On the magnetic nanoparticle injection strategy for hyperthermia treatment

We developed a dedicated computational framework by coupling the lattice-Boltzmann-method (LBM) model-ing and the particle-swarm-optimization (PSO) algorithm to search optimal strategies of magnetic nanoparticle (MNP) injection for hyperthermia-based cancer treatment. Two simplified tumor models were considered: a circular model representing geometrically regular tumors and an elliptic model representing geometrically irregular tumors, both sharing the same area. The temperature distribution in the tumor and its surrounding healthy tissue was predicted by solving the Pennes' bio-heat transfer equation (PBHTE). Both single-and multi -site injection strategies were explored. The results suggest that the multi-site injection strategies generally work well, while the single-site injection strategy fails even on the simplest circular tumor model. The more the injection sites, the better the performance. In particular, when the number of injection sites reaches eight, all temperature requirements can be nearly 100% satisfied in both tumor models. Whether or not including the minimum dose requirement in the objective function only affects the optimization results by less than 2%. The thermal dose was also assessed by considering both temperature and heat exposure time. It was found that the optimal multi-site injection strategies perform reasonably well for both tumor models. Although the setting is only two dimensional and the optimization is on very simplified tumor models, the framework adopted in this present study works well and can provide useful insights into magnetic hyperthermia treatment.

Automated summary

In this study, a computational framework combining the lattice-Boltzmann method (LBM) and the particle-swarm optimization (PSO) algorithm was developed to find optimal strategies for magnetic nanoparticle (MNP) injection in hyperthermia-based cancer treatment. The results showed that multi-site injection strategies performed better than single-site injection strategies, and the more injection sites, the better the performance. The assessment of thermal dose considering both temperature and heat exposure time also indicated that the optimal multi-site injection strategies worked well for both tumor models.