Study on antioxidant activity of wheat bran extract microcapsules in vitro and in vivo

Wheat bran extracts (WBE, mainly composed of feruloyl oligosaccharides (FOs)) have been approved by FDA in GRAS Notice. WBE was utilised in octenyl succinate anhydride-modified starch (OSA-starch)-based microcapsules as wall materials to protect beta-carotene (BC) from oxygen. The storage retention and antioxidant indexes in vivo and in vitro of microcapsules were determined. The results showed that these characteristics were positively related to the proportion of WBE in the wall material. The in vivo antioxidant indexes in mouse serum and liver were positively regulated at gavage dose around content in wheat grain (normal dose), while at a higher dosage, the in vivo free oxidative stress fell into disorder. The results indicated that WBE was a good component of wall material, which can improve the antioxidant environment during both storage and consumption. This experiment provides a theoretical basis for the industrial application of WBE in the field of microcapsules.

Automated summary

Wheat bran extracts (WBE), consisting primarily of feruloyl oligosaccharides (FOs), have been approved by the FDA for use in microcapsules made with octenyl succinate anhydride-modified starch (OSA-starch) as a protective wall material for beta-carotene (BC) against oxidation. The retention and antioxidant properties of the microcapsules were studied in vivo and in vitro, and it was found that these characteristics were dependent on the amount of WBE in the wall material. In mouse serum and liver, the in vivo antioxidant properties were regulated positively at a dosage similar to that found in wheat grain, but became imbalanced at higher dosages. These findings demonstrate that WBE is a beneficial component for improving the antioxidant environment during storage and consumption, providing a theoretical basis for its industrial application in microcapsules.