Cancer stem cell-immune cell collusion in immunotherapy

Article Oncology

The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1

Hongzhong Li et al.

Summary: Antihistamines can improve survival in cancer patients by reversing T cell dysfunction through modulation of histamine receptor H1 (HRH1), thereby enhancing immunotherapy responses.

CANCER CELL (2022)

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Article Biochemistry & Molecular Biology

Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma

Zhengrong Ren et al.

Summary: This study identifies the Sox9/CXCL5 axis as an endogenous factor in controlling HCC cell growth and invasion, and raises the possibility of pharmacologic intervention with CXCL5/CXCR2 pathway inhibitors in therapy for HCC patients with higher Sox9 expression.

FEBS JOURNAL (2022)

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Article Immunology

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Kebria Hezaveh et al.

Summary: The study demonstrates the critical role of AhR in the function of tumor-associated macrophages (TAMs) in PDAC, showing that deletion of Ahr reduces PDAC growth, increases the frequency of IFN CD8(+) T cells, and dietary tryptophan metabolism affects AhR activity through the conversion of tryptophan to indoles by Lactobacillus. High AHR expression in PDAC patients is associated with disease progression, mortality, and an immune-suppressive TAM phenotype, indicating a conserved regulatory axis in human disease.

IMMUNITY (2022)

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Article Biotechnology & Applied Microbiology

The foundations of immune checkpoint blockade and the ipilimumab approval decennial

Alan J. Korman et al.

Summary: Cancer immunotherapy has significantly impacted patient survival in multiple high-incidence cancer indications over the past decade, mainly due to the success of immune checkpoint blockade (ICB) drugs. These drugs block specific pathways to attenuate T cell activation, prevent, or reverse, acquired peripheral tolerance, leading to their effectiveness.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Review Oncology

Hallmarks of Cancer: New Dimensions

Douglas Hanahan

Summary: The concept of the hallmarks of cancer is a tool for simplifying the complexity of cancer phenotypes and genotypes into basic principles. This article proposes phenotypic plasticity and disrupted differentiation as distinct hallmark capabilities, and discusses nonmutational epigenetic reprogramming and polymorphic microbiomes as enabling characteristics. Additionally, the importance of senescent cells in the tumor microenvironment is highlighted. The integrative concept of the hallmarks of cancer helps in understanding the mechanisms of cancer development and applying that knowledge to cancer medicine.

CANCER DISCOVERY (2022)

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Article Oncology

Novel molecular regulators of breast cancer stem cell plasticity and heterogeneity

Rui Zhang et al.

Summary: Tumors are comprised of different cell populations, and the heterogeneity of tumor cells plays crucial roles in tumorigenesis, metastasis, recurrence and resistance to anti-cancer therapies. Cancer stem cells (CSCs) have been found to promote these processes and contribute to tumor heterogeneity. CD24-CD44+ and ALDH+ are commonly used markers for breast cancer stem cells (BCSCs). It has been observed that different markers for BCSCs label distinct subpopulations, indicating the heterogeneity of BCSCs. Therefore, understanding the regulatory mechanisms of heterogeneous BCSCs is essential for targeted therapies and effectively treating breast cancer.

SEMINARS IN CANCER BIOLOGY (2022)

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Article Gastroenterology & Hepatology

Combination of Sulindac and Eflornithine Delays the Need for Lower Gastrointestinal Surgery in Patients With Familial Adenomatous Polyposis: Post Hoc Analysis of a Randomized Clinical Trial

Francesc Balaguer et al.

Summary: The combination therapy of eflornithine and sulindac is superior to monotherapy in delaying or preventing the need for lower GI tract surgery in patients with familial adenomatous polyposis.

DISEASES OF THE COLON & RECTUM (2022)

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Article Cell Biology

The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

Hai Wang et al.

Summary: The metabolite TMAO in the microbiota of breast cancer patients enhances the response to immunotherapy by promoting an activated immune microenvironment.

CELL METABOLISM (2022)

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Article Immunology

Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing cells in renal cell cancer

Maxime Meylan et al.

Summary: The presence of intratumoral tertiary lymphoid structures (TLS) is associated with positive clinical outcomes and responses to immunotherapy in renal cell carcinoma (RCC). B cells are enriched in TLS and demonstrate diverse maturation stages, with the presence of fully mature clonotypes. Additionally, IgG-and IgA-producing plasma cells (PCs) disseminate into the tumor beds along fibroblastic tracks in TLS+ tumors, indicating potential anti-tumor effector activity. Furthermore, the presence of IgG-stained tumor cells correlates with therapeutic responses and progression-free survival in RCC patients treated with immune checkpoint inhibitors.

IMMUNITY (2022)

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Review Oncology

Mismatch Repair-Deficient Colorectal Cancer: Building on Checkpoint Blockade

Zhaohui Jin et al.

Summary: Immunotherapy with immune checkpoint inhibitors (ICIs) has transformed the treatment of colorectal cancer (CRC) with deficient DNA mismatch repair (dMMR) by producing frequent and durable responses. However, resistance mechanisms and biomarkers to identify resistant patients are still needed. Understanding these mechanisms may lead to the development of novel strategies to overcome resistance and broaden the benefit of ICIs.

JOURNAL OF CLINICAL ONCOLOGY (2022)

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Article Gastroenterology & Hepatology

Loss of SIRT5 promotes bile acid-induced immunosuppressive microenvironment and hepatocarcinogenesis

Renqiang Sun et al.

Summary: This study uncovers a new function of SIRT5 in regulating bile acid metabolism to prevent tumor immune evasion and suppress HCC development.

JOURNAL OF HEPATOLOGY (2022)

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Article Gastroenterology & Hepatology

Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma

Guang-Yu Ding et al.

Summary: The prognostic value and functional involvement of tertiary lymphoid structures (TLSs) in intrahepatic cholangiocarcinoma (iCCA) were evaluated. The study found that the spatial distribution and abundance of TLSs significantly correlated with prognosis and provided a useful immune classification for iCCA. T follicular helper and regulatory T cells were identified as critical factors in determining the functional orientation of spatially different TLSs.

JOURNAL OF HEPATOLOGY (2022)

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Review Oncology

Preparing for CAR T cell therapy: patient selection, bridging therapies and lymphodepletion

Leila Amini et al.

Summary: Chimeric antigen receptor (CAR) T cell therapy is an effective treatment for certain hematological cancers. Successful CAR-T cell infusion requires timely preparation and consideration of various factors. This review provides a summary of the considerations in preparing patients for CAR-T cell therapy and highlights current limitations and future research areas.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Review Oncology

Context-dependent functions of pattern recognition receptors in cancer

Si Ming Man et al.

Summary: The immune system plays a critical role in cancer, and while the importance of adaptive immunity has been recognized and utilized in immunotherapy, the potential of innate immunity has not been fully exploited. Pattern recognition receptors (PRRs) have emerged as key regulators in the immune response to cancer, both in immune cells and cancer cells. Targeting PRRs shows promise in cancer drug development and biomarker discovery.

NATURE REVIEWS CANCER (2022)

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Review Oncology

CAR T cell therapies for patients with multiple myeloma

Lekha Mikkilineni et al.

Summary: Despite significant therapeutic advancements, multiple myeloma (MM) remains incurable, highlighting the necessity for new treatment strategies. CAR T cell therapy, which targets specific cell-surface antigens, has shown promise in achieving objective responses in patients with relapsed and/or refractory MM. Further research is being conducted to improve the efficacy and safety of these therapies, with a focus on identifying new target antigens and enhancing BCMA expression on MM cells.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

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Article Dermatology

Predictive Factors of Non-Response to Vismodegib in Locally Advanced Basal-Cell Carcinoma

Helene Marescassier et al.

Summary: In a retrospective multicenter study, factors associated with non-response to vismodegib in patients with locally advanced basal cell carcinomas (laBCC) were identified. Muscle involvement, history of radiotherapy, and intermittent use of vismodegib were significantly associated with non-response. Further studies are needed to confirm these findings due to the limited sample size.

DERMATOLOGY (2021)

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Article Biochemistry & Molecular Biology

Cell softness regulates tumorigenicity and stemness of cancer cells

Jiadi Lv et al.

Summary: Microfluidic devices can sort cancer stem cells into mechanically stiff and soft subpopulations, with soft tumor cells showing higher tumorigenicity. The upregulation of Wnt signaling protein BCL9L in soft tumor cells is associated with their stemness and tumorigenicity. These findings suggest that intrinsic softness can serve as a unique marker for highly tumorigenic and metastatic tumor cells.

EMBO JOURNAL (2021)

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Review Oncology

NK cell upraise in the dark world of cancer stem cells

Alireza Shokouhifar et al.

Summary: NK cells have emerged as important immune cells with the ability to kill CSCs, and the development of CAR-NK cells technology has brought more efficient NK cells, increasing hope for cancer treatment.

CANCER CELL INTERNATIONAL (2021)

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Article Oncology

ALDH1A1 Activity in Tumor-Initiating Cells Remodels Myeloid-Derived Suppressor Cells to Promote Breast Cancer Progression

Cuicui Liu et al.

Summary: The enzymatic activity of ALDH1A1 promotes breast tumor growth by decreasing intracellular pH and triggering NFkB signaling. Inhibitors of ALDH1A1 and activation of T-cell immunity can cooperatively inhibit tumor growth. ALDH1A1 induces MDSC expansion and creates a pro-cancer immune microenvironment in breast cancer, suggesting a new therapeutic target.

CANCER RESEARCH (2021)

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Article Oncology

ALKBH5 Facilitates Hypoxia-Induced Paraspeckle Assembly and IL8 Secretion to Generate an Immunosuppressive Tumor Microenvironment

Feng Dong et al.

Summary: This study reveals that hypoxia-induced upregulation of m(6)A demethylase ALKBH5 leads to the formation of NEAT1-mediated paraspeckles, resulting in increased CXCL8/IL8 expression and enhanced TAM recruitment and tumor progression in GBM. The findings provide evidence for the link between hypoxia-induced epitranscriptomic changes and the formation of an immunosuppressive microenvironment.

CANCER RESEARCH (2021)

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Review Biochemistry & Molecular Biology

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

Golnaz Morad et al.

Summary: This passage discusses the unprecedented advances in cancer treatment with immune checkpoint blockade (ICB), highlighting the critical need for insights into factors intrinsic and extrinsic to the host that impact ICB response and toxicity. There has been substantial progress in understanding the impact of host-intrinsic factors and the exposome on host physiology and response to treatment, representing the hallmarks of response, resistance, and toxicity to ICB in current day.

CELL (2021)

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Review Cell Biology

Cancer Stemness Meets Immunity: From Mechanism to Therapy

Peiwen Chen et al.

Summary: This review explores the symbiotic interactions between cancer stem cells and immune cells, highlighting the importance of tumor-associated macrophages, myeloid-derived suppressor cells, and T cells in maintaining CSC stemness and survival niche. It also discusses therapeutic strategies targeting this co-dependency to disrupt tumor-promoting ecosystems.

CELL REPORTS (2021)

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Article Oncology

Targeting the Sonic Hedgehog Pathway to Suppress the Expression of the Cancer Stem Cell (CSC)-Related Transcription Factors and CSC-Driven Thyroid Tumor Growth

Yurong Lu et al.

Summary: The Sonic Hedgehog (Shh) pathway plays a crucial role in regulating thyroid cancer stem cell self-renewal, with inhibition of this pathway showing potential in preventing tumor initiation driven by thyroid cancer stem cells.

CANCERS (2021)

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Review Cell & Tissue Engineering

Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors

Courtney L. Jones et al.

Summary: The article explores the significance of malignant stem cells in leukemia and how targeting energy metabolism can offer more effective treatment options for leukemia patients. It discusses the metabolic properties of leukemia stem cells and compares them with malignant stem cells from solid tumors.

CELL STEM CELL (2021)

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Article Oncology

Phase 1 study of single-agent WNT974, a first-in-class Porcupine inhibitor, in patients with advanced solid tumours

Jordi Rodon et al.

Summary: The Phase 1 study evaluated the safety and efficacy of Porcupine inhibitor WNT974 in patients with advanced solid tumours. The recommended dose for expansion was 10 mg once-daily, with dysgeusia being the most common adverse event. The study suggested that WNT974 may influence immune cell recruitment to tumours and enhance checkpoint inhibitor activity.

BRITISH JOURNAL OF CANCER (2021)

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Article Cell & Tissue Engineering

CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

Cheng Wang et al.

Summary: Cancer stem cells (CSCs) evade immune surveillance by upregulating the immune checkpoint molecule CD276, but can be eliminated by anti-CD276 antibodies, inhibiting tumor growth and lymph node metastases. Targeting CD276 may reduce CSCs in head and neck squamous cell carcinoma (HNSCC).

CELL STEM CELL (2021)

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Article Oncology

MEVITEM-a phase I/II trial of vismodegib plus temozolomide vs temozolomide in patients with recurrent/refractory medulloblastoma with Sonic Hedgehog pathway activation

Didier Frappaz et al.

Summary: The study evaluated the treatment of SHH recurrent/refractory adult medulloblastoma with vismodegib + temozolomide and found no improvement in 6-month progression-free survival. Further refinements are needed for predicting sensitivity to vismodegib.

NEURO-ONCOLOGY (2021)

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Review Biochemistry & Molecular Biology

Failure of Immunotherapy-The Molecular and Immunological Origin of Immunotherapy Resistance in Lung Cancer

Justyna Blach et al.

Summary: Immune checkpoint inhibitors have a significant impact on clinical treatment outcomes in NSCLC, but many patients develop resistance to this therapy. Currently, there is a lack of reliable biomarkers for predicting sensitivity to immune therapy. Research is focused on using immunotherapy in combination with other treatment strategies to increase cancer immunogenicity by targeting immune checkpoints and the tumor microenvironment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Cell Biology

Translational control of stem cell function

James A. Saba et al.

Summary: Stem cells are characterized by their ability to self-renew and differentiate into different cell types, and recent studies have shown that their behavior is closely tied to the regulation of protein synthesis by the ribosome. Understanding how translation mechanisms control stem cell function, including pluripotency and differentiation, may provide insights into mechanisms of tumorigenesis.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

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Article Oncology

Tumor Microenvironment-Derived R-spondins Enhance Antitumor Immunity to Suppress Tumor Growth and Sensitize for Immune Checkpoint Blockade Therapy

Yuting Tang et al.

Summary: R-spondin 3 expression is associated with favorable prognosis and enhances infiltration and function of NK cells and T cells in tumors, leading to tumor regression, and also increases tumor sensitivity to anti-PD-1 therapy.

CANCER DISCOVERY (2021)

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Review Oncology

The impact of mitochondria on cancer treatment resistance

Michelle van der Merwe et al.

Summary: Research has shown that mitochondria play a significant role in promoting treatment resistance in cancer cells, such as through mutations leading to the accumulation of oncometabolites, or stromal cells providing intact mitochondria to restore function. Targeting mitochondria may be an effective strategy to mitigate treatment resistance.

CELLULAR ONCOLOGY (2021)

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Article Dermatology

Key Clinical Adverse Events in Patients with Advanced Basal Cell Carcinoma Treated with Sonidegib or Vismodegib: A Post Hoc Analysis

Ralf Gutzmer et al.

Summary: This analysis compared the incidence and onset of adverse events in patients treated with sonidegib and vismodegib for basal cell carcinoma. Sonidegib-treated patients experienced lower incidence and delayed onset of adverse events compared to those treated with vismodegib.

DERMATOLOGY AND THERAPY (2021)

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Review Oncology

Cancer stem cell-immune cell crosstalk in tumour progression

Defne Bayik et al.

Summary: The development of tumors is affected by cellular heterogeneity and an immunosuppressive tumor microenvironment, which interact with each other and lead to therapeutic resistance. The interaction between cancer stem cells and infiltrating immune cell populations in the tumor microenvironment promotes tumor development and immune evasion.

NATURE REVIEWS CANCER (2021)

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Article Biochemical Research Methods

Generation of a squamous cell carcinoma mouse model for lineage tracing of BMI1+ cancer stem cells

Demeng Chen et al.

Summary: Cancer stem cells expressing BMI1 are crucial in the development, progression, therapy resistance, recurrence, and metastasis of head and neck squamous cell carcinoma (HNSCC). A chemically-induced HNSCC mouse model genetically and pathologically similar to human HNSCC is presented, along with a genetic lineage tracing protocol to study the regulation and targeting of BMI1+ CSCs in primary tumors and lymph node metastases. For detailed information, refer to Chen et al. (2017) and Jia et al. (2020).

STAR PROTOCOLS (2021)

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Review Medicine, Research & Experimental

Turning cold tumors into hot tumors by improving T-cell infiltration

Yuan-Tong Liu et al.

Summary: Immunotherapy, particularly through immune checkpoint inhibitors, has significantly improved the treatment of malignant tumors by enhancing T cell infiltration into tumors. Understanding the mechanisms underlying cold tumors, which lack T cell infiltration, is crucial to improving immunotherapy efficacy. Strategies to transform cold tumors into hot tumors and increase T cell infiltration are discussed, along with the potential of nanomedicines in enhancing tumor immunotherapy.

THERANOSTICS (2021)

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Review Oncology

Linking EMT programmes to normal and neoplastic epithelial stem cells

Arthur W. Lambert et al.

Summary: Epithelial stem cells play critical roles in tissue generation, maintenance, and repair, while cancer stem cells are implicated in the growth and recurrence of many carcinomas. The activation of epithelial-mesenchymal transition (EMT) is linked to the formation of both normal and neoplastic stem cells, but the mechanistic basis of this connection remains unclear. Understanding the elusive links between EMT programs and the stem cell state will advance our knowledge of normal stem cell biology and cancer pathogenesis.

NATURE REVIEWS CANCER (2021)

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Article Oncology

Integrin β4-Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis

Shasha Ruan et al.

CANCER RESEARCH (2020)

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Article Oncology

CAR T cells: continuation in a revolution of immunotherapy

Anurag K Singh et al.

LANCET ONCOLOGY (2020)

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Review Oncology

Targeting signalling pathways and the immune microenvironment of cancer stem cells - a clinical update

Joseph A. Clara et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

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Review Multidisciplinary Sciences

Neoadjuvant checkpoint blockade for cancer immunotherapy

Suzanne L. Topalian et al.

SCIENCE (2020)

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Article Multidisciplinary Sciences

Inhibiting WNT and NOTCH in renal cancer stem cells and the implications for human patients

Annika Fendler et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Myeloid-derived suppressor cells promote epithelial ovarian cancer cell stemness by inducing the CSF2/p-STAT3 signalling pathway

Xiaofeng Li et al.

FEBS JOURNAL (2020)

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Review Oncology

Emerging agents that target signaling pathways in cancer stem cells

Yue Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Oncology

Tumor-infiltrating regulatory T cells, CD8/Treg ratio, and cancer stem cells are correlated with lymph node metastasis in patients with early breast cancer

Luis Alberto Solis-Castillo et al.

BREAST CANCER (2020)

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Article Ophthalmology

Outcomes of Vismodegib for Periocular Locally Advanced Basal Cell Carcinoma From an Open-label Trial

Meydan Ben Ishai et al.

JAMA OPHTHALMOLOGY (2020)

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Review Immunology

Inducers, Attractors and Modulators of CD4+ Treg Cells in Non-Small-Cell Lung Cancer

Mengxiao Xie et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cell Biology

Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways

Phuong Doan et al.

CELLS (2020)

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Article Cell Biology

Overcoming Wnt-β-catenin dependent anticancer therapy resistance in leukaemia stem cells

John M. Perry et al.

NATURE CELL BIOLOGY (2020)

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Article Oncology

The role of myeloid-derived suppressor cells in increasing cancer stem-like cells and promoting PD-L1 expression in epithelial ovarian cancer

Naoko Komura et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2020)

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Article Oncology

Effect of Low-dose and Standard-dose Aspirin on PGE2 Biosynthesis Among Individuals with Colorectal Adenomas: A Randomized Clinical Trial

David A. Drew et al.

CANCER PREVENTION RESEARCH (2020)

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Article Cell & Tissue Engineering

BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

Lingfei Jia et al.

CELL STEM CELL (2020)

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Article Immunology

Differential IRF8 Transcription Factor Requirement Defines Two Pathways of Dendritic Cell Development in Humans

Urszula Cytlak et al.

IMMUNITY (2020)

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Article Oncology

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

Chia-Sing Lu et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

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Article Oncology

Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells

Karina E. Gomez et al.

CANCER RESEARCH (2020)

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Review Chemistry, Multidisciplinary

Cancer stem cell-targeted bio-imaging and chemotherapeutic perspective

Jiyou Han et al.

CHEMICAL SOCIETY REVIEWS (2020)

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Article Geriatrics & Gerontology

Tumor-Derived Soluble MICA Obstructs the NKG2D Pathway to Restrain NK Cytotoxicity

Qizhi Luo et al.

AGING AND DISEASE (2020)

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Article Medicine, Research & Experimental

HIF-1α-regulated miR-1275 maintains stem cell-like phenotypes and promotes the progression of LUAD by simultaneously activating Wnt/β-catenin and Notch signaling

Neng Jiang et al.

THERANOSTICS (2020)

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Review Biochemistry & Molecular Biology

Targeting cancer stem cell pathways for cancer therapy

Liqun Yang et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Article Gastroenterology & Hepatology

Intra-tumoral tertiary lymphoid structures are associated with a low risk of early recurrence of hepatocellular carcinoma

Julien Calderaro et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Cell Biology

Inhibiting Glutamine-Dependent mTORC1 Activation Ameliorates Liver Cancers Driven by β-Catenin Mutations

Adeola O. Adebayo Michael et al.

CELL METABOLISM (2019)

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Article Oncology

Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer

Wei-Lun Hwang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Oncology

MicroRNA-92 Expression in CD133+ Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGFβ

Chris Shidal et al.

CANCER RESEARCH (2019)

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Article Oncology

CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

Xing Li et al.

EXPERIMENTAL CELL RESEARCH (2019)

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Review Oncology

Recent Advances Targeting CCR5 for Cancer and Its Role in Immuno-Oncology

Xuanmao Jiao et al.

CANCER RESEARCH (2019)

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Article Gastroenterology & Hepatology

Reduction of immunosuppressive tumor microenvironment in cholangiocarcinoma by ex vivo targeting immune checkpoint molecules

Guoying Zhou et al.

JOURNAL OF HEPATOLOGY (2019)

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Article Biochemistry & Molecular Biology

A new strategy for enhancing antitumor immune response using dendritic cells loaded with chemo-resistant cancer stem-like cells in experimental mice model

Nahla E. El-Ashmawy et al.

MOLECULAR IMMUNOLOGY (2019)

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Review Biotechnology & Applied Microbiology

Optimizing oncolytic virotherapy in cancer treatment

Kevin Harrington et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

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Article Oncology

Ovarian cancer stem cells and macrophages reciprocally interact through the WNT pathway to promote pro-tumoral and malignant phenotypes in 3D engineered microenvironments

Shreya Raghavan et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Article Oncology

Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study

Daniel Morgensztern et al.

CLINICAL CANCER RESEARCH (2019)

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Review Oncology

The great debate at Immunotherapy Bridge 2018, Naples, November 29th, 2018

Paolo A. Ascierto et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

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Review Oncology

Tumor-intrinsic signaling pathways: key roles in the regulation of the immunosuppressive tumor microenvironment

Li Yang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Article Plant Sciences

Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis

Luo Chen et al.

PHYTOMEDICINE (2019)

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Article Oncology

Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk

Tao Sun et al.

CANCER RESEARCH (2019)

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Article Biochemistry & Molecular Biology

IL-8-induced O-GlcNAc modification via GLUT3 and GFAT regulates cancer stem cell-like properties in colon and lung cancer cells

Masahiro Shimizu et al.

ONCOGENE (2019)

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Article Oncology

Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer

Hai Huang et al.

CLINICAL CANCER RESEARCH (2018)

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Review Oncology

Treatment resistance in urothelial carcinoma: an evolutionary perspective

Panagiotis J. Vlachostergios et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

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Article Cell Biology

Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer

Kristiaan J. Lenos et al.

NATURE CELL BIOLOGY (2018)

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Article Immunology

Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer

Gemma A. Foulds et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Article Immunology

Ovarian cancer stem cells promote tumour immune privilege and invasion via CCL5 and regulatory T cells

Y. You et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2018)

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Article Oncology

Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis)

Shivaani Kummar et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

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Article Biochemistry & Molecular Biology

Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

Sherif Abdelaziz Ibrahim et al.

MOLECULAR CANCER (2017)

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Article Cell Biology

Differential effects on lung and bone metastasis of breast cancer by Wnt signalling inhibitor DKK1

Xueqian Zhuang et al.

NATURE CELL BIOLOGY (2017)

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Review Oncology

Monitoring immune-checkpoint blockade: response evaluation and biomarker development

Mizuki Nishino et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Article Multidisciplinary Sciences

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