☆ 4.7 Review

Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Review Pharmacology & Pharmacy

3D Printing: Applications in Tissue Engineering, Medical Devices, and Drug Delivery

B. G. Pavan Kalyan et al.

Summary: Three-dimensional (3D) printing, especially in the field of bioprinting, has become increasingly relevant in the pharmaceutical industry. It offers advantages such as rapid prototyping, flexible design, and environmental friendliness. This technology has found applications in various domains and shows great potential in drug development and manufacturing.

AAPS PHARMSCITECH (2022)

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Review Biochemistry & Molecular Biology

Application of 3D-Printed, PLGA-Based Scaffolds in Bone Tissue Engineering

Fengbo Sun et al.

Summary: This review systematically summarizes the research progress of 3D-printed, PLGA-based scaffolds, introduces the properties of the modified components, analyzes the influence of structure and printing method change in the printing process, illustrates the advantages and disadvantages of their applications with examples, and finally discusses the limitations and future development direction of current 3D-printed, PLGA-based materials for bone tissue repair.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

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Article Materials Science, Multidisciplinary

Novel degradable super-paramagnetic bone cement with self-controlled hyperthermia ability

Santuan Zhao et al.

Summary: This study reports a novel super-paramagnetic injectable radiopaque bone cement that can control hyperthermia temperature by itself. The cement shows good biocompatibility and mineralization ability, providing a new option for improving the thermal safety of magnetic hyperthermia treatment of bone tumors.

MATERIALS & DESIGN (2022)

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Review Pathology

Grading of invasive breast carcinoma: the way forward

C. van Dooijeweert et al.

Summary: Histologic grading is a simple and cost-effective method to assess tumor behavior in invasive breast cancer, with important prognostic value. Properly performed histologic grading is crucial for guiding treatment decisions in breast cancer patients.

VIRCHOWS ARCHIV (2022)

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Article Chemistry, Multidisciplinary

Magnetic Nanoparticles in Bone Tissue Engineering

Akshith Dasari et al.

Summary: Tissue engineering approaches offer the possibility to induce new functional bone regeneration by creating a regenerative niche at the site of damage. Magnetic nanoparticles, as a potential tool in bone tissue engineering, leverage the inherent magnetism to enhance the properties of osteoinduction, osteoconduction, and angiogenesis in scaffold design.

NANOMATERIALS (2022)

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Review Cell Biology

Bone Morphogenetic Protein Signaling in Cancer; Some Topics in the Recent 10 Years

Shogo Ehata et al.

Summary: Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) family, are multifunctional cytokines that play a dual role in cancer, acting as both tumor promoters and suppressors. They regulate cancer cell proliferation, malignant phenotypes, and angiogenesis in the tumor microenvironment.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2022)

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Article Engineering, Biomedical

Bifunctional scaffolds for tumor therapy and bone regeneration: Synergistic effect and interplay between therapeutic agents and scaffold materials

Jiongpeng Yuan et al.

Summary: This review summarizes the latest research progress in bifunctional scaffolds for therapeutic applications and regeneration, with a focus on the synergistic effect and interplay between therapeutic agents and scaffold materials.

MATERIALS TODAY BIO (2022)

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Article Orthopedics

Donor site morbidity in autologous bone grafting - A comparison between different techniques of anterior iliac crest bone harvesting: A prospective study

Gyneshwar Tonk et al.

Summary: This study compares the morbidities at the donor site in autologous bone harvesting using different techniques. The results show that the most common morbidities observed were pain, numbness, and abnormal gait. The table splitting technique had the lowest morbidity, making it a good option for bone harvesting.

JOURNAL OF ORTHOPAEDICS TRAUMA AND REHABILITATION (2022)

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Article Medicine, General & Internal

Custom-Made Implants in Ankle Bone Loss: A Retrospective Assessment of Reconstruction/Arthrodesis in Sequelae of Septic Non-Union of the Tibial Pilon

Silvio Caravelli et al.

Summary: 3D printing allows for customized implants based on patient anatomy, providing a new approach for treating segmental tibial and ankle bone loss. By combining high-performance antibiotic therapy and surgery, the use of custom-made tibial spacers can improve overall functionality and reduce pain in patients.

MEDICINA-LITHUANIA (2022)

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Review Engineering, Biomedical

Hydroxyapatite Nanoparticles for Improved Cancer Theranostics

Saeid Kargozar et al.

Summary: Hydroxyapatite nanoparticles (HAp NPs) have promising applications in cancer therapy. Their chemical structure allows for loading and delivering a wide range of anticancer drugs in a targeted manner, minimizing complications. Incorporating therapeutic elements into the basic composition of HAp NPs enhances their anticancer effects. HAp NPs can be transformed into smart anticancer agents through surface modifications for targeted killing of cancer cells.

JOURNAL OF FUNCTIONAL BIOMATERIALS (2022)

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Article Engineering, Biomedical

Construction of magnetic nanochains to achieve magnetic energy coupling in scaffold

Cijun Shuai et al.

Summary: In this study, magnetic nanochains were successfully synthesized by magnetic-field-guided interface co-assembly of Fe3O4 nanoparticles. The Fe3O4@SiO2 nanochains with unique core-shell structure exhibited orderly assembly of nanoparticles, resulting in magnetic energy coupling and a highly magnetic micro-field. In vitro tests showed that PLLA/Fe3O4@SiO2 scaffolds had superior capacity in enhancing cell activity, improving osteogenesis-related gene expressions, and inducing cell mineralization compared with other scaffolds.

BIOMATERIALS RESEARCH (2022)

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Review Biochemistry & Molecular Biology

Stem cell-based therapy for human diseases

Duc M. Hoang et al.

Summary: Recent advancements in stem cell technology have provided new treatment options for patients with untreatable diseases and disorders. Human pluripotent stem cells (hPSCs) and multipotent mesenchymal stem cells (MSCs) have emerged as important players in regenerative medicine. Clinical applications of hPSCs and MSCs derived from different tissues, such as bone marrow, adipose tissue, and umbilical cord, have shown promising results in treating neurological disorders, pulmonary dysfunctions, metabolic/endocrine-related diseases, reproductive disorders, skin burns, and cardiovascular conditions. The mechanisms underlying the therapeutic effects of these stem cells vary depending on their tissue origin.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Cell & Tissue Engineering

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Simona Bolamperti et al.

Summary: Bone remodeling is a continuous cellular process that replaces old and damaged bone with new bone on the same surface. Recent research has shown that all bone cells participate in bone remodeling by interacting with their progenitors, other cells, and bone matrix constituents at different differentiation stages.

BONE RESEARCH (2022)

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Article Oncology

Osteosarcoma

Bree R. Eaton et al.

Summary: Osteosarcoma requires complex multidisciplinary management, with standard treatment involving chemotherapy and surgical resection, and radiotherapy used primarily for cases that cannot be surgically removed or for cases of incomplete resection.

PEDIATRIC BLOOD & CANCER (2021)

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Review Engineering, Biomedical

Review on current limits and potentialities of technologies for biomedical ceramic scaffolds production

Ana Marques et al.

Summary: Osseointegration is defined as a stable and functional union between bone and a material's surface. Studies show that ceramic materials are strong competitors in bone tissue engineering, with ceramic scaffolds enhancing the osseointegration phenomenon. The manufacturing processes of ceramic scaffolds, such as 3D printing and selective laser sintering, affect the scaffold's geometric parameters and, subsequently, its mechanical properties.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2021)

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Article Biochemistry & Molecular Biology

Magnetically Responsive Polymeric Microparticles for the Triggered Delivery of a Complex Mixture of Human Placental Proteins

Olivia L. Lanier et al.

Summary: Researchers have developed a magnetically triggerable polymeric microparticle platform for on-demand release of complex human placental proteins, aiming to provide a more comprehensive regenerative response. The experiments demonstrate that the proteins retain function after being magnetically released.

MACROMOLECULAR BIOSCIENCE (2021)

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Article Chemistry, Multidisciplinary

Combinatorial Photothermal 3D-Printing Scaffold and Checkpoint Blockade Inhibits Growth/Metastasis of Breast Cancer to Bone and Accelerates Osteogenesis

Chao He et al.

Summary: A BG@NbSiR scaffold has been developed to effectively treat bone metastasis of breast cancer by activating immune response, suppressing metastases, preventing tumor relapses, and promoting osteogenesis. Single-cell sequencing has been used to identify critical factors responding to this scaffold-based therapy, providing insights into underlying therapeutic mechanisms.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Applied

Magnetic bioactive glasses/Cisplatin loaded-chitosan (CS)-grafted- poly (ε-caprolactone) nanofibers against bone cancer treatment

Zahra Amini et al.

Summary: Bioactive glasses and magnetic bioactive glasses doped with Cisplatin were incorporated into chitosan-grafted-poly(epsilon-caprolactone) nanofibers for controlled drug release, resulting in accelerated release at lower pH and higher temperature conditions. The optimal concentration for killing MG-63 osteosarcoma cells was found to be 100 μg/mL of nanofibers. Future research may focus on the application of these nanofibers as implantable devices for bone cancer therapy.

CARBOHYDRATE POLYMERS (2021)

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Article Pharmacology & Pharmacy

The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials

Xi Cheng et al.

Summary: The importance of optimized drug delivery systems for the treatment of cancer metastatic osteolysis was discussed in this review, introducing some novel nanotechnology and nanomaterials that offer new perspectives for scientists.

DRUG DELIVERY (2021)

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Review Biochemistry & Molecular Biology

Advances in Growth Factor Delivery for Bone Tissue Engineering

Erica Resende Oliveira et al.

Summary: Tissue engineering and regenerative medicine have addressed some shortcomings in the treatment of bone diseases, particularly in simulating the extracellular matrix and guiding bone repair. Combining scaffolding and growth factors shows great potential in promoting the effectiveness of bone regeneration methods.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Bone Biomarkers in Mucopolysaccharidoses

Akari Nakamura-Utsunomiya

Summary: The review discusses the impact of glycosaminoglycans accumulation in bone and cartilage on bone metabolism, as well as the pathophysiology of bone metabolism disorder mucopolysaccharidoses (MPS). It also emphasizes the importance of identifying bone and cartilage biomarkers for MPS patients.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Critical Care Medicine

Autologous bone graft: Is it still the gold standard? *

Andrew H. Schmidt

Summary: Bone grafting has a long history of successful clinical use, with autograft bone transplantation being the most common approach despite its associated complications. This article reviews the biology of fracture healing, the properties of bone grafts, and the specific advantages and problems of autograft bone. Recent techniques such as the Reamer Irrigator Aspirator have significantly reduced complications in bone autograft harvesting.

INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED (2021)

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Review Biochemistry & Molecular Biology

Microbial Polyhydroxyalkanoates Granules: An Approach Targeting Biopolymer for Medical Applications and Developing Bone Scaffolds

Moushmi Goswami et al.

Summary: Microbial polyhydroxyalkanoates (PHA) are proteinaceous storage granules ranging from 100 nm to 500 nm, produced by unique sources like Bacillus sp. These bioplastics can be enhanced by adding functional groups for industrial use, such as in nanocomposites with hydroxyapatite for improved mechanical and thermal properties. PHA can be utilized in various industries as nanofillers or drug carriers, and also for fabricating bone scaffolds using different strategies for bone regeneration.

MOLECULES (2021)

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Review Dentistry, Oral Surgery & Medicine

Advances in biomineralization-inspired materials for hard tissue repair

Shuxian Tang et al.

Summary: Biomineralization is the process of organisms forming mineralized tissues with excellent properties, providing inspiration for designing and constructing materials to repair hard tissues. Bioinspired materials can replicate mineral formation processes, including bone repair, dentin remineralization, and enamel remineralization, with advantages and limitations for future directions.

INTERNATIONAL JOURNAL OF ORAL SCIENCE (2021)

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Article Materials Science, Biomaterials

Bioprinting of Magnetically Deformable Scaffolds

Janina Spangenberg et al.

Summary: The study developed a new magnetic bioink for 3D bioprinting of scaffolds, enabling spatially defined distribution of magnetically inducible scaffold regions. The viscosity, printability, and magnetization strength of the ink were characterized and evaluated. The ink has been proven to be cytocompatible in indirect cell culture and bioplotting experiments.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Chemistry, Medicinal

New Progress in Improving the Delivery Methods of Bisphosphonates in the Treatment of Bone Tumors

Yu Zhong et al.

Summary: Bone tumors can be treated with bisphosphonates, but traditional administration may lead to adverse reactions, so novel methods are needed to improve their delivery. Positive progress has been made in targeting anti-tumors systems, but more studies are needed to verify their safety and effectiveness in the human body.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Oncology

Game of Bones: How Myeloma Manipulates Its Microenvironment

Tyler Moser-Katz et al.

Summary: Multiple myeloma is a clonal disease characterized by malignant plasma cells in the bone marrow that depend on the bone marrow microenvironment. There is currently no routine treatment for early stages of the disease, but recent therapeutic efforts have improved patient survival.

FRONTIERS IN ONCOLOGY (2021)

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Review Cell Biology

Mechanisms, Diagnosis and Treatment of Bone Metastases

Jozef Ban et al.

Summary: Bone and bone marrow are common metastatic sites of cancer, often associated with poor disease prognosis. Current therapeutic options for bone metastases are limited and mainly palliative. Further research into the molecular pathways of bone metastasis is needed to develop more successful treatments for improved patient outcomes.

CELLS (2021)

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Article Engineering, Biomedical

3D magnetic nanocomposite scaffolds enhanced the osteogenic capacities of rat bone mesenchymal stem cells in vitro and in a rat calvarial bone defect model by promoting cell adhesion

Liping Han et al.

Summary: The study demonstrated that 3D-printed scaffolds coated with IONPs exhibit enhanced proliferation and osteogenic properties of rat bone mesenchymal stem cells (rBMSCs) compared to untreated scaffolds, promoting cell adhesion and new bone formation. The improved outcomes were attributed to alterations in hydrophilicity, surface roughness, and chemical composition of the scaffolds.

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2021)

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Review Biochemistry & Molecular Biology

Poly Lactic Acid (PLA) Nanocomposites: Effect of Inorganic Nanoparticles Reinforcement on Its Performance and Food Packaging Applications

Mehrajfatema Zafar Mulla et al.

Summary: Poly lactic acid (PLA) is a compostable and recyclable sustainable alternative, with challenges in brittleness and delicacy that can be improved through nanoparticle reinforcement. PLA shows promising potential as a replacement for traditional petrochemical-based polymers in food packaging applications.

MOLECULES (2021)

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Review Polymer Science

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds

M. Sai Bhargava Reddy et al.

Summary: Tissue engineering and regenerative medicine aim to restore or replace damaged tissues and organs using information and technology from various fields. Careful selection of scaffold materials and development of components are essential to achieve this goal.

POLYMERS (2021)

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Article Engineering, Biomedical

Magnetic 3D scaffolds for tissue engineering applications: bioactive glass (45S5) coated with iron-loaded hydroxyapatite nanoparticles

Maria Laura Dittler et al.

Summary: The study shows that magnetic Fe-HA coated scaffolds based on iron-loaded hydroxyapatite nanoparticles displayed good biocompatibility in vitro, promoting hydroxyapatite formation and providing support for human MG-63 cells and mouse ST-2 cell line.

BIOMEDICAL MATERIALS (2021)

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Review Biochemistry & Molecular Biology

Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine

Jingqi Qi et al.

Summary: Bone tissue engineering (BTE) is a new cross-disciplinary science aimed at facilitating bone regeneration and growth through the combination of stem cells, scaffolds, and growth factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Physical

Silver Decorated βTCP-Poly(3hydroxybutyrate) Scaffolds for Bone Tissue Engineering

Joanna Czechowska et al.

Summary: Silver-coated beta tricalcium phosphate porous scaffolds were prepared in this study, showing promising performance for bone tissue regeneration in non-load bearing applications. Materials coated with the biopolymer P(3HB) exhibited higher compressive strength and surgical maneuverability, with the sintering temperature affecting the physicochemical properties of the scaffolds.

MATERIALS (2021)

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Article Polymer Science

Relationship between the Stereocomplex Crystallization Behavior and Mechanical Properties of PLLA/PDLA Blends

Hye-Seon Park et al.

Summary: Poly (l-lactic acid) (PLLA) is a promising biomedical polymer material with a wide range of applications. By blending PLLA with different amounts of poly (d-lactic acid) (PDLA) through a melt blending process, the study systematically investigated the effect of PDLA on the crystallization behavior, thermal, and mechanical properties of PLLA. The results showed that increasing PDLA content led to easier formation of stereocomplexes, increased crystallinity, and enhanced mechanical strength in the PLLA/PDLA blends.

POLYMERS (2021)

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Review Cell Biology

Macrophages in Acute Myeloid Leukaemia: Significant Players in Therapy Resistance and Patient Outcomes

Katerina E. Miari et al.

Summary: This review discusses the potential links between macrophages, the development of therapy resistance, and patient outcomes in AML. It specifically focuses on AML cell reprogramming of macrophages, macrophage-driven activation of anti-cell death pathways in AML cells, and the association between macrophage phenotypes and clinical outcomes in AML. The therapeutic targeting of macrophages to overcome therapy resistance in AML and the use of genomic and proteomic-based approaches to address challenges in this research field are also highlighted.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Engineering, Biomedical

Bioactive glasses and glass-ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives

S. S. Danewalia et al.

Summary: Bioactive glasses and glass-ceramics show promise in both bone-tissue engineering and hyperthermia treatment of cancer, with advantages in bonding to natural bone and sometimes soft tissues for regeneration of affected areas. Researchers are focusing on developing magnetic glass-ceramics with optimized characteristics for these applications, facing challenges in fast crystallization and magnetic phase control.

MATERIALS TODAY BIO (2021)

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Article Biochemistry & Molecular Biology

Silk fibroin promotes mineralization of gellan gum hydrogels

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Article Engineering, Biomedical

Orthogonal test design for the optimization of superparamagnetic chitosan plasmid gelatin microspheres that promote vascularization of artificial bone

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Review Engineering, Biomedical

Four-dimensional bioprinting: Current developments and applications in bone tissue engineering

Zhuqing Wan et al.

ACTA BIOMATERIALIA (2020)

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Article Oncology

Anti-PD-1 antibody decreases tumour-infiltrating regulatory T cells

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BMC CANCER (2020)

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Article Biochemistry & Molecular Biology

Electrospun poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)/silk fibroin film is a promising scaffold for bone tissue engineering

Shaik Ling Ang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

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Review Biotechnology & Applied Microbiology

Reconstruction of Large Skeletal Defects: Current Clinical Therapeutic Strategies and Future Directions Using 3D Printing

Luciano Vidal et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Multidisciplinary Sciences

3D Patterning of cells in Magnetic Scaffolds for Tissue Engineering

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SCIENTIFIC REPORTS (2020)

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Preparation and Application of Magnetic Responsive Materials in Bone Tissue Engineering

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CURRENT STEM CELL RESEARCH & THERAPY (2020)

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Review Engineering, Biomedical

Magnetic Nanoparticles in Cancer Therapy and Diagnosis

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Hierarchical porous Mg2SiO4-CoFe2O4 nanomagnetic scaffold for bone cancer therapy and regeneration: Surface modification and in vitro studies

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Materials Science, Biomaterials

Impact of the magnetic field on 3T3-E1 preosteoblasts inside SMART silk fibroin-based scaffolds decorated with magnetic nanoparticles

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Multidisciplinary Sciences

Biomaterial scaffold-based local drug delivery systems for cancer immunotherapy

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SCIENCE BULLETIN (2020)

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Article Multidisciplinary Sciences

Electrostatic self-assembly of pFe(3)O(4) nanoparticles on graphene oxide: A co-dispersed nanosystem reinforces PLLA scaffolds

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JOURNAL OF ADVANCED RESEARCH (2020)

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Article Biotechnology & Applied Microbiology

Ultrasmall Superparamagnetic Iron Oxide Labeled Silk Fibroin/Hydroxyapatite Multifunctional Scaffold Loaded With Bone Marrow-Derived Mesenchymal Stem Cells for Bone Regeneration

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Nanoscience & Nanotechnology

Elaboration of Superparamagnetic and Bioactive Multicore-Shell Nanoparticles (γ-Fe2O3@SiO2-CaO): A Promising Material for Bone Cancer Treatment

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ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Materials Science, Biomaterials

Effect of magnetite nanoparticles on the biological and mechanical properties of hydroxyapatite porous scaffolds coated with ibuprofen drug

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Polymer Science

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

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POLYMERS (2020)

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Review Endocrinology & Metabolism

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FRONTIERS IN ENDOCRINOLOGY (2020)

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Review Cell Biology

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CELLS (2020)

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Review Biotechnology & Applied Microbiology

Nanostructured Biomaterials for Bone Regeneration

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FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Hydrogels Loaded with Magnetically Responsive Microspheres as 2D and 3D Scaffolds

Estela O. Carvalho et al.

NANOMATERIALS (2020)

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Article Oncology

Prognostic Impact of Bone Metastasis on Survival Outcomes in Patients with Metastatic Renal Cell Carcinoma Treated by First Line Tyrosine Kinase Inhibitors: A Propensity-Score Matching Analysis

Minyong Kang et al.

JOURNAL OF CANCER (2020)

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Article Materials Science, Biomaterials

Magnetic lanthanum-doped hydroxyapatite/chitosan scaffolds with endogenous stem cell-recruiting and immunomodulatory properties for bone regeneration

Qiyang Wang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Review Immunology

RANKL biology: bone metabolism, the immune system, and beyond

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INFLAMMATION AND REGENERATION (2020)

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Article Orthopedics

Incidence, prevalence, and outcomes of systemic malignancy with bone metastases

Wenli Jiang et al.

JOURNAL OF ORTHOPAEDIC SURGERY (2020)

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Article Biophysics

Magnetic bioinspired micro/nanostructured composite scaffold for bone regeneration

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COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Biochemistry & Molecular Biology

Biopolymers - Calcium phosphates composites with inclusions of magnetic nanoparticles for bone tissue engineering

Florina D. Cojocaru et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Review Biotechnology & Applied Microbiology

Polylactic acid: synthesis and biomedical applications

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JOURNAL OF APPLIED MICROBIOLOGY (2019)

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Article Medicine, General & Internal

Magnetic Composite Scaffolds for Potential Applications in Radiochemotherapy of Malignant Bone Tumors

Florina Daniela Cojocaru et al.

MEDICINA-LITHUANIA (2019)

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Article Biochemistry & Molecular Biology

A novel magnetic bifunctional nanocomposite scaffold for photothermal therapy and tissue engineering

Samaneh Saber-Samandari et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Materials Science, Biomaterials

Osteogenesis effects of magnetic nanoparticles modified-porous scaffolds for the reconstruction of bone defect after bone tumor resection

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REGENERATIVE BIOMATERIALS (2019)

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Hydrogel-based magnetoelectric microenvironments for tissue stimulation

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COLLOIDS AND SURFACES B-BIOINTERFACES (2019)

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Article Biochemistry & Molecular Biology

A New Approach for the Fabrication of Cytocompatible PLLA-Magnetite Nanoparticle Composite Scaffolds

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Bioinspired Three-Dimensional Magnetoactive Scaffolds for Bone Tissue Engineering

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Carbon nanotube/iron oxide hybrid particles and their PCL-based 3D composites for potential bone regeneration

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3D Cytocompatible Composites of PCL/Magnetite

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MATERIALS (2019)

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Review Materials Science, Multidisciplinary

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Article Oncology

Osteoblasts are educated by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment

Alexus D. Kolb et al.

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Article Engineering, Biomedical

Preparation and characterization of 3D porous conductive scaffolds with magnetic resonance enhancement in tissue engineering

Jie Chen et al.

BIOMEDICAL MATERIALS (2019)

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Article Nanoscience & Nanotechnology

Fabrication and Biocompatibility of Core-Shell Structured Magnetic Fibrous Scaffold

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JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Article Nanoscience & Nanotechnology

Positive Effect of Magnetic-Conductive Bifunctional Fibrous Scaffolds on Guiding Double Electrical and Magnetic Stimulations to Pre-Osteoblasts

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JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2019)

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Permanently hydrophilic, piezoelectric PVDF nanofibrous scaffolds promoting unaided electromechanical stimulation on osteoblasts

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NANOSCALE (2019)

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Review Dentistry, Oral Surgery & Medicine

Bone metastasis: Interaction between cancer cells and bone microenvironment

Toru Hiraga

JOURNAL OF ORAL BIOSCIENCES (2019)

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Review Engineering, Biomedical

Bioactive calcium phosphate materials and applications in bone regeneration

Jiwoon Jeong et al.

BIOMATERIALS RESEARCH (2019)

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Article Engineering, Biomedical

Bone regeneration in a rabbit critical femoral defect by means of magnetic hydroxyapatite macroporous scaffolds

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS (2018)

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Article Engineering, Biomedical

Current Approaches to Bone Tissue Engineering: The Interface between Biology and Engineering

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ADVANCED HEALTHCARE MATERIALS (2018)

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Induction heating and in vitro cytotoxicity studies of MnZnFe2O4 nanoparticles for self-controlled magnetic particle hyperthermia

S. V. Jadhav et al.

JOURNAL OF ALLOYS AND COMPOUNDS (2018)

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Review Oncology

Osteosarcoma, Chondrosarcoma, and Chordoma

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JOURNAL OF CLINICAL ONCOLOGY (2018)

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Review Oncology

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JOURNAL OF HEMATOLOGY & ONCOLOGY (2018)

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Threshold heating temperature for magnetic hyperthermia: Controlling the heat exchange with the blocking temperature of magnetic nanoparticles

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Article Engineering, Biomedical

Diopside-magnetite; A novel nanocomposite for hyperthermia applications

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JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2018)

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Article Cell & Tissue Engineering

Enhanced bone regeneration and visual monitoring via superparamagnetic iron oxide nanoparticle scaffold in rats

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Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold

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MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2018)

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Magnetic nanoparticles modified-porous scaffolds for bone regeneration and photothermal therapy against tumors

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Review Oncology

Immunotherapy for osteosarcoma: Where do we go from here?

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Magnetic Mesoporous Calcium Sillicate/Chitosan Porous Scaffolds for Enhanced Bone Regeneration and Photothermal-Chemotherapy of Osteosarcoma

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SCIENTIFIC REPORTS (2018)

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Comparing morbidities of bone graft harvesting from the anterior iliac crest and proximal tibia: a retrospective study

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JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH (2018)

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The promoting effect on pre-osteoblast growth under electrical and magnetic double stimulation based on PEDOT/Fe3O4/PLGA magnetic-conductive bi-functional scaffolds

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Review Medical Laboratory Technology

The bone remodelling cycle

J. S. Kenkre et al.

ANNALS OF CLINICAL BIOCHEMISTRY (2018)

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3D-printed bioceramic scaffolds: From bone tissue engineering to tumor therapy

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ACTA BIOMATERIALIA (2018)

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Current state of fabrication technologies and materials for bone tissue engineering

Abiy Wubneh et al.

ACTA BIOMATERIALIA (2018)

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Review Engineering, Biomedical

Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration

Yang Xia et al.

BIOMATERIALS (2018)

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Roles of the immune system in cancer: from tumor initiation to metastatic progression

Hugo Gonzalez et al.

GENES & DEVELOPMENT (2018)

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Magnetic iron oxide nanoparticles accelerate osteogenic differentiation of mesenchymal stem cells via modulation of long noncoding RNA INZEB2

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NANO RESEARCH (2017)

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Review Biochemistry & Molecular Biology

Bone Niches, Hematopoietic Stem Cells, and Vessel Formation

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Article Biotechnology & Applied Microbiology

Magnetic silk fibroin e-gel scaffolds for bone tissue engineering applications

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Article Engineering, Biomedical

Mechanical response of 3D Insert® PCL to compression

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JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2017)

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Article Engineering, Biomedical

Synergistic structures from magnetic freeze casting with surface magnetized alumina particles and platelets

Michael B. Frank et al.

JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS (2017)

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Multifunctional magnetic nanostructured hardystonite scaffold for hyperthermia, drug delivery and tissue engineering applications

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Stiff, porous scaffolds from magnetized alumina particles aligned by magnetic freeze casting

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MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Super-paramagnetic responsive silk fibroin/chitosan/magnetite scaffolds with tunable pore structures for bone tissue engineering applications

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Scaffolds for Bone Tissue Engineering: State of the art and new perspectives

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MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2017)

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Review Cell & Tissue Engineering

Biomimetic Approaches for Bone Tissue Engineering

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TISSUE ENGINEERING PART B-REVIEWS (2017)

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Osteogenic differentiation of bone marrow mesenchymal stem cells by magnetic nanoparticle composite scaffolds under a pulsed electromagnetic field

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SAUDI PHARMACEUTICAL JOURNAL (2017)

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Review Materials Science, Biomaterials

3D printed porous ceramic scaffolds for bone tissue engineering: a review

Yu Wen et al.

BIOMATERIALS SCIENCE (2017)

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Bone grafts and biomaterials substitutes for bone defect repair: A review

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BIOACTIVE MATERIALS (2017)

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Nanoparticles for Bone Tissue Engineering

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BIOTECHNOLOGY PROGRESS (2017)

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Engineering growth factors for regenerative medicine applications

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ACTA BIOMATERIALIA (2016)

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Magnetic nanocomposite scaffolds combined with static magnetic field in the stimulation of osteoblastic differentiation and bone formation

Hyung-Mun Yun et al.

BIOMATERIALS (2016)

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Response of MAPK pathway to iron oxide nanoparticles in vitro treatment promotes osteogenic differentiation of hBMSCs

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BIOMATERIALS (2016)

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Proving the suitability of magnetoelectric stimuli for tissue engineering applications

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COLLOIDS AND SURFACES B-BIOINTERFACES (2016)

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Article Dentistry, Oral Surgery & Medicine

Magnetic nanofiber scaffold-induced stimulation of odontogenesis and pro-angiogenesis of human dental pulp cells through Wnt/MAPK/NF-κB pathways

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The effect of low static magnetic field on osteogenic and adipogenic differentiation potential of human adipose stromal/stem cells

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JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS (2016)

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Magnetic forces and magnetized biomaterials provide dynamic flux information during bone regeneration

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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2016)

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Spherical porous hydroxyapatite granules containing composites of magnetic and hydroxyapatite nanoparticles for the hyperthermia treatment of bone tumor

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P(3HB) Based Magnetic Nanocomposites: Smart Materials for Bone Tissue Engineering

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Physiological Bone Remodeling: Systemic Regulation and Growth Factor Involvement

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PHYSIOLOGY (2016)

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Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering

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SMALL (2016)

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Superparamagnetic iron-doped nanocrystalline apatite as a delivery system for doxorubicin

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Article Materials Science, Biomaterials

3D-printed bioceramic scaffolds with a Fe3O4/graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells

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JOURNAL OF MATERIALS CHEMISTRY B (2016)

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Proceedings Paper Engineering, Biomedical

Viscoelastic properties of rapid prototyped magnetic nanocomposite scaffolds for osteochondral tissue regeneration

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SECOND CIRP CONFERENCE ON BIOMANUFACTURING (2016)

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Multilayered Magnetic Gelatin Membrane Scaffolds

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ACS APPLIED MATERIALS & INTERFACES (2015)

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Biomimetic Magnetic Silk Scaffolds

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ACS APPLIED MATERIALS & INTERFACES (2015)

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In situ preparation of iron oxide nanoparticles in natural hydroxyapatite/chitosan matrix for bone tissue engineering application

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CERAMICS INTERNATIONAL (2015)

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Review Nanoscience & Nanotechnology

Nanotechnology in bone tissue engineering

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2015)

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Review Cell & Tissue Engineering

The translation of cell-based therapies: clinical landscape and manufacturing challenges

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REGENERATIVE MEDICINE (2015)

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Review Biotechnology & Applied Microbiology

Harnessing magnetic-mechano actuation in regenerative medicine and tissue engineering

Livia J. Santos et al.

TRENDS IN BIOTECHNOLOGY (2015)

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Review Pharmacology & Pharmacy

New therapeutic targets for cancer bone metastasis

Jing Y. Krzeszinski et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2015)

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Acceleration of bone-defect repair by using A-W MGC loaded with BMP2 and triple point-mutant HIF1α-expressing BMSCs

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Combination immunotherapy with α-CTLA-4 and α-PD-L1 antibody blockade prevents immune escape and leads to complete control of metastatic osteosarcoma

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JOURNAL FOR IMMUNOTHERAPY OF CANCER (2015)

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Article Nanoscience & Nanotechnology

Magnetic Bioinspired Hybrid Nanostructured Collagen-Hydroxyapatite Scaffolds Supporting Cell Proliferation and Tuning Regenerative Process

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Article Engineering, Biomedical

Platelet-derived growth-factor-releasing aligned collagen-nanoparticle fibers promote the proliferation and tenogenic differentiation of adipose-derived stem cells

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ACTA BIOMATERIALIA (2014)

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Article Engineering, Biomedical

Effect of nano-structured bioceramic surface on osteogenic differentiation of adipose derived stem cells

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BIOMATERIALS (2014)

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Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers

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CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2014)

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Review Genetics & Heredity

Function of matrix IGF-1 in coupling bone resorption and formation

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JOURNAL OF MOLECULAR MEDICINE-JMM (2014)

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Article Nanoscience & Nanotechnology

Control of smooth muscle alpha-actin (SMA) up-regulation in HBMSCs using remote magnetic particle mechano-activation

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NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2014)

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Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

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NATURE CELL BIOLOGY (2014)

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Potential of Magnetic Nanofiber Scaffolds with Mechanical and Biological Properties Applicable for Bone Regeneration

Rajendra K. Singh et al.

PLOS ONE (2014)

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Bone Environment is Essential for Osteosarcoma Development from Transformed Mesenchymal Stem Cells

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STEM CELLS (2014)

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Magnetic scaffolds of polycaprolactone with functionalized magnetite nanoparticles: physicochemical, mechanical, and biological properties effective for bone regeneration

Jung-Ju Kim et al.

RSC ADVANCES (2014)

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Article Chemistry, Multidisciplinary

Hybrid magnetic scaffolds of gelatin-siloxane incorporated with magnetite nanoparticles effective for bone tissue engineering

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RSC ADVANCES (2014)

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Osteogenesis of Mesenchymal Stem Cells by Nanoscale Mechanotransduction

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Modifying bone scaffold architecture in vivo with permanent magnets to facilitate fixation of magnetic scaffolds

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BONE (2013)

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Article Oncology

Cancer Stem-like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production

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CANCER RESEARCH (2013)

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Review Pharmacology & Pharmacy

Composite polymer-bioceramic scaffolds with drug delivery capability for bone tissue engineering

Viviana Mourino et al.

EXPERT OPINION ON DRUG DELIVERY (2013)

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Article Biochemistry & Molecular Biology

Receptor-Targeted, Magneto-Mechanical Stimulation of Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Bin Hu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)

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Review Physics, Condensed Matter

Thermoseeds for interstitial magnetic hyperthermia: from bioceramics to nanoparticles

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JOURNAL OF PHYSICS-CONDENSED MATTER (2013)

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Article Multidisciplinary Sciences

Magnetic poly(ε-caprolactone)/iron-doped hydroxyapatite nanocomposite substrates for advanced bone tissue engineering

A. Gloria et al.

JOURNAL OF THE ROYAL SOCIETY INTERFACE (2013)

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Review Pharmacology & Pharmacy

Cancer stem cells and their role in metastasis

Yusuke Shiozawa et al.

PHARMACOLOGY & THERAPEUTICS (2013)

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In vitro and in vivo evaluation of electrospun PCL/PMMA fibrous scaffolds for bone regeneration

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SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS (2013)

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Article Engineering, Biomedical

Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite

Anna Tampieri et al.

ACTA BIOMATERIALIA (2012)

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Review Cell & Tissue Engineering

Cancer Stem Cells: Current Status and Evolving Complexities

Jane E. Visvader et al.

CELL STEM CELL (2012)

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Article Pharmacology & Pharmacy

Synthesis, characterization and in vitro assessment of the magnetic chitosan-carboxymethylcellulose biocomposite interactions with the prokaryotic and eukaryotic cells

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INTERNATIONAL JOURNAL OF PHARMACEUTICS (2012)

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Article Oncology

Disseminated Prostate Cancer Cells Can Instruct Hematopoietic Stem and Progenitor Cells to Regulate Bone Phenotype

Jeena Joseph et al.

MOLECULAR CANCER RESEARCH (2012)

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Review Biotechnology & Applied Microbiology

Magnetic nanoparticle-based approaches to locally target therapy and enhance tissue regeneration in vivo

Richard Sensenig et al.

NANOMEDICINE (2012)

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Article Multidisciplinary Sciences

Magnetic Hydroxyapatite Bone Substitutes to Enhance Tissue Regeneration: Evaluation In Vitro Using Osteoblast-Like Cells and In Vivo in a Bone Defect

Silvia Panseri et al.

PLOS ONE (2012)

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Review Cell & Tissue Engineering

The Use of Micro- and Nanospheres as Functional Components for Bone Tissue Regeneration

Huanan Wang et al.

TISSUE ENGINEERING PART B-REVIEWS (2012)

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Article Cell & Tissue Engineering

Vascularized Bone Tissue Engineering: Approaches for Potential Improvement

Lonnissa H. Nguyen et al.

TISSUE ENGINEERING PART B-REVIEWS (2012)

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Review Oncology

Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior

Anne Kallioniemi

CANCER GENETICS (2012)

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Article Chemistry, Multidisciplinary

Superparamagnetic nano-composite scaffolds for promoting bone cell proliferation and defect reparation without a magnetic field

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RSC ADVANCES (2012)

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Article Engineering, Biomedical

Multifunctional magnetic mesoporous bioactive glass scaffolds with a hierarchical pore structure

Chengtie Wu et al.

ACTA BIOMATERIALIA (2011)

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Article Engineering, Biomedical

Magnetic biodegradable Fe3O4/CS/PVA nanofibrous membranes for bone regeneration

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BIOMEDICAL MATERIALS (2011)

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Review Oncology

A novel hyperthermia treatment for bone metastases using magnetic materials

Akihiko Matsumine et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2011)

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Article Engineering, Biomedical

A novel route in bone tissue engineering: Magnetic biomimetic scaffolds

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ACTA BIOMATERIALIA (2010)

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Article Engineering, Biomedical

A novel calcium phosphate ceramic-magnetic nanoparticle composite as a potential bone substitute

Yao Wu et al.

BIOMEDICAL MATERIALS (2010)

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Review Dentistry, Oral Surgery & Medicine

Aging and Bone

A. L. Boskey et al.

JOURNAL OF DENTAL RESEARCH (2010)

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Article Engineering, Biomedical

The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles

Dong-Ming Huang et al.

BIOMATERIALS (2009)

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Article Engineering, Biomedical

pH- and temperature-sensitive polymeric microspheres for drug delivery: the dissolution of copolymers modulates drug release

Gheorghe Fundueanu et al.

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE (2009)

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Article Cell Biology

BMP4 induces an epithelial-mesenchymal transition-like response in adult airway epithelial cells

Emer L. Molloy et al.

GROWTH FACTORS (2008)

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Article Biotechnology & Applied Microbiology

Magnetic force-based cell patterning using Arg-Gly-Asp (RGD) peptide-conjugated magnetite cationic Liposomes

Akira Ito et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2007)

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Article Cell Biology

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

XY Wang et al.

JOURNAL OF CELL BIOLOGY (2006)

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Review Biochemistry & Molecular Biology

Crosstalk between cancer cells and bone microenvironment in bone metastasis

T Yoneda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Multidisciplinary Sciences

Involvement of chemokine receptors in breast cancer metastasis

A Müller et al.

NATURE (2001)

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