☆ 4.7 Review

The Microbiome in Systemic Sclerosis: Pathophysiology and Therapeutic Potential

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Allergy

Current Concepts on the Pathogenesis of Systemic Sclerosis

Marie Elise Truchetet et al.

Summary: Systemic sclerosis (SSc) is a disease characterized by skin and internal organ fibrosis, vascular modifications, and autoimmunity. It predominantly affects women and has heterogeneous clinical presentations and courses. The pathogenesis involves genetic predisposition, environmental factors, and epigenetic modifications that lead to immune-inflammatory dysregulation and abnormal cell behavior. Myofibroblasts play a crucial role in the disease by promoting fibrosis and matrix deposition. Other cell types, such as pericytes, platelets, and keratinocytes, are also involved. T cell subsets and autoantibodies contribute to fibroblast and endothelial cell dysfunction. Recent studies have revealed heterogeneity in SSc cell differentiation and functional states. Understanding the heterogeneity and pathogenic mechanisms will aid in developing personalized therapeutic approaches.

CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY (2023)

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Review Microbiology

Current Perspectives on Gastrointestinal Models to Assess Probiotic-Pathogen Interactions

Mehreen Anjum et al.

Summary: There are various models available to study the interaction between probiotics and pathogens in the gastrointestinal tract, with in vitro methods being faster, cost-effective, and ethically superior. The selection of the optimal model depends on the research question.

FRONTIERS IN MICROBIOLOGY (2022)

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Article Pharmacology & Pharmacy

Current advances in the treatment of systemic sclerosis

Heather Bukiri et al.

Summary: Systemic sclerosis is a rare autoimmune disease with unknown cause. The lack of disease modifying therapies has contributed to its high mortality. Recent randomized controlled trials have provided valuable insights into the pathogenesis and potential treatments for systemic sclerosis, leading to the approval of novel therapies for interstitial lung disease associated with systemic sclerosis.

CURRENT OPINION IN PHARMACOLOGY (2022)

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Review Immunology

Bacteriocin-Producing Probiotic Lactic Acid Bacteria in Controlling Dysbiosis of the Gut Microbiota

Anjana et al.

Summary: Lactic acid bacteria can cure diseases and modulate gut microbiota by producing bacteriocins, making them effective in treating various human disorders.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2022)

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Review Immunology

The Yin and Yang of IL-17 in Systemic Sclerosis

Lanxuan Wei et al.

Summary: IL-17 is a pro-inflammatory cytokine that plays an important role in host defense. It activates transcription and stabilizes mRNAs through multiple pathways, mainly acting on stromal cells to promote the secretion of other immunomodulatory factors and support the growth and differentiation of immune cells. IL-17 has a dual role in immune reactions and inflammatory diseases, and it also plays a significant role in autoimmune diseases.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Biochemistry & Molecular Biology

Plasma Metabolomic Profiling Reveals Four Possibly Disrupted Mechanisms in Systemic Sclerosis

Thomas Boegl et al.

Summary: A study analyzed the metabolomic profiles of plasma from systemic sclerosis (SSc) patients and identified four dysfunctional metabolic mechanisms associated with inflammation, vascular damage, fibrosis, and gut dysbiosis.

BIOMEDICINES (2022)

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Review Biology

Animal Models of Systemic Sclerosis: Using Nailfold Capillaroscopy as a Potential Tool to Evaluate Microcirculation and Microangiopathy: A Narrative Review

Angelica Mandujano et al.

Summary: Systemic sclerosis is an autoimmune disease characterized by inflammation, vasculopathy, and fibrosis. Despite the development of various animal models, none fully replicate all aspects of the disease. Nailfold capillaroscopy, widely used in humans, has potential applications in animal models for studying vasculopathy and developing novel treatment options.

LIFE-BASEL (2022)

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Review Immunology

Role of B-Cell in the Pathogenesis of Systemic Sclerosis

Benjamin Thoreau et al.

Summary: Systemic sclerosis (SSc) is a rare autoimmune disease characterized by fibrosis, vasculopathy, and autoimmunity. Recent studies have shown the significant role of B-cells in SSc, with disrupted subpopulations and activated phenotype. B-cells also exhibit impaired regulatory capacities and contribute to fibrosis through the production of autoantibodies and cytokines. Targeting B-cells may be a potential treatment for early-stage SSc patients with severe organ damage.

FRONTIERS IN IMMUNOLOGY (2022)

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Review Rheumatology

Type 1 interferon activation in systemic sclerosis: a biomarker, a target or the culprit

Vishal Kakkar et al.

Summary: Recent findings have shown increased expression and activation of T1 IFN-regulated genes in a significant proportion of SSc patients. These markers have been found to predict response to treatment and severity of organ involvement. Inhibition of the IFN-alpha receptor has been effective in SLE, supporting the potential therapeutic benefit of targeting T1 IFN in SSc.

CURRENT OPINION IN RHEUMATOLOGY (2022)

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Article Allergy

Gut microbiome in systemic sclerosis: a potential therapeutic target

Beata Polkowska-Pruszynska et al.

Summary: This study investigated the prevalence and characteristics of small intestinal bacterial overgrowth (SIBO) in systemic sclerosis (SSc) patients, as well as the efficacy of rifaximin in treating SIBO in these patients. The results showed a higher prevalence of SIBO in SSc patients compared to the control group, and rifaximin treatment led to successful eradication of SIBO in a significant percentage of SSc patients.

POSTEPY DERMATOLOGII I ALERGOLOGII (2022)

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Article Gastroenterology & Hepatology

Low-Fat, High-Fiber Diet Reduces Markers of Inflammation and Dysbiosis and Improves Quality of Life in Patients With Ulcerative Colitis

Julia Fritsch et al.

Summary: In patients with UC, both a low-fat, high-fiber diet and an improved standard American diet increased quality of life, but the low-fat, high-fiber diet decreased markers of inflammation and reduced intestinal dysbiosis in fecal samples.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

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Review Biology

New Insights into Profibrotic Myofibroblast Formation in Systemic Sclerosis: When the Vascular Wall Becomes the Enemy

Eloisa Romano et al.

Summary: In systemic sclerosis (SSc), abnormalities in microvessel morphology evolve into a distinctive vasculopathy that progresses alongside tissue fibrosis orchestrated by myofibroblasts. The endothelial-to-mesenchymal transition (EndoMT) process may play a central role in the pathogenesis of SSc, contributing to both fibrotic vascular lesions and tissue fibrosis. A deeper understanding of the mechanisms underlying myofibroblast differentiation inside vessel walls provides the basis for targeted therapeutic strategies for SSc.

LIFE-BASEL (2021)

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Article Rheumatology

Fecal microbiome differs between patients with systemic sclerosis with and without small intestinal bacterial overgrowth

Daniel Levin et al.

Summary: The study investigated the fecal microbiota of systemic sclerosis patients with and without small intestinal bacterial overgrowth, comparing them to healthy controls. Differences in microbial composition were observed between different groups, suggesting potential associations between specific bacterial taxa and clinical manifestations of systemic sclerosis. The findings indicate a potential role of altered microbiome in the development of systemic sclerosis, which warrants further investigation.

JOURNAL OF SCLERODERMA AND RELATED DISORDERS (2021)

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Review Pharmacology & Pharmacy

The influence of the gut microbiota on the bioavailability of oral drugs

Xintong Zhang et al.

Summary: Oral administration is popular due to its safety, convenience, low cost, and good compliance, but the bioavailability of many oral drugs is limited by the gut microbiota. Research on the relationship between gut microbiota and the bioavailability of oral drugs is crucial for designing novel drug delivery systems or achieving personalized medicine.

ACTA PHARMACEUTICA SINICA B (2021)

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Review Biochemistry & Molecular Biology

Effect of probiotics and gut microbiota on anti-cancer drugs: Mechanistic perspectives

Aja Badgeley et al.

Summary: Studies have shown that probiotics, particularly Lactobacillus and Bifidobacterium, induce anti-cancer action and decrease cancer-producing microorganisms. Gut microbes not only enhance the action of chemotherapy drugs but also reduce the side effects of these medications.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2021)

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Article Rheumatology

Dysfunctional Keratinocytes Increase Dermal Inflammation in Systemic Sclerosis: Results From Studies Using Tissue-Engineered Scleroderma Epidermis

Barbara Russo et al.

Summary: Objective evidence suggests that keratinocyte-fibroblast interactions are abnormal in systemic sclerosis (SSc). This study found that SSc epidermal equivalents (EEs) exhibited aberrant differentiation and enhanced expression of activation markers, replicating the abnormalities seen in SSc epidermis. The dysregulation of genes from the homeobox family and increased metabolic and oxidative stress in SSc EEs may contribute to chronic inflammation and dermal fibrosis.

ARTHRITIS & RHEUMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Butyrate Improves Skin/Lung Fibrosis and Intestinal Dysbiosis in Bleomycin-Induced Mouse Models

Hee Jin Park et al.

Summary: The study found that butyrate has potential therapeutic effects in a mouse model of SSc and human dermal fibroblasts, by modulating intestinal microbiota, controlling macrophage differentiation, and inhibiting proinflammatory gene expression, thus improving fibrosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Genetics & Heredity

Congruent microbiome signatures in fibrosis-prone autoimmune diseases: IgG4-related disease and systemic sclerosis

Damian R. Plichta et al.

Summary: The study analyzed the gut microbiomes of IgG4-RD and SSc patients, revealing distinct differences compared to healthy controls. There were significantly overabundant pathogenic bacteria and depleted beneficial bacteria in the patients, suggesting a potential role of gut microbiome in the pathophysiology of these diseases.

GENOME MEDICINE (2021)

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Review Rheumatology

The microbiome and systemic sclerosis: A review of current evidence

Tze Chin Tan et al.

Summary: Systemic sclerosis (SSc) is a disease characterized by immune dysregulation, vasculopathy, and fibrosis of multiple organs, with the gastrointestinal (GI) tract being the most commonly affected organ. Recent studies have found unique microbial taxa alterations in the GI microbiome of SSc patients compared to healthy controls (HC), with potential associations with disease manifestations and severity.

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY (2021)

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Review Immunology

Endothelial-to-mesenchymal transition in systemic sclerosis

P. Di Benedetto et al.

Summary: Systemic sclerosis is an autoimmune disease characterized by vascular alterations and multi-organ fibrosis. The process of endothelial-to-mesenchymal transition plays a crucial role in the development of progressive fibrosis in SSc, and understanding this mechanism is important for identifying therapeutic targets.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2021)

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Review Rheumatology

B cells in systemic sclerosis: from pathophysiology to treatment

Konstantinos Melissaropoulos et al.

Summary: Systemic sclerosis is a debilitating autoimmune disease with unknown pathogenesis, characterized by vascular and immunologic aberrations. B cells play a dysregulated role in the disease, with abnormal subsets observed in peripheral blood and target organs like the skin and lungs. Therapeutic targeting of B cells has shown promise as a treatment alongside current options like mycophenolate.

CLINICAL RHEUMATOLOGY (2021)

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Review Rheumatology

A review and roadmap of the skin, lung and gut microbiota in systemic sclerosis

Shannon Teaw et al.

Summary: As our understanding of the genetic basis of SSc grows, questions about the environmental triggers that induce and propagate SSc in predisposed individuals are emerging. The interplay between the environment, the immune system, and the microbial species in the skin and gastrointestinal tract of SSc patients is an unexplored frontier. This review aims to provide an overview of methodologies, experimental results, and future directions for elucidating the relationship between the SSc host and their microbiome.

RHEUMATOLOGY (2021)

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Review Immunology

Modulatory Effects of Probiotics During Pathogenic Infections With Emphasis on Immune Regulation

Abdul Raheem et al.

Summary: The widespread use of antibiotics can lead to a range of adverse effects, prompting the search for probiotics as alternatives. Probiotics play an important role in regulating host immune responses, with a focus on their application in infectious disease treatments garnering significant research interest.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Rheumatology

TGFβ promotes low IL10-producing ILC2 with profibrotic ability involved in skin fibrosis in systemic sclerosis

Paoline Laurent et al.

Summary: Our study demonstrated that in SSc patients, ILC2 numbers were increased in the skin and correlated with skin fibrosis severity. The dominance of natural ILC2 over inflammatory ILC2 in SSc skin was favored by the activity of TGF-beta. TGF-beta-stimulated ILC2 showed enhanced profibrotic activity by decreasing IL10 production and increasing myofibroblast differentiation, while therapeutic intervention in a mouse model combining pirfenidone with IL10 administration effectively reduced skin infiltrating ILC2 and alleviated skin fibrosis.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Review Biochemistry & Molecular Biology

Idiopathic pulmonary fibrosis and systemic sclerosis: pathogenic mechanisms and therapeutic interventions

Hamid Mattoo et al.

Summary: This review focuses on the pathogenesis of fibrotic diseases, mainly looking at triggers, progression processes, therapies, and therapeutic trials. It primarily discusses idiopathic pulmonary fibrosis and systemic sclerosis, highlighting the contributions of inflammatory mechanisms and adaptive immunity respectively.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

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Review Rheumatology

Advances in epigenetics in systemic sclerosis: molecular mechanisms and therapeutic potential

Pei-Suen Tsou et al.

Summary: Systemic sclerosis (SSc) is a complex inflammatory fibrotic disease with unknown etiology and partially understood pathogenesis, carrying the highest mortality rate among rheumatic diseases. Epigenetic aberrations play a crucial role in SSc pathogenesis, affecting immune cells, endothelial cells, and fibroblasts, presenting potential new avenues for therapeutic interventions.

NATURE REVIEWS RHEUMATOLOGY (2021)

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Article Medicine, General & Internal

Safety and efficacy of faecal microbiota transplantation by Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis: study protocol for the randomised controlled phase II ReSScue trial

Anna-Maria Hoffmann-Vold et al.

Summary: This study aims to evaluate the safety and efficacy of fecal microbiota transplantation using Anaerobic Cultivated Human Intestinal Microbiome (ACHIM) in patients with systemic sclerosis and gastrointestinal symptoms. The trial consists of three parts including an induction phase, maintenance phase, and extended monitoring period, with primary endpoint focused on changes in gastrointestinal symptoms such as diarrhea and bloating.

BMJ OPEN (2021)

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Article Immunology

Gut Microbiota Aberration in Patients of Systemic Sclerosis and Bleomycin-Induced Mice Model

Jungen Tang et al.

Summary: Systemic sclerosis (SSc) is an immune-mediated systemic autoimmune disease with high morbidity and mortality. Establishing appropriate animal models to explore the role of gut microbiota in the pathogenesis of SSc is essential. Through 16S rRNA gene sequencing, similar gut microbiota aberration was found in SSc patients and BLM-induced mice, providing a potential platform for studying gut microbiota aberration in SSc patients and developing disease-modifying treatments.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Microbiology

Oral Lactobacillus Species in Systemic Sclerosis

Daniela Melchiorre et al.

Summary: This study found a lower presence of Lactobacillus in the oral cavity of systemic sclerosis (SSc) patients, supporting the hypothesis that Lactobacillus may have both protective and therapeutic roles in these patients.

MICROORGANISMS (2021)

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Review Immunology

Gut-Brain Connection: Microbiome, Gut Barrier, and Environmental Sensors

Min-Gyu Gwak et al.

Summary: The gut microbiome plays a key role in regulating immune, metabolic, and nervous systems in cooperation with the host. Disruptions in microbial communities have been linked to neurological disorders, highlighting the importance of the gut-brain axis. The dynamic communication between the gut and brain can impact mood and behaviors.

IMMUNE NETWORK (2021)

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Review Immunology

Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

Cezmi A. Akdis

Summary: The increase in allergic, autoimmune, and chronic diseases may be related to epithelial barrier-damaging agents associated with industrialization, urbanization, and modern life. These diseases are more prevalent in industrialized countries and are on the rise in developing countries, affecting over one billion people globally.

NATURE REVIEWS IMMUNOLOGY (2021)

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Article Dermatology

IL-17A Dissociates Inflammation from Fibrogenesis in Systemic Sclerosis

Aleksandra Maria Dufour et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2020)

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Article Gastroenterology & Hepatology

Effectiveness of Saccharomyces boulardii and Metronidazole for Small Intestinal Bacterial Overgrowth in Systemic Sclerosis

Grettel Garcia-Collinot et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

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Article Rheumatology

Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile

Brian Skaug et al.

ANNALS OF THE RHEUMATIC DISEASES (2020)

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Editorial Material Immunology

The potential of fecal microbiota transplantation in systemic sclerosis

Anna-Maria Hoffmann-Vold et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2020)

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Review Rheumatology

Nintedanib: New indication for systemic sclerosis-associated interstitial lung disease

Masataka Kuwana et al.

MODERN RHEUMATOLOGY (2020)

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Review Rheumatology

Raynaud phenomenon and digital ulcers in systemic sclerosis

Michael Hughes et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

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Article Medicine, Research & Experimental

Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis

Takashi Maehara et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

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Article Multidisciplinary Sciences

Fecal microbiota transplantation in systemic sclerosis: A double-blind, placebo-controlled randomized pilot trial

Havard Fretheim et al.

PLOS ONE (2020)

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Editorial Material Rheumatology

T cells in SSc skin lesions: knowing your enemy

Patrizia Fuschiotti

NATURE REVIEWS RHEUMATOLOGY (2020)

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Review Biochemistry & Molecular Biology

Role of Alarmins in the Pathogenesis of Systemic Sclerosis

Antonello Giovannetti et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Systemic Sclerosis Perturbs the Architecture of the Immunome

Bhairav Paleja et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Circulating microbial small RNAs are altered in patients with rheumatoid arthritis

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Irene Rosa et al.

EUROPEAN JOURNAL OF RHEUMATOLOGY (2020)

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The Role of Butyrate in Attenuating Pathobiont-Induced Hyperinflammation

Jiezhong Chen et al.

IMMUNE NETWORK (2020)

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Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Laure Ricard et al.

ANNALS OF THE RHEUMATIC DISEASES (2019)

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PU.1 controls fibroblast polarization and tissue fibrosis

Thomas Wohlfahrt et al.

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Involvement of the myeloid cell compartment in fibrogenesis and systemic sclerosis

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Effect of probiotics on gastrointestinal symptoms and immune parameters in systemic sclerosis: a randomized placebo-controlled trial

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A double-blind randomized placebo-controlled trial of probiotics in systemic sclerosis associated gastrointestinal disease

Andrea Hsiu Ling Low et al.

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CXCL4 assembles DNA into liquid crystalline complexes to amplify TLR9-mediated interferon-α production in systemic sclerosis

Roberto Lande et al.

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The Roles of IL-1 Family Cytokines in the Pathogenesis of Systemic Sclerosis

Dan Xu et al.

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Gastrointestinal involvement in systemic sclerosis: an update

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M. Brown et al.

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The efficacy of dietary intervention on gastrointestinal involvement in systemic sclerosis: A systematic literature review

Elizabeth Smith et al.

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Lung Microbiota Contribute to Pulmonary Inflammation and Disease Progression in Pulmonary Fibrosis

David N. O'Dwyer et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2019)

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Gut Disease in Systemic Sclerosis-New Approaches to Common Problems

Jessica Zhu et al.

CURRENT TREATMENT OPTIONS IN RHEUMATOLOGY (2019)

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Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic sclerosis skin

Michael E. Johnson et al.

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Elevated serum levels of interleukin-1β and interleukin-33 in patients with systemic sclerosis in Chinese population

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Dariush Shokri et al.

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Microbial and metabolic multi-omic correlations in systemic sclerosis patients

Chiara Bellocchi et al.

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Soluble CD163 as a Potential Biomarker in Systemic Sclerosis

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Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

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Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases

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IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis

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Imbalance between T helper 17 and regulatory T cell subsets plays a significant role in the pathogenesis of systemic sclerosis

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Systemic Sclerosis Dermal Fibroblasts Suppress Th1 Cytokine Production via Galectin-9 Overproduction due to Fli1 Deficiency

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Early-Life Antibiotic Exposure Causes Intestinal Dysbiosis and Exacerbates Skin and Lung Pathology in Experimental Systemic Sclerosis

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High Fat Diet Alters Gut Microbiota and the Expression of Paneth Cell-Antimicrobial Peptides Preceding Changes of Circulating Inflammatory Cytokines

Xiulan Guo et al.

MEDIATORS OF INFLAMMATION (2017)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Multidisciplinary Sciences

Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine

Leore T. Geller et al.

SCIENCE (2017)

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Review Rheumatology

The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis

Konstantinos Ntelis et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2017)

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Review Multidisciplinary Sciences

The molecular basis of endothelial cell plasticity

Elisabetta Dejana et al.

NATURE COMMUNICATIONS (2017)

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Article Gastroenterology & Hepatology

Strain-specific probiotic properties of lactic acid bacteria and their interference with human intestinal pathogens invasion

Raffaella Campana et al.

GUT PATHOGENS (2017)

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Article Genetics & Heredity

A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis

Jaclyn N. Taroni et al.

GENOME MEDICINE (2017)

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Article Rheumatology

Scleroderma Peripheral B Lymphocytes Secrete Interleukin-6 and Transforming Growth Factor β and Activate Fibroblasts

Nicolas Dumoitier et al.

ARTHRITIS & RHEUMATOLOGY (2017)

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Article Multidisciplinary Sciences

Gut microbiota profile in systemic sclerosis patients with and without clinical evidence of gastrointestinal involvement

Vania Patrone et al.

SCIENTIFIC REPORTS (2017)

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Article Immunology

Increased proportions of functionally impaired regulatory T cell subsets in systemic sclerosis

Emese Ugor et al.

CLINICAL IMMUNOLOGY (2017)

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Review Rheumatology

Intestinal microbiome in scleroderma: recent progress

Elizabeth R. Volkmann

CURRENT OPINION IN RHEUMATOLOGY (2017)

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Article Gastroenterology & Hepatology

Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts

Elizabeth R. Volkmann et al.

BMJ OPEN GASTROENTEROLOGY (2017)

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Article Rheumatology

Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages

Christiane Maier et al.

ANNALS OF THE RHEUMATIC DISEASES (2017)

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Article Rheumatology

IL-22 capacitates dermal fibroblast responses to TNF in scleroderma

Nicolo Costantino Brembilla et al.

ANNALS OF THE RHEUMATIC DISEASES (2016)

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Article Gastroenterology & Hepatology

Role of muscarinic-3 receptor antibody in systemic sclerosis: correlation with disease duration and effects of IVIG

Sumit Kumar et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

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Review Rheumatology

Animal models of scleroderma: recent progress

Roberta G. Marangoni et al.

CURRENT OPINION IN RHEUMATOLOGY (2016)

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Review Immunology

The Lung Microbiome, Immunity, and the Pathogenesis of Chronic Lung Disease

David N. O'Dwyer et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Rheumatology

Association of Systemic Sclerosis With a Unique Colonic Microbial Consortium

Elizabeth R. Volkmann et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Rheumatology

Platelets Induce Thymic Stromal Lymphopoietin Production by Endothelial Cells: Contribution to Fibrosis in Human Systemic Sclerosis

Marie-Elise Truchetet et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Article Rheumatology

Breg Cells Are Numerically Decreased and Functionally Impaired in Patients With Systemic Sclerosis

Athanasios Mavropoulos et al.

ARTHRITIS & RHEUMATOLOGY (2016)

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Review Immunology

Immune-microbiota interactions in health and disease

Noah W. Palm et al.

CLINICAL IMMUNOLOGY (2015)

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Risk and Safety of Probiotics

Shira Doron et al.

CLINICAL INFECTIOUS DISEASES (2015)

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Article Allergy

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis

Katherine G. MacDonald et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Article Rheumatology

The Endothelial-mesenchymal Transition in Systemic Sclerosis Is Induced by Endothelin-1 and Transforming Growth Factor-β and May Be Blocked by Macitentan, a Dual Endothelin-1 Receptor Antagonist

Paola Cipriani et al.

JOURNAL OF RHEUMATOLOGY (2015)

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Article Medicine, General & Internal

Fructose Malabsorption in Systemic Sclerosis

Isabelle Marie et al.

MEDICINE (2015)

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Review Pathology

Cellular and molecular mechanisms in the pathophysiology of systemic sclerosis

T. Hua-Huy et al.

PATHOLOGIE BIOLOGIE (2015)

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Identification and isolation of a dermal lineage with intrinsic fibrogenic potential

Yuval Rinkevich et al.

SCIENCE (2015)

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Review Immunology

The role of the acquired immune response in systemic sclerosis

Carlo Chizzolini et al.

SEMINARS IN IMMUNOPATHOLOGY (2015)

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Article Microbiology

Analysis of the Upper Respiratory Tract Microbiotas as the Source of the Lung and Gastric Microbiotas in Healthy Individuals

Christine M. Bassis et al.

MBIO (2015)

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Article Biochemical Research Methods

Systems Level Analysis of Systemic Sclerosis Shows a Network of Immune and Profibrotic Pathways Connected with Genetic Polymorphisms

J. Matthew Mahoney et al.

PLOS COMPUTATIONAL BIOLOGY (2015)

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Review Immunology

Pathogenesis of systemic sclerosis

Debendra Pattanaik et al.

FRONTIERS IN IMMUNOLOGY (2015)

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NATURE REVIEWS DISEASE PRIMERS (2015)

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Article Rheumatology

Evidence for oesophageal and anorectal involvement in very early systemic sclerosis (VEDOSS): report from a single VEDOSS/EUSTAR centre

Gemma Lepri et al.

ANNALS OF THE RHEUMATIC DISEASES (2015)

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The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2014)

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Article Biochemistry & Molecular Biology

Oxidative Stress Elicits Platelet/Leukocyte Inflammatory Interactions via HMGB1: A Candidate for Microvessel Injury in Sytemic Sclerosis

Norma Maugeri et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Article Microbiology

Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

Suryasarathi Dasgupta et al.

CELL HOST & MICROBE (2014)

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Article Microbiology

Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2

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CELL HOST & MICROBE (2014)

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Review Biochemistry & Molecular Biology

Molecular dialogue between the human gut microbiota and the host: a Lactobacillus and Bifidobacterium perspective

Francesca Turroni et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

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Article Immunology

Skin Wound Healing Is Accelerated and Scarless in the Absence of Commensal Microbiota

Maria C. C. Canesso et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Dermatology

High Rhodotorula Sequences in Skin Transcriptome of Patients with Diffuse Systemic Sclerosis

Sarah T. Arron et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2014)

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Review Rheumatology

Transforming growth factor β-at the centre of systemic sclerosis

Robert Lafyatis

NATURE REVIEWS RHEUMATOLOGY (2014)

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Article Multidisciplinary Sciences

Correction: Molecular Subsets in the Gene Expression Signatures of Scleroderma Skin

Ausra Milano et al.

PLoS One (2014)

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Article Multidisciplinary Sciences

Administration of a Probiotic Can Change Drug Pharmacokinetics: Effect of E. coli Nissle 1917 on Amidarone Absorption in Rats

Zuzana Matuskova et al.

PLOS ONE (2014)

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Article Cell Biology

FibronectinEDA Promotes Chronic Cutaneous Fibrosis Through Toll-like Receptor Signaling

Swati Bhattacharyya et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Article Rheumatology

Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis

Giuseppina Stifano et al.

ARTHRITIS RESEARCH & THERAPY (2014)

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Article Rheumatology

Interleukin-17A promotes functional activation of systemic sclerosis patient-derived dermal vascular smooth muscle cells by extracellular-regulated protein kinases signalling pathway

Mengguo Liu et al.

ARTHRITIS RESEARCH & THERAPY (2014)

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Article Rheumatology

Identification of Cadherin 11 as a Mediator of Dermal Fibrosis and Possible Role in Systemic Sclerosis

Minghua Wu et al.

ARTHRITIS & RHEUMATOLOGY (2014)

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Editorial Material Rheumatology

Increased serum IL-33 levels may indicate vascular involvement in systemic sclerosis

Sarah Terras et al.

ANNALS OF THE RHEUMATIC DISEASES (2013)

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Article Rheumatology

Toll-like receptor-mediated, enhanced production of profibrotic TIMP-1 in monocytes from patients with systemic sclerosis: role of serum factors

Marzena Ciechomska et al.

ANNALS OF THE RHEUMATIC DISEASES (2013)

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Article Rheumatology

Interleukin-13-producing CD8+T cells mediate dermal fibrosis in patients with systemic sclerosis

Patrizia Fuschiotti et al.

ARTHRITIS AND RHEUMATISM (2013)

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Review Biochemistry & Molecular Biology

Role of Interleukin-13 in fibrosis, particularly systemic sclerosis

Steven O'Reilly

BIOFACTORS (2013)

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Article Microbiology

A Single Strain of Clostridium butyricum Induces Intestinal IL-10-Producing Macrophages to Suppress Acute Experimental Colitis in Mice

Atsushi Hayashi et al.

CELL HOST & MICROBE (2013)

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Article Immunology

IL-1β and TGFβ2 synergistically induce endothelial to mesenchymal transition in an NFκB-dependent manner

Monika Maleszewska et al.

IMMUNOBIOLOGY (2013)

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Article Dermatology

Serum levels of interleukin-1 in patients with systemic sclerosis

Takeo Maekawa et al.

JOURNAL OF DERMATOLOGY (2013)

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Article Dermatology

Molecular Signatures in Skin Associated with Clinical Improvement during Mycophenolate Treatment in Systemic Sclerosis

Monique Hinchcliff et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Article Multidisciplinary Sciences

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

Koji Atarashi et al.

NATURE (2013)

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Article Multidisciplinary Sciences

IL-17A Induces Endothelial Inflammation in Systemic Sclerosis via the ERK Signaling Pathway

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PLOS ONE (2013)

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Review Gastroenterology & Hepatology

Gastrointestinal complications of systemic sclerosis

Xin-Ping Tian et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Article Rheumatology

B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis

Antoine Francois et al.

ARTHRITIS RESEARCH & THERAPY (2013)

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Editorial Material Rheumatology

B cells tell scleroderma fibroblasts to produce collagen

Dimitrios Daoussis et al.

ARTHRITIS RESEARCH & THERAPY (2013)

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Review Immunology

The role of type 1 interferon in systemic sclerosis

Minghua Wu et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Article Cell Biology

Direct isolation of myofibroblasts and fibroblasts from bleomycin-injured lungs reveals their functional similarities and differences

Taisuke Akamatsu et al.

FIBROGENESIS & TISSUE REPAIR (2013)

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Article Rheumatology

A rare polymorphism in the gene for Toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators

J. C. A. Broen et al.

ARTHRITIS AND RHEUMATISM (2012)

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Article Rheumatology

Potential roles of interleukin-17A in the development of skin fibrosis in mice

Yoshinobu Okamoto et al.

ARTHRITIS AND RHEUMATISM (2012)

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Article Biochemistry & Molecular Biology

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

Heidi H. Kong et al.

GENOME RESEARCH (2012)

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Article Dermatology

Intrinsic Gene Expression Subsets of Diffuse Cutaneous Systemic Sclerosis Are Stable in Serial Skin Biopsies

Sarah A. Pendergrass et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

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Article Rheumatology

Gut fibrosis with altered colonic contractility in a mouse model of scleroderma

Nora M. Thoua et al.

RHEUMATOLOGY (2012)

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Review Multidisciplinary Sciences

Host-Gut Microbiota Metabolic Interactions

Jeremy K. Nicholson et al.

SCIENCE (2012)

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Article Rheumatology

Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis

Koichi Yanaba et al.

CLINICAL RHEUMATOLOGY (2011)

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Article Immunology

Platelet-derived serotonin links vascular disease and tissue fibrosis

Clara Dees et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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Article Immunology

Blocking IL-17A Promotes the Resolution of Pulmonary Inflammation and Fibrosis Via TGF-β1-Dependent and -Independent Mechanisms

Su Mi et al.

JOURNAL OF IMMUNOLOGY (2011)

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Review Microbiology

The skin microbiome

Elizabeth A. Grice et al.

NATURE REVIEWS MICROBIOLOGY (2011)

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The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

June L. Round et al.

SCIENCE (2011)

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Article Rheumatology

Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts

Sandeep K. Agarwal et al.

ARTHRITIS RESEARCH & THERAPY (2011)

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Article Cell Biology

Cooperative interaction of CTGF and TGF-beta in animal models of fibrotic disease

Qingjian Wang et al.

FIBROGENESIS & TISSUE REPAIR (2011)

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Article Rheumatology

The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis

Mirko Manetti et al.

ANNALS OF THE RHEUMATIC DISEASES (2010)

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Article Rheumatology

Systemic Sclerosis and Lupus Points in an Interferon-Mediated Continuum

Shervin Assassi et al.

ARTHRITIS AND RHEUMATISM (2010)

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Article Immunology

Bleomycin and IL-1β-mediated pulmonary fibrosis is IL-17A dependent

Mark S. Wilson et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2010)

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Article Immunology

IL-33 Induces IL-13-Dependent Cutaneous Fibrosis

Andrew L. Rankin et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Hematology

IL-17-producing human peripheral regulatory T cells retain suppressive function

Gaelle Beriou et al.

BLOOD (2009)

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Article Immunology

Clinical Significance of Serum HMGB-1 and sRAGE Levels in Systemic Sclerosis: Association with Disease Severity

Ayumi Yoshizaki et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2009)

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Article Immunology

IL-33 Amplifies the Polarization of Alternatively Activated Macrophages That Contribute to Airway Inflammation

Mariola Kurowska-Stolarska et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Biochemistry & Molecular Biology

Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury

Yuping Lai et al.

NATURE MEDICINE (2009)

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Article Rheumatology

Induction of interferon-α by scleroderma sera containing autoantibodies to topoisomerase I

Daniel Kim et al.

ARTHRITIS AND RHEUMATISM (2008)

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Article Cell Biology

The IL-6 promoter polymorphism is associated with disease activity and disability in systemic sclerosis

Roxana Sfrent-Cornateanu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2006)

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Article Rheumatology

Elevated serum BAFF levels in patients with systemic sclerosis - Enhanced BAFF signaling in systemic sclerosis B lymphocytes

T Matsushita et al.

ARTHRITIS AND RHEUMATISM (2006)

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Article Biotechnology & Applied Microbiology

pH-, lactic acid-, and non-lactic acid-dependent activities of probiotic lactobacilli against Salmonella enterica serovar typhimurium

D Fayol-Messaoudi et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2005)

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Article Pathology

Alterations of mononuclear inflammatory cells, CD4/CD8+T cells, interleukin 1β, and tumour necrosis factor a in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis

MR Hussein et al.

JOURNAL OF CLINICAL PATHOLOGY (2005)

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Review Immunology

Fibrotic disease and the TH1/TH2 paradigm

TA Wynn

NATURE REVIEWS IMMUNOLOGY (2004)

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Article Medicine, Research & Experimental

Differential effects of short-chain fatty acids on proliferation and production of pro- and anti-inflammatory cytokines by cultured lymphocytes

CR Cavaglieri et al.

LIFE SCIENCES (2003)

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Article Dermatology

Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis

S Sato et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)

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Article Dermatology

Serum levels of interleukin-6 and interleukin-10 correlate with total skin thickness score in patients with systemic sclerosis

S Sato et al.

JOURNAL OF DERMATOLOGICAL SCIENCE (2001)

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Article Gastroenterology & Hepatology

Sildenafil inhibits gastroduodenal motility

M Bortolotti et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2001)

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