4.7 Review

The Journey of Mitochondrial Protein Import and the Roadmap to Follow

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

Honokiol improves cognitive impairment in APP/PS1 mice through activating mitophagy and mitochondrial unfolded protein response

Mingyue Hou et al.

Summary: The study confirms the protective effect of HKL on AD by activating mitophagy and UPRmt.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

Review Biochemistry & Molecular Biology

Cytosolic Quality Control of Mitochondrial Protein Precursors-The Early Stages of the Organelle Biogenesis

Anna M. Lenkiewicz et al.

Summary: The synthesis and targeting of mitochondrial proteins are essential processes for maintaining mitochondrial function and cell survival. The cytosolic protein homeostasis mechanism and the ubiquitin-proteasome system play critical roles in controlling the quality and supply of mitochondrial proteins. Mislocalization of mitochondrial proteins can contribute to disease development. Pathways involved in precursor maintenance and guidance in the cytosolic stages are crucial for restoring protein homeostasis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Review Oncology

The mitochondrial unfolded protein response (UPRmt): shielding against toxicity to mitochondria in cancer

Joseph R. Inigo et al.

Summary: Mitochondria play a crucial role in tumor growth and progression. However, the increased demand for mitochondrial activity in cancer leads to the production of more reactive oxygen species, accumulation of mutations in mitochondrial DNA, and the development of mitochondrial dysfunction. The mitochondrial unfolded protein response (UPRmt) is an evolutionary quality control mechanism that helps combat mitochondrial stress and maintain mitochondrial integrity to support tumor growth.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Review Biochemistry & Molecular Biology

Activation of the Mitochondrial Unfolded Protein Response: A New Therapeutic Target?

Juan M. Suarez-Rivero et al.

Summary: Mitochondrial dysfunction is a common feature in many diseases, and new therapeutic approaches such as activating UPRmt are being explored. UPRmt activation has shown potential benefits in neurodegenerative diseases, cardiopathies, and mitochondrial diseases, but overactivation could lead to undesired side effects.

BIOMEDICINES (2022)

Article Biochemistry & Molecular Biology

Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids

Maria Jose Perez et al.

Summary: Mutations in the PITRM1 gene lead to a slow-progressing syndrome characterized by cerebellar ataxia and cognitive decline. Studies using PITRM1-knockout iPSCs show induction of mitochondrial unfolded protein response and increased mitochondrial clearance in neurons, as well as elevated levels of amyloid precursor protein and amyloid beta. Astrocytes also show dysregulated immune transcriptional signatures in PITRM1-knockout cerebral organoids.

MOLECULAR PSYCHIATRY (2021)

Review Biochemistry & Molecular Biology

Mitochondrial unfolded protein response: An emerging pathway in human diseases

Li Zhu et al.

Summary: Mitochondrial unfolded protein response (UPRmt) is a stress response system in mitochondria that regulates proteostasis and has beneficial effects on delaying aging and extending lifespan. UPRmt plays a crucial role in various diseases, especially aging-related ones, and its activation can potentially be therapeutic for neurodegenerative diseases, cancers, and heart diseases.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Physiology

Neurogenic Hypertension Mediated Mitochondrial Abnormality Leads to Cardiomyopathy: Contribution of UPRmt and Norepinephrine-miR-18a-5p-HIF-1α Axis

Shyam S. Nandi et al.

Summary: The study investigated the molecular mechanisms behind neurogenic hypertension-induced cardiac dysfunction, suggesting that enhanced sympatho-excitation suppresses miR-18a-5p/HIF-1 alpha signaling and leads to mitochondrial abnormalities, cardiac remodeling, and pathological cardiac hypertrophy commonly seen in neurogenic hypertension.

FRONTIERS IN PHYSIOLOGY (2021)

Review Cardiac & Cardiovascular Systems

Role of the Mitochondrial Protein Import Machinery and Protein Processing in Heart Disease

Fujie Zhao et al.

Summary: Mitochondria play essential roles in cellular functions and various diseases, including heart disease. The protein import machinery of mitochondria is crucial for these functions and warrants further research for potential therapeutic strategies in heart disease.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Biochemistry & Molecular Biology

Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

Anna M. Schlagowski et al.

Summary: The study investigates the regulation of aggregation-prone polyQ protein behavior by mitochondrial processes, revealing that Mia40 plays a rate-limiting role in the import of mitochondrial precursor proteins and can be exploited to stabilize cytosolic proteostasis.

EMBO JOURNAL (2021)

Review Biochemistry & Molecular Biology

Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis

Mary Adebayo et al.

Summary: Mitochondria are dynamic organelles inherited maternally, fulfilling cellular energy demand and playing roles in cell signaling, metabolism, and apoptosis. Maintenance of mitochondrial integrity and homeostasis through fusion and fission is crucial, and imbalance can lead to various diseases.

FASEB JOURNAL (2021)

Review Cell Biology

How the Mitoprotein-Induced Stress Response Safeguards the Cytosol: A Unified View

Felix Boos et al.

TRENDS IN CELL BIOLOGY (2020)

Article Neurosciences

Activation of Mitochondrial Unfolded Protein Response in SHSY5Y Expressing APP Cells and APP/PS1 Mice

Yang Shen et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Article Oncology

Activation of mitochondrial unfolded protein response is associated with Her2-overexpression breast cancer

Fang-Ming Chen et al.

BREAST CANCER RESEARCH AND TREATMENT (2020)

Article Multidisciplinary Sciences

Structural insight into mitochondrial β-barrel outer membrane protein biogenesis

Kathryn A. Diederichs et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Insights into Disease-Associated Tau Impact on Mitochondria

Leonora Szabo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cell Biology

Atomic structure of human TOM core complex

Wenhe Wang et al.

CELL DISCOVERY (2020)

Review Oncology

Mitochondrial Stress Response and Cancer

Jordan O'Malley et al.

TRENDS IN CANCER (2020)

Article Cardiac & Cardiovascular Systems

Cardioprotective Effect of the Mitochondrial Unfolded Protein Response During Chronic Pressure Overload

Ioannis Smyrnias et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Cell Biology

Mitohormesis Primes Tumor Invasion and Metastasis

Timothy C. Kenny et al.

CELL REPORTS (2019)

Article Cardiac & Cardiovascular Systems

Cardioprotection by the mitochondrial unfolded protein response requires ATF5

Yves T. Wang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2019)

Article Oncology

Hsp60 and IL-8 axis promotes apoptosis resistance in cancer

Sandeep Kumar et al.

BRITISH JOURNAL OF CANCER (2019)

Article Cardiac & Cardiovascular Systems

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo

Sundararajan Venkatesh et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2019)

Review Biochemistry & Molecular Biology

The role of cell type-specific mitochondrial dysfunction in the pathogenesis of Alzheimer's disease

Dong Kyu Kim et al.

BMB REPORTS (2019)

Review Biochemistry & Molecular Biology

mPOS is a novel mitochondrial trigger of cell death - implications for neurodegeneration

Liam P. Coyne et al.

FEBS LETTERS (2018)

Review Biochemistry & Molecular Biology

Chaperoning the guardian of the genome. The two-faced role of molecular chaperones in p53 tumor suppressor action

Bartosz Wawrzynow et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

Review Neurosciences

Mitochondria and Mitochondrial Cascades in Alzheimer's Disease

Russell H. Swerdlow

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Neurosciences

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Ying Cheng et al.

FRONTIERS IN NEUROSCIENCE (2018)

Review Biochemistry & Molecular Biology

Endoplasmic Reticulum Stress and Oxidative Stress: A Vicious Nexus Implicated in Bowel Disease Pathophysiology

Wai Chin Chong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Multidisciplinary Sciences

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Vincenzo Sorrentino et al.

NATURE (2017)

Article Geriatrics & Gerontology

Mitochondrial Omi/HtrA2 Promotes Caspase Activation Through Cleavage of HAX-1 in Aging Heart

Xin Liu et al.

REJUVENATION RESEARCH (2017)

Article Cell Biology

Mitochondrial OXA Translocase Plays a Major Role in Biogenesis of Inner-Membrane Proteins

Sebastian B. Stiller et al.

CELL METABOLISM (2016)

Article Clinical Neurology

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease

John S. Beck et al.

CURRENT ALZHEIMER RESEARCH (2016)

Article Neurosciences

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

Marthe H. R. Ludtmann et al.

JOURNAL OF NEUROSCIENCE (2016)

Review Biochemistry & Molecular Biology

Metabolism and the UPRmt

Yi-Fan Lin et al.

MOLECULAR CELL (2016)

Article Multidisciplinary Sciences

Characterization of the targeting signal in mitochondrial β-barrel proteins

Tobias Jores et al.

NATURE COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Jae Ho Seo et al.

PLOS BIOLOGY (2016)

Review Biochemistry & Molecular Biology

Endosymbiosis and Eukaryotic Cell Evolution

John M. Archibald

CURRENT BIOLOGY (2015)

Article Multidisciplinary Sciences

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

Lidia Wrobel et al.

NATURE (2015)

Review Biochemistry & Molecular Biology

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

Xinglong Wang et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Pharmacology & Pharmacy

Unravelling mitochondrial pathways to Parkinson's disease

I. Celardo et al.

BRITISH JOURNAL OF PHARMACOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Oxidative Post-Translational Modifications Develop LONP1 Dysfunction in Pressure Overload Heart Failure

Atsushi Hoshino et al.

CIRCULATION-HEART FAILURE (2014)

Review Biochemistry & Molecular Biology

Mitochondrial protein import: Common principles and physiological networks

Jan Dudek et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)

Article Oncology

HSP60 Predicts Survival in Advanced Serous Ovarian Cancer

Elisabet Hjerpe et al.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2013)

Article Biochemistry & Molecular Biology

Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins

Romina Durigon et al.

EMBO REPORTS (2012)

Article Multidisciplinary Sciences

Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides

Jitin Bali et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Multidisciplinary Sciences

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

Amrita M. Nargund et al.

SCIENCE (2012)

Article Medicine, Research & Experimental

Mitochondrial Biology and Parkinson's Disease

Celine Perier et al.

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Biochemistry & Molecular Biology

BCL-2 Is a Downstream Target of ATF5 That Mediates the Prosurvival Function of ATF5 in a Cell Type-dependent Manner

Douglas Dluzen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

p300-Dependent ATF5 Acetylation Is Essential for Egr-1 Gene Activation and Cell Proliferation and Survival

David X. Liu et al.

MOLECULAR AND CELLULAR BIOLOGY (2011)

Article Medicine, Research & Experimental

Overexpression of activating transcription factor 5 in human rectal cancer

Xiangheng Kong et al.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2011)

Review Biochemistry & Molecular Biology

New insights into the role of mitochondrial dysfunction and protein aggregation in Parkinson's disease

Weilin Xie et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)

Article Biochemistry & Molecular Biology

Cooperation of Stop-Transfer and Conservative Sorting Mechanisms in Mitochondrial Protein Transport

Maria Bohnert et al.

CURRENT BIOLOGY (2010)

Article Oncology

HSP60, a protein downregulated by IGFBP7 in colorectal carcinoma

Wenjing Ruan et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)

Review Biochemistry & Molecular Biology

Importing Mitochondrial Proteins: Machineries and Mechanisms

Agnieszka Chacinska et al.

Review Biochemistry & Molecular Biology

Mitochondrial DNA nucleoids determine mitochondrial genetics and dysfunction

Robert W. Gilkerson

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

Dual Targeting of Nfs1 and Discovery of Its Novel Processing Enzyme, Icp55

Adi Naamati et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Cell Biology

Identification of the Signal Directing Tim9 and Tim10 into the Intermembrane Space of Mitochondria

Dusanka Milenkovic et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Review Biochemistry & Molecular Biology

The MIA system for protein import into the mitochondrial intermembrane space

Diana Stojanovski et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)

Review Oncology

Hsp60 expression, new locations, functions and perspectives for cancer diagnosis and therapy

Francesco Cappello et al.

CANCER BIOLOGY & THERAPY (2008)

Article Biochemistry & Molecular Biology

Dissecting membrane insertion of mitochondrial β-barrel proteins

Stephan Kutik et al.

Article Biochemistry & Molecular Biology

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini et al.

Review Biochemistry & Molecular Biology

Multiple pathways for sorting mitochondrial precursor proteins

Natalia Bolender et al.

EMBO REPORTS (2008)

Article Biochemistry & Molecular Biology

Assembly of the three small Tim proteins precedes docking to the mitochondrial carrier translocase

Natalia Gebert et al.

EMBO REPORTS (2008)

Article Biochemistry & Molecular Biology

The zinc-binding protein Hot13 promotes oxidation of the mitochondrial import receptor Mia40

Nikola Mesecke et al.

EMBO REPORTS (2008)

Article Biochemistry & Molecular Biology

The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases

Karina Wagner et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Hsp60 regulation of tumor cell apoptosis

Jagadish C. Ghosh et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Cell Biology

The disulfide relay system of mitochondria is connected to the respiratory chain

Karl Bihlmaier et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

A role for cytochrome c and cytochrome c peroxidase in electron shuttling from Erv1

Deepa V. Dabir et al.

EMBO JOURNAL (2007)

Article Gastroenterology & Hepatology

Modulation of mitochondrial membrane permeability in pathogenesis, autophagy and control of metabolism

John J. Lemasters

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2007)

Article Biochemistry & Molecular Biology

The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes

Reinhard Albrecht et al.

EMBO REPORTS (2006)

Article Biochemistry & Molecular Biology

A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria

Martin van der Laan et al.

CURRENT BIOLOGY (2006)

Article Biochemistry & Molecular Biology

Crystal structure of yeast mitochondrial outer membrane translocon member Tom70p

Yunkun Wu et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)

Article Multidisciplinary Sciences

Tim50 maintains the permeability barrier of the mitochondrial inner membrane

Michael Meinecke et al.

SCIENCE (2006)

Review Biotechnology & Applied Microbiology

Mitochondrial preprotein translocases as dynamic molecular machines

Martin van der Laan et al.

FEMS YEAST RESEARCH (2006)

Article Biochemistry & Molecular Biology

Signal-anchored proteins follow a unique insertion pathway into the outer membrane of mitochondria

U Ahting et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Multidisciplinary Sciences

ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease

JW Lustbader et al.

SCIENCE (2004)

Article Multidisciplinary Sciences

Protein insertion into the mitochondrial inner membrane by a twin-pore translocase

P Rehling et al.

SCIENCE (2003)

Article Biochemistry & Molecular Biology

A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23

KN Truscott et al.

NATURE STRUCTURAL BIOLOGY (2001)

Review Oncology

Role of the heat shock response and molecular chaperones in oncogenesis and cell death

C Jolly et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)