期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 24, 页码 -出版社
MDPI
DOI: 10.3390/ijms232415792
关键词
adipogenesis; miR-19 family; morbid obesity; adipose tissue; bariatric surgery; PPAR gamma
资金
- National Plan for Scientific Research, Development and Technological Innovation 2013-2016 [PI16/00884]
- ISCIII (Instituto de Salud Carlos III)-General Sub-Direction of the Assessment and Promotion of the Research-European Regional Development Fund (FEDER), A way of making Europe
The miR-19 family has been found to play a crucial role in lipid accumulation and adipose tissue expansion in obesity, serving as key actors in adipogenesis and lipid accumulation.
microRNAs (miRNAs) are a class of small endogenous RNA that play pivotal roles in both the differentiation and function of adipocytes during the development of obesity. Despite this, only a few miRNA families have been identified as key players in adipogenesis. Here, we show the relevance of the miR-19 family, miR-19a and miR-19b, in lipid accumulation and the expansion of the adipose tissue in obesity. We observed that miR-19s were upregulated in the abdominal subcutaneous adipose tissue (aSAT) of human patients with morbid obesity, whereas after bariatric surgery, their expression was reduced. In vitro experiments identified miR-19a and b as crucial actors in adipogenesis and lipid accumulation. Overall, our results suggest a novel role of the miR-19 family in the regulatory networks underlying adipogenesis and, therefore, adipose tissue dysfunction.
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