4.5 Article

Efficacy of chemotherapy according to BRCA status in patients with high-grade serous ovarian carcinoma at first platinum-sensitive relapse

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Homologous recombination deficiency (HRD) signature-3 in ovarian and uterine carcinosarcomas correlates with preclinical sensitivity to Olaparib, a poly (adenosine diphosphate [ADP]- ribose) polymerase (PARP) inhibitor

Joan R. Tymon-Rosario et al.

Summary: The study found that ovarian and uterine carcinosarcoma with HRD signature were more sensitive to olaparib. The experiments showed that olaparib inhibited the growth of carcinosarcoma cells by blocking the cell cycle and inducing apoptosis. In the xenograft experiment, olaparib significantly suppressed the growth of HRD carcinosarcoma and improved overall survival.

GYNECOLOGIC ONCOLOGY (2022)

Article Medicine, General & Internal

Randomized Trial of Cytoreductive Surgery for Relapsed Ovarian Cancer

P. Harter et al.

Summary: The study demonstrates that in patients with recurrent ovarian cancer, secondary cytoreductive surgery followed by chemotherapy results in longer overall survival compared to chemotherapy alone. Quality of life measures did not differ significantly between the two treatment groups.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Oncology

Secondary cytoreduction followed by chemotherapy versus chemotherapy alone in platinum-sensitive relapsed ovarian cancer (SOC-1): a multicentre, open-label, randomised, phase 3 trial

Tingyan Shi et al.

Summary: In patients with platinum-sensitive relapsed ovarian cancer, secondary cytoreduction followed by chemotherapy significantly prolongs progression-free survival compared to chemotherapy alone. Patients should be informed about the option of secondary cytoreduction in specialized centers.

LANCET ONCOLOGY (2021)

Article Oncology

Atezolizumab, Bevacizumab, and Chemotherapy for Newly Diagnosed Stage III or IV Ovarian Cancer: Placebo-Controlled Randomized Phase III Trial (IMagyn050/GOG 3015/ENGOT-OV39)

Kathleen N. Moore et al.

Summary: The study evaluated the addition of the humanized monoclonal antiprogrammed death ligand-1 (PD-L1) antibody atezolizumab to platinum-based chemotherapy and bevacizumab in newly diagnosed stage III or IV ovarian cancer, showing a significant progression-free survival advantage in the PD-L1-positive population. However, no significant overall survival benefit was observed from atezolizumab in the interim analysis. The most common grade 3 or 4 adverse events were neutropenia, hypertension, and anemia.

JOURNAL OF CLINICAL ONCOLOGY (2021)

Article Oncology

Clinicopathological characterization of a real-world multicenter cohort of endometrioid ovarian carcinoma: Analysis of the French national ESME-Unicancer database

Alexandre De Nonneville et al.

Summary: Endometrioid and serous EOC patients exhibit differences in clinical, pathological, and biological features. Endometrioid histology serves as an independent prognostic factor in EOC.

GYNECOLOGIC ONCOLOGY (2021)

Article Oncology

A phase III, randomized, double blinded trial of platinum based chemotherapy with or without atezolizumab followed by niraparib maintenance with or without atezolizumab in patients with recurrent ovarian, tubal, or peritoneal cancer and platinum treatment free interval of more than 6 months: ENGOT-Ov41/GEICO 69-O/ANITA Trial

Antonio Gonzalez Martin et al.

Summary: Platinum-based chemotherapy is the preferred treatment for ovarian cancer patients with a platinum-free interval of more than 6 months. Niraparib and atezolizumab have shown promising activity in preclinical models and have been approved for maintenance therapy in certain ovarian cancer patients. The ANITA trial aims to evaluate the addition of atezolizumab to carboplatin-based chemotherapy followed by maintenance niraparib in recurrent ovarian cancer patients with a platinum-free interval of more than 6 months.

INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER (2021)

Review Oncology

Targeting Topoisomerase I in the Era of Precision Medicine

Anish Thomas et al.

CLINICAL CANCER RESEARCH (2019)

Article Medicine, General & Internal

Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer

I. Ray-Coquard et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Biochemistry & Molecular Biology

Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial

Andrew Tutt et al.

NATURE MEDICINE (2018)

Article Medicine, General & Internal

Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer

M. R. Mirza et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Medicine, General & Internal

Association Between BRCA1 and BRCA2 Mutations and Survival in Women With Invasive Epithelial Ovarian Cancer

Kelly L. Bolton et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

Article Multidisciplinary Sciences

Integrated genomic analyses of ovarian carcinoma

D. Bell et al.

NATURE (2011)