Probing Interleukin-6 in Stroke Pathology and Neural Stem Cell Transplantation

Stem cell transplantation is historically understood as a powerful preclinical therapeutic following stroke models. Current clinical strategies including clot busting/retrieval are limited by their time windows (tissue plasminogen activator: 3-4 h) and inevitable reperfusion injuries. However, 24+ h post-stroke, stem cells reduce infarction size, improve neurobehavioral performance, and reduce inflammatory agents including interleukins. Typically, interleukin-6 (IL-6) is regarded as proinflammatory, and thus, preclinical studies often discuss it as beneficial for neurological recuperation when stem cells reduce IL-6 ' s expression. However, some studies have also demonstrated neurological benefit with upregulation of IL-6 or preconditioning of stem cells with IL-6. This review specifically focuses on stem cells and IL-6, and their occasionally disparate, occasionally synergistic roles in the setting of ischemic cerebrovascular insults.

Automated summary

Stem cell transplantation has potential in stroke treatment, reducing infarction size and improving neurobehavioral performance. Interleukin-6 (IL-6), typically considered proinflammatory, can also have beneficial effects on the nervous system when upregulated or when stem cells are preconditioned.