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Article
Engineering, Biomedical
Qinghao Zhang et al.
Summary: Exposure to a growth factor abundant milieu has significant regenerative effects on organ diseases, tissue damage, and regeneration. However, traditional approaches face challenges with limited types of growth factors and the asynchronous activation of stem cells. This study reports the development of a innovative hydrogel that can mimic a growth factor-enriched microenvironment, leading to improved bone regeneration and enhanced cytokine secretion.
BIOACTIVE MATERIALS
(2023)
Article
Polymer Science
Aparna Yerra et al.
Summary: The developed silk fibroin-based extracellular electrospun nanofibrous matrix showed positive effects on wound healing, antimicrobial sensitivity activity, and promotion of cell proliferation without losing the chemical properties of antibiotics.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Materials Science, Biomaterials
Jiawei Wei et al.
Summary: This study successfully prepared HA/PLGA three-dimensional porous scaffolds with similar composition to natural bone and strong mechanical strength. By modifying HA microspheres, the scaffolds showed improved composition, structure, mechanical properties, and degradability. In vitro and in vivo experiments demonstrated that the HA/PLGA composite scaffold with 45wt% HA exhibited the best performance in terms of cell compatibility and osteogenic activity. The prepared HA/PLGA composite scaffold with HA microsphere reinforcement has promising application potential in the field of large bone defect repair.
BIOMATERIALS ADVANCES
(2022)
Review
Pharmacology & Pharmacy
Zhaoju Gao et al.
Summary: Diabetic wounds are complications of diabetes caused by skin dystrophy due to local ischemia and hypoxia. Electrospun nanofibers, with their similar structure to the extracellular matrix, promote the formation of new skin tissue at the wound. The composition, size, and drug release of electrospun nanofiber membranes can be easily adjusted, and their porous structure allows for gas exchange and exudate absorption at the wound. Electrospun fibers have great potential in the treatment of diabetic wounds.
Article
Engineering, Multidisciplinary
Liang Song et al.
Summary: This study reports on a biomaterial formulation that prevents soft tissue migration into bone defects through a barrier membrane, leading to successful bone regeneration. The nanofibrous membrane, encapsulating EGCG, demonstrates desirable properties and sustained release capability, resulting in repair of 70% of the defect area.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Daniel A. Canales et al.
Summary: Electrospun fibers of poly (lactic acid) (PLA) containing bioactive glass and magnesium oxide nanoparticles were prepared for bone tissue engineering. The addition of these nanoparticles increased the bioactivity and antimicrobial behavior of the PLA fibers. The presence of bioactive glass resulted in the precipitation of hydroxyapatite structures on the fiber surface, while magnesium oxide nanoparticles exhibited antimicrobial properties. The different composites also enhanced alkaline phosphatase expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Hossein Mirmusavi et al.
Summary: This study fabricated electrospun nanocomposite scaffolds based on polycaprolactone (PCL)-chitosan/carboxyl-functionalized multi-walled carbon nanotubes (MWCNTs) with different concentrations of MWCNTs. The scaffolds were characterized and it was found that the scaffold containing 0.5 wt% MWCNTs had the smallest fiber diameter and highest tensile strength, with a porosity suitable for tissue engineering. Increasing the MWCNTs content decreased the water contact angle and increased the scaffold's crystallinity, leading to enhanced bioactivity and stability for cartilage healing. Chondrocytes cultured on the scaffold with MWCNTs showed good viability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Wenhao Wang et al.
Summary: Regardless of the advancement of synthetic bone substitutes, allograft-derived bone substitutes still dominate in the orthopaedic circle in the treatments of bone diseases. Nevertheless, the stringent devitalization process jeopardizes their osseointegration with host bone and therefore prone to long-term failure. Hence, improving osseointegration and transplantation efficiency remains important. The alteration of bone tissue microenvironment (TME) to facilitate osseointegration has been generally recognized.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Han Shang et al.
Summary: This research presents a microwave-assisted functionalization approach for enhancing the affinity and mechanical properties of wood fibers (FWFs) in PLA composite films. The addition of FWFs significantly increases the tensile strength and toughness of the films, while also providing excellent UV-blocking properties. UV-barrier packaging for perishable fruits has been successfully fabricated using FWFs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mehdi Movahedi et al.
Summary: A fibrous scaffold composed of PHB-starch/HNTs, produced via electrospinning, demonstrated improved textural properties, including decreased fiber diameter, increased tensile strength, and enhanced surface hydrophilicity. The scaffold supported chondrocyte cell growth and attachment, making it a potential candidate for cartilage tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Runyi Mao et al.
Summary: This study developed a piezoelectric nerve conduit using a composite of PCL/ZnO nanofiber, which demonstrated faster and superior sciatic nerve repair compared to conventional materials. The piezoelectric stimulation from PZNF increased the expression of nerve growth factor/vascular endothelial growth factor and activated downstream pathways, leading to accelerated nerve repair and function recovery. This novel strategy offers potential for rapid peripheral nerve regeneration.
Article
Biochemistry & Molecular Biology
Huan Xu et al.
Summary: The anisotropic hierarchical structures of naturally derived materials have been used as design principles to fabricate high-strength and functional materials. In this study, a structure-by-bionics approach was used to create pea pod-mimicking architecture for poly(lactic acid) (PLA) composites incorporated with hydroxyapatite nanowhiskers (HANWs). The resulting structured PLA composites showed improved mechanical properties and bioactivity, making them promising for guided bone/tissue regeneration therapy.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Lv Ke et al.
Summary: This study proposes an environmentally friendly and efficient method to improve the performance of poly(lactic acid) (PLA) packaging materials using microwave-assisted functionalization. The resulting PLA biocomposites have high mechanical properties, exceptional resistance to heat deflection, excellent water barrier performance, nearly 100% UV-blocking ratio, and resistance to high temperature deformation. This method provides a way for the elegant implementation of high-heat and UV-resistant packaging materials with natural fibers that have a high affinity to PLA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Mohammadalipour et al.
Summary: The choice of materials and preparation methods are crucial for the characteristics of scaffolds. In this study, cellulose nanofibers were used as nano-additives to prepare a polyhydroxybutyrate (PHB) based nanocomposite scaffold. The properties of the PHB/CNF scaffold were compared with pure PHB, and the results showed improvements in crystallinity, water contact angle, degradation rate, biomineralization, toughness factor, and surface roughness. Moreover, the PC nanocomposite demonstrated better cell viability and spreading, indicating its potential in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Esra Altay Ozturk et al.
Summary: In this study, Mg-Al layered double hydroxide nanoparticles were synthesized and used as inorganic fillers to enhance the mechanical properties of poly(lactic acid)/poly(ethylene oxide) electrospun composite fibers. The addition of the nanoparticles significantly improved the tensile strength and elongation at break of the composite fibers, while maintaining good cytocompatibility for cell attachment and proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Cell & Tissue Engineering
Hongpu Wei et al.
Summary: Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. To address this problem, researchers have designed various implantable biomaterials that can play a role in bone therapy and regeneration. External physical stimuli, endogenous disease microenvironments, and multiple integrated strategies can improve bone tissue therapy and regeneration.
Article
Engineering, Biomedical
Lu Liu et al.
Summary: The study found that BMSCs-derived exosomes stimulated by strontium-substituted calcium silicate significantly promoted in vitro angiogenesis of HUVECs, and accelerated vascularized bone regeneration in zebrafish and rat models.
ACTA BIOMATERIALIA
(2021)
Article
Biotechnology & Applied Microbiology
En-ji Cheon et al.
Summary: The composite of beta-TCP and collagen (beta-TCP/col) showed a comparable bone-regenerating ability to the most commercially available Bio-Oss Collagen (R), inducing significantly accelerated bone formation in in vitro and in vivo experiments. Cells on the beta-TCP/col scaffold exhibited higher expression levels of osteogenic differentiation marker genes compared to Bio-Oss/col scaffold, indicating the potential of beta-TCP/col as a substitute for bone substitute materials.
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2021)
Article
Materials Science, Biomaterials
Jian Xie et al.
Summary: Electrospun fiber scaffolds, mimicking the bone extracellular matrix, have become important biomaterials in bone tissue engineering. The topographic cues of aligned nanofibers were found to significantly influence BMSCs cellular responses, including morphology, migration, proliferation, and osteogenesis. Aligned nanofiber scaffolds demonstrated higher osteogenic induction proficiency compared to aligned microfibers and random fiber substrates.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Huihua Yuan et al.
Summary: The study developed highly-aligned poly(L-lactic acid) fibers decorated with type 1 collagen and chondroitin sulfate, which showed enhanced tenogenic differentiation of human mesenchymal stem cells in vitro. The biomimetic fibers promoted cell spreading and proliferation, increased expression of tendon-associated genes and proteins, and activated the TGF-beta signaling pathway. Animal study validated the promoting role of these fibers in tendon regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Farzana Nazir et al.
Summary: In this study, a novel poly(l-lactic acid)/cyclo olefin copolymer/nanohydroxyapatite (PLLA/COC10-nHA) scaffold was successfully developed for bone-tissue regeneration and repair. Compared to PLLA/nHA, PLLA/COC10-nHA exhibited better morphology and dispersion of nanoparticles, higher crystallinity, improved mechanical properties, and enhanced antibacterial activity.
Article
Biochemistry & Molecular Biology
Aysegul Gul et al.
Summary: This review discusses the recent advances in using electrospun antibacterial nanomaterials for wound dressings, highlighting the importance of this technology in wound healing and discussing the current research and patent situation.
Review
Dentistry, Oral Surgery & Medicine
Bowen Tan et al.
Summary: Maxillofacial tumours not only involve dealing with the tumours themselves, but also repairing jaw bone defects. Utilizing biomaterials can enhance tumour treatment efficiency, reduce recurrence and metastasis, and provide new promising anti-tumour therapies for patients.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2021)
Article
Orthopedics
Zeyu Fu et al.
Summary: The review discusses the importance and applications of polyester/hydroxyapatite (polyester/HA) composites in bone tissue repairing, as well as their properties and geometries. Results show that polyester/HA composites have ideal osteogenic abilities, appropriate mechanical strength, and good biodegradability.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Engineering, Biomedical
Bin Yu et al.
Summary: The study developed a HCBG for promoting bone regeneration, overcoming the drawbacks of traditional ISPGs, and successfully achieving enhanced osteogenesis differentiation of bone marrow mesenchymal stem cells in vitro and bone regeneration in vivo.
Article
Engineering, Chemical
Huan Xu et al.
Summary: By directly electrospinning microfibers impregnated with coffee-ground-derived quantum dots, osteoconductive and antibacterial porous poly(lactic acid) membranes can be fabricated, allowing for regulation of microfiber diameter and distribution, as well as enhancing hydrophilicity. The quantum dots have high affinity to the PLA matrix, leading to a significant increase in tensile strength and elastic modulus of the QD-modified PLA membranes while maintaining extensibility. Additionally, osteoblast adhesion and stretching are greatly enhanced on the electrospun membranes with the presence of quantum dots, resulting in improved cell viability and biomimetic mineralization.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Physical
Hotaka Kawai et al.
Summary: This study demonstrated that u-HA/PLLA had greater bioactive bone conductivity and higher biocompatibility for direct bone attachment compared to u-HA/PLLA/PGA, with the potential for bone formation in the stroma.
Review
Biotechnology & Applied Microbiology
Devan L. Puhl et al.
Summary: Electrospun fiber scaffolds mimic the structure of the nervous system extracellular matrix and provide contact guidance for regenerating axons. Glial cells respond differently to fiber alignment, diameter, surface nanotopography, and surface chemistry, offering potential for design and optimization of electrospun fiber scaffolds to target glial cell response in nerve injury and regeneration. Additionally, electrospun fibers can be loaded with therapeutics for local, sustained release to alter glial cell phenotype and support regeneration.
BIOENGINEERING-BASEL
(2021)
Review
Medicine, Research & Experimental
Filippo Migliorini et al.
Summary: Various surgical strategies are available for managing large bone defects, with autologous graft being the most commonly used for reconstruction due to its optimal properties. However, the choice of the best surgical technique is still debated, and no consensus has been reached.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Surgery
Anderson S. M. Leung et al.
Summary: This study reported the histological outcome of a pelvic recycled frozen autograft, which showed no obvious sign of revitalization, patchy inflammation, no residual tumor, only fibrous union, but remained mechanically stable.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2021)
Article
Materials Science, Multidisciplinary
Huan Xu et al.
Summary: Despite the technological feasibility and industrial scalability of toughening PLA by direct blending, maintaining mechanical strength and full renewability remains a challenge. The synthesis of low-molecular-weight PEF-b-PLA copolymer provided a biobased alternative with partial miscibility with PLA, leading to improved toughness and strength in PLA blends. Additionally, the nanostructured dispersion phase formed due to favorable interfacial adhesion and the UV-shielding properties of the functional groups on the PEF blocks contribute to the potential use of these copolymers in functional packing materials.
ACS APPLIED POLYMER MATERIALS
(2021)
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Materials Science, Multidisciplinary
Afarin Karimi Tar et al.
MATERIALS TECHNOLOGY
(2020)
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Optics
Junjie Wen et al.
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Mohamad Alsaadi et al.
POLYMER COMPOSITES
(2020)
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Chemistry, Multidisciplinary
Xin Xing et al.
ARABIAN JOURNAL OF CHEMISTRY
(2020)
Article
Materials Science, Ceramics
Xinhui Geng et al.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2020)
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Z. X. Deng et al.
PROCESS BIOCHEMISTRY
(2020)
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Carlos Alberto Amaral Valladao Jr et al.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2020)
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Liang Cheng et al.
Review
Biotechnology & Applied Microbiology
Badri Narayanan Narasimhan et al.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
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Biyun Li et al.
Review
Chemistry, Multidisciplinary
Yu Zhuang et al.
FRONTIERS IN CHEMISTRY
(2019)
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Yili Zhao et al.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2019)
Review
Cell & Tissue Engineering
Qi Zhang et al.
CURRENT STEM CELL RESEARCH & THERAPY
(2018)
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Weili Shao et al.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
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Engineering, Biomedical
Shahrzad Rayatpisheh et al.
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Kaili Lin et al.
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SR Kim et al.
