4.7 Article

Dimethyl Fumarate Alleviates Adult Neurogenesis Disruption in Hippocampus and Olfactory Bulb and Spatial Cognitive Deficits Induced by Intracerebroventricular Streptozotocin Injection in Young and Aged Rats

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Neurosciences

Dimethyl Fumarate is a Potential Therapeutic Option for Alzheimer's Disease

Xiaodi Sun et al.

Summary: This study demonstrates that DMF is a potential therapeutic option for Alzheimer's disease (AD) through its antioxidant, anti-inflammatory, anti-apoptotic, and other anti-AD effects by activating the Nrf2 pathway.

JOURNAL OF ALZHEIMERS DISEASE (2022)

Review Cell Biology

Neurogenesis in aging and age-related neurodegenerative diseases

Luka Culig et al.

Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.

AGEING RESEARCH REVIEWS (2022)

Review Geriatrics & Gerontology

Spatial navigation in older adults with mild cognitive impairment and dementia: A systematic review and meta-analysis

Jessica Placido et al.

Summary: This systematic review and meta-analysis compared the spatial navigation performance of older adults with mild cognitive impairment, Alzheimer's Disease, and other dementias, and found a strong correlation between spatial navigation impairment and cognitive decline. The study suggests that spatial navigation ability can serve as a behavioral biomarker for early diagnosis of dementia.

EXPERIMENTAL GERONTOLOGY (2022)

Review Geriatrics & Gerontology

Role of Aducanumab in the Treatment of Alzheimer?s Disease: Challenges and Opportunities

Miguel Vaz et al.

Summary: This review summarizes the clinical development of aducanumab until regulatory agencies' decisions, the available trials data, and the controversy over aducanumab approval for Alzheimer's disease (AD).

CLINICAL INTERVENTIONS IN AGING (2022)

Review Pharmacology & Pharmacy

Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases

Irena Majkutewicz

Summary: This review analyzes and compares the neuroprotective, antioxidative, and anti-inflammatory effects of DMF and its active metabolite, MMF, in cellular and animal models of neurodegenerative diseases. There are currently over twenty studies in this field, mostly focused on models of Alzheimer's disease and Parkinson's disease, but there are discrepancies in the results of these studies.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Article Neurosciences

Inhibition of NLRP1-Dependent Pyroptosis Prevents Glycogen Synthase Kinase-3β Overactivation-Induced Hyperphosphorylated Tau in Rats

Xiangying Liu et al.

Summary: This study confirmed the impact of NLRP1-dependent pyroptosis on hyperphosphorylation of tau protein and indicated that inhibition of NLRP1-dependent neuronal pyroptosis could improve spatial memory in rats.

NEUROTOXICITY RESEARCH (2022)

Article Endocrinology & Metabolism

Dimethyl fumarate improves cognitive impairment by enhancing hippocampal brain-derived neurotrophic factor levels in hypothyroid rats

Haiyan Pan et al.

Summary: The study found that DMF can improve cognitive dysfunction in hypothyroid rats by increasing the level of BDNF in the brain tissue.

BMC ENDOCRINE DISORDERS (2022)

Article Multidisciplinary Sciences

Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb

Jane S. Huang et al.

Summary: The study reveals that immature olfactory sensory neurons (OSNs) play a crucial role in the olfactory bulb (OB) circuit of mice by providing odor input and forming monosynaptic connections with excitatory neurons. Immature OSNs show stronger selective responses to odorants and graded responses across a wider range of odorant concentrations compared to mature OSNs. Furthermore, mice can successfully perform odor detection and discrimination tasks using sensory input from immature OSNs alone.

NATURE COMMUNICATIONS (2022)

Article Neurosciences

Dimethyl fumarate does not mitigate cognitive decline and β-amyloidosis in female APPPS1 mice

Luisa Mohle et al.

Summary: The study investigated the potential of using DMF as a treatment for AD using a transgenic mouse model. The results showed that oral DMF treatment did not have an effect on disease progression in terms of learning and memory parameters, beta-amyloid accumulation, plaque formation, microglia activation, and recruitment of immune cells to the brain. These findings do not support the use of DMF as a therapeutic for AD patients and suggest the need for further research to understand the conflicting results seen in different animal models.

BRAIN RESEARCH (2021)

Review Neurosciences

Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question

Domenica Donatella Li Puma et al.

Summary: Adult hippocampal neurogenesis is a physiological mechanism contributing to hippocampal memory formation. Studies have shown an association between altered neurogenesis and cognitive decline in elderly and AD patients, suggesting potential implications for AD pathogenesis.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Article Neurosciences

Verapamil Prevents Development of Cognitive Impairment in an Aged Mouse Model of Sporadic Alzheimer's Disease

Heba A. Ahmed et al.

Summary: The study found that long-term low-dose verapamil effectively prevented ICV/STZ-induced cognitive impairment and reduced astrogliosis and synaptic toxicity in the hippocampus of aged animals. These results suggest that long-term, low-dose verapamil may delay progression of sporadic Alzheimer's disease in susceptible subjects of advanced age.

MOLECULAR NEUROBIOLOGY (2021)

Review Neurosciences

Insulin Resistance as a Common Link Between Current Alzheimer's Disease Hypotheses

Suelen Santos Alves et al.

Summary: Alzheimer's disease is a severe public health problem and current medical approaches are limited to symptomatic interventions, with a high failure rate in clinical trials. While most studies have focused on the amyloid cascade hypothesis, it is clear that AD is a multifactorial disorder.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Neurosciences

Evidences for Adult Hippocampal Neurogenesis in Humans

Elena P. Moreno-Jimenez et al.

Summary: The rodent hippocampus generates new neurons throughout life, but direct evidence of adult neurogenesis in humans remains elusive. Research indicates that adult hippocampal neurogenesis may persist until the 10th decade of human life, with marked impairments in patients with Alzheimer's disease. Methodological aspects in processing and analyzing postmortem human brain samples may limit the detection of markers of adult hippocampal neurogenesis, highlighting the need for strict controls in human studies.

JOURNAL OF NEUROSCIENCE (2021)

Review Biochemistry & Molecular Biology

Brain-Derived Neurotrophic Factor Signaling in the Pathophysiology of Alzheimer's Disease: Beneficial Effects of Flavonoids for Neuroprotection

Tadahiro Numakawa et al.

Summary: BDNF plays a crucial role in various neural functions through the activation of its high-affinity receptor TrkB, and abnormalities in BDNF signaling have been implicated in neurodegenerative diseases such as Alzheimer's disease. Studies have shown the potential involvement of deregulated BDNF signaling in the pathophysiology of AD, and compounds like flavonoids may offer promise as BDNF-targeting therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Biochemistry & Molecular Biology

Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/ SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories

Israa M. Abd El-Fatah et al.

Summary: The study demonstrates that DMF can ameliorate cognitive deficits, reduce neurodegeneration, enhance neuroprotective parameters, and suppress the expression of AD surrogate markers in a rat model of postmenopausal dementia.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Neurosciences

Intranasal Insulin Enhances Intracerebroventricular Streptozotocin-Induced Decrease in Olfactory Discriminative Learning via Upregulation of Subventricular Zone-Olfactory Bulb Neurogenesis in the Rat Model

Sandeep K. Mishra et al.

Summary: The study demonstrated that intranasal insulin treatment increased olfactory discriminative learning in the ICV STZ rat model by reversing the decline in SVZ-OB neurogenesis. However, there was no significant impact on olfactory memory post-treatment with ICV STZ and intranasal insulin.

MOLECULAR NEUROBIOLOGY (2021)

Review Chemistry, Medicinal

Advance of sporadic Alzheimer's disease animal models

Lili Zhang et al.

MEDICINAL RESEARCH REVIEWS (2020)

Article Neurosciences

Single-cell analysis of olfactory neurogenesis and differentiation in adult humans

Michael A. Durante et al.

NATURE NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

BDNF deficiency and enriched environment treatment affect neurotransmitter gene expression differently across ages

Brittany E. Dong et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Article Biochemistry & Molecular Biology

NRF2 and PPAR-gamma Pathways in Oligodendrocyte Progenitors: Focus on ROS Protection, Mitochondrial Biogenesis and Promotion of Cell Differentiation

Chiara De Nuccio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Medicine, General & Internal

Diagnosis and Management of Dementia: Review

Zoe Arvanitakis et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)

Review Neurosciences

Adult Neurogenesis and the Promise of Adult Neural Stem Cells

Hiyaa S. Ghosh

JOURNAL OF EXPERIMENTAL NEUROSCIENCE (2019)

Review Neurosciences

Untold New Beginnings: Adult Hippocampal Neurogenesis and Alzheimer's Disease

Catia M. Teixeira et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Clinical Neurology

Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease?

Gillian Coughlan et al.

NATURE REVIEWS NEUROLOGY (2018)

Review Neurosciences

The Functional Role of Olfactory Bulb Granule Cell Subtypes Derived From Embryonic and Postnatal Neurogenesis

Hiroo Takahashi et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy.

Antonio Cuadrado et al.

REDOX BIOLOGY (2018)

Review Neurosciences

Imaging the evolution and pathophysiology of Alzheimer disease

William Jagust

NATURE REVIEWS NEUROSCIENCE (2018)

Article Critical Care Medicine

Fumaric Acid Esters Attenuate Secondary Degeneration after Spinal Cord Injury

Marika Cordaro et al.

JOURNAL OF NEUROTRAUMA (2017)

Review Neurosciences

The Aging Navigational System

Adam W. Lester et al.

NEURON (2017)

Article Neurosciences

Spatial Navigation in Preclinical Alzheimer's Disease

Samantha L. Allison et al.

JOURNAL OF ALZHEIMERS DISEASE (2016)

Article Cell & Tissue Engineering

Oxidative Stress and Adult Neurogenesis

Ti-Fei Yuan et al.

STEM CELL REVIEWS AND REPORTS (2015)

Article Cell & Tissue Engineering

Oxidative Stress and Adult Neurogenesis

Ti-Fei Yuan et al.

STEM CELL REVIEWS AND REPORTS (2015)

Review Physiology

REGULATION AND FUNCTION OF ADULT NEUROGENESIS: FROM GENES TO COGNITION

James B. Aimone et al.

PHYSIOLOGICAL REVIEWS (2014)

Review Pharmacology & Pharmacy

Genetic mouse models of brain ageing and Alzheimer's disease

Andras Bilkei-Gorzo

PHARMACOLOGY & THERAPEUTICS (2014)

Article Geriatrics & Gerontology

Spatial navigation in young versus older adults

Ivana Gazova et al.

FRONTIERS IN AGING NEUROSCIENCE (2013)

Article Psychology, Biological

Early and late neurodegeneration and memory disruption after intracerebroventricular streptozotocin

Taisa de Oliveira Santos et al.

PHYSIOLOGY & BEHAVIOR (2012)

Article Pharmacology & Pharmacy

Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway

Robert H. Scannevin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)

Article Clinical Neurology

Longitudinal Assessment of A beta and Cognition in Aging and Alzheimer Disease

Victor L. Villemagne et al.

ANNALS OF NEUROLOGY (2011)

Review Clinical Neurology

Distinguishing Alzheimer's disease from other major forms of dementia

Stella Karantzoulis et al.

EXPERT REVIEW OF NEUROTHERAPEUTICS (2011)

Article Clinical Neurology

Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study

Melita Salkovic-Petrisic et al.

JOURNAL OF NEURAL TRANSMISSION (2011)

Review Clinical Neurology

Implications of decreased hippocampal neurogenesis in chronic temporal lobe epilepsy

Bharathi Hattiangady et al.

EPILEPSIA (2008)

Review Neurosciences

The neurogenic reserve hypothesis: what is adult hippocampal neurogenesis good for?

Gerd Kempermann

TRENDS IN NEUROSCIENCES (2008)

Review Neurosciences

The effect of neurodegenerative diseases on the subventricular zone

Maurice A. Curtis et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Article Cardiac & Cardiovascular Systems

Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats

Jason D. Huber et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2006)

Article Cell Biology

The aging neurogenic subventricular zone

J Luo et al.

AGING CELL (2006)