期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 24, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms24032856
关键词
drug transporters; kidney
The kidney is not only involved in metabolite elimination, but also plays a critical role in pharmacotherapy. Membrane carriers and transporters expressed in kidney tubule epithelial cells are important in drug elimination, determining drug nephrotoxicity and drug-drug interactions, as well as serving as direct drug targets. This review discusses these aspects of kidney transport proteins.
The kidney functions not only as a metabolite elimination organ but also plays an important role in pharmacotherapy. The kidney tubule epithelia cells express membrane carriers and transporters, which play an important role in drug elimination, and can determine drug nephrotoxicity and drug-drug interactions, as well as constituting direct drug targets. The above aspects of kidney transport proteins are discussed in the review.
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