期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 23, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/ijms232315222
关键词
pteridines; photonics; computational chemistry; photosensitization; coenzymes
This review focuses on the quantum chemistry and photonics of pterins, providing a comprehensive overview of their electronic structure and potential applications in biomedicine. The study suggests that UV irradiation of pterins can affect enzymatic reactions and that the emission properties of pterins can be used in fluorescence diagnostics. The use of two-photon absorption and metal nanostructures is also proposed for pterin-related infrared therapy and spectroscopy detection of biomarkers.
Pterins are an inseparable part of living organisms. Pterins participate in metabolic reactions mostly as tetrahydropterins. Dihydropterins are usually intermediates of these reactions, whereas oxidized pterins can be biomarkers of diseases. In this review, we analyze the available data on the quantum chemistry of unconjugated pterins as well as their photonics. This gives a comprehensive overview about the electronic structure of pterins and offers some benefits for biomedicine applications: (1) one can affect the enzymatic reactions of aromatic amino acid hydroxylases, NO synthases, and alkylglycerol monooxygenase through UV irradiation of H(4)pterins since UV provokes electron donor reactions of H(4)pterins; (2) the emission properties of H(2)pterins and oxidized pterins can be used in fluorescence diagnostics; (3) two-photon absorption (TPA) should be used in such pterin-related infrared therapy because single-photon absorption in the UV range is inefficient and scatters in vivo; (4) one can affect pathogen organisms through TPA excitation of H(4)pterin cofactors, such as the molybdenum cofactor, leading to its detachment from proteins and subsequent oxidation; (5) metal nanostructures can be used for the UV-vis, fluorescence, and Raman spectroscopy detection of pterin biomarkers. Therefore, we investigated both the biochemistry and physical chemistry of pterins and suggested some potential prospects for pterin-related biomedicine.
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