Extracellular Vesicles' Role in the Pathophysiology and as Biomarkers in Cystic Fibrosis and COPD

Article Hematology

The Pathophysiological Role of Platelet-Derived Extracellular Vesicles

Meryem Mabrouk et al.

Summary: Platelet-derived extracellular vesicles play an important role in the blood, carrying diverse contents and performing various functions under different physiological and pathophysiological conditions.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2023)

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Review Cell Biology

Platelet extracellular vesicles in COVID-19: Potential markers and makers

Florian Puhm et al.

Summary: This article explores the potential of pEVs as valuable biomarkers in disease, with a special focus on their role as predictors of and contributors to COVID-19.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Cell Biology

Neutrophil-derived extracellular vesicles promote feed-forward inflammasome signaling in cystic fibrosis airways

Osric A. Forrest et al.

Summary: Neutrophils in cystic fibrosis (CF) airways contribute to chronic inflammation by packaging proinflammatory signals in extracellular vesicles (EVs). These EVs can induce reprogramming of naive neutrophils and activate caspase-1 and IL-1β production. Additionally, EVs from activated neutrophils can deliver active caspase-1 to tracheal epithelial cells and induce the release of IL-1α.

JOURNAL OF LEUKOCYTE BIOLOGY (2022)

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Article Pharmacology & Pharmacy

Small-molecule drugs for cystic fibrosis: Where are we now?

Onofrio Laselva et al.

Summary: This paper provides an overview of old and novel CFTR modulators as well as strategies based on small-molecule drugs for the treatment of cystic fibrosis. It highlights the advancements in pharmacotherapy and the need for further research to improve clinical outcomes in CF management.

PULMONARY PHARMACOLOGY & THERAPEUTICS (2022)

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Article Medicine, Research & Experimental

An in vivo model for extracellular vesicle- induced emphysema

Camilla Margaroli et al.

Summary: This study established a mouse model to simulate COPD induced by lung EVs and found that neutrophil-derived EVs play a key role in the pathogenesis and mechanism of COPD. This research contributes to the development of targeted therapies for severe lung diseases.

JCI INSIGHT (2022)

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Article Biotechnology & Applied Microbiology

Macrophage-Derived Exosomes Promote Bone Mesenchymal Stem Cells Towards Osteoblastic Fate Through microRNA-21a-5p

Kun Liu et al.

Summary: The effective healing of bone defects relies on the coordination between inflammatory and bone-forming cells. This study investigated the interaction between polarized macrophages and bone mesenchymal stem cells (BMSCs), as well as their effects on osteogenesis. The results showed that exosomes from both pro-inflammatory M1 and anti-inflammatory M2 macrophages can promote the osteogenesis of BMSCs, especially M1 macrophage-derived exosomes through microRNA-21a-5p in the early stage of inflammation. This research helps us understand the complex interactions between BMSCs and macrophages, and provides insights for improving bone healing and other regenerative processes through the release of exosomes.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

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Article Respiratory System

Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration

Tsukasa Kadota et al.

Summary: The lung has a low turnover rate in its unperturbed state, but it has the ability to regenerate and repair once damaged. Understanding the mechanisms of lung injury, repair, and regeneration is important for practical and therapeutic purposes. Cell therapy and extracellular vesicle therapy show promising potential for treating lung diseases.

EUROPEAN RESPIRATORY REVIEW (2022)

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Review Biochemistry & Molecular Biology

Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Use in Central Nervous System Demyelinating Disorders

Caterina Allegretta et al.

Summary: Autoimmune demyelinating diseases are a heterogeneous group of diseases characterized by neuroinflammation and loss of myelin. Mesenchymal stem cells (MSCs) have the potential to treat these diseases due to the anti-inflammatory and neuroprotective molecules in their secretome.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Immunology

Lipidomic Profiling of Bronchoalveolar Lavage Fluid Extracellular Vesicles Indicates Their Involvement in Lipopolysaccharide-Induced Acute Lung Injury

Teja Srinivas Nirujogi et al.

Summary: This study reveals the presence of diverse lipid mediators in extracellular vesicles (EVs) during acute lung injury (ALI), which are correlated with the inflammatory status of lung macrophages. These EVs modulate the function of macrophages and alveolar epithelial cells during ALI.

JOURNAL OF INNATE IMMUNITY (2022)

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Review Urology & Nephrology

Extracellular vesicles in kidney disease

Cristina Grange et al.

Summary: Extracellular vesicles play significant roles in kidney physiology and pathology by facilitating cell-to-cell communication and modulating gene expression and fate of target cells. They have potential diagnostic, prognostic, and therapeutic applications in kidney diseases, including in the field of kidney regeneration and inflammation reduction. Stem cell-derived extracellular vesicles are considered as promising therapeutic agents, but standardized production strategies are still needed for their clinical application.

NATURE REVIEWS NEPHROLOGY (2022)

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Review Pathology

The Role of Extracellular Vesicles in Liver Pathogenesis

Gang Liu et al.

Summary: Extracellular vesicles (EVs) are a type of mediator produced by cells that can be taken up by neighboring cells and have functional impact on the engulfing cells. They play important roles in both physiological and pathological processes and have potential as sensitive diagnostic tools for certain diseases and as therapeutic targets. This review summarizes the latest findings of EVs in liver research, focusing on their different contents and their impact on liver function, inflammation, fibrosis, and tumor development, aiming to provide readers with knowledge of the molecules that mediate EVs' function.

AMERICAN JOURNAL OF PATHOLOGY (2022)

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Review Cell Biology

The Role of Extracellular Vesicles in COVID-19 Pathology

Aline Seiko Carvalho Tahyra et al.

Summary: Extracellular vesicles play a crucial role in viral infection and immune regulation, serving as a new communication paradigm between cells.

CELLS (2022)

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Article Respiratory System

Evaluation of airway and circulating inflammatory biomarkers for cystic fibrosis drug development

Raksha Jain et al.

Summary: This analysis examined relationships between airway and systemic measurements of inflammation, as well as associations between inflammatory biomarkers and lung function in cystic fibrosis patients. Promising candidates for anti-inflammatory clinical trials included serum hsCRP and sputum neutrophil elastase. Standard deviation within subjects was consistently lower than between subjects for all serum biomarkers. Freezing and delayed processing did not significantly affect sputum analyte measurements.

JOURNAL OF CYSTIC FIBROSIS (2021)

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Review Medicine, Research & Experimental

Exosomes in chronic respiratory diseases

Beatrice Purghe et al.

Summary: Exosomes are nano-sized vesicles released by cells, playing a central role in intercellular communication and potentially serving as biomarkers and therapeutic tools for chronic respiratory disorders. However, the exact relationship between different phenotypes and pathophysiological mechanisms of these diseases remains unclear, requiring further studies.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Review Cell Biology

Extracellular vesicles: mediators of intercellular communication in tissue injury and disease

Greg Berumen Sanchez et al.

Summary: EVs play a crucial role in intercellular communication by carrying a variety of factors that can impact recipient cells. Studying the role of EVs provides insights into the molecular mechanisms of cancer, metabolic disorders, and inflammatory lung diseases.

CELL COMMUNICATION AND SIGNALING (2021)

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Article Respiratory System

Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

Johnatas Dutra Silva et al.

Summary: In acute respiratory distress syndrome (ARDS), mitochondrial dysfunction contributes to damage of the alveolar epithelial and endothelial barriers. Mesenchymal stromal cells-derived extracellular vesicles (MSC-EVs) can improve alveolar-capillary barrier integrity through mitochondrial transfer, restoring normal barrier properties and mitochondrial functions in a model of ARDS.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Multidisciplinary Sciences

Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells

Manjunatha Shivaraju et al.

Summary: Recent research has shown that airway basal stem cells have the ability to sense hypoxia and differentiate into solitary NE cells, which secrete a protective peptide called CGRP to mitigate hypoxic injury. This mechanism helps to explain the role of NE cells in the respiratory system and their response to environmental stimuli.

SCIENCE (2021)

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Article Oncology

Genomic profiling of extracellular vesicle-derived DNA from bronchoalveolar lavage fluid of patients with lung adenocarcinoma

Seung Eun Lee et al.

Summary: This study found that DNA derived from BALF EV showed better technical performance in targeted NGS for mutation detection compared to tissue DNA, with mutation concordance ranging from 56% to 81%. Allele frequencies of EGFR and TP53 were higher in tissue DNA (10-25%) compared to BALF EV DNA (<5%).

TRANSLATIONAL LUNG CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Beyond cells: The extracellular circulating 20S proteasomes

Vandita Dwivedi et al.

Summary: Evidence from clinical studies show that functional 20S proteasome complexes circulate in plasma, with elevated levels in patients with various diseases. The levels of circulating c20S correlate positively with treatment efficacy and survival rates, indicating a potential role in pathophysiology.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

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Review Respiratory System

Role of extracellular vesicles in chronic lung disease

Anne Trappe et al.

Summary: Extracellular vesicles (EVs) play crucial roles in chronic lung diseases as mediators of intercellular communication and potential biomarkers and drug carriers. Research indicates that EVs are key players in inflammatory processes, offering new avenues for therapies and pathological investigations in a range of lung diseases.

THORAX (2021)

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Review Chemistry, Multidisciplinary

Extracellular Vesicles in Airway Homeostasis and Pathophysiology

Alberto Fucarino et al.

Summary: EMTU and MML play crucial roles in maintaining airway homeostasis and the pathogenesis of airway diseases, with nanovesicles produced by them potentially serving as key communication tools among different cell types.

APPLIED SCIENCES-BASEL (2021)

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Review Immunology

Emerging roles of extracellular vesicles in COVID-19, a double-edged sword?

Xiaohuan Xia et al.

Summary: The sudden outbreak of COVID-19 originated from Wuhan, China, has become a global pandemic. Extracellular vesicles (EVs) play key roles in the pathogenesis and treatment of COVID-19, facilitating viral spreading and potential therapeutic interventions.

IMMUNOLOGY (2021)

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Article Medicine, General & Internal

Circulating Extracellular Vesicles Are Associated with Disease Severity and Interleukin-6 Levels in COPD: A Pilot Study

Dario Nieri et al.

Summary: The study grouped 35 COPD patients and found an increase in EEV and MEV levels with disease severity, along with a significant correlation with IL-6. This suggests that EV could serve as markers for high-risk extrapulmonary events.

JOURNAL OF CLINICAL MEDICINE (2021)

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Article Oncology

Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology

Akira Yokoi et al.

Summary: This review summarizes recent studies on EVs from the perspective of EV heterogeneity and highlights their role in various steps from oncogenic to metastatic processes. Recognizing EV subtypes is crucial for identifying pathways affected by EVs and targeting specific subtypes in therapeutic approaches or liquid biopsies.

SEMINARS IN CANCER BIOLOGY (2021)

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Article Medicine, General & Internal

Circulating extracellular vesicles are endowed with enhanced procoagulant activity in SARS-CoV-2 infection

Carolina Balbi et al.

Summary: The study characterized the surface antigen profile of circulating extracellular vesicles (EV) in COVID-19 patients and found a specific surface marker signature that can differentiate COVID-19 patients. CD142 showed the highest discriminating performance and was found to be biologically active on the surface of EV in COVID-19 patients.

EBIOMEDICINE (2021)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles as Potential Therapeutics for Inflammatory Diseases

Hee Sook Hwang et al.

Summary: Extracellular vesicles play an important role in inflammatory diseases, and can be engineered to target specific cells, making them promising nanoparticles for personalized therapeutic carriers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, General & Internal

Cystic fibrosis

Michal Shteinberg et al.

LANCET (2021)

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Article Pharmacology & Pharmacy

The role of extracellular vesicles in regulating local and systemic inflammation in cardiovascular disease

Lee Ohayon et al.

Summary: Extracellular vesicles, including exosomes and micro-vesicles, play a significant role in cardiovascular diseases by transporting bioactive molecules and impacting target cells and tissues through autocrine and paracrine signaling. They can have both beneficial and detrimental effects on inflammation processes in cardiovascular diseases.

PHARMACOLOGICAL RESEARCH (2021)

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Review Oncology

Extracellular Vesicles in Lung Cancer: Prospects for Diagnostic and Therapeutic Applications

Taketo Kato et al.

Summary: Extracellular vesicles (EVs) are nano-sized lipid-bound particles containing proteins, nucleic acids and metabolites released by cells, which are widely distributed in various biological fluids. In tumors, EVs derived from cancer and immune cells mediate intercellular communication and exchange, and can affect immunomodulatory functions. In the context of lung cancer, emerging evidence implicates EV involvement during various stages of tumor development and progression, including angiogenesis, epithelial to mesenchymal transformation, immune system suppression, metastasis and drug resistance.

CANCERS (2021)

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Article Cell Biology

Human bronchial epithelial cell-derived extracellular vesicle therapy for pulmonary fibrosis via inhibition of TGF-β-WNT crosstalk

Tsukasa Kadota et al.

Summary: Idiopathic pulmonary fibrosis (IPF) is characterized by progressive lung fibrosis and poor prognosis, with aberrant gene expression and extracellular vesicles (EVs) playing critical roles in inhibiting myofibroblast differentiation and cellular senescence. Human bronchial epithelial cell-derived EVs (HBEC EVs), particularly through microRNA cargo, show promising anti-fibrotic properties by modulating WNT signaling pathways.

JOURNAL OF EXTRACELLULAR VESICLES (2021)

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Article Cardiac & Cardiovascular Systems

Respiratory viral infection in lung transplantation induces exosomes that trigger chronic rejection

Muthukumar Gunasekaran et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

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Review Multidisciplinary Sciences

The biology, function, and biomedical applications of exosomes

Raghu Kalluri et al.

SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Endocytosis of Extracellular Vesicles and Release of Their Cargo from Endosomes

Bhagyashree S. Joshi et al.

ACS NANO (2020)

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Review Pharmacology & Pharmacy

Extracellular vesicles as drug delivery systems: Why and how?

Omnia M. Elsharkasy et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Review Cell & Tissue Engineering

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future

Maria C. Basil et al.

CELL STEM CELL (2020)

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Article Oncology

Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells

Jung Hwan Yoon et al.

GASTRIC CANCER (2020)

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Review Pharmacology & Pharmacy

CFTR Modulators: The Changing Face of Cystic Fibrosis in the Era of Precision Medicine

Miqueias Lopes-Pacheco

FRONTIERS IN PHARMACOLOGY (2020)

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Article Environmental Sciences

MSC-Derived Extracellular Vesicles: New Emergency Treatment to Limit the Development of Radiation-Induced Hematopoietic Syndrome?

Sophie Cavallero et al.

HEALTH PHYSICS (2020)

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Article Immunology

NK cell-derived exosomes carry miR-207 and alleviate depression-like symptoms in mice

Dongping Li et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Respiratory System

Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis

Zivile Useckaite et al.

THORAX (2020)

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Article Biochemistry & Molecular Biology

Extracellular Vesicles from Fibroblasts Induce Epithelial-Cell Senescence in Pulmonary Fibrosis

Tsukasa Kadota et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

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Review Biotechnology & Applied Microbiology

Multiple Biological Roles of Extracellular Vesicles in Lung Injury and Inflammation Microenvironment

Gang Su et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Article Cell Biology

Exosomes derived from human exfoliated deciduous teeth ameliorate adult bone loss in mice through promoting osteogenesis

Jizhen Wei et al.

JOURNAL OF MOLECULAR HISTOLOGY (2020)

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Article Respiratory System

Macrophage-derived exosomes attenuate fibrosis in airway epithelial cells through delivery of antifibrotic miR-142-3p

Julien Guiot et al.

THORAX (2020)

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Article Biochemistry & Molecular Biology

Urinary Exosomes of Patients with Cystic Fibrosis Unravel CFTR-Related Renal Disease

Sebastien Gauthier et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Nanoscience & Nanotechnology

Exosome: A Review of Its Classification, Isolation Techniques, Storage, Diagnostic and Targeted Therapy Applications

Yi Zhang et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Article Respiratory System

Efficacy and Safety of the CFTR Potentiator Icenticaftor (QBW251) in COPD: Results from a Phase 2 Randomized Trial

Steven M. Rowe et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2020)

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Review Cell Biology

Extracellular Vesicles in Alzheimer's and Parkinson's Disease: Small Entities with Large Consequences

Charysse Vandendriessche et al.

CELLS (2020)

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Review Infectious Diseases

The role of extracellular vesicles in COVID-19 virus infection

Mehdi Hassanpour et al.

INFECTION GENETICS AND EVOLUTION (2020)

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Article Cell & Tissue Engineering

Transformation of Hematopoietic Stem and Progenitor Cells by Leukemia Extracellular Vesicles: A Step Toward Leukemogenesis

Amir Samii et al.

STEM CELL REVIEWS AND REPORTS (2020)

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Review Biochemistry & Molecular Biology

Application of exosomes as liquid biopsy in clinical diagnosis

Biting Zhou et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Cell Biology

Subpopulations of extracellular vesicles from human metastatic melanoma tissue identified by quantitative proteomics after optimized isolation

Rossella Crescitelli et al.

JOURNAL OF EXTRACELLULAR VESICLES (2020)

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Review Biochemistry & Molecular Biology

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

Sushma Anand et al.

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)

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Review Biochemical Research Methods

Exosomes in Inflammation and Inflammatory Disease

Brandon Dow Chan et al.

PROTEOMICS (2019)

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Review Biochemistry & Molecular Biology

Exosomes: biogenesis, biologic function and clinical potential

Yuan Zhang et al.

CELL AND BIOSCIENCE (2019)

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Review Medicine, Research & Experimental

Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer

Man Wang et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

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Article Pharmacology & Pharmacy

Mesenchymal stromal cells-derived exosomes alleviate ischemia/reperfusion injury in mouse lung by transporting anti-apoptotic miR-21-5p

Ji wei Li et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2019)

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Article Oncology

Exosomes derived from microRNA-30b-3p-overexpressing mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting SAA3

Xiaomeng Yi et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Article Biochemistry & Molecular Biology

Cardiomyocytes capture stem cell-derived, anti-apoptotic microRNA-214 via clathrin-mediated endocytosis in acute myocardial infarction

Shunsuke Eguchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

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Review Cell Biology

Cellular crosstalk in the development and regeneration of the respiratory system

Jarod A. Zepp et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Cell Biology

Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

Laura M. Doyle et al.

CELLS (2019)

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Article Chemistry, Multidisciplinary

Proteomic Analysis of Plasma-Derived Extracellular Vesicles in Smokers and Patients with Chronic Obstructive Pulmonary Disease

Isaac K. Sundar et al.

ACS OMEGA (2019)

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Article Cell Biology

Macrophages exposed to HIV viral protein disrupt lung epithelial cell integrity and mitochondrial bioenergetics via exosomal microRNA shuttling

Zhihong Yuan et al.

CELL DEATH & DISEASE (2019)

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Article Cell Biology

DNA analysis of low- and high-density fractions defines heterogeneous subpopulations of small extracellular vesicles based on their DNA cargo and topology

Elisa Lazaro-Ibanez et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Multidisciplinary Sciences

Cigarette Smoke Exposure Induces Retrograde Trafficking of CFTR to the Endoplasmic Reticulum

Abigail J. Marklew et al.

SCIENTIFIC REPORTS (2019)

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Article Cell Biology

Small RNA-sequence analysis of plasma-derived extracellular vesicle miRNAs in smokers and patients with chronic obstructive pulmonary disease as circulating biomarkers

Isaac Kirubakaran Sundar et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Cell Biology

Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

Ashley E. Russell et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Biochemistry & Molecular Biology

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung

Kristopher R. Genschmer et al.

CELL (2019)

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Article Cell Biology

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

Mathilde Mathieu et al.

NATURE CELL BIOLOGY (2019)

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Article Cardiac & Cardiovascular Systems

The therapeutic and diagnostic role of exosomes in cardiovascular diseases

Parvin Zamani et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

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Review Engineering, Biomedical

Exploiting Exosomes in Cancer Liquid Biopsies and Drug Delivery

Coy Austin Fitts et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Article Medicine, Research & Experimental

Exosomes and Their Role in Cancer Progression

Mitsuhiko Osaki et al.

YONAGO ACTA MEDICA (2019)

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Review Immunology

Transcriptome of Extracellular Vesicles: State-of-the-Art

Andrey Turchinovich et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Cell Biology

Toward characterizing extracellular vesicles at a single-particle level

Chun-yi Chiang et al.

JOURNAL OF BIOMEDICAL SCIENCE (2019)

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Article Cell Biology

Metabolic signature of extracellular vesicles depends on the cell culture conditions

Mari Palviainen et al.

JOURNAL OF EXTRACELLULAR VESICLES (2019)

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Article Radiology, Nuclear Medicine & Medical Imaging

A novel approach based on low-field NMR for the detection of the pathological components of sputum in cystic fibrosis patients

Michela Abrami et al.

MAGNETIC RESONANCE IN MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles: New Players in Lung Immunity

Yu Fujita et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2018)

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Article Pharmacology & Pharmacy

Microglia-derived extracellular vesicles in Alzheimer's Disease: A double-edged sword

Teresa Trotta et al.

BIOCHEMICAL PHARMACOLOGY (2018)

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Article Critical Care Medicine

Extracellular Vesicles in Lung Disease

Hiroshi Kubo

CHEST (2018)

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Article Immunology

Functional Evidence of Pulmonary Extracellular Vesicles in Infectious and Noninfectious Lung Inflammation

Heedoo Lee et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Biochemical Research Methods

Comparative proteomics of respiratory exosomes in cystic fibrosis, primary ciliary dyskinesia and asthma

Rollet-Cohen Virginie et al.

JOURNAL OF PROTEOMICS (2018)

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Review Biochemistry & Molecular Biology

Subpopulations of extracellular vesicles and their therapeutic potential

Cecilia Lasser et al.

MOLECULAR ASPECTS OF MEDICINE (2018)

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Article Cell Biology

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Haiying Zhang et al.

NATURE CELL BIOLOGY (2018)

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Review Cell Biology

Cigarette Smoke-Induced Acquired Dysfunction of Cystic Fibrosis Transmembrane Conductance Regulator in the Pathogenesis of Chronic Obstructive Pulmonary Disease

Juan Shi et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Review Pharmacology & Pharmacy

Biogenesis and function of extracellular vesicles in cancer

Maarten P. Bebelman et al.

PHARMACOLOGY & THERAPEUTICS (2018)

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Article Cell & Tissue Engineering

Mesenchymal stem cell-derived extracellular vesicles attenuate influenza virus-induced acute lung injury in a pig model

Mahesh Khatri et al.

STEM CELL RESEARCH & THERAPY (2018)

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Review Immunology

The Potential Biomarkers and Immunological Effects of Tumor-Derived Exosomes in Lung Cancer

Shamila D. Alipoor et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Immunology

Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression

Eduard Willms et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Review Medicine, General & Internal

Circulating Extracellular Vesicles in Human Disease

Ravi Shah et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Microenvironmental Influences on Extracellular Vesicle-Mediated Communication in the Lung

Mikel D. Haggadone et al.

TRENDS IN MOLECULAR MEDICINE (2018)

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Review Cell Biology

Repairing the lungs one breath at a time: How dedicated or facultative are you?

John P. Leach et al.

GENES & DEVELOPMENT (2018)

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Article Cell Biology

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Clotilde Thery et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Cell Biology

Summary of the ISEV workshop on extracellular vesicles as disease biomarkers, held in Birmingham, UK, during December 2017

Aled Clayton et al.

JOURNAL OF EXTRACELLULAR VESICLES (2018)

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Article Allergy

Fibroblast-derived exosomes promote epithelial cell proliferation through TGF-2 signalling pathway in severe asthma

I. Haj-Salem et al.

ALLERGY (2018)

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Review Biochemistry & Molecular Biology

Current knowledge on exosome biogenesis and release

Nina Pettersen Hessvik et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2018)

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Article Medicine, Research & Experimental

Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking

Hui Xu et al.

THERANOSTICS (2018)

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Review Allergy

Exosomes in immunoregulation of chronic lung diseases

K. P. Hough et al.

ALLERGY (2017)

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Review Cell Biology

Reverse-topology membrane scission by the ESCRT proteins

Johannes Schoneberg et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)

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Letter Allergy

RNA-containing exosomes in induced sputum of asthmatic patients

Sara Sanchez-Vidaurre et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Cardiac & Cardiovascular Systems

Exosomes From Adipose-derived Mesenchymal Stem Cells Protect the Myocardium Against Ischemia/Reperfusion Injury Through Wnt/β-Catenin Signaling Pathway

Xiaojun Cui et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2017)

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Article Cell Biology

Macrophage-derived apoptotic bodies promote the proliferation of the recipient cells via shuttling microRNA-221/222

Ziwen Zhu et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2017)

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Review Chemistry, Medicinal

Pharmacokinetics of Exosomes-An Important Factor for Elucidating the Biological Roles of Exosomes and for the Development of Exosome-Based Therapeutics

Masaki Morishita et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Review Medicine, General & Internal

Chronic obstructive pulmonary disease

Klaus F. Rabe et al.

LANCET (2017)

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Article Neurosciences

Next-generation sequencing-based small RNA profiling of cerebrospinal fluid exosomes

Yohsuke Yagi et al.

NEUROSCIENCE LETTERS (2017)

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Article Cardiac & Cardiovascular Systems

Elevated levels of circulating exosome in COPD patients are associated with systemic inflammation

Dino B. A. Tan et al.

RESPIRATORY MEDICINE (2017)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cell Microvesicles Attenuate Acute Lung Injury in Mice Partly Mediated by Ang-1 mRNA

Xiao-Dan Tang et al.

STEM CELLS (2017)

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Review Biochemistry & Molecular Biology

Exosomes as Reconfigurable Therapeutic Systems

R. Steven Conlan et al.

TRENDS IN MOLECULAR MEDICINE (2017)

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Article Oncology

A new bioluminescent reporter system to study the biodistribution of systematically injected tumor-derived bioluminescent extracellular vesicles in mice

Prakash Gangadaran et al.

ONCOTARGET (2017)

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Article Cell & Tissue Engineering

Exosome miR-371b-5p promotes proliferation of lung alveolar progenitor type II cells by using PTEN to orchestrate the PI3K/Akt signaling

Yuan Quan et al.

STEM CELL RESEARCH & THERAPY (2017)

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Review Cell & Tissue Engineering

Focus on Mesenchymal Stem Cell-Derived Exosomes: Opportunities and Challenges in Cell-Free Therapy

Lin Cheng et al.

STEM CELLS INTERNATIONAL (2017)

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Article Multidisciplinary Sciences

Disturbed blood flow worsens endothelial dysfunction in moderate-severe chronic obstructive pulmonary disease

Otto F. Barak et al.

SCIENTIFIC REPORTS (2017)

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Article Biochemistry & Molecular Biology

The Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Ivacaftor Augments Mucociliary Clearance Abrogating Cystic Fibrosis Transmembrane Conductance Regulator Inhibition by Cigarette Smoke

S. Vamsee Raju et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2017)

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Article Pharmacology & Pharmacy

The therapeutic potential of CFTR modulators for COPD and other airway diseases

George M. Solomon et al.

CURRENT OPINION IN PHARMACOLOGY (2017)

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Review Biochemistry & Molecular Biology

Characteristics and Roles of Exosomes in Cardiovascular Disease

Yuan Zhang et al.

DNA AND CELL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes

Tomasz Szul et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2016)

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Article Biochemistry & Molecular Biology

Exosomes as new diagnostic tools in CNS diseases

Katja M. Kanninen et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2016)

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Review Biochemistry & Molecular Biology

Neutrophils in cystic fibrosis

Julie Laval et al.

BIOLOGICAL CHEMISTRY (2016)

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Article Oncology

Bovine milk-derived exosomes for drug delivery

Radha Munagala et al.

CANCER LETTERS (2016)

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Article Oncology

STAT3-regulated exosomal miR-21 promotes angiogenesis and is involved in neoplastic processes of transformed human bronchial epithelial cells

Yi Liu et al.

CANCER LETTERS (2016)

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Review Oncology

Extracellular vesicle transfer of cancer pathogenic components

Yu Fujita et al.

CANCER SCIENCE (2016)

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Review Biochemistry & Molecular Biology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Mercedes Tkach et al.

CELL (2016)

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Article Respiratory System

Acquired Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction in Chronic Bronchitis and Other Diseases of Mucus Clearance

S. Vamsee Raju et al.

CLINICS IN CHEST MEDICINE (2016)

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Article Pharmacology & Pharmacy

The roles of miRNAs as potential biomarkers in lung diseases

Shamila D. Alipoor et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Article Biochemistry & Molecular Biology

TGF-β-induced profibrotic signaling is regulated in part by the WNT receptor Frizzled-8

Anita I. R. Spanjer et al.

FASEB JOURNAL (2016)

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Review Biochemistry & Molecular Biology

Exosomes in the Pathology of Neurodegenerative Diseases

Jason Howitt et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

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Review Medicine, Research & Experimental

The biology and function of exosomes in cancer

Raghu Kalluri

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Review Medicine, Research & Experimental

Versatile roles of extracellular vesicles in cancer

Nobuyoshi Kosaka et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

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Article Oncology

Lung tumor exosomes induce a pro-inflammatory phenotype in mesenchymal stem cells via NFκB-TLR signaling pathway

Xiaoxia Li et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2016)

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Review Immunology

Cystic Fibrosis Lung Immunity: The Rose of the Macrophage

Emanuela M. Bruscia et al.

JOURNAL OF INNATE IMMUNITY (2016)

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Editorial Material Biotechnology & Applied Microbiology

Post isolation modification of exosomes for nanomedicine applications

Joshua L. Hood

NANOMEDICINE (2016)

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Article Multidisciplinary Sciences

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

Joanna Kowal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Respiratory System

Persistence of circulating endothelial microparticles in COPD despite smoking cessation

Yael Strulovici-Barel et al.

THORAX (2016)

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Article Oncology

Lung cancer exosomes as drivers of epithelial mesenchymal transition

Mohammad A. Rahman et al.

ONCOTARGET (2016)

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Article Critical Care Medicine

Pilot evaluation of ivacaftor for chronic bronchitis

George M Solomon et al.

Lancet Respiratory Medicine (2016)

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Article Multidisciplinary Sciences

Structural and functional characterization of endothelial microparticles released by cigarette smoke

Karina A. Serban et al.

SCIENTIFIC REPORTS (2016)

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Article Cell Biology

Techniques used for the isolation and characterization of extracellular vesicles: results of a worldwide survey

Chris Gardiner et al.

JOURNAL OF EXTRACELLULAR VESICLES (2016)

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Review Biochemistry & Molecular Biology

Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles

Nunzio Iraci et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Review Physiology

Extracellular vesicles in diagnosis and therapy of kidney diseases

Wei Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

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Review Biochemistry & Molecular Biology

Extracellular Vesicles in Chronic Obstructive Pulmonary Disease

Tsukasa Kadota et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

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Article Respiratory System

Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis

Tomonori Makiguchi et al.

RESPIRATORY RESEARCH (2016)

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Article Critical Care Medicine

Glycolytic Reprogramming in Myofibroblast Differentiation and Lung Fibrosis

Na Xie et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Article Critical Care Medicine

Therapeutic Effects of Human Mesenchymal Stem Cell-derived Microvesicles in Severe Pneumonia in Mice

Antoine Monsel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

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Article Chemistry, Analytical

Exosomes: improved methods to characterize their morphology, RNA content, and surface protein biomarkers

Yueting Wu et al.

ANALYST (2015)

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Article Biology

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

Mikolaj P. Zaborowski et al.

BIOSCIENCE (2015)

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Article Medicine, General & Internal

Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management

Prescott G. Woodruff et al.

LANCET (2015)

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Article Multidisciplinary Sciences

Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration

Tien Peng et al.

NATURE (2015)

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Article Cell & Tissue Engineering

HucMSC-Exosome Mediated-Wnt4 Signaling Is Required for Cutaneous Wound Healing

Bin Zhang et al.

STEM CELLS (2015)

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Review Biochemistry & Molecular Biology

Extracellular vesicles in lung microenvironment and pathogenesis

Yu Fujita et al.

TRENDS IN MOLECULAR MEDICINE (2015)

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Article Cell Biology

Lung epithelial cell-derived extracellular vesicles activate macrophage-mediated inflammatory responses via ROCK1 pathway

H-G Moon et al.

CELL DEATH & DISEASE (2015)

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Article Oncology

Large oncosomes contain distinct protein cargo and represent a separate functional class of tumor-derived extracellular vesicles

Valentina R. Minciacchi et al.

ONCOTARGET (2015)

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Article Oncology

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes

Shivakumar Keerthikumar et al.

ONCOTARGET (2015)

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Review Biotechnology & Applied Microbiology

Role of Exosomal Noncoding RNAs in Lung Carcinogenesis

Tao Sun et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Article Multidisciplinary Sciences

Second-Hand Cigarette Smoke Impairs Bacterial Phagocytosis in Macrophages by Modulating CFTR Dependent Lipid-Rafts

Inzer Ni et al.

PLOS ONE (2015)

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Review Immunology

Exosomes - Structure, Biogenesis and Biological Role in Non-Small- Cell Lung Cancer

M. Frydrychowicz et al.

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2015)

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Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Cell Biology

Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis

Yu Fujita et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

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Article Physiology

CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke

Hyung-Geun Moon et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2014)

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Article Cell Biology

Mesenchymal stem cells enhance autophagy and increase beta-amyloid clearance in Alzheimer disease models

Jin Young Shin et al.

AUTOPHAGY (2014)

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Article Cell Biology

Autophagy regulates the therapeutic potential of mesenchymal stem cells in experimental autoimmune encephalomyelitis

Shipeng Dang et al.

AUTOPHAGY (2014)

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Review Biochemistry & Molecular Biology

Exosomes as new vesicular lipid transporters involved in cell-cell communication and various pathophysiologies

Michel Record et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)

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Article Immunology

Umbilical cord blood-derived dendritic cells loaded with BGC823 tumor antigens and DC-derived exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumor immunity in vitro and in vivo

Shasha Guan et al.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2014)

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Review Cell Biology

Biogenesis and secretion of exosomes

Joanna Kowal et al.

CURRENT OPINION IN CELL BIOLOGY (2014)

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Article Gastroenterology & Hepatology

Shotgun Proteomics: Identification of Unique Protein Profiles of Apoptotic Bodies From Biliary Epithelial Cells

Ana Lleo et al.

HEPATOLOGY (2014)

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Article Cell Biology

Rapid shedding of proinflammatory microparticles by human mononuclear cells exposed to cigarette smoke is dependent on Ca2+ mobilization

Cinzia Cordazzo et al.

INFLAMMATION RESEARCH (2014)

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Article Biochemistry & Molecular Biology

Cigarette Smoke-induced Ca2+ Release Leads to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Dysfunction

Julia E. Rasmussen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

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Article Medicine, Research & Experimental

Cardiac fibroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hypertrophy

Claudia Bang et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

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Article Immunology

Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

Jonathan M. Pitt et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Multidisciplinary Sciences

Active Trafficking of Alpha 1 Antitrypsin across the Lung Endothelium

Angelia D. Lockett et al.

PLOS ONE (2014)

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Article Respiratory System

Accumulation of metals in GOLD4 COPD lungs is associated with decreased CFTR levels

Fatemat Hassan et al.

RESPIRATORY RESEARCH (2014)

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Review Immunology

Exosomes: An emerging factor in stress-induced immunomodulation

Lida A. Beninson et al.

SEMINARS IN IMMUNOLOGY (2014)

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Article Cell & Tissue Engineering

Human Mesenchymal Stem Cell Microvesicles for Treatment of Escherichia coli Endotoxin- Induced Acute Lung Injury in Mice

Ying-gang Zhu et al.

STEM CELLS (2014)

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Article Multidisciplinary Sciences

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

Yusuke Yoshioka et al.

NATURE COMMUNICATIONS (2014)

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Review Oncology

Functions and therapeutic roles of exosomes in cancer

Jacob A. Tickner et al.

FRONTIERS IN ONCOLOGY (2014)

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Review Cell Biology

Routes and mechanisms of extracellular vesicle uptake

Laura Ann Mulcahy et al.

JOURNAL OF EXTRACELLULAR VESICLES (2014)

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Article Pathology

Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke

Chun-Jun Li et al.

AMERICAN JOURNAL OF PATHOLOGY (2013)

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Review Physiology

Cigarette smoke and CFTR: implications in the pathogenesis of COPD

Andras Rab et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2013)

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Article Critical Care Medicine

Cigarette Smoke Induces Systemic Defects in Cystic Fibrosis Transmembrane Conductance Regulator Function

S. Vamsee Raju et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Article Critical Care Medicine

Endothelial Microparticles in Mild Chronic Obstructive Pulmonary Disease and Emphysema The Multi-Ethnic Study of Atherosclerosis Chronic Obstructive Pulmonary Disease Study

Michael A. Thomashow et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

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Article Hematology

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

Noura Ismail et al.

BLOOD (2013)

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Article Oncology

Epidermal Growth Factor Receptor-Containing Exosomes Induce Tumor-Specific Regulatory T Cells

Shao-hong Huang et al.

CANCER INVESTIGATION (2013)

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Review Oncology

Vesicle Trafficking and RNA Transfer Add Complexity and Connectivity to Cell-Cell Communication

Charles T. Roberts et al.

CANCER RESEARCH (2013)

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Article Critical Care Medicine

Systematic Review of Blood Biomarkers in Cystic Fibrosis Pulmonary Exacerbations

Alborz Hakimi Shoki et al.

CHEST (2013)

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Review Medicine, Research & Experimental

Functions of S100 Proteins

R. Donato et al.

CURRENT MOLECULAR MEDICINE (2013)

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Article Allergy

Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation

Ankur Kulshreshtha et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2013)

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Editorial Material Cell Biology

Exosomes: Looking back three decades and into the future

Clifford V. Harding et al.

JOURNAL OF CELL BIOLOGY (2013)

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Article Respiratory System

Pro-inflammatory effect of cystic fibrosis sputum microparticles in the murine lung

Chiara Porro et al.

JOURNAL OF CYSTIC FIBROSIS (2013)

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Article Gastroenterology & Hepatology

Exosomes in the pathogenesis, diagnostics and therapeutics of liver diseases

Anatoliy I. Masyuk et al.

JOURNAL OF HEPATOLOGY (2013)

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Review Oncology

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

Johnny C. Akers et al.

JOURNAL OF NEURO-ONCOLOGY (2013)

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Article Biotechnology & Applied Microbiology

Extracellular vesicles: biology and emerging therapeutic opportunities

Samir EL Andaloussi et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

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Article Multidisciplinary Sciences

CCN1 Secretion Induced by Cigarette Smoking Extracts Augments IL-8 Release from Bronchial Epithelial Cells

Hyung-Geun Moon et al.

PLOS ONE (2013)

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Article Genetics & Heredity

Circulating miRNAs: cell–cell communication function?

A. Turchinovich et al.

Frontiers in Genetics (2013)

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Article Cell Biology

Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

Kenneth W. Witwer et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Cell Biology

EVpedia: an integrated database of high-throughput data for systemic analyses of extracellular vesicles

Dae-Kyum Kim et al.

JOURNAL OF EXTRACELLULAR VESICLES (2013)

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Article Clinical Neurology

Myeloid microvesicles are a marker and therapeutic target for neuroinflammation

Claudia Verderio et al.

ANNALS OF NEUROLOGY (2012)

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Review Biochemistry & Molecular Biology

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

Alexander V. Vlassov et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2012)

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Article Immunology

Lipocalin-2 ameliorates granulocyte functionality

Andrea Schroll et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

Cigarette smoke exposure induces CFTR internalization and insolubility, leading to airway surface liquid dehydration

Lucy A. Clunes et al.

FASEB JOURNAL (2012)

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Review Immunology

Membrane Vesicle Release in Bacteria, Eukaryotes, and Archaea: a Conserved yet Underappreciated Aspect of Microbial Life

Brooke L. Deatherage et al.

INFECTION AND IMMUNITY (2012)

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Review Respiratory System

Innate immunity in cystic fibrosis lung disease

D. Hartl et al.

JOURNAL OF CYSTIC FIBROSIS (2012)

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Article Immunology

Activated T Cell Exosomes Promote Tumor Invasion via Fas Signaling Pathway

Zhijian Cai et al.

JOURNAL OF IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

ExoCarta 2012: database of exosomal proteins, RNA and lipids

Suresh Mathivanan et al.

NUCLEIC ACIDS RESEARCH (2012)

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Article Multidisciplinary Sciences

Sputum Biomarkers and the Prediction of Clinical Outcomes in Patients with Cystic Fibrosis

Theodore G. Liou et al.

PLOS ONE (2012)

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Article Respiratory System

Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility

Toru Takahashi et al.

THORAX (2012)

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Article Cell Biology

Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes

Olivier G. de Jong et al.

JOURNAL OF EXTRACELLULAR VESICLES (2012)

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Article Critical Care Medicine

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

Cynthia Gordon et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

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Review Cell Biology

Epithelial Progenitor Cells in Lung Development, Maintenance, Repair, and Disease

Jason R. Rock et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

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Review Biochemistry & Molecular Biology

Vascular Cell Adhesion Molecule-1 Expression and Signaling During Disease: Regulation by Reactive Oxygen Species and Antioxidants

Joan M. Cook-Mills et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

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Article Cell & Tissue Engineering

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

Jason R. Rock et al.

CELL STEM CELL (2011)

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Article Biochemistry & Molecular Biology

TLR4 Protein Contributes to Cigarette Smoke-induced Matrix Metalloproteinase-1 (MMP-1) Expression in Chronic Obstructive Pulmonary Disease

Patrick Geraghty et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

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Review Cell Biology

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Angelique Bobrie et al.

TRAFFIC (2011)

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Article Multidisciplinary Sciences

Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells

Maria Mittelbrunn et al.

NATURE COMMUNICATIONS (2011)

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Review Respiratory System

Pathogenic triad in COPD: oxidative stress, protease-antiprotease imbalance, and inflammation

Bernard M. Fischer et al.

INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (2011)

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Article Biochemistry & Molecular Biology

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

Nobuyoshi Kosaka et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

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Article Cell Biology

Microvesicles: mediators of extracellular communication during cancer progression

Vandhana Muralidharan-Chari et al.

JOURNAL OF CELL SCIENCE (2010)

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Review Biochemical Research Methods

Exosomes: Extracellular organelles important in intercellular communication

Suresh Mathivanan et al.

JOURNAL OF PROTEOMICS (2010)

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Review Cell Biology

Membrane budding and scission by the ESCRT machinery: it's all in the neck

James H. Hurley et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

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Article Multidisciplinary Sciences

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

Robert J. Snelgrove et al.

SCIENCE (2010)

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Article Multidisciplinary Sciences

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

Tsukasa Okiyoneda et al.

SCIENCE (2010)

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Article Cell Biology

Cellular Internalization of Exosomes Occurs Through Phagocytosis

Du Feng et al.

TRAFFIC (2010)

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Article Respiratory System

Isolation and characterization of microparticles in sputum from cystic fibrosis patients

Chiara Porro et al.

RESPIRATORY RESEARCH (2010)

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Article Biochemistry & Molecular Biology

The Role of Interleukin-1β in Murine Cigarette Smoke-induced Emphysema and Small Airway Remodeling

Andrew Churg et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2009)

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Article Hematology

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

Esther N. M. Nolte-'t Hoen et al.

BLOOD (2009)

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Review Cell Biology

Endothelial microparticles in diseases

Gilles N. Chironi et al.

CELL AND TISSUE RESEARCH (2009)

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Article Biochemistry & Molecular Biology

Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense

Mehmet Kesimer et al.

FASEB JOURNAL (2009)

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Article Immunology

P2X7 Receptor-Stimulated Secretion of MHC Class II-Containing Exosomes Requires the ASC/NLRP3 Inflammasome but Is Independent of Caspase-1

Yan Qu et al.

JOURNAL OF IMMUNOLOGY (2009)

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Article Hematology

Differential stimulation of monocytic cells results in distinct populations of microparticles

M. Bernimoulin et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2009)

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Article Multidisciplinary Sciences

Basal cells as stem cells of the mouse trachea and human airway epithelium

Jason R. Rock et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Article Biochemical Research Methods

ExoCarta: A compendium of exosomal proteins and RNA

Suresh Mathivanan et al.

PROTEOMICS (2009)

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Article Biochemistry & Molecular Biology

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

Alma Zernecke et al.

SCIENCE SIGNALING (2009)

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Review Cell Biology

Shedding microvesicles: artefacts no more

Emanuele Cocucci et al.

TRENDS IN CELL BIOLOGY (2009)

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Review Immunology

Membrane vesicles as conveyors of immune responses

Clotilde Thery et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Article Respiratory System

N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD

Philip O'Reilly et al.

RESPIRATORY RESEARCH (2009)

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Review Physiology

Structure and function of the cell surface (tethered) mucins

Christine L. Hattrup et al.

ANNUAL REVIEW OF PHYSIOLOGY (2008)

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Article Immunology

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation

Amit Gaggar et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Cardiac & Cardiovascular Systems

Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function

Christian Heiss et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2008)

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Article Cardiac & Cardiovascular Systems

Different expression ratio of S100A8/A9 and S100A12 in acute and chronic lung diseases

Eva Lorenz et al.

RESPIRATORY MEDICINE (2008)

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Review Cell Biology

Exosome function: From tumor immunology to pathogen biology

Jeffrey S. Schorey et al.

TRAFFIC (2008)

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Article Allergy

B cell-derived exosomes can present allergen peptides and activate allergen-specific T cells to proliferate and produce TH2-like cytokines

Charlotte Admyre et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Review Immunology

SOCS proteins, cytokine signalling and immune regulation

Akihiko Yoshimura et al.

NATURE REVIEWS IMMUNOLOGY (2007)

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Article Cell Biology

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Hadi Valadi et al.

NATURE CELL BIOLOGY (2007)

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Review Immunology

Exosomes: From biogenesis and secretion to biological function

Sascha Keller et al.

IMMUNOLOGY LETTERS (2006)

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Article Pathology

α-1 Antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis

Irina Petrache et al.

AMERICAN JOURNAL OF PATHOLOGY (2006)

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Article Critical Care Medicine

A novel antiapoptotic role for α1-antitrypsin in the prevention of pulmonary emphysema

Lrina Petrache et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

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Article Critical Care Medicine

Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers

Andre M. Cantin et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2006)

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Article Oncology

Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

J Ratajczak et al.

LEUKEMIA (2006)

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Article Biochemistry & Molecular Biology

A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation

NM Weathington et al.

NATURE MEDICINE (2006)

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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

RN Kaplan et al.

NATURE (2005)

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Review Biochemistry & Molecular Biology

The short apical membrane half-life of rescued ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) results from accelerated endocytosis of ΔF508-CFTR in polarized human airway epithelial cells

A Swiatecka-Urban et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

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Article Hematology

Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses

E Segura et al.

BLOOD CELLS MOLECULES AND DISEASES (2005)

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Article Immunology

Exosomal-like vesicles are present in human blood plasma

MP Caby et al.

INTERNATIONAL IMMUNOLOGY (2005)

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Article Cell Biology

Increase in macrophage elastase (MMP-12) in lungs from patients with chronic obstructive pulmonary disease

S Molet et al.

INFLAMMATION RESEARCH (2005)

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Article Cell Biology

Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

M Sharma et al.

JOURNAL OF CELL BIOLOGY (2004)

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Article Critical Care Medicine

Tumor necrosis factor-α drives 70% of cigarette smoke-induced emphysema in the mouse

A Churg et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

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Article Medicine, General & Internal

The nature of small-airway obstruction in chronic obstructive pulmonary disease

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NEW ENGLAND JOURNAL OF MEDICINE (2004)

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Review Critical Care Medicine

Pathophysiology and management of pulmonary infections in cystic fibrosis

RL Gibson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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Review Critical Care Medicine

American Thoracic Society/European Respiratory Society Statement: Standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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Article Respiratory System

Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid

C Admyre et al.

EUROPEAN RESPIRATORY JOURNAL (2003)

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Article Respiratory System

Expression of S100A12 (EN-RAGE) in cystic fibrosis

D Foell et al.

THORAX (2003)

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Article Oncology

Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils

O Gasser et al.

EXPERIMENTAL CELL RESEARCH (2003)

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Article Physiology

Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung

RF Foronjy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2003)

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Article Critical Care Medicine

Decreased level of vascular endothelial growth factor in bronchoalveolar lavage fluid of normal smokers and patients with pulmonary fibrosis

S Koyama et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)

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Article Critical Care Medicine

Macrophages and the pathogenesis of COPD

TD Tetley

CHEST (2002)

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Review Cell Biology

The biogenesis and functions of exosomes

W Stoorvogel et al.

TRAFFIC (2002)

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Article Biochemical Research Methods

Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin-layer chromatography

AM Weerheim et al.

ANALYTICAL BIOCHEMISTRY (2002)

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Article Respiratory System

Cytokines in chronic obstructive pulmonary disease

KF Chung

EUROPEAN RESPIRATORY JOURNAL (2001)

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Article Immunology

Proteomic analysis of dendritic cell-derived exosomes:: A secreted subcellular compartment distinct from apoptotic vesicles

C Théry et al.

JOURNAL OF IMMUNOLOGY (2001)

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Extracellular Vesicles' Role in the Pathophysiology and as Biomarkers in Cystic Fibrosis and COPD

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