Serum Fat-Soluble Vitamin Levels of 6,082 Minors in Zhuzhou City

Objective. To explore the nutritional status of serum fat-soluble vitamins such as vitamin A, 25-hydroxyvitamin D, and vitamin E of minors in the Zhuzhou area to provide a scientific basis for clinical guidance to supplement fat-soluble vitamins reasonably. Method. A total of 6,082 minors who underwent physical examination from January 2017 to February 2019 in the Children's Health Department of Zhuzhou Hospital affiliated with XiangYa School of Medicine of Central South University were selected as the subjects to measure the levels of serum fat-soluble vitamins A, D, and E. Results. (1) Their average levels of serum vitamin A, 25-hydroxyvitamin D, and vitamin E were (0.34 +/- 0.08) mg/mL, (34.65 +/- 10.24) ng/mL, and (10.11 +/- 2.65) mg/mL, respectively. (2) Serum vitamin E showed a gender difference (P < 0.001). (3) The average levels of serum 25-hydroxyvitamin D and vitamin E in infancy, early childhood, preschool age, school age, and adolescence decreased gradually (P < 0.05). In contrast, the average level of serum vitamin A ranged between 0.32 mg/mL and 0.37 mg/mL. (4) The age was negatively correlated with serum 25-hydroxyvitamin D (r = -0.517, P < 0.001) and weakly negatively correlated with vitamin E (r = -0.366, P < 0.001), but weakly positively correlated with vitamin A (r = 0.269, P < 0.001). Conclusion. Minors from infancy to adolescence in Zhuzhou should strengthen their supplementation of fat-soluble vitamins.

Automated summary

This study investigated the nutritional status of fat-soluble vitamins (vitamin A, 25-hydroxyvitamin D, and vitamin E) in the serum of minors in the Zhuzhou area. It was found that children and adolescents should strengthen their supplementation of fat-soluble vitamins.