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Human Lung Mast Cells: Therapeutic Implications in Asthma

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Phase 2a randomized, placebo-controlled study of anti-IL-33 in peanut allergy

Sharon Chinthrajah et al.

JCI INSIGHT (2019)

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Review Immunology

Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family

Corinne Cayrol et al.

IMMUNOLOGICAL REVIEWS (2018)

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Article Allergy

The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria

T. Zuberbier et al.

ALLERGY (2018)

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Review Immunology

Human mast cells and basophils-How are they similar how are they different?

Gilda Varricchi et al.

IMMUNOLOGICAL REVIEWS (2018)

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Article Allergy

Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy

Melanie C. Dispenza et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Article Immunology

Elevated Expression of IL-33 and TSLP in the Airways of Human Asthmatics In Vivo: A Potential Biomarker of Severe Refractory Disease

Yan Li et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Pharmacology & Pharmacy

TAS05567, a Novel Potent and Selective Spleen Tyrosine Kinase Inhibitor, Abrogates Immunoglobulin-Mediated Autoimmune and Allergic Reactions in Rodent Models

Hiroaki Hayashi et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2018)

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Article Dermatology

Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: partII

A. Wollenberg et al.

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY (2018)

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Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

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Article Critical Care Medicine

Tralokinumab for severe, uncontrolled asthma (STRATOS 1 and STRATOS 2): two randomised, double-blind, placebo-controlled, phase 3 clinical trials

Reynold A. Panettieri et al.

LANCET RESPIRATORY MEDICINE (2018)

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Review Immunology

Thymic Stromal Lymphopoietin Isoforms, Inflammatory Disorders, and Cancer

Gilda Varricchi et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Allergy

A phase 2a study of toreforant, a histamine H4 receptor antagonist, in eosinophilic asthma

Alexa P. Kollmeier et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2018)

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Article Pharmacology & Pharmacy

Histamine H4 receptor mediates chemotaxis of human lung mast cells

Linda J. Kay et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2018)

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Article Immunology

Bronchial Allergen Challenge of Patients with Atopic Asthma Triggers an Alarmin (IL-33, TSLP, and IL-25) Response in the Airways Epithelium and Submucosa

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JOURNAL OF IMMUNOLOGY (2018)

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Article Biochemistry & Molecular Biology

Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting

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CELL (2018)

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Article Respiratory System

TSLP promotes asthmatic airway remodeling via p38-STAT3 signaling pathway in human lung fibroblast

Liuzhao Cao et al.

EXPERIMENTAL LUNG RESEARCH (2018)

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Review Immunology

The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity

Claudia Afferni et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Dermatology

Controversial role of mast cells in skin cancers

Gilda Varricchi et al.

EXPERIMENTAL DERMATOLOGY (2017)

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Article Dermatology

Membrane-bound stem cell factor is the major but not only driver of fibroblast-induced murine skin mast cell differentiation

Mandy Leist et al.

EXPERIMENTAL DERMATOLOGY (2017)

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Article Allergy

IL-33 fine tunes mast cell degranulation and chemokine production at the single-cell level

Regis Joulia et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

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Article Immunology

Skin-derived TSLP systemically expands regulatory T cells

Theresa M. Leichner et al.

JOURNAL OF AUTOIMMUNITY (2017)

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Article Immunology

Transcriptional Heterogeneity of Mast Cells and Basophils upon Activation

Krishan D. Chhiba et al.

JOURNAL OF IMMUNOLOGY (2017)

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Article Medicine, General & Internal

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma

Katherine N. Cahill et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Article Medicine, General & Internal

Tezepelumab in Adults with Uncontrolled Asthma

Jonathan Corren et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

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Review Medical Laboratory Technology

Skin microbiome and mast cells

Satomi Igawa et al.

TRANSLATIONAL RESEARCH (2017)

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Article Critical Care Medicine

Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial

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LANCET RESPIRATORY MEDICINE (2017)

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Article Critical Care Medicine

Efficacy of mepolizumab add-on therapy on health-related quality of life and markers of asthma control in severe eosinophilic asthma (MUSCA): a randomised, double-blind, placebo-controlled, parallel-group, multicentre, phase 3b trial

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LANCET RESPIRATORY MEDICINE (2017)

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Article Allergy

Real-life Effectiveness Studies of Omalizumab in Adult Patients with Severe Allergic Asthma: Meta-analysis

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2017)

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Article Hematology

KIT signaling is dispensable for human mast cell progenitor development

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BLOOD (2017)

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Article Critical Care Medicine

Effects of Omalizumab on Rhinovirus Infections, Illnesses, and Exacerbations of Asthma

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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

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Review Medicine, General & Internal

Anti-Interleukin 5 (IL-5) and IL-5Ra Biological Drugs: Efficacy, Safety, and Future Perspectives in Severe Eosinophilic Asthma

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FRONTIERS IN MEDICINE (2017)

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Review Medicine, General & Internal

Bidirectional Mast Cell-Eosinophil Interactions in Inflammatory Disorders and Cancer

Maria Rosaria Galdiero et al.

FRONTIERS IN MEDICINE (2017)

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Article Allergy

Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2-induced airway inflammation and remodeling

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ALLERGY (2017)

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Review Immunology

Mast cells in rheumatoid arthritis: friends or foes?

Felice Rivellese et al.

AUTOIMMUNITY REVIEWS (2017)

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Target interaction profiling of midostaurin and its metabolites in neoplastic mast cells predicts distinct effects on activation and growth

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LEUKEMIA (2016)

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Article Allergy

Elevated plasma levels of vascular permeability factors in C1 inhibitor-deficient hereditary angioedema

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ALLERGY (2016)

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Article Biochemistry & Molecular Biology

The modulatory effect of TLR2 on LL-37-induced human mast cells activation

Yuan-Yuan Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

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Article Pharmacology & Pharmacy

Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices

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BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Article Pharmacology & Pharmacy

The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma

A. L. da Silva et al.

BRITISH JOURNAL OF PHARMACOLOGY (2016)

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Review Allergy

Mast cells in asthma - state of the art

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CLINICAL AND EXPERIMENTAL ALLERGY (2016)

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Article Allergy

Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria

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CLINICAL AND EXPERIMENTAL ALLERGY (2016)

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Article Pharmacology & Pharmacy

Mast cell proteases as pharmacological targets

George H. Caughey

EUROPEAN JOURNAL OF PHARMACOLOGY (2016)

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Review Allergy

Are Basophils and Mast Cells Masters in HIV Infection?

Gianni Marone et al.

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2016)

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Article Medicine, General & Internal

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

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LANCET (2016)

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Article Medicine, General & Internal

Dupilumab efficacy and safety in adults with uncontrolled persistent asthma despite use of medium-to-high-dose inhaled corticosteroids plus a long-acting β2 agonist: a randomised double-blind placebo-controlled pivotal phase 2b dose-ranging trial

Sally Wenzel et al.

LANCET (2016)

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Article Immunology

Expression profiling of constitutive mast cells reveals a unique identity within the immune system

Daniel F. Dwyer et al.

NATURE IMMUNOLOGY (2016)

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Article Multidisciplinary Sciences

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

Glenn Cruse et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

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NATURE COMMUNICATIONS (2016)

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Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials

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LANCET RESPIRATORY MEDICINE (2016)

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Article Multidisciplinary Sciences

Mast cell phenotype, TNFα expression and degranulation status in non-small cell lung cancer

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SCIENTIFIC REPORTS (2016)

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Article Allergy

IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk

D. Kaur et al.

ALLERGY (2015)

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Article Allergy

Differential TLR-induced cytokine production by human mast cells is amplified by FcεRI triggering

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CLINICAL AND EXPERIMENTAL ALLERGY (2015)

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Article Immunology

Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33

Geethani Bandara et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2015)

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Article Allergy

IL-25 as a novel therapeutic target in nasal polyps of patients with chronic rhinosinusitis

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Article Allergy

Human mast cells are major IL-22 producers in patients with psoriasis and atopic dermatitis

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

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Review Oncology

KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis

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LEUKEMIA (2015)

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Review Cardiac & Cardiovascular Systems

Mast cells in human and experimental cardiometabolic diseases

Guo-Ping Shi et al.

NATURE REVIEWS CARDIOLOGY (2015)

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Article Medicine, General & Internal

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

NEW ENGLAND JOURNAL OF MEDICINE (2015)

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Article Biochemistry & Molecular Biology

Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8-Akt-Slug pathway

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ONCOGENE (2015)

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Article Pharmacology & Pharmacy

A novel inhaled Syk inhibitor blocks mast cell degranulation and early asthmatic response

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PHARMACOLOGICAL RESEARCH (2015)

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Article Rheumatology

Ability of Interleukin-33-and Immune Complex-Triggered Activation of Human Mast Cells to Down-Regulate Monocyte-Mediated Immune Responses

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ARTHRITIS & RHEUMATOLOGY (2015)

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Article Critical Care Medicine

Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials

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LANCET RESPIRATORY MEDICINE (2015)

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Article Critical Care Medicine

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

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LANCET RESPIRATORY MEDICINE (2015)

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Article Rheumatology

Toll-like receptor triggering augments activation of human mast cells by anti-citrullinated protein antibodies

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ANNALS OF THE RHEUMATIC DISEASES (2015)

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Article Hematology

Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells

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BLOOD (2015)

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Article Dermatology

Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis

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JOURNAL OF DERMATOLOGY (2015)

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Article Hematology

Redefinition of the human mast cell transcriptome by deep-CAGE sequencing

Efthymios Motakis et al.

BLOOD (2014)

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Letter Allergy

Siglec-7 is an inhibitory receptor on human mast cells and basophils

Sa'ar Mizrahi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2014)

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Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

Elisabeth H. Bel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Medicine, General & Internal

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Hector G. Ortega et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

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Article Critical Care Medicine

Benralizumab, an anti-interleukin 5 receptor α monoclonal antibody, versus placebo for uncontrolled eosinophilic asthma: a phase 2b randomised dose-ranging study

Mario Castro et al.

LANCET RESPIRATORY MEDICINE (2014)

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Article Dermatology

Topical administration of the pan-Src kinase inhibitors, dasatinib and LCB 03-0110, prevents allergic contact dermatitis in mice

S. H. Jung et al.

BRITISH JOURNAL OF DERMATOLOGY (2013)

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Article Medicine, General & Internal

Dupilumab in Persistent Asthma with Elevated Eosinophil Levels

Sally Wenzel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

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Review Allergy

Contribution of stress to asthma worsening through mast cell activation

Theoharis C. Theoharides et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2012)

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Article Critical Care Medicine

Mast Cell-Airway Smooth Muscle Crosstalk The Role of Thymic Stromal Lymphopoietin

Davinder Kaur et al.

CHEST (2012)

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Article Immunology

Experimentally induced psoriatic lesion associates with interleukin (IL)-6 in mast cells and appearance of dermal cells expressing IL-33 and IL-6 receptor

M. -M. Suttle et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2012)

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Article Dermatology

Expressions and inhibitory functions of CD300a receptors on purified human basophils

Bernhard F. Gibbs et al.

EXPERIMENTAL DERMATOLOGY (2012)

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Article Immunology

Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to FeγRIIb

Saso Cemerski et al.

IMMUNOLOGY LETTERS (2012)

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Article Allergy

The Tyrosine Kinase Inhibitor Masitinib Blunts Airway Inflammation and Improves Associated Lung Mechanics in a Feline Model of Chronic Allergic Asthma

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INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2012)

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Article Allergy

Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

Jessica H. Savage et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Allergy

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma

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JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2012)

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Article Medicine, General & Internal

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial

Ian D. Pavord et al.

LANCET (2012)

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Article Multidisciplinary Sciences

Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor

Beomkyu Kim et al.

NATURE (2012)

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Article Gastroenterology & Hepatology

Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy

K. Vaali et al.

NEUROGASTROENTEROLOGY AND MOTILITY (2012)

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Review Pharmacology & Pharmacy

Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

Takumi Kiwamoto et al.

PHARMACOLOGY & THERAPEUTICS (2012)

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Review Dermatology

Mast Cells as Regulators of Skin Inflammation and Immunity

Ilkka T. Harvima et al.

ACTA DERMATO-VENEREOLOGICA (2011)

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Article Allergy

Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein

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ALLERGY (2011)

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Article Medicine, General & Internal

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy A Randomized Trial

Nicola A. Hanania et al.

ANNALS OF INTERNAL MEDICINE (2011)

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Review Immunology

Basophils: emerging roles in the pathogenesis of allergic disease

John T. Schroeder

IMMUNOLOGICAL REVIEWS (2011)

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Article Allergy

Allergen-induced expression of IL-25 and IL-25 receptor in atopic asthmatic airways and late-phase cutaneous responses

Chris J. Corrigan et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2011)

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Article Immunology

Developmental, Malignancy-Related, and Cross-Species Analysis of Eosinophil, Mast Cell, and Basophil Siglec-8 Expression

Sherry A. Hudson et al.

JOURNAL OF CLINICAL IMMUNOLOGY (2011)

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Article Multidisciplinary Sciences

TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation

Mark C. Siracusa et al.

NATURE (2011)

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Article Medicine, General & Internal

Lebrikizumab Treatment in Adults with Asthma

Jonathan Corren et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Medicine, General & Internal

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

William W. Busse et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Article Multidisciplinary Sciences

Tyrosine Kinase Syk Non-Enzymatic Inhibitors and Potential Anti-Allergic Drug-Like Compounds Discovered by Virtual and In Vitro Screening

Bruno O. Villoutreix et al.

PLOS ONE (2011)

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Review Allergy

Angiogenesis and lymphangiogenesis in bronchial asthma

A. Detoraki et al.

ALLERGY (2010)

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Article Pathology

Mast Cell-Derived TNF Can Exacerbate Mortality during Severe Bacterial Infections in C57BL/6-KitW-sh/W-sh Mice

Adrian M. Piliponsky et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

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Article Cell Biology

IL-33 synergizes with IgE-dependent and IgE-independent agents to promote mast cell and basophil activation

Matthew R. Silver et al.

INFLAMMATION RESEARCH (2010)

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Article Allergy

Thymic stromal lymphopoietin-induced human asthmatic airway epithelial cell proliferation through an IL-13-dependent pathway

Abdelhabib Semlali et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2010)

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Article Immunology

Production of Vascular Endothelial Growth Factors from Human Lung Macrophages Induced by Group IIA and Group X Secreted Phospholipases A2

Francescopaolo Granata et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Immunology

Mast Cell Fibroblastoid Differentiation Mediated by Airway Smooth Muscle in Asthma

Davinder Kaur et al.

JOURNAL OF IMMUNOLOGY (2010)

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Article Biochemistry & Molecular Biology

Mast cells have a protumorigenic role in human thyroid cancer

R. M. Melillo et al.

ONCOGENE (2010)

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Article Multidisciplinary Sciences

IL-33 Is Produced by Mast Cells and Regulates IgE-Dependent Inflammation

Chia-Lin Hsu et al.

PLOS ONE (2010)

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Review Pharmacology & Pharmacy

CRTH2 and D-Type Prostanoid Receptor Antagonists as Novel Therapeutic Agents for Inflammatory Diseases

Rufina Schuligoi et al.

PHARMACOLOGY (2010)

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Article Multidisciplinary Sciences

IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin

Theoharis C. Theoharides et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

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Article Allergy

Masitinib, a c-kit/PDGF receptor tyrosine kinase inhibitor, improves disease control in severe corticosteroid-dependent asthmatics

M. Humbert et al.

ALLERGY (2009)

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Article Critical Care Medicine

A Randomized, Double-blind, Placebo-controlled Study of Tumor Necrosis Factor-α Blockade in Severe Persistent Asthma

Sally E. Wenzel et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2009)

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Review Peripheral Vascular Disease

The role of the Angiopoietins in vascular morphogenesis

Markus Thomas et al.

ANGIOGENESIS (2009)

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Article Allergy

Midostaurin (PKC412) inhibits immunoglobulin E-dependent activation and mediator release in human blood basophils and mast cells

M. -T. Krauth et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2009)

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Article Respiratory System

FcεRI-mediated thymic stromal lymphopoietin production by interleukin-4-primed human mast cells

Y. Okayama et al.

EUROPEAN RESPIRATORY JOURNAL (2009)

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Article Allergy

Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects

Aikaterini Detoraki et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2009)

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Editorial Material Dermatology

Mast Cell Stabilizing Properties of Antihistamines

Francesca Levi-Schaffer et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2009)

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Article Medicine, General & Internal

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

Pranabashis Haldar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Article Hematology

The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils

Michael Kneidinger et al.

BLOOD (2008)

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Article Immunology

Human airway smooth muscle promotes human lung mast cell survival, proliferation, and constitutive activation: Cooperative roles for CADM1, stem cell factor, and IL-6

Fay Hollins et al.

JOURNAL OF IMMUNOLOGY (2008)

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Article Immunology

Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a

Ido Bachelet et al.

JOURNAL OF IMMUNOLOGY (2008)

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Editorial Material Immunology

The cysteinyl leukotrienes: Where do they come from? What are they? Where are they going?

K. Frank Austen

NATURE IMMUNOLOGY (2008)

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Article Allergy

Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

Sarah J. Ballantyne et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Article Medicine, Research & Experimental

IL-33 can promote survival, adhesion and cytokine production in human mast cells

Motoyasu Iikura et al.

LABORATORY INVESTIGATION (2007)

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Article Biochemistry & Molecular Biology

Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation

Merel C. M. Strik et al.

MOLECULAR IMMUNOLOGY (2007)

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Article Immunology

Thymic stfomal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells

Zoulfia Allakhverdi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2007)

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Review Allergy

Proximal signaling events in Fc epsilon RI-mediated mast cell activation

Taku Kambayashi et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2007)

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Article Immunology

Expression and functions of the vascular endothelial growth factors and their receptors in human basophils

Amato de Paulis et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Immunology

Human mast cell-derived gelatinase B (matrix metalloproteinase-9) is regulated by inflammatory cytokines: Role in cell migration

Nick Di Girolamo et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Allergy

Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells

H Yokoi et al.

ALLERGY (2006)

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Article Allergy

Mast cell inhibitor R112 is well tolerated and affects prostaglandin D2 but not other mediators, symptoms, or nasal volumes in a nasal challenge model of allergic rhinitis

Brenda J. Guyer et al.

ALLERGY AND ASTHMA PROCEEDINGS (2006)

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Article Pharmacology & Pharmacy

Corticotropin-releasing hormone induces vascular endothelial growth factor release from human mast cells via the cAMP/protein kinase A/p38 mitogen-activated protein kinase pathway

J Cao et al.

MOLECULAR PHARMACOLOGY (2006)

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Review Pharmacology & Pharmacy

Stem cell factor expression, mast cells and inflammation in asthma

CA Da Silva et al.

FUNDAMENTAL & CLINICAL PHARMACOLOGY (2006)

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Article Immunology

Human lung mast cells adhere to human airway smooth muscle, in part, via tumor suppressor in lung cancer-1

WD Yang et al.

JOURNAL OF IMMUNOLOGY (2006)

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Article Allergy

Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a

Ido Bachelet et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2006)

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Article Immunology

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast

I Bachelet et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Allergy

IL-9 and c-Kit+ mast cells in allergic rhinitis during seasonal allergen exposure:: Effect of immunotherapy

KT Nouri-Aria et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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Article Immunology

Thymic stromal lymphopoietin expression is increased in asthmatic airways and correlates with expression of TH2-attracting chemokines and disease severity

S Ying et al.

JOURNAL OF IMMUNOLOGY (2005)

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Article Dermatology

Mast cell tryptase and chymase in chronic leg ulcers: chymase is potentially destructive to epithelium and is controlled by proteinase inhibitors

M Huttunen et al.

BRITISH JOURNAL OF DERMATOLOGY (2005)

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Article Biochemistry & Molecular Biology

A chimeric human-cat fusion protein blocks cat-induced allergy

DC Zhu et al.

NATURE MEDICINE (2005)

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Article Allergy

An intranasal Syk-kinase inhibitor (R112) improves the symptoms of seasonal allergic rhinitis in a park environment

EO Meltzer et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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Article Allergy

Amphiregulin expression in human mast cells and its effect on the primary human lung fibroblasts

SW Wang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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Article Allergy

FcεRI-mediated amphiregulin production by human mast cells increases mucin gene expression in epithelial cells

S Okumura et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2005)

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Article Allergy

Omalizumab-induced reductions in mast cell FcεRI expression and function

LA Beck et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

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Article Allergy

Inhibition of allergen-specific IgE reactivity by a human Ig Fcγ-Fcε bifunctional fusion protein

K Zhang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

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Article Allergy

Activation of mast cells by double-stranded RNA: Evidence for activation through Toll-like receptor 3

M Kulka et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2004)

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Article Pharmacology & Pharmacy

Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells

CL Hofstra et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

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Article Critical Care Medicine

Vascular component of airway remodeling in asthma is reduced by high dose of fluticasone

A Chetta et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2003)

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Article Immunology

Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human FcεRI+ cells through interaction with the κ light chains of IgE

A Genovese et al.

JOURNAL OF IMMUNOLOGY (2003)

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Article Medicine, General & Internal

Mast-cell infiltration of airway smooth muscle in asthma

CE Brightling et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

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Article Biochemistry & Molecular Biology

A novel human immunoglobulin Fcγ-Fcε bifunctional fusion protein inhibits FcεRI-mediated degranulation

DC Zhu et al.

NATURE MEDICINE (2002)

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Article Cell Biology

Ultrastructural immunolocalization of basic fibroblast growth factor to lipid bodies and secretory granules in human mast cells

AM Dvorak et al.

HISTOCHEMICAL JOURNAL (2001)

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Article Immunology

A comparison of mediators released or generated by IFN-γ-treated human mast cells following aggregation of FcγRI or FcεRI

Y Okayama et al.

JOURNAL OF IMMUNOLOGY (2001)

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Article Immunology

Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors

M Triggiani et al.

JOURNAL OF IMMUNOLOGY (2001)

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Article Allergy

Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis

M Hoshino et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2001)

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Article Allergy

Identification of SAF-2, a novel siglec expressed on eosinophils, mast cells, and basophils

KK Kikly et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2000)

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Article Immunology

The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils

C Florio et al.

AIDS (2000)

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Article Immunology

Expression of a functional high-affinity IgG receptor, FcγRI, on human mast cells:: Up-regulation by IFN-γ

Y Okayama et al.

JOURNAL OF IMMUNOLOGY (2000)

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Article Immunology

HIV-1 gp120 induces IL-4 and IL-13 release from human FcεRI+ cells through interaction with the VH3 region of IgE

V Patella et al.

JOURNAL OF IMMUNOLOGY (2000)

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Article Immunology

Human intestinal mast cells are capable of producing different cytokine profiles: Role of IgE receptor cross-linking and IL-4

A Lorentz et al.

JOURNAL OF IMMUNOLOGY (2000)

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