Chitosan - dextran phosphate carbamate hydrogels for locally controlled co-delivery of doxorubicin and indomethacin: From computation study to in vivo pharmacokinetics

Article Biochemistry & Molecular Biology

Polyester Dendrimers Based on Bis-MPA for Doxorubicin Delivery

Mara Goncalves et al.

Summary: The study evaluated the potential of bis-MPA-based dendrimers as delivery vehicles for doxorubicin and found that surface functionalization could affect drug delivery properties.

BIOMACROMOLECULES (2022)

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Article Biochemistry & Molecular Biology

Cytocompatible drug delivery hydrogels based on carboxymethylagarose/chitosan pH-responsive polyelectrolyte complexes

J. Andres Ortiz et al.

Summary: In this study, pH-responsive CMA/CS hydrogels were prepared and the model drug DS was successfully loaded into the PCE. The results showed that the hydrogels had high loading capacity and release efficiency. Cell viability assay demonstrated the non-toxic nature of the hydrogels. Therefore, CMA/CS PECs can be applied for dermal drug delivery.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2022)

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Article Chemistry, Multidisciplinary

Coaxial electrospray of uniform polylactide core-shell microparticles for long-acting contraceptive

Jie Tang et al.

Summary: This study aimed to develop an injectable poly(D,L-lactide) (PLA) microparticle for sustained release of contraceptive hormone, etonogestrel (ENG). The ENG-cs-MPs prepared by the coaxial electrospray method showed high drug loading, high encapsulation efficiency, and long-term stable release, suggesting their potential as a long-acting injectable contraceptive with improved pharmacokinetic profile.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Applied

Chitosan-reinforced PHB hydrogel and aerogel monoliths fabricated by phase separation with the solvent-exchange method

Jiseon Kang et al.

Summary: In this study, poly(3-hydroxybutyrate) (PHB) organogel monoliths were prepared using nonsolvent-induced phase separation (NIPS) and loaded with chitosan (CS). The resulting composite hydrogels exhibited excellent injectability and thixotropy, and could be freeze-dried into composite aerogels with improved compressive modulus/collapse strength. The presence of CS also affected the gel crystallization and structure, and the drug release behavior was influenced by the charge interactions between drugs and CS.

CARBOHYDRATE POLYMERS (2022)

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Article Pharmacology & Pharmacy

Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration

Bhanu Teja Surikutchi et al.

Summary: A drug-loaded hydrogel has been developed for drug delivery into the peritoneal cavity. The hydrogel's stability and drug release properties were evaluated through in vitro and in vivo experiments. This hydrogel has potential applications as a biodegradable drug delivery system that can be implanted in the peritoneal cavity.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2022)

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Article Pharmacology & Pharmacy

Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats

Xuguang Zhang et al.

Summary: Alpinia officinarum alters the pharmacokinetic parameters of indomethacin, reducing its systemic exposure and increasing elimination. Co-administration of A. officinarum does not reduce indomethacin accumulation in target tissues, but accelerates excretion of indomethacin and its metabolites. This suggests that A. officinarum may have a gastrointestinal protective effect through interactions with indomethacin in rats.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2021)

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Article Chemistry, Physical

Adsorption of eosin Y on polyelectrolyte complexes based on chitosan and arabinogalactan sulfate

Nina Slyusarenko et al.

Summary: Positively charged polyelectrolyte complexes (PECs) were synthesized from chitosan and arabinogalactan sulfate by self-assembly method, showing potential high efficiency in adsorption for medical and environmental purposes, with a high adsorption capacity for eosin Y dye. The synthesized PECs demonstrated high colloidal stability and removal efficiency of dye at low pH values, making them attractive eco-friendly dye adsorbents with improved biocompatibility.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2021)

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Article Chemistry, Applied

New insights into physicochemical aspects involved in the formation of polyelectrolyte complexes based on chitosan and dextran sulfate

Suzana Goncalves Carvalho et al.

Summary: The study evaluates the influence of pH, molecular weight, and polymeric proportion on the formation of polyelectrolyte complexes based on chitosan:dextran sulfate. Results showed that nanoparticles with an excess of polycation formed aggregates, while an excess of dextran sulfate reduced the size of the particles. The graph of zeta potential as a function of pH is a promising tool in the choice of polymers and a better pH condition for the development of polyelectrolyte complexes.

CARBOHYDRATE POLYMERS (2021)

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Article Biochemistry & Molecular Biology

Biodegradable polyelectrolyte complexes of chitosan and partially crosslinked dextran phosphate with potential for biomedical applications

Sergey O. Solomevich et al.

Summary: Polyelectrolyte complexes (PECs) formed by mixing oppositely charged polyelectrolyte solutions without organic solvents and chemical crosslinkers are potential carriers for drug delivery. Biodegradable antimicrobial polyelectrolyte complexes of chitosan - dextran phosphate (DPCS) containing cefazolin were developed, showing good in vitro biocompatibility, pH sensitivity and sustained drug release, as well as antimicrobial activity against Escherichia coli and Staphylococcus aureus. The tunable degradation behavior and high antibacterial efficacy of drug-loaded hydrogels make them promising materials for biomedical applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Engineering, Biomedical

Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds

Rossella Laurano et al.

Bioactive Materials (2021)

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Article Pharmacology & Pharmacy

Cancer-specific calcium nanoregulator suppressing the generation and circulation of circulating tumor cell clusters for enhanced anti-metastasis combinational chemotherapy

Dan Li et al.

Summary: The study introduces cancer-specific calcium nanoregulators to suppress the generation and circulation of CTC clusters, providing a novel approach for anti-metastasis combinational chemotherapy.

ACTA PHARMACEUTICA SINICA B (2021)

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Article Biochemistry & Molecular Biology

Injectable, Self-Healing, and Biocompatible N,O-Carboxymethyl Chitosan/Multialdehyde Guar Gum Hydrogels for Sustained Anticancer Drug Delivery

Ashiq Hussain Pandit et al.

Summary: The synthesized N,O-CMCS/MAGG hydrogel showed promising applications in localized delivery of anticancer drugs. The hydrogel exhibited pH-responsive swelling behavior, good mechanical properties, excellent self-healing and thixotropic properties due to the reversible Schiff base linkages. The Dox-loaded hydrogel demonstrated significant killing effect against breast cancer cells, indicating its potential in anticancer drug delivery.

BIOMACROMOLECULES (2021)

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Article Biochemistry & Molecular Biology

Study on polysaccharide polyelectrolyte complex and fabrication of alginate/chitosan derivative composite fibers

Tongyao Zhao et al.

Summary: The study focused on the binary blending of sodium alginate and quaternary ammonium chitosan to fabricate composite fibers. The results showed changes in solution state and electrical potential at different mass ratios, leading to the production of fibers with excellent properties.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Materials Science, Multidisciplinary

Millimeter-sized chitosan/dextran phosphate capsules and calcium/ dextran phosphate beads for regulating prospidine release

Sergey O. Solomevich et al.

Summary: In this study, calcium/dextran phosphate beads (Ca-DP) and chitosan/dextran phosphate capsules (CS-DP) were synthesized as potential drug delivery systems through ionic gelation method and formation of polyelectrolyte complexes. The experiments showed that they had low cytotoxicity and prolonged release effect on prospidine.

MATERIALS LETTERS (2021)

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Article Pharmacology & Pharmacy

Formulation development and evaluation of lidocaine hydrochloride loaded in chitosan-pectin-hyaluronic acid polyelectrolyte complex for dry socket treatment

Nuttawut Supachawaroj et al.

Summary: This study evaluated a lidocaine hydrochloride-loaded chitosan-pectin-hyaluronic polyelectrolyte complex for rapid onset and sustained release in dry socket wound treatment. The complex demonstrated appropriate release characteristics, non-cytotoxicity, and good stability in high hyaluronic acid formulations, making it a promising candidate for future topical oral formulations.

SAUDI PHARMACEUTICAL JOURNAL (2021)

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Article Chemistry, Physical

Illustration of potential energy surface from DFT calculation along with fuzzy logic modelling for optimization of N-acetylglycine

N. Kanagathara et al.

Summary: In this study, the energy optimization of the N-acetylglycine molecule using a fuzzy logic scheme was supported by Density Functional Theory results. Vibrational frequencies were computed to identify the functional groups in the molecule, and the best torsional angles were compared between fuzzy logic input and DFT results, showing reliable information about structure optimization.

COMPUTATIONAL AND THEORETICAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

Control and Preparation of Quaternized Chitosan and Carboxymethyl Chitosan Nanoscale Polyelectrolyte Complexes Based on Reactive Flash Nanoprecipitation

Rizwan Ahmed et al.

Summary: Nanoscale polyelectrolyte complex materials have been extensively studied for their potential applications in protocell, drug carriers, imaging, and catalysis. By utilizing reactive flash nanoprecipitation (RFNP), a more homogeneous mixing and preparation process for these materials has been achieved, resulting in stable nanoscale complexes with controllable size and narrow size distribution. The method allows for continuous and tunable production of these complexes, showing promise for practical translation in the future.

ACS OMEGA (2021)

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Article Biochemistry & Molecular Biology

Understanding co-loading of doxorubicin and camptothecin on graphene and folic acid-conjugated graphene for targeting drug delivery: classical MD simulation and DFT calculation

Abutaleb Alinejad et al.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2020)

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Review Chemistry, Applied

Chitosan-based Colloidal Polyelectrolyte Complexes for Drug Delivery: A Review

Danjun Wu et al.

CARBOHYDRATE POLYMERS (2020)

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Article Chemistry, Applied

Indomethacin-grafted and pH-sensitive dextran micelles for overcoming inflammation-mediated multidrug resistance in breast cancer

Xiaoli Zeng et al.

CARBOHYDRATE POLYMERS (2020)

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Review Polymer Science

Challenges in developing of chitosan - Based polyelectrolyte complexes as a platform for mucosal and skin drug delivery

Joanna Potas et al.

EUROPEAN POLYMER JOURNAL (2020)

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Article Biochemistry & Molecular Biology

Chitosan-Chondroitin sulfate based polyelectrolyte complex for effective management of chronic wounds

Swati Sharma et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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Article Chemistry, Physical

Acid-Base Properties and Biological Activity of Starch Phosphate Microgels

T. L. Yurkshtovich et al.

COLLOID JOURNAL (2019)

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Article Pharmacology & Pharmacy

Oxaliplatin-loaded chemically cross-linked hydrogels for prevention of postoperative abdominal adhesion and colorectal cancer therapy

Jee Eun Lee et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2019)

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Article Chemistry, Physical

Salt formation of two BCS II drugs (indomethacin and naproxen) with (1R, 2R)-1,2-diphenylethylenediamine: Crystal structures, solubility and thermodynamics analysis

Qiang Fu et al.

JOURNAL OF MOLECULAR STRUCTURE (2019)

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Article Engineering, Chemical

Theoretical Study of the Adsorption Process of Antimalarial Drugs into Acrylamide-Base Hydrogel Model Using DFT Methods: The First Approach to the Rational Design of a Controlled Drug Delivery System

Eliceo Cortes et al.

PROCESSES (2019)

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Article Chemistry, Applied

Development of a fluid-absorptive alginate-chitosan bioplatform for potential application as a wound dressing

Hillary Mndlovu et al.

CARBOHYDRATE POLYMERS (2019)

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Article Polymer Science

Self-healable hyaluronic acid/chitosan polyelectrolyte complex hydrogels and multilayers

Nagore Barroso et al.

EUROPEAN POLYMER JOURNAL (2019)

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Article Chemistry, Applied

Biodegradable pH-sensitive prospidine-loaded dextran phosphate based hydrogels for local tumor therapy

Sergey O. Solomevich et al.

CARBOHYDRATE POLYMERS (2019)

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Article Chemistry, Applied

Doxorubicin/cisplatin co-loaded hyaluronic acid/chitosan-based nanoparticles for in vitro synergistic combination chemotherapy of breast cancer

Yaping Wang et al.

CARBOHYDRATE POLYMERS (2019)

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Article Polymer Science

pH-responsive chitosan/alginate polyelectrolyte complex membranes reinforced by tripolyphosphate

Magdalena Gierszewska et al.

EUROPEAN POLYMER JOURNAL (2018)

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Article Spectroscopy

A combined molecular dynamics simulation and quantum mechanics study on mercaptopurine interaction with the cucurbit [6,7] urils: Analysis of electronic structure

Maryam Zaboli et al.

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY (2018)

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Review Oncology

Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018

J. Ferlay et al.

EUROPEAN JOURNAL OF CANCER (2018)

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Article Chemistry, Applied

Chitosan coated-phosphorylated starch films: Water interaction, transparency and antibacterial properties

Danila Merino et al.

REACTIVE & FUNCTIONAL POLYMERS (2018)

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Article Polymer Science

Elastic-Plastic Transformation of Polyelectrolyte Complex Hydrogels from Chitosan and Sodium Hyaluronate

Ran Shi et al.

MACROMOLECULES (2018)

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Article Pharmacology & Pharmacy

Shear-responsive injectable supramolecular hydrogel releasing doxorubicin loaded micelles with pH-sensitivity for local tumor chemotherapy

Zhijia Liu et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Chemistry, Physical

Assessment of solvent effects on the interaction of Carmustine drug with the pristine and COOH-functionalized single-walled carbon nanotubes: A DFT perspective

Rabeeh Khorram et al.

JOURNAL OF MOLECULAR LIQUIDS (2017)

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Review Cell Biology

Cancer-Incidence, prevalence and mortality in the oldest-old. A comprehensive review

Shantell C. Nolen et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2017)

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Article Pharmacology & Pharmacy

Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid

Suhua Li et al.

ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Review Pharmacology & Pharmacy

A comprehensive review on polyelectrolyte complexes

Venkata S. Meka et al.

DRUG DISCOVERY TODAY (2017)

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Article Engineering, Biomedical

Chemosensitizing indomethacin-conjugated chitosan oligosaccharide nanoparticles for tumor-targeted drug delivery

Jae-Young Lee et al.

ACTA BIOMATERIALIA (2017)

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Article Chemistry, Applied

Preparation and characterization of chitosan physical hydrogels with enhanced mechanical and antibacterial properties

Peng Li et al.

CARBOHYDRATE POLYMERS (2017)

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Article Chemistry, Applied

Influence of the Properties of Modified Dextran Hydrogel Polymer Network on the Kinetics of the Release of Prospidin Antitumor Agent

S. O. Solomevich et al.

RUSSIAN JOURNAL OF APPLIED CHEMISTRY (2016)

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Article Polymer Science

Study on Alginate-Chitosan Complex Formed with Different Polymers Ratio

Dominika Kulig et al.

POLYMERS (2016)

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Article Chemistry, Applied

Liposome-loaded chitosan physical hydrogel: Toward a promising delayed-release biosystem

Aurelien Billard et al.

CARBOHYDRATE POLYMERS (2015)

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Article Biochemistry & Molecular Biology

Production and Evaluation of Dry Alginate-Chitosan Microcapsules as an Enteric Delivery Vehicle for Probiotic Bacteria

Michael T. Cook et al.

BIOMACROMOLECULES (2011)

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Article Oncology

Indomethacin and SC236 enhance the cytotoxicity of doxorubicin in human hepatocellular carcinoma cells via inhibiting P-glycoprotein and MRP1 expression

Cai-Guo Ye et al.

CANCER LETTERS (2011)

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Article Biochemistry & Molecular Biology

Preparation and chemical and biological characterization of a pectin/chitosan polyelectrolyte complex scaffold for possible bone tissue engineering applications

P. Coimbra et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2011)

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Article Oncology

Celecoxib inhibits MDR1 expression through COX-2-dependent mechanism in human hepatocellular carcinoma (HepG2) cell line

Karnati R. Roy et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2010)

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Article Polymer Science

Characterization and biodegradation of chitosan-alginate polyelectrolyte complexes

Xiaoxia Li et al.

POLYMER DEGRADATION AND STABILITY (2009)

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Article Pharmacology & Pharmacy

Chitosan-carboxymethylcellulose interpolymer complexes for gastric-specific delivery of clarithromycin

M. Gomez-Burgaz et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2008)

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Article Biochemical Research Methods

A rapid and sensitive microscale HPLC method for the determination of indomethacin in plasma of premature neonates with patent ductus arteriousus

MA Al Za'abi et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2006)

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Article Chemistry, Medicinal

Modulation of MRP-1-mediated multidrug resistance by indomethacin analogues

C Rosenbaum et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

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Chitosan - dextran phosphate carbamate hydrogels for locally controlled co-delivery of doxorubicin and indomethacin: From computation study to in vivo pharmacokinetics

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