期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/ijms232315342
关键词
breast cancer; androgen receptor; targeted therapy; novel treatment; prognosis
资金
- Health and Medical Research Fund
- Research Grants Council, Hong Kong General Research Fund [07182026, 07182046]
- Committee on Research and Conference Grants from the University of Hong Kong [17113020]
- [202111159194]
Activation of the androgen receptor (AR) can suppress disease progression in estrogen receptor alpha-positive breast cancer, while blocking AR might provide better prognosis in estrogen receptor alpha-negative breast cancer. Modulating AR activity could be a potential strategy for treating breast cancer.
The androgen receptor (AR) is a steroid hormone receptor widely detected in breast cancer. Evidence suggests that the AR might be a tumor suppressor in estrogen receptor alpha-positive (ER alpha+ve) breast cancer but a tumor promoter in estrogen receptor alpha-negative (ER alpha-ve) breast cancer. Modulating AR activity could be a potential strategy for treating breast cancer. For ER alpha+ve breast cancer, activation of the AR had been demonstrated to suppress the disease. In contrast, for ER alpha-ve breast cancer, blocking the AR could confer better prognosis to patients. These studies support the feasibility of utilizing AR modulators as anti-cancer drugs for different subtypes of breast cancer patients. Nevertheless, several issues still need to be addressed, such as the lack of standardization in the determination of AR positivity and the presence of AR splice variants. In future, the inclusion of the AR status in the breast cancer report at the time of diagnosis might help improve disease classification and treatment decision, thereby providing additional treatment strategies for breast cancer.
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