☆ 4.7 Review

Macrophage-, Dendritic-, Smooth Muscle-, Endothelium-, and Stem Cells-Derived Foam Cells in Atherosclerosis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Cardiac & Cardiovascular Systems

Autophagy Is Differentially Regulated in Leukocyte and Nonleukocyte Foam Cells During Atherosclerosis

Sabrina Robichaud et al.

Summary: This study compared autophagy flux in lipid-rich aortic intimal populations to determine whether VSMC-derived foam cells metabolize LDs similarly to their macrophage counterparts. The findings indicate that VSMC and macrophage foam cells have distinct mechanisms of cholesterol efflux, with impaired autophagy flux in VSMC foam cells that can be induced by pharmacological means. Further research targeting autophagy specifically in VSMC foam cells is warranted to promote the resolution of atherosclerotic plaques.

CIRCULATION RESEARCH (2022)

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Review Pharmacology & Pharmacy

ABCA1 and ABCG1 as potential therapeutic targets for the prevention of atherosclerosis

Michinori Matsuo

Summary: Prevention of atherosclerosis is of great importance due to its association with cardiovascular diseases globally. Recent studies have highlighted the significance of ABCA1 and ABCG1 proteins in preventing the progression of atherosclerosis by enhancing cholesterol efflux activity and suppressing inflammation in cells. These proteins have the potential to serve as therapeutic targets for preventing atherosclerosis and other related diseases.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2022)

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Review Cardiac & Cardiovascular Systems

Lipid-Laden Macrophages and Inflammation in Atherosclerosis and Cancer: An Integrative View

Miriam Lee-Rueckert et al.

Summary: Macrophages play important roles in atherosclerosis and malignant tumors, showing phenotypic and functional plasticity in response to different microenvironments. In atherosclerosis, macrophages form foam cells, which have anti-atherogenic effects. In malignant tumors, macrophages can exhibit either anti-tumoral or pro-tumoral characteristics, but their specific roles are still poorly understood.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Review Cardiac & Cardiovascular Systems

Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms

Yuzhou Gui et al.

Summary: Foam cells play a vital role in atherosclerosis and are derived from multiple cell types. Novel technologies have improved our understanding of different subtypes of foam cells. Foam cells undergo various cell death pathways, affecting plaque formation. Cholesterol uptake, efflux, and esterification are crucial for foam cell formation.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2022)

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Review Medicine, Research & Experimental

Through the layers: how macrophages drive atherosclerosis across the vessel wall

Leah Susser et al.

Summary: Cardiovascular disease is the leading cause of death worldwide, with coronary artery disease being the most common underlying condition. CVDs are now recognized as chronic inflammatory conditions, with arterial blockages and atherosclerosis being key factors. Macrophages play a crucial role in the progression and regression of atherosclerosis.

JOURNAL OF CLINICAL INVESTIGATION (2022)

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Review Pharmacology & Pharmacy

LDL receptors, caveolae and cholesterol in endothelial dysfunction: oxLDLs accomplices or victims?

Francesca Luchetti et al.

Summary: Oxidized LDLs and oxysterols play a crucial role in endothelial dysfunction and atherosclerosis, with caveolae and caveolin-1 emerging as important targets and mediators in this process. Their involvement in lipid transcytosis and signalling pathways highlights the complex interplay that contributes to endothelial cell dysfunction induced by oxLDLs.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

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Article Developmental Biology

The polarized localization of lipoprotein receptors and cholesterol transporters in the syncytiotrophoblast of the placenta is reproducible in a monolayer of primary human trophoblasts

Barbara Fuenzalida et al.

Summary: This study demonstrates that polarized STB monolayers express LDLR, SR-BI, ABCA1, and ABCG1, with their localization resembling that in human placental tissue. Furthermore, ABCA1 and SR-BI are shown to participate in cholesterol efflux to the maternal side of the cells.

PLACENTA (2021)

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Article Cell Biology

CTRP9 alleviates foam cells apoptosis by enhancing cholesterol efflux

Shengyun Lei et al.

Summary: CTRP9 protects foam cells from apoptosis by regulating cholesterol efflux, inhibiting the Wnt3a/β-catenin pathway, and activating the AdipoR1/AMPK pathway.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2021)

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Review Nutrition & Dietetics

The Role of Obesity-Induced Perivascular Adipose Tissue (PVAT) Dysfunction in Vascular Homeostasis

Agata Stanek et al.

Summary: PVAT plays a significant role in regulating vascular tone, thermoregulation, and VSMC proliferation. Obesity-induced dysfunction can be improved by physical activity and diet interventions.

NUTRIENTS (2021)

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Editorial Material Chemistry, Multidisciplinary

Introduction: Transporters, Porins, and Efflux Pumps

Helen I. Zgurskaya

Summary: Biological membranes act as permeability barriers that regulate the transport of molecules between the inside and outside of cells. Insights into the structure and function of these membranes are crucial for the development of effective therapeutic interventions.

CHEMICAL REVIEWS (2021)

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Review Immunology

Foam Cell Macrophages in Tuberculosis

Pooja Agarwal et al.

Summary: Mycobacterium tuberculosis primarily infects macrophages in the lungs, forming granulomata. In response to TB, foam cell macrophages, filled with lipid droplets, are generated. Lipid droplets play an important role in Tuberculosis, with differences from atherosclerosis foam cells.

FRONTIERS IN IMMUNOLOGY (2021)

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Editorial Material Biochemistry & Molecular Biology

Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology

Evgeny E. Bezsonov et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Autophagy blockage promotes the pyroptosis of ox-LDL-treated macrophages by modulating the p62/Nrf2/ARE axis

Jiaru Liu et al.

Summary: In this study, ox-LDL was found to induce pyroptosis of THP-1 derived macrophages, with chloroquine regulating this process through impairing autophagy. Further investigation revealed a correlation between the p62/Nrf2/ARE axis and macrophage pyroptosis.

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Cell Biology

Necroptosis in Macrophage Foam Cells Promotes Fat Graft Fibrosis in Mice

Xihang Chen et al.

Summary: The study revealed that macrophage necroptosis plays a critical role in fat graft fibrosis after transplantation, with the necroptotic macrophages activating collagen synthesis in fibroblasts through a paracrine mechanism. Inhibition of necroptosis in macrophages could potentially prevent fibrosis in fat grafts.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biochemistry & Molecular Biology

Mitochondrial Dysfunction in Vascular Wall Cells and Its Role in Atherosclerosis

Diana Salnikova et al.

Summary: Altered mitochondrial function plays a crucial role in the initiation and progression of atherosclerosis, leading to changes in cellular metabolism, respiration, and increased production of reactive oxygen species. Mitochondrial dysfunction is associated with vascular disease and chronic inflammation, and targeted approaches to reduce oxidative stress and inflammation show promise in atherosclerosis treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Pharmacology & Pharmacy

Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies

Suowen Xu et al.

Summary: The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in maintaining multiorgan health and homeostasis. Dysfunction of the vascular endothelium is associated with various diseases and is implicated in severe coronavirus disease 2019. Therapeutic approaches targeting endothelial dysfunction may have potential for treatment of cardiovascular and many other diseases.

PHARMACOLOGICAL REVIEWS (2021)

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Article Medicine, Research & Experimental

Inhibition of miR-200b-3p alleviates lipid accumulation and promotes cholesterol efflux by targeting ABCA1 in macrophage-derived foam cells

Yu-Ting Wu et al.

Summary: The study demonstrated that overexpression of miR-200b-3p and downregulation of ABCA1 can promote lipid accumulation and inhibit cholesterol efflux, while inhibiting miR-200b-3p may alleviate these effects.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Recognition of Oxidized Lipids by Macrophages and Its Role in Atherosclerosis Development

Nataliya Mushenkova et al.

Summary: Atherosclerosis is a chronic disease with inflammatory components, now recognized as an active autoimmune process involving both innate and adaptive immune pathways. One of the key factors driving this process is the presence of modified LDL, which leads to the formation of oxidation-specific epitopes recognized by immune cells. Macrophage response to these epitopes is crucial for initiating and promoting inflammation in the arteries.

BIOMEDICINES (2021)

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Article Medicine, General & Internal

A case of premature and recurrent myocardial infarction associated with ABCA.1 gene mutation

K. Subramaniam et al.

Summary: Coronary heart disease is a significant cause of cardiovascular death in the community, particularly affecting the most productive population when occurring prematurely. Early onset CHD often has a specific etiology that, when diagnosed, can aid in secondary prevention for the individual.

JOURNAL OF POSTGRADUATE MEDICINE (2021)

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Review Biochemistry & Molecular Biology

Advances in HDL: Much More than Lipid Transporters

Soumaya Ben-Aicha et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Immunology

Lysophosphatidylcholine Induces NLRP3 Inflammasome-Mediated Foam Cell Formation and Pyroptosis in Human Monocytes and Endothelial Cells

Rafael Correa et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Biochemistry & Molecular Biology

Transport of LDLs into the arterial wall: impact in atherosclerosis

Xinbo Zhang et al.

CURRENT OPINION IN LIPIDOLOGY (2020)

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Review Biochemistry & Molecular Biology

Lipid Metabolism in Macrophages: Focus on Atherosclerosis

Vasily N. Sukhorukov et al.

BIOMEDICINES (2020)

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Review Cell Biology

Cholesterol Handling in Lysosomes and Beyond

Ying Meng et al.

TRENDS IN CELL BIOLOGY (2020)

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Editorial Material Immunology

Cancer metastasis linked to macrophage size, shape, and metabolism

Peter J. Murray

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

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Review Developmental Biology

Reciprocal interactions between mesenchymal stem cells and macrophages

Malgorzata Kloc et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2020)

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Review Hematology

Perivascular Adipose Tissue and Vascular Perturbation/Atherosclerosis

Ha Won Kim et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

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Review Biochemistry & Molecular Biology

Role of Ox-LDL and LOX-1 in Atherogenesis

Ajoe John Kattoor et al.

CURRENT MEDICINAL CHEMISTRY (2019)

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Review Pharmacology & Pharmacy

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

Eithne M. Maguire et al.

VASCULAR PHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis

Volha I. Summerhill et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Cell Biology

Dynamics and functions of lipid droplets

James A. Olzmann et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Immunology

Foam Cells: One Size Doesn't Fit All

Valentina Guerrini et al.

TRENDS IN IMMUNOLOGY (2019)

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Review Immunology

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Karen V. Swanson et al.

NATURE REVIEWS IMMUNOLOGY (2019)

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Review Physiology

SR-B1: A Unique Multifunctional Receptor for Cholesterol Influx and Efflux

Wen-Jun Shen et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

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Review Biochemistry & Molecular Biology

Lysosomal acid lipase and lipid metabolism: new mechanisms, new questions, and new therapies

Hanrui Zhang

CURRENT OPINION IN LIPIDOLOGY (2018)

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Article Biochemistry & Molecular Biology

Cholesterol transport system: An integrated cholesterol transport model involved in atherosclerosis

Xiao-Hua Yu et al.

PROGRESS IN LIPID RESEARCH (2018)

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Review Cardiac & Cardiovascular Systems

Endothelial Transcytosis of Lipoproteins in Atherosclerosis

Xinbo Zhang et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

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Article Biochemistry & Molecular Biology

NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis

Scott B. Widenmaier et al.

CELL (2017)

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Review Cell Biology

Macrophage-mediated cholesterol handling in atherosclerosis

Dimitry A. Chistiakov et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2016)

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Review Biochemistry & Molecular Biology

So Much Cholesterol: the unrecognized importance of smooth muscle cells in atherosclerotic foam cell formation

Joshua A. Dubland et al.

CURRENT OPINION IN LIPIDOLOGY (2016)

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Article Hematology

Dendritic Cells in Atherosclerosis Evidence in Mice and Humans

Alma Zernecke

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Editorial Material Hematology

Can a Vascular Smooth Muscle-Derived Foam-Cell Really Change its Spots?

Murray W. Huff et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Article Hematology

Cholesterol Loading Reprograms the MicroRNA-143/145-Myocardin Axis to Convert Aortic Smooth Muscle Cells to a Dysfunctional Macrophage-Like Phenotype

Yuliya Vengrenyuk et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Article Hematology

Monocyte-Derived Dendritic Cells Upregulate Extracellular Catabolism of Aggregated Low-Density Lipoprotein on Maturation, Leading to Foam Cell Formation

Abigail S. Haka et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2015)

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Review Immunology

Defining dendritic cells

Barbara U. Schraml et al.

CURRENT OPINION IN IMMUNOLOGY (2015)

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Article Biochemistry & Molecular Biology

K Domain CR9 of Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1) Is Critical for Aggregated LDL-induced Foam Cell Formation from Human Vascular Smooth Muscle Cells

Paula Costales et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

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Article Biochemistry & Molecular Biology

Human monocyte-derived dendritic cells turn into foamy dendritic cells with IL-17A

Giulia Salvatore et al.

JOURNAL OF LIPID RESEARCH (2015)

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Article Biochemistry & Molecular Biology

KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis

Laura S. Shankman et al.

NATURE MEDICINE (2015)

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Article Pharmacology & Pharmacy

Impact of Matrix Metalloproteinases on Atherosclerosis

Juntang Lin et al.

CURRENT DRUG TARGETS (2014)

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Review Medicine, General & Internal

Practical strategies for modulating foam cell formation and behavior

Elisabeth Uitz et al.

WORLD JOURNAL OF CLINICAL CASES (2014)

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Article Hematology

Adventitial Stem Cells in Vein Grafts Display Multilineage Potential That Contributes to Neointimal Formation

Yikuan Chen et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)

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Article Cardiac & Cardiovascular Systems

Distribution of macrophage polarization markers in human atherosclerosis

J. Lauran Stoger et al.

ATHEROSCLEROSIS (2012)

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Article Biochemistry & Molecular Biology

Cholesterol accumulation inhibits ER to Golgi transport and protein secretion: studies of apolipoprotein E and VSVGt

Maaike Kockx et al.

BIOCHEMICAL JOURNAL (2012)

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Article Pathology

Endothelial cell activation promotes foam cell formation by monocytes following transendothelial migration in an in vitro model

Clare L. V. Westhorpe et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2012)

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Article Cell & Tissue Engineering

Mesenchymal Stem Cells

Dah-Ching Ding et al.

CELL TRANSPLANTATION (2011)

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Article Cardiac & Cardiovascular Systems

Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPARγ and LXRα Pathways

Giulia Chinetti-Gbaguidi et al.

CIRCULATION RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Cytokines, macrophage lipid metabolism and foam cells: Implications for cardiovascular disease therapy

James E. McLaren et al.

PROGRESS IN LIPID RESEARCH (2011)

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Article Cardiac & Cardiovascular Systems

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

Kim E. Paulson et al.

CIRCULATION RESEARCH (2010)

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Article Biochemistry & Molecular Biology

Hyperlipidemia induces endothelial-derived foam cells in culture

Luminita Ivan et al.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION (2010)

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Review Medicine, Research & Experimental

Dendritic cells and their role in atherogenesis

Yuri V. Bobryshev

LABORATORY INVESTIGATION (2010)

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Article Hematology

Platelet Aggregates-Induced Human CD34+ Progenitor Cell Proliferation and Differentiation to Macrophages and Foam Cells Is Mediated by Stromal Cell Derived Factor 1 in Vitro

Konstantinos Stellos et al.

SEMINARS IN THROMBOSIS AND HEMOSTASIS (2010)

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Review Biochemistry & Molecular Biology

Mechanisms of Endocytosis

Gary J. Doherty et al.

ANNUAL REVIEW OF BIOCHEMISTRY (2009)

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Review Immunology

Immune and Inflammatory Mechanisms of Atherosclerosis

Elena Galkina et al.

ANNUAL REVIEW OF IMMUNOLOGY (2009)

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Article Cell Biology

Macrophages Create an Acidic Extracellular Hydrolytic Compartment to Digest Aggregated Lipoproteins

Abigail S. Haka et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

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Article Chemistry, Multidisciplinary

Lentiviral vector-mediated siRNA knockdown of SR-PSOX inhibits foam cell formation in vitro

Li Zhang et al.

ACTA PHARMACOLOGICA SINICA (2008)

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Review Hematology

CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden

Peng Liu et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)

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Article Cardiac & Cardiovascular Systems

Absence of CD36 protects against atherosclerosis in ApoE knock-out mice with no additional protection provided by absence of scavenger receptor A I/II

Sai Kuchibhotla et al.

CARDIOVASCULAR RESEARCH (2008)

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Review Immunology

Mesenchymal stem cells in health and disease

Antonio Uccelli et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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Article Biochemistry & Molecular Biology

Platelets induce differentiation of human CD34+ progenitor cells into foam cells and endothelial cells

Karin Daub et al.

FASEB JOURNAL (2006)

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Review Cardiac & Cardiovascular Systems

Mesenchymal stem cells and the artery wall

M Abedin et al.

CIRCULATION RESEARCH (2004)

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Article Multidisciplinary Sciences

Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading

JX Rong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Biochemistry & Molecular Biology

Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

VV Kunjathoor et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

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Article Biochemistry & Molecular Biology

ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein

N Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

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