期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 61, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2023.106710
关键词
Antimicrobial stewardship; Antibiotic spectrum index; Paediatric; Intensive care
This study aimed to evaluate antibiotic use in different patient groups in a pediatric intensive care unit using the antibiotic spectrum index (ASI). The results showed that ASI/antibiotic days increased with age and immunocompromised patients used broader-spectrum antibiotics. The study revealed complex changes in antibiotic consumption and prescribing in the pediatric hospital, and ASI can be used to identify patient groups and time periods where broader-spectrum antibiotics are used.
Objectives: Antibiotic spectrum index (ASI) is a recently developed antimicrobial stewardship (AMS) tool that aims to classify antibiotics based on activity against clinically relevant bacterial pathogens.Methods: We utilised ASI in a 2-year retrospective study between April 2019 and April 2021 in four paediatric intensive care units of a specialist UK children's hospital to quantify antibiotic use based on age, presence of immunosuppression and AMS input. We then compared ASI to days of therapy (DOT) to determine the utility of this AMS metric. We have made changes to Gerber's original ASI list and score of antibiotics to align with prescribing and resistance patterns in the UK.Results: Median ASI/antibiotic days increased with age: for infants under 1 year of age 4.1 (IQR 4.0-4.3), for children 1-5 years 4.4 (IQR 4.0-4.6) and for children over 5 years 4.5 (IQR 4.1-4.6). Immunocompro-mised patients received much broader-spectrum antibiotics than immunocompetent patients throughout the whole study period. Patients who had AMS input had a higher ASI compared with those who did not throughout the whole period, likely due to more complex patients being discussed on such rounds.Conclusions: Our results show a complex picture of changing antibiotic consumption and prescribing in a large specialist paediatric hospital in the UK with a long-standing AMS programme before and through-out the COVID-19 pandemic. ASI shows less variability than DOT and can potentially be used to identify patient groups and time periods where broader-spectrum antibiotics are used to help guide further AMS effort s.(c) 2023 Elsevier Ltd and International Society of Antimicrobial Chemotherapy. All rights reserved.
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