期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 228, 期 -, 页码 273-285出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2022.12.243
关键词
Chitosan; Dextran phosphate carbamate; Polyelectrolyte complexes; Drug release; Co -delivery; Pharmacokinetics
In this study, all-polysaccharide biodegradable polyelectrolyte complex hydrogels (DPCS) based on dextran phos-phate carbamate (DP) and chitosan (CS) were developed for controlled co-delivery of the anticancer drug doxorubicin (DOX) and the non-steroidal anti-inflammatory drug indomethacin (IND). The release profile of both drugs from the hydrogels was tuned by changing the molecular weight and functional groups content of the polysaccharides. The optimized DPCS showed a steady release of DOX both in vitro and in vivo, and a gradual release of IND, making it a promising long-acting polysaccharide-based antitumor platform.
The development of synergistic drug combinations is a promising strategy for effective cancer suppression. Here, we report all-polysaccharide biodegradable polyelectrolyte complex hydrogels (DPCS) based on dextran phos-phate carbamate (DP) and chitosan (CS) for controlled co-delivery of the anticancer drug doxorubicin (DOX) and the non-steroidal anti-inflammatory drug indomethacin (IND). IND can induce more apoptosis in tumor cells by reducing the level of multidrug resistance-associated protein 1. Based on calculations using density functional theory and zeta potential analysis data, carriers with high drug loading were obtained. The release profile of both drugs from the hydrogels was tuned by changing the molecular weight and functional groups content of the polysaccharides. The optimized DPCS showed a steady release of DOX both in vitro and in vivo, and a gradual release of IND, which constantly induced the action of DOX. Considering all of these benefits, DOX-and IND-loaded DPCS offer a promising long-acting polysaccharide-based antitumor platform.
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