期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijms232214412
关键词
mycobacteria; immunology; antigen presentation
资金
- National Institutes of Health [T32GM141938, R21AI151079, K08AI153359]
This review discusses the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.
MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from Mycobacterium tuberculosis to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of Mycobacterium tuberculosis infection.
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