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A comprehensive review on pharmaceutical uses of plant-derived biopolysaccharides

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ELSEVIER
DOI: 10.1016/j.ijbiomac.2023.123454

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Plant -based sources; Biopolysaccharides; Pharmaceutical excipient

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Biopolysaccharides extracted from plants have gained significant attention as pharmaceutical excipients in various dosage forms due to their wide availability, sustainable production, easy extraction methods, aqueous solubility, swelling capability, non-toxicity, and biodegradability. This comprehensive review highlights the extensive use of plant-derived biopolysaccharides as effective pharmaceutical excipients in the formulation of different dosage forms such as gels, pastes, films, emulsions, suspensions, capsules, tablets, nanoparticles, microparticles, beads, buccal formulations, transdermal formulations, ocular formulations, nasal formulations, etc.
Biopolysaccharides extracted from plants are mainly photosynthetic byproducts found in leaves, pods, stems, fruits, grains, seeds, corms, rhizomes, roots, bark exudates, and other plant parts. Recently, these plant-derived biopolysaccharides have received a great deal of attention as pharmaceutical excipients in a range of different dosage forms because of several key advantages, such as widespread accessibility from nature as plant-based sources are readily available, sustainable production, availability of easy and cost-effective extraction methodologies, aqueous solubility, swelling capability in the aqueous medium, non-toxicity, biodegradability, etc. The current review presents a comprehensive overview of the uses of plant-derived biopolysaccharides as effective pharmaceutical excipients in the formulations of different kinds of dosage forms, for example gels, pastes, films, emulsions, suspensions, capsules, tablets, nanoparticles, microparticles, beads, buccal formulations, transdermal formulations, ocular formulations, nasal formulations, etc.

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