期刊
INTERNATIONAL JOURNAL OF CARDIOLOGY
卷 368, 期 -, 页码 78-84出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.ijcard.2022.08.033
关键词
Obesity; Visceral fat; Arterial stiffness; Left ventricular remodeling; Type 2 diabetes
资金
- Science and Technology Planning Project of Shenzhen Municipality
- Young Scientific Talent Research Project of China Endocrinology and Metabolism
- [JCYJ20210324130204011]
- [2021-N-03]
This study investigated the association of fat distribution, arterial stiffness, left ventricular (LV) structure and diastolic function in T2DM patients. The results indicated that visceral fat might impact LV remodeling through changes in arterial stiffness, thus influencing diastolic function in T2DM patients.
Aims: Visceral fat (VF) influences left ventricular (LV) structure and diastolic function in type 2 diabetes (T2DM). However, there are limited data on the association among them based on different BMI levels as well as ac-counting for arterial stiffness. This study investigated the association of fat distribution, arterial stiffness, left ventricular (LV) structure and diastolic function in T2DM patients. Materials and methods: This cross-sectional study comprised 905 patients. VF area (VFA) and subcutaneous fat area (SFA) were assessed by a dual bioelectrical impedance analyzer. Brachial-ankle pulse wave velocity (baPWV) was measured by a volume-plethysmographic apparatus and LV structure and diastolic function were echocardiography. Patients were divided into three groups based on BMI levels. Linear and logistic regression analysis were used to investigate the association.Results: In multivariate linear regression, relative wall thickness (RWT) was negatively correlated with E/A in obese patients (beta =-0.203, p = 0.004). LV mass/height2.7 was positively correlated with E/E' in normal weight (beta = 0.232, p = 0.002) and obese patients (beta = 0.232, p = 0.008). In multivariate logistic regression, baPWV was an independent determinant of LV remodeling (LVRM) in normal weight (OR = 1.001; 95% CI, 1.000, 1.002; P = 0.006), overweight (OR = 1.001; 95% CI, 1.000, 1.002; P = 0.008) and obese groups (OR = 1.003; 95% CI, 1.001, 1.004; P = 0.001), while VFA was correlated with arterial stiffness in normal weight (OR =1.032; 95% CI, 1.017, 1.047; P < 0.001) and overweight groups (OR = 1.011; 95% CI, 1.002, 1.021; P = 0.015).Conclusions: VF might impact LVRM through changes in baPWV in T2DM patients, thus influencing diastolic function.
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