4.4 Article

Epstein Barr Virus Reactivation during COVID-19 Hospitalization Significantly Increased Mortality/Death in SARS-CoV-2(+)/EBV(+) than SARS-CoV-2(+)/EBV(-) Patients: A Comparative Meta-Analysis

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Critical Care Medicine

Reactivation of EBV and CMV in Severe COVID-19-Epiphenomena or Trigger of Hyperinflammation in Need of Treatment? A Large Case Series of Critically ill Patients

Jan-Hendrik Naendrup et al.

Summary: In this study, reactivation of EBV and CMV in critically ill patients with severe COVID-19 was common, especially in those receiving corticosteroid treatment. The impact of these reactivations on patient outcomes and the potential benefits of targeted treatments remain uncertain, warranting further investigation. However, early initiation of treatment showed a decrease in viral load, suggesting a potential benefit for patients with EBV and CMV reactivations.

JOURNAL OF INTENSIVE CARE MEDICINE (2022)

Article Immunology

COVID-19 associated EBV reactivation and effects of ganciclovir treatment

Mei Meng et al.

Summary: A high proportion of COVID-19 patients had EBV reactivation, which may be associated with an increased risk of death. Ganciclovir treatment may improve the survival rate of COVID-19 patients.

IMMUNITY INFLAMMATION AND DISEASE (2022)

Review Infectious Diseases

Baricitinib for the Management of SARS-CoV-2-Infected Patients: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Sivananthan Manoharan et al.

Summary: Baricitinib significantly reduces mortality and disease progression in COVID-19 patients, but the data are inconsistent.

CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY (2022)

Review Cardiac & Cardiovascular Systems

Does baricitinib reduce mortality and disease progression in SARS-CoV-2 virus infected patients? A systematic review and meta analysis

Sivananthan Manoharan et al.

Summary: The current meta-analyses showed that baricitinib significantly reduced mortality rate and disease progression in COVID-19 patients. Both randomized control trials and non-randomized control trials demonstrated positive outcomes.

RESPIRATORY MEDICINE (2022)

Article Rheumatology

Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: an observational cohort study

Jose Luis Rodriguez-Garcia et al.

Summary: In patients with moderate to severe SARS-CoV-2 pneumonia, a combination of baricitinib with corticosteroids showed greater improvement in pulmonary function compared to corticosteroids alone. The use of baricitinib may block viral entry and prevent cytokine storm, leading to better outcomes in these patients.

RHEUMATOLOGY (2021)

Article Infectious Diseases

EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count

Stefania Paolucci et al.

Summary: This study monitored the immunologic profile and opportunistic viral DNA increase in Italian patients with COVID-19 to identify markers of disease severity. It found a correlation between reduced CD8(+) T cells and NK counts, elevated EBV DNA levels, and COVID-19 severity, highlighting the importance of further evaluating the relationship between EBV load and disease severity in longitudinal studies.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Article Infectious Diseases

Clinical characteristics and outcomes of critically ill patients with acute COVID-19 with Epstein-Barr virus reactivation

Yun Xie et al.

Summary: This retrospective single-center study found that COVID-19 patients with EBV reactivation had higher rates of tachypnoea, greater decreases in lymphocyte and albumin levels, higher levels of D-dimer and serum calcium, higher rates of CRP and occurrence of respiratory failure, ARDS, and hypoproteinaemia, as well as significantly higher 28-day and 14-day mortality rates compared to patients without EBV reactivation. These patients also received more immuno-supportive treatment.

BMC INFECTIOUS DISEASES (2021)

Editorial Material Health Care Sciences & Services

Conducting proportional meta-analysis in different types of systematic reviews: a guide for synthesisers of evidence

Timothy Hugh Barker et al.

Summary: Proportional meta-analysis is an increasingly common technique for synthesizing single group data, sharing similarities with comparative meta-analysis. However, there is a scarcity of methodological guidance available to assist synthesisers of evidence in the conduct of proportional meta-analysis in systematic reviews.

BMC MEDICAL RESEARCH METHODOLOGY (2021)

Article Multidisciplinary Sciences

Positive Epstein-Barr virus detection in coronavirus disease 2019 (COVID-19) patients

Ting Chen et al.

Summary: This study revealed a high incidence of EBV coinfection in COVID-19 patients. Coinfection with EBV and SARS-CoV-2 was associated with fever and increased inflammation, indicating a potentially more severe condition.

SCIENTIFIC REPORTS (2021)

Article Microbiology

Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation

Jeffrey E. Gold et al.

Summary: The study found a prevalence of 30.3% for long COVID symptoms among COVID-19 patients, with some initially asymptomatic patients developing long-term symptoms. Additionally, a significantly higher rate of EBV reactivation was observed in long COVID subjects compared to control subjects, suggesting a potential association between COVID-19 inflammation and EBV reactivation.

PATHOGENS (2021)

Article Infectious Diseases

Herpesvirus reactivation during severe COVID-19 and high rate of immune defect

A. Saade et al.

Summary: The study found that the incidence of herpesvirus reactivation in patients treated in the ICU for severe COVID-19 was high, but in most cases did not require antiviral treatment. Pre-existing hematological malignancy and solid organ transplantation were independently associated with viral reactivation, but viral reactivation was not associated with mortality.

INFECTIOUS DISEASES NOW (2021)

Review Medicine, General & Internal

Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement

David Moher et al.

PLOS MEDICINE (2009)