATEs: a large-scale toxicogenomics database

Yoshinobu Igarashi et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Pharmacology & Pharmacy

Signaling Pathways Involved in Antidepressant-Induced Cell Proliferation and Synaptic Plasticity

Fuencisla Pilar-Cuellar et al.

CURRENT PHARMACEUTICAL DESIGN (2014)

Article Neurosciences

Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior

Ambalika Sarkar et al.

NEUROPSYCHOPHARMACOLOGY (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Clinical Neurology

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

Vanja Duric et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

Article Clinical Neurology

microRNAs as novel antidepressant targets: converging effects of ketamine and electroconvulsive shock therapy in the rat hippocampus

Richard M. O'Connor et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

Review Clinical Neurology

Psychotropic Drug Effects on Gene Transcriptomics Relevant to Alzheimer Disease

Edward C. Lauterbach

ALZHEIMER DISEASE & ASSOCIATED DISORDERS (2012)

Article Biochemistry & Molecular Biology

Identification of the Cortical Neurons that Mediate Antidepressant Responses

Eric F. Schmidt et al.

Article Biochemistry & Molecular Biology

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

Hyo Jung Kang et al.

NATURE MEDICINE (2012)

Article Multidisciplinary Sciences

Behavioral Abnormalities Observed in Zfhx2-Deficient Mice

Yuriko Komine et al.

PLOS ONE (2012)

Article Biochemistry & Molecular Biology

Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

C. Anacker et al.

MOLECULAR PSYCHIATRY (2011)

Review Endocrinology & Metabolism

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

Christoph Anacker et al.

PSYCHONEUROENDOCRINOLOGY (2011)

Article Biochemistry & Molecular Biology

Intersectin 1: a versatile actor in the synaptic vesicle cycle

Arndt Pechstein et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2010)

Article Biochemical Research Methods

A framework for oligonucleotide microarray preprocessing

Benilton S. Carvalho et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene

Toshio Maekawa et al.

EMBO JOURNAL (2010)

Review Neurosciences

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

Michael S. Fanselow et al.

NEURON (2010)

Article Psychiatry

A Molecular Signature of Depression in the Amygdala

Etienne Sibille et al.

AMERICAN JOURNAL OF PSYCHIATRY (2009)

Article Biotechnology & Applied Microbiology

Some molecular effectors of antidepressant action of quetiapine revealed by DNA microarray in the frontal cortex of anhedonic rats

Marco Orsetti et al.

PHARMACOGENETICS AND GENOMICS (2009)

Article Behavioral Sciences

Generation and behavioral characterization of β-catenin forebrain-specific conditional knock-out mice

Todd D. Gould et al.

BEHAVIOURAL BRAIN RESEARCH (2008)

Article Behavioral Sciences

Gene expression patterns in brain cortex of three different animal models of depression

L. Uriguen et al.

GENES BRAIN AND BEHAVIOR (2008)

Article Neurosciences

Genetic regulation of behavioral and neuronal responses to fluoxetine

Brooke H. Miller et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Article Biochemical Research Methods

GEOquery: a bridge between the gene expression omnibus (GEO) and BioConductor

Davis Sean et al.

BIOINFORMATICS (2007)

Review Pharmacology & Pharmacy

Antidepressant action: to the nucleus and beyond

JE Malberg et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2005)

Article Multidisciplinary Sciences

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)

P Svenningsson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)